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1 t CAR-T cells directed against HER2 can kill uveal and cutaneous melanoma cells in vitro and in vivo.
2 clinical translation of CAR-T cells against uveal and cutaneous melanoma that do not respond to TIL
3 ermline BAP1 mutations with a propensity for uveal and cutaneous melanomas and other internal maligna
5 als; as well as pathophysiologic features of uveal biocompatibility, capsular biocompatibility, and p
8 [51.1%] and 23 men [48.9%]) and 349 with OA-uveal DLBCL (192 women [55.0%] and 157 men [45.0%]) had
9 months; 95% CI, 14.2-61.8 months) than in OA-uveal DLBCL (96.0 months; 95% CI, 67.3-124.7 months; Man
11 RL was 41.4% (SE, 8.6%); among those with OA-uveal DLBCL, 59.1% (SE, 2.8%; Mantel-Cox test, P = .007)
14 ion with external drainage for nanophthalmic uveal effusion can provide immediate and stable gain in
15 report an unusual case of non-nanophthalmic uveal effusion syndrome (UES) with histologically normal
20 anterior chamber, where they caused profound uveal inflammation and release of proinflammatory cytoki
21 ent in 53 patients; 42 had massive posterior uveal invasion (>= 3 mm); 15 had concomitant peripapilla
27 tely half of the patients died of metastatic uveal melanoma (10-year rate, 48.5%; 95% CI, 43.0%-54.4%
28 uveal melanoma xenografts, 57 patients with uveal melanoma (17 patients whose tumors metastasized an
30 lignancies among BAP1 mutation carriers were uveal melanoma (n = 60 [28%]), mesothelioma (n = 48 [22%
33 e of genetic risk factors in the etiology of uveal melanoma (UM) has been strongly suggested, the gen
34 ound Overall survival (OS) for patients with uveal melanoma (UM) hepatic metastases is extremely poor
47 eration (SCD) has been observed in eyes with uveal melanoma (UM), but, to our knowledge, a definitive
48 n 1 (BAP1) are associated with metastasis in uveal melanoma (UM), the deadliest adult eye cancer.
49 11) proteins, occur in about 85% of cases of uveal melanoma (UM), the most common cancer of the adult
53 e been described in the following 5 genes in uveal melanoma (UM): BAP1, EIF1AX, GNA11, GNAQ, and SF3B
54 aluated 48 patients with local recurrence of uveal melanoma after primary treatment with brachytherap
56 52 studies, reporting on 1010 patients with uveal melanoma and 34 intraocular metastases, were eligi
57 ent selection criteria included diagnosis of uveal melanoma and adequate records to allow tumor stagi
58 ermline BAP1 mutations occur infrequently in uveal melanoma and are associated with larger tumors and
60 t is the most robust prognostic indicator in uveal melanoma and early studies of mostly larger tumors
61 responses were observed in one patient with uveal melanoma and four of 15 evaluable patients with RC
62 issense variants we identified are common in uveal melanoma and have been shown to constitutively act
63 between the BAP1 immunoreactivity of primary uveal melanoma and other clinicopathologic features.
