ライフサイエンスコーパス: utricle

1 in all inner ear epithelia (saccule, lagena, utricle).

2 he dissection and culture of the adult mouse utricle.

3 caudal ends that fuse to form the prostatic utricle.

4 supporting cell proliferation in the mature utricle.

5 on spontaneous hair cell death in the chick utricle.

6 II beta-tubulin and beta-actin from the same utricle.

7 al canal and ampulla, as well as part of the utricle.

8 myosin Ibeta in hair bundles of the bullfrog utricle.

9 om hair cells in the epithelium of the mouse utricle.

10 hair cells) increased in all regions of the utricle.

11 ents associated with establishing PCP in the utricle.

12 liferation in a murine vestibular organ, the utricle.

13 ifferentiation, and PCP establishment in the utricle.

14 evelopment of a murine vestibular organ, the utricle.

15 -Seq) of hair cell regeneration in the chick utricle.

16 nd Pcdh15 and were not detected in the chick utricle.

17 en supporting cells in the gravity-sensitive utricle.

18 mechanoelectrical transduction in the turtle utricle.

19 the vestibular dark cells in the ampulla and utricle.

20 c and little proliferation occurred in mouse utricles.

21 of striolar supporting cells, even in adult utricles.

22 d recovery in saccules comparable to that in utricles.

23 eat-shocked utricles and the nonheat-shocked utricles.

24 of MST1/2 in chicken utricles than in mouse utricles.

25 g cells into hair cells in cisplatin-treated utricles.

26 led to striolar proliferation in adult mouse utricles.

27 epithelium of embryonic and 2-week-old mouse utricles.

28 ecipitated from purified hair bundles of rat utricle, 2w was the only site A variant detected; moreov

29 munolocalization of HCN protein in the mouse utricle, a mechanosensitive organ that contributes to th

30 generated and regenerated hair cells in the utricle, a vestibular organ detecting linear acceleratio

31 l phenotype during regeneration in the avian utricle, a vestibular organ that detects linear accelera

32 hic evidence that, in cultured postnatal rat utricles, a substantial number of hair cells can survive

33 Taller and more compact bundles of the mouse utricle account for this difference.

34 ere we show that HC damage in neonatal mouse utricle activates the Wnt target gene Lgr5 in striolar s

35 We asked whether hair cells of the mouse utricle adapt, and if so, whether the adaptation was sim

36 ion of YAP1 in supporting cells of the mouse utricle after short periods in organotypic culture.

37 ar translocation was observed in the chicken utricle after streptomycin treatment in vitro and in viv

38 contribute to hair cell regeneration in rat utricles after injury, it is very limited.

39 t-shocked utricles protected nonheat-shocked utricles against hair cell death.

40 Asynchrony within utricles allows reconstruction of the temporal progressi

41 lts indicated that hair cell survival in the utricle and ampulae does not require Cx30.

42 in both hair cells and support cells in the utricle and basilar papilla, and its expression does not

43 d in areas of cell proliferation in both the utricle and basilar papilla.

44 zed within sensory epithelia of the saccule, utricle and cochlea throughout development and into adul

45 complex, are differentially expressed in the utricle and contribute to frequency sensitivity in zebra

46 ells and surrounding cells, from cochlea and utricle and from E16 to P7, we performed a comprehensive

47 transcriptional landscape of the adult human utricle and its early response to ototoxic damage using

48 ore hair cell specification when the nascent utricle and saccule constitute a continuous prosensory d

49 lar canal crista, as well as a fusion of the utricle and saccule endolymphatic spaces into a common u

50 lineage tracing in Dreher mutants, where the utricle and saccule fail to segregate, labels a continuo

51 Only the utricle and saccule have an extremely dense matrix, the

52 ion and head position is the function of the utricle and saccule in mammals.

53 Otoconia are biominerals within the utricle and saccule of the inner ear that are critical f

54 ect in tlt homozygous mice is limited to the utricle and saccule of the inner ear, which completely l

55 The defect in het mutants is limited to the utricle and saccule of the inner ear, which completely l

56 nuclei and cerebellum similar to that of the utricle and saccule suggest that the primary role of the

57 Afferents innervating the utricle and saccule terminated generally in the lateral

58 In the utricle and saccule the hair cells are arranged in an or

59 a from experimental preparations of ampulla, utricle and saccule were found to be significantly highe

60 rcular canals and reduced innervation to the utricle and saccule were observed.

