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1 recipients were infected with gB1 genotype (vaccine strain).
2 the single-dose group (p>=0.20 for the three vaccine strains).
3 structed using the live-attenuated HSV-1 VC2 vaccine strain.
4 ies barrier and warrants selection of an H10 vaccine strain.
5 ne, mg0359, unique to M. gallisepticum ts-11 vaccine strain.
6 protein in the background of the current MV vaccine strain.
7 tion inhibition antibody titers against each vaccine strain.
8 cally distinct from the current A(H1N1)pdm09 vaccine strain.
9 significantly lower levels than against the vaccine strain.
10 eason's B/Massachusetts/02/2012-like clade 2 vaccine strain.
11 ower in mice immunized with the conventional vaccine strain.
12 against the 2009 pandemic influenza A(H1N1) vaccine strain.
13 pulmonary infection with F. tularensis live vaccine strain.
14 pulmonary infection with F. tularensis live vaccine strain.
15 e L. major strain and its potential use as a vaccine strain.
16 2016 compared with the A/Hong Kong/4801/2014 vaccine strain.
17 lla (n = 2) or zoster (n = 2) due to the Oka/vaccine strain.
18 No child shed A/H1N1 vaccine strain.
19 tion and predict the efficacy of a candidate vaccine strain.
20 ses and examples of three different types of vaccine strain.
21 t to assist in monitoring disease due to Oka-vaccine strain.
22 3c2.A and 3c2.A2 H3N2 viruses, and the H1N1 vaccine strain.
23 ortugal/79906/2009 (H10N7) as a suitable H10 vaccine strain.
24 CHMI using Pf parasites heterologous to the vaccine strain.
25 lution and extensive virus passaging to make vaccine strains.
26 berculosis drugs and attenuated tuberculosis vaccine strains.
27 dentity between the two variants and classic vaccine strains.
28 age matches with recommended influenza virus vaccine strains.
29 polymerases might serve as live, attenuated vaccine strains.
30 rt limited T cell immunity restricted to the vaccine strains.
31 rrant further development as live-attenuated vaccine strains.
32 [DISC]) strain to generate a series of DISC vaccine strains.
33 -secreting cells elicited by historical H1N1 vaccine strains.
34 tment between the G1P[5] and G6P[8] parental vaccine strains.
35 cluster that were genetically distinct from vaccine strains.
36 ere immunized at birth with one of three BCG vaccine strains.
37 proinflammatory reaction to live attenuated vaccine strains.
38 tion neutralization test (PRNT) against both vaccine strains.
39 ystems commonly used to generate and amplify vaccine strains.
40 Nashville, TN, differ markedly from those of vaccine strains.
41 ses were antigenically similar to cell-grown vaccine strains.
42 nd humoral immune responses against the four vaccine strains.
43 enza surveillance to inform the selection of vaccine strains.
44 immune system very differently than those of vaccine strains.
45 imens containing viruses representing recent vaccine strains.
46 e strain, and 15 mug of haemagglutinin per B vaccine strain) (1) by microneedle patch or (2) by intra
47 cted in 82% of specimens (84% wild-type, 15% vaccine-strain, 1% possible vaccine-wild-type recombinan
48 (fluvirin: 18 mug of haemagglutinin per H1N1 vaccine strain, 17 mug of haemagglutinin per H3N2 vaccin
49 as a model the yellow fever virus (YFV) live vaccine strain 17D-204 and its wild-type parental strain
53 he notable exception of the responses to the vaccine strain A244 Env that were dominated by V2, where
54 f attenuation of the Sabin 2 oral poliovirus vaccine strain (A481 in the 5'-untranslated region [5'-U
55 the clinical-like strain TB40-BAC4 or to the vaccine strain AD169varATCC, prior to their long-term ma
56 able to detect RNA from five currently used vaccine strains, AIK-C, CAM-70, Edmonston-Zagreb, Morate
57 o achieved in cattle with a mixture of three vaccine strains, albeit at a lesser level than in sheep.