68 Recent advances in the molecular genetics of uveal melanoma are revolutionizing our understanding of
69 mber 2013 among 120 patients with metastatic uveal melanoma at 15 academic oncology centers in the Un
70 Sampling of a clinically diagnosed posterior uveal melanoma at a single site for prognostic GEP testi
71 treated with primary proton beam therapy for uveal melanoma at the oncology service at Charite-Berlin
72 lopment of a new molecular classification of uveal melanoma based on a widely available 15-gene expre
73 linical macular edema is common in eyes with uveal melanoma before and at 4 months after plaque radio
74 Quantification of the risk of developing uveal melanoma can enhance counseling regarding surveill
77 t was studied in the conditioned medium of 9 uveal melanoma cell lines and in the blood serum samples
80 resistance in newly characterized metastatic uveal melanoma cell lines to clinical-grade MEK inhibito
81 ARF6 with a small-molecule inhibitor reduces uveal melanoma cell proliferation and tumorigenesis in a
82 ere, in a series of experiments, using human uveal melanoma cells (MEL 270), human embryonic kidney c
87 bility and for MC1R-specific cytotoxicity in uveal melanoma cells, and the lanthanum-DOTA-MC1RL analo
88 Galphaq promotes the YAP-dependent growth of uveal melanoma cells, thereby identifying YAP as a suita
94 ic FNAB had an unequivocal primary posterior uveal melanoma clinically, while patients who underwent
96 From the Wills Eye Hospital Oncology Service Uveal Melanoma Cytogenetic Database (N = 1172), 128 pati
97 every 4 months after plaque radiotherapy for uveal melanoma demonstrated OCT-evident macular edema, c
98 , whereas somatic Galpha11 mutations mediate uveal melanoma development by constitutively up-regulati
102 astatic death in 299 patients with posterior uveal melanoma evaluated by fine-needle aspiration biops
104 ent selection criteria included diagnosis of uveal melanoma from April 1, 2001, to April 1, 2011, ade
106 All patients with a clinical diagnosis of uveal melanoma from May 2009 to July 2013 who underwent
109 One patient without a family history of uveal melanoma had a single nucleotide substitution in t
115 se patients from 6 families had a history of uveal melanoma in 1 relative, and 2 patients from 2 addi
118 ons between vitamin D signaling elements and uveal melanoma in comparison to uveal tract encourage fu
121 ents who underwent secondary enucleation for uveal melanoma in the London Ocular Oncology Service, be
122 d, repeatable system for dividing metastatic uveal melanoma into distinct prognostic subgroups, espec
126 pression of the oncoprotein c-Met in primary uveal melanoma is associated with metastatic progression
127 loss following episcleral brachytherapy for uveal melanoma is difficult to predict for individual pa
128 results challenge the belief that metastatic uveal melanoma is immunotherapy resistant and support th
132 ion regarding the long-term risk of dying of uveal melanoma may be useful to clinicians when counseli
134 tin 1 receptor (MC1R) is expressed in 94% of uveal melanoma metastases, and a MC1R-specific ligand (M
141 of certain heterotrimeric G proteins, drive uveal melanoma oncogenesis by triggering multiple downst
143 onsecutive patients diagnosed with posterior uveal melanoma over a 5-year period who were evaluated w
147 rm outcomes concerning globe preservation in uveal melanoma patients after proton beam therapy with t
148 in vivo and a subset of liver metastases of uveal melanoma patients express activated forms of ERBB2
150 The age at diagnosis and the gender of the uveal melanoma patients with BAP1 germline pathogenic va
157 of proinflammatory genes in freshly cultured uveal melanoma samples was studied in an in vitro 24-hou
162 e after I-125 brachytherapy in patients with uveal melanoma treated and followed in a Spanish referra
163 dy reviewing data from patients with primary uveal melanoma treated between October 2003 and October
164 nd histology slides of patients with primary uveal melanoma treated by enucleation were reviewed.
166 onic lymphocytic leukemia, breast cancer and uveal melanoma tumor samples, we show that hundreds of c
167 Severe combined immunodeficient mice bearing uveal melanoma tumors or engineered MC1R-positive and -n
168 BASE for studies reporting survival data for uveal melanoma undergoing prognostic testing with chromo
169 sc-Met levels in patients with nonmetastatic uveal melanoma vs patients with metastatic uveal melanom
170 quencing from blood samples of patients with uveal melanoma was correlated with clinical characterist
171 Two hundred fifteen patients whose primary uveal melanoma was managed in the Helsinki University Ho
172 nts aged 45 to 79 years with newly diagnosed uveal melanoma was recruited between 2002 and 2004 from
174 Main prognostic factors for the death of uveal melanoma were ciliary body involvement (HR: 1.7 (9
175 l of 21 consecutive patients with metastatic uveal melanoma were enrolled between June 7, 2013, and S
178 tant Galpha11 proteins causing FHH2, ADH2 or uveal melanoma were transfected in CaSR-expressing HEK29
179 Indications for secondary enucleations for uveal melanoma were tumor recurrence, neovascular glauco
180 ariants in consecutive Finnish patients with uveal melanoma who come from a high-risk region for the
181 logy referral center among 507 patients with uveal melanoma who consented for collection of blood sam
182 ic variants of BAP1 in Finnish patients with uveal melanoma who live in a high-risk region for this c
183 survival in high-risk patients with primary uveal melanoma who received adjuvant sunitinib with inst
184 ce of 96 patients with clinical diagnosis of uveal melanoma who underwent prognostication at the time
186 cutive patients with a clinical diagnosis of uveal melanoma who were treated at the Cleveland Clinic
188 metastasis differs in patients with primary uveal melanoma with different grades of nuclear BAP1 imm
189 sion was found to be a peripapillary primary uveal melanoma with distinct non-pigmented and pigmented
191 al was significantly longer in patients with uveal melanoma with high nuclear BAP1 stain (P = 0.004).