61 In addition, the maculae of the utricle and saccule were partially fused.

62 ead translations (detected by maculae of the utricle and saccule).

63 hatic duct and sac, in distinct areas of the utricle and saccule, and in the external sulcus region w

64 e striolar and extra-striolar regions of the utricle and saccule.

65 ng angular acceleration) and otolith organs (utricle and saccule; detecting linear acceleration, vibr

66 N) and vestibular hair cells in the saccule, utricle and semicircular canals.

67 splatin-induced hair cell death in the mouse utricle and suggest that treatment with EGCG may be a us

68 find that only a subset of hair cells in the utricle and the crista ampullaris express BK channels.

69 Comparisons of cell types from utricles and cochleae demonstrate divergence between aud

70 y suppresses YAP-TEAD signaling in mammalian utricles and contributes to maintaining the proliferativ

71 onditional hair cell ablation in adult mouse utricles and demonstrates that hair cells are spontaneou

72 mulated in supporting cell nuclei in chicken utricles and promoted regenerative proliferation, but YA

73 d STAT1 phosphorylation in cisplatin-treated utricles and resulted in concentration-dependent increas

74 ibular hair cell renewal in ototoxin-damaged utricles and the maturation of stereociliary bundle morp

75 ction was abolished in both the heat-shocked utricles and the nonheat-shocked utricles.

76 epletion of sensory cells in the saccule and utricle, and a complete loss of the horizontal semicircu

77 on patterns of Cx26 and Cx30 in the saccule, utricle, and ampulla by immunolabeling.

78 maining sensory epithelia (posterior crista, utricle, and cochlea) that closely corresponds to the de

79 and ventral projections from the saccule and utricle, and medial and dorsal projections from the lage

80 troma of the cristae ampullaris, the maculae utricle, and saccule in the human and mouse.

81 rnible IE substructures such as the cochlea, utricle, and saccule.

82 ing the auditory ganglion, cochlea, saccule, utricle, and semicircular canals.

83 ncluding three semicircular canals, saccule, utricle, and their associated sensory organs, detects an

84 sed within the striolar reversal zone of the utricle, and we show here that this regionalized express

85 ELISA in the media surrounding heat-shocked utricles, and depletion of HSP70 from the media abolishe

86 Similarly, inputs from the utricle are also segregated to distal regions, synapsing

87 Sensory hair cells (HCs) in the utricle are mechanoreceptors required to detect linear a

88 semicircular canals, endolymphatic duct and utricle, are malformed or absent.

89 In GSI-treated utricles as old as P12, differentiated striolar SCs conv

90 nd medial extrastriolar (MES) regions of the utricle at embryonic day 11.5 (E11.5), while cells in th

91 Here, we profiled mouse utricles at 14 time points, and defined transcriptomes o

92 related with morphological changes, we fixed utricles at different times between P0 and P28.

93 rmation of afferent nerve terminals in mouse utricles between postnatal days 0 (P0) and P17.

94 elow 5 Hz, within the frequency range of the utricle, but because it was incomplete, substantial resp

95 e/Cwe animals had very few hair cells in the utricle, but their ampullae and cochlea were devoid of a

96 iled to induce proliferation in neonatal rat utricles, but brief (</=1 hr) exposures to forskolin or

97 ve ablation of hair cells in the adult mouse utricle by inserting the human diphtheria toxin receptor

98 of opposite bundle orientation in embryonic utricles by live-imaging GFP-labeled centrioles in HCs.

99 Lesions in embryonic utricles closed in <24 h via localized expansion of supp

100 ated for their ability to reduce the size of utricles (comedolytic activity) in a rhino mouse model o

101 ratio was significantly elevated in rda/rda utricles compared with controls, and the level of ARF6-G

102 The utricle consists of two hair cell subtypes with distinct

103 e show that the regenerative response of the utricle correlates with a more accessible chromatin stru

104 this we used neomycin to kill hair cells in utricles cultured from mice of different ages and found

105 In utricles damaged ex vivo, both CMV-ATOH1 and GFAP-ATOH1

106 In utricles damaged in vivo, GFAP-ATOH1 induced regeneratio

107 close proximity between the saccules and the utricles, deeply grooved sulci on the saccular otoliths,

108 In the utricle, deletion at E14.5 or E16.5 did not cause cell d

109 Closer analysis of adult mouse utricles demonstrated that the basolateral processes of

110 -fold more abundant in vestibular schwannoma utricles, demonstrating the existence of ongoing regener

111 ngential nucleus, that are essential for the utricle-dependent VOR.