58 magglutinin glycoprotein and the egg-adapted vaccine strain also bore mutations, notably T160K loss-o
59 ce glycosaminoglycans are utilized by both a vaccine strain and a clinical isolate of CHIKV to mediat
60 of A(H1N1)pdm09 viruses well-matched to the vaccine strain and A(H3N2) viruses, the majority of whic
62 luded B. mallei DeltatonB Deltahcp1 (CLH001) vaccine strain and investigated its ability to protect a
63 high antibody titers against the egg-adapted vaccine strain and lower titers against circulating viru
64 irculate in the United States and from swine vaccine strains and also showed antigenic drift from hum
65 emonstrated the genetic stabilities of these vaccine strains and also the complementing cell line.
68 nt study to distinguish the M. gallisepticum vaccine strains and field isolates based on mutations in
69 erful framework for rational design of safer vaccine strains and for forecasting virulence of viruses
70 roadmap both for the development of improved vaccine strains and for the creation of a framework to '
71 influenza A/Hong Kong/4801/2014(H3N2) virus vaccine strains and representative circulating viruses (
73 h amino acid identity between the E genes of vaccine strains and wild-type viruses from trial partici
74 mumps virus vaccine strain (hereafter, the "vaccine strain") and the MuVi/Utrecht.NLD/40.10 outbreak
75 s in vaccinated children (both wild-type and vaccine-strain) and 230 per 100,000 person-years in unva
76 ne strain, 17 mug of haemagglutinin per H3N2 vaccine strain, and 15 mug of haemagglutinin per B vacci
77 following MMR-3 receipt, levels of IgG, anti-vaccine strain, and anti-outbreak strain antibodies incr
79 red with the A/Texas/50/2012-like clade 3C.1 vaccine strain, and more than half were antigenically mi
80 st strains were antigenically similar to the vaccine strain, and no resistance or known pathogenicity
81 genome differences among vaccine revertants, vaccine strains, and field isolates, whole-genome sequen
82 y, some vaccines may revert to virulence and vaccine strains are generally difficult to distinguish f
87 urvival of Salmonella enterica serovar Typhi vaccine strains at pHs 3.0 and 2.5 to compensate for the
89 ynthesis, was introduced into two Salmonella vaccine strains attenuated by auxotrophic traits or by t
90 is genetically distinct from the commercial vaccine strains B1 and LaSota, which belong to genotype
91 isabled infectious single-cycle (DISC) viral vaccine strain based on a guinea pig cytomegalovirus (GP
92 ss in animal models, including an attenuated vaccine strain based on an isolate from La Reunion incor
93 ncovers the evolutionary strategies by which vaccine strains become pathogenic and provides a powerfu
94 irus strains were different clades, with the vaccine strain being clade 3C.2a and the circulating vir
95 ive antibodies against not only the dominant vaccine strains but also minor circulating strains that
96 ging from 18% to 49%; p<=0.019 for the three vaccine strains), but were similar between the two-singl
98 ainst plague, we developed a live-attenuated vaccine strain by deleting the Braun lipoprotein (lpp) a
99 anslational viability of the HSV-1 0DeltaNLS vaccine strain by demonstrating that, while it is compar
100 ome differs from the 1950s-era prototype and vaccine strains by a lateral gene transfer, substituting
101 ed assays enable the differentiation of live vaccine strains by targeting two or three markers/vaccin
103 e applied to identify antigenic variants and vaccine strain candidates for pathogens with rapid antig
105 ly interested in the F. tularensis LVS (live vaccine strain) clpB (FTL_0094) mutant because this stra
107 MRC-DPRU442/2012/G1P[8], exhibited a RotaTeq vaccine strain constellation of G1-P[8]-I2-R2-C2-M2-A3-N
108 urthermore, to test if mixtures of different vaccine strains could be tolerated, we tested cocktails