192 nes and the blood serum samples of mice with uveal melanoma xenografts contained significant levels o
194 d in the blood serum samples of 24 mice with uveal melanoma xenografts, 57 patients with uveal melano
195 c uveal melanoma vs patients with metastatic uveal melanoma yielded an area under the curve of 0.82 (
197 y period 515 enucleations were performed for uveal melanoma, 99 (19%) of which were secondary enuclea
198 aluated the mechanisms of BETi resistance in uveal melanoma, a disease with little treatment options,
199 ying YAP as a suitable therapeutic target in uveal melanoma, a GNAQ/GNA11-initiated human malignancy.
202 enase [LDH]) perform poorly in patients with uveal melanoma, and the search for new biomarkers is nee
204 shed new light on the molecular genetics of uveal melanoma, delineating it as an atypical tumor of t
205 high local tumor control rates in recurrent uveal melanoma, especially if the primary therapy was tr
206 ing brachytherapy in patients with posterior uveal melanoma, given that an understanding of the recur
207 his analysis, we included 3088 patients with uveal melanoma, identified from a hospital-based cohort
208 etecting metastases in patients with primary uveal melanoma, if combined with LFT and, in case of any
209 naling pathways in the human uveal tract and uveal melanoma, including analysis of the expression of
210 ted protein-1 (BAP1) gene has been linked to uveal melanoma, mesothelioma, meningioma, renal cell car
212 on exists was derived from the prevalence of uveal melanoma, prevalence of germline BAP1 pathogenic v
213 s-generating study of patients with advanced uveal melanoma, selumetinib compared with chemotherapy r
216 ntroduce the first transgenic mouse model of uveal melanoma, which develops cancers induced by expres
217 therapies are greatly needed for metastatic uveal melanoma, which has a very poor prognosis with a m
218 ilimumab demonstrates activity in metastatic uveal melanoma, with deep and sustained confirmed respon
219 ee on Cancer's 7th Edition Classification of Uveal Melanoma," published online January 2, 2015, in JA
223 edle aspiration biopsy for cytopathology and uveal melanoma-specific GEP testing for molecular progno
262 r molecular prognostication in patients with uveal melanoma; however, class 1 and class 2 test result
263 Comprehensive multiplatform analysis of 80 uveal melanomas (UM) identifies four molecularly distinc
265 is associated with more benign behavior for uveal melanomas (UMs) with an otherwise high risk of met
266 is an efficacious primary method of treating uveal melanomas and intraocular metastases, with reliabl
269 ormed multi-region DNA sequencing of primary uveal melanomas and their matched metastases from 35 pat
272 egate the clinical outcomes of patients with uveal melanomas or intraocular metastases treated primar
273 EER database, the median age at diagnosis of uveal melanomas was 63 (range 3-99 years) with a male-to
274 nal experience with plaque brachytherapy for uveal melanomas with a focus on local control rates, fac
276 iated protein-1 (BAP1) expression of primary uveal melanomas without and with metastasis, and to anal
292 flammatory condition in which the retina and uveal tissues become a target of autoreactive immune cel
294 he vitamin D signaling pathways in the human uveal tract and uveal melanoma, including analysis of th
296 of new diagnostic and therapeutic methods in uveal tract disorders, especially in uveal melanoma.
298 elements and uveal melanoma in comparison to uveal tract encourage future clinical research with larg
299 nalysis supported a diagnosis of extraocular uveal tumor spread rather than a primary conjunctival tu