112 induced a local, dose-dependent reduction in utricle diameter after seven daily dermal doses.

113 In mature utricles, exogenous stimulation with lysophosphatidic ac

114 In both the undamaged and damaged utricle, fate-mapping and electrophysiology experiments

115 uting the BLB in the human vestibular macula utricle from normal and Meniere's disease.

116 In contrast, lesions in utricles from 2-week-old and older mice remained open ev

117 When heat-shocked utricles from Hsp70-/- mice were used in cocultures, pro

118 We used cultured utricles from mature Swiss Webster mice to investigate t

119 ter photobleaching (FRAP) of SC junctions in utricles from mice that express a gamma-actin-GFP fusion

120 In utricles from neonatal mice, time-lapse recordings in th

121 Here we procured live, mature utricles from organ donors and vestibular schwannoma pat

122 pha were assayed in organo-typic cultures of utricles from the mature, undamaged (normal) chicken inn

123 t proliferation increased tenfold in damaged utricles from the youngest neonates.

124 When we cultured utricles from young mice with gamma-secretase inhibitors

125 In the toadfish utricle, glutamatergic hair cells are present throughout

126 15 using mass spectrometry of purified chick utricle hair bundles, we did not detect USH1G.

127 w that HES7 is specifically expressed during utricle hair cell regeneration and closely parallels the

128 In rda/rda mice, cuticular plates of utricle hair cells initially formed normally, then degen

129 stereocilia actin dynamics in more than 500 utricle hair cells.

130 The utricle has a structure and hair cell orientation patter

131 cochlea, vestibular hair cells of the murine utricle have some regenerative capacity.

132 th widely expressed in the cochlear duct and utricle in an overlapping pattern, suggesting coexpressi

133 bundles in the extrastriolar regions of the utricle in Ptprq(-/-) mice become significantly longer t

134 ia also occurs in the striolar region of the utricle in Ptprq(-/-) mice, but is not accompanied by ha

135 tivated in the hair cells of the adult mouse utricle in response to neomycin exposure in vitro.

136 contrast to adults, HC ablation in neonatal utricles in vivo recruits Lgr5+ cells to regenerate stri

137 at high levels in stereocilia of the chicken utricle, in an approximate 1:1 molar ratio with radixin.

138 Genes up-regulated in the utricle included SMAD2, KIT, beta-AMYLOID, LOC51637, HMG

139 The human utricle is a vestibular organ essential for balance, a f

140 The utricle is composed of sensory and non-sensory cells, wh

141 n and its expression in the mouse vestibular utricle is restricted, resulting in two regions of oppos

142 t E11.5 in the future striolar region of the utricle, labeling hair cells following EdU birthdating,

143 in different regions of the lagena, saccule, utricle, macula neglecta, and cristae was characterized

144 n other annexin genes are expressed in mouse utricles, mass spectrometry showed that none were presen

145 st that gravity-sensing hair cells in murine utricles may increase in number during neonatal developm

146 cluded hypospadias, opacification of a small utricle (not in the patient with hypospadias), ejaculato

147 ulin, along with that for beta-actin, in the utricle of chicks after hair cell damage both in vitro a

148 otentials of short latency in the guinea pig utricle of either sex.

149 supernumerary hair cells in the cochlea and utricle of the inner ear.

150 egenerative capacity in acceleration-sensing utricles of chickens and mice of both sexes.

151 zed the cellular localization of YAP1 in the utricles of mice and chicks, both under normal condition

152 ar translocation of YAP1 was observed in the utricles of neonatal or mature mice after ototoxic injur

153 Both the epidermis and utricles of the VDR-null animals overexpress elements of

154 ated along one side of the LPR in the mature utricle or saccule, indicating that this boundary is fir

155 higher than that of sensory epithelium from utricle or saccule.

156 rientation-selectivity of afferents in mouse utricle or zebrafish neuromasts.

157 ked specific structures such as the cochlea, utricle, or saccule throughout late IE development.

158 Ventral to the mid-level of the presumptive utricle, Otx1 and Otx2 were co-expressed, in regions suc

159 After damage, the mammalian utricle partially restores the HC population and organ f

160 the number of BK-positive hair cells in the utricle peaks in juvenile rats and declines in early adu

161 Coculture with heat-shocked utricles protected nonheat-shocked utricles against hair

162 After damage, non-mammalian utricles regenerate HCs via both proliferation and direc

163 Supporting cells in those utricles remained compact and columnar and had significa

164 The inner ear utricle requires mechanosensory hair cells (HCs) to dete

165 periods, total RNA was extracted from single utricles, reverse transcribed to cDNA and the cDNA ampli

166 accompanied by significant expansion of the utricle's central zone, called the striola.

167 hich triggers proliferation and restores the utricle's growth; interfering with Yap's activity revers

168 ave a misshapen and smaller ear with a fused utricle, saccule, and cochlea and absent horizontal cana

169 ular attention was focused on the developing utricle, saccule, and cochlea.

170 e numbers of hair cells differentiate in the utricle, saccule, and cochlear base but sensory epitheli

171 ferents from the three otolithic organs (the utricle, saccule, and lagena) project to the intermediat

172 domains within the three macular organs, the utricle, saccule, and lagena, consistent with the report

173 t, including the mature semicircular canals, utricle, saccule, cochlear duct, endolymphatic duct and

174 Mice deficient in Rdh10 exhibit failure of utricle-saccule separation, otoconial formation and zona

175 lia of the three mechanoreceptor organs, the utricle/saccule, cristae, and cochlea, with distinct typ

176 munoreactive sensory epithelia of the macula utricle, sacule, and crista ampullaris, and the membrano

177 Sensory hair cells in the avian utricle SE are in a constant state of turnover, where dy

178 uished from that resulting in a reduction in utricle size.

179 We used this difference to enrich for utricle-specific genes, using reiterative cDNA subtracti

180 A subtraction and demonstrate enrichment for utricle-specific sequences.

181 cells of the sensory epithelium of the chick utricle subjected to aminoglycoside-induced damage under

182 ith a more accessible chromatin structure in utricle supporting cells compared to their cochlear coun

183 transcriptional and epigenetic responses of utricle supporting cells to damage and Atoh1 transductio

184 nner ear endorgans (the saccule, lagena, and utricle) synapse directly on the ipsilateral M-cell, the

185 e change and inhibition of MST1/2 in chicken utricles than in mouse utricles.

186 hroughout the sensory epithelium of cultured utricles that were isolated from adult mice of either se

187 d into a morphologically distinct structure (utricle) that maintains epidermal function.

188 agena as two separate pouches ventral to the utricle, the lungfish has a single large ventral pouch t

189 the anterior crista, the lateral crista, the utricle, the saccule, and both the basilar papilla and l

190 We report that in mouse utricles this electrophysiological differentiation occur

191 Although sparse, the projections of the utricle to the flocculus/ventral paraflocculus suggest a

192 dult mice of both sexes caused many cells in utricles to acquire features unique to type I hair cells

193 ir cells and support cells after exposure of utricles to cisplatin.

194 associated virus (AAV)9-PHP.B capsid via the utricle transduce both inner and outer hair cells of the

195 and organ cultures of the chick cochlea and utricle, we found that cisplatin treatment caused apopto

196 In the utricle, we observed high levels of alpha9 AChR expressi

197 pieces of sensory epithelia from the chicken utricle were cultured in glass microwells.

198 Chick utricles were cultured in media supplemented with the ot

199 Utricles were removed from 1-day-old chicks and incubate

200 Isolated exosomes from heat-shocked utricles were sufficient to improve survival of hair cel

201 he number of otoconia in the saccule and the utricle, were consistently observed in the Raldh3 mutant

202 mainly in the medial striolar region of the utricle, where they constitute at most 12% of hair cells

203 s regenerative proliferation in nonmammalian utricles, whereas constitutive LATS1/2 kinase activity s

204 abundant in a subpopulation of cells in the utricle, which undergoes continual postembryonic hair ce

205 three semicircular canals extending from the utricle, with the typical hair cell orientations, but th