109 e, nonreplicating avirulent uracil auxotroph vaccine strain (cps) of Toxoplasma triggers novel innate
110 ttenuated Vibrio cholerae O1 classical Inaba vaccine strain CVD 103-HgR, elicits seroconversion of vi
111 HAI titers of 1:40 or more to the influenza vaccine strains decreased from more than 56% in the firs
114 least 1 (ID 69% vs IM 68%; P = .7) of the 3 vaccine strains did not differ significantly between ID
115 us serotypes 1 to 4 and the yellow fever 17D vaccine strain, did not antagonize STAT5 phosphorylation
117 e genetics system for the live-attenuated MV vaccine strain Edmonston-Zagreb (EZ), allowing recovery
119 e tested the ability of oral M. tuberculosis vaccine strains expressing SIV Env and Gag proteins, fol
120 irus (NDV) recombinants, based on the LaSota vaccine strain, expressing glycoproteins B (gB) and D (g
121 could be engineered into a thermolabile NDV vaccine strain for developing novel thermostable NDV vac
122 variants of influenza viruses and to select vaccine strains for use in controlling and preventing di
126 rase) deletion mutant of Ft. live attenuated vaccine strain (Ft.LVS), designated Ft.LVS::Deltawzy, wa
132 est) against both the Jeryl Lynn mumps virus vaccine strain (hereafter, the "vaccine strain") and the
135 could bind infectious virions (including the vaccine strains HIV-1 CM244 and HIV-1 MN and an HIV-1 st
136 the genetic design of replication-competent vaccine strains holds the promise for a potent, broadly
137 ne strains by targeting two or three markers/vaccine strain; however, considering the high variabilit
138 lipid (FtL) from Francisella tularensis live-vaccine strain (i) induces FtL-specific B-1a to produce
139 ging G9 porcine RV strains and a human G1 RV vaccine strain in a susceptible host (swine) will allow
140 chorioallantois vaccinia virus Ankara (CVA) vaccine strain in chicken embryo fibroblasts during whic
142 ompared with those of the WT strains and the vaccine strain in two different murine models: infant CD
144 This study assessed inactivated prepandemic vaccine strains in a One Health framework across human a
148 imary was seroconversion rate to each of the vaccine strains in the mothers 1 month after completion
149 eplicating, live attenuated uracil auxotroph vaccine strains in the type II Deltaku80 genetic backgro
150 viruses, including the YF and measles virus vaccine strains, in the absence or presence of exogenous
151 ell (MBC) activation, and recognition of non-vaccine strains) indicated that, overall, Vaxxas HD-MAP
152 isabled infectious single-cycle (DISC) GPCMV vaccine strain induced an antibody immune response to th
153 ensis strain SchuS4, but not attenuated live vaccine strain, inhibit inflammatory responses in vitro
155 ation "bottleneck." We demonstrated that the vaccine strain is genetically heterogeneous at 46 chromo
156 at Mycobacterium bovis BCG, the tuberculosis vaccine strain, is severely deficient in HIA, and we exp
157 ule inhibition or by genetic modification of vaccine strains, is expected to reduce the pathogenic po
158 pulmonary infection with F. tularensis live vaccine strain, its production is tightly regulated by I
159 ure of the parental strain, whereas the live vaccine strain lacks diversity according to multiple ind
160 86.5 to 87.9% identities, respectively, with vaccine strain LaSota, indicative of considerable divers
161 a virulence factor of the F. tularensis live vaccine strain (LVS) and demonstrated that a DeltatolC m
162 racellular trafficking of F. tularensis Live Vaccine Strain (LVS) and LVS with disruptions of wbtDEF
163 from mice vaccinated with F. tularensis Live Vaccine Strain (LVS) and related attenuated strains, we
164 spiratory infection with the attenuated Live Vaccine Strain (LVS) and the highly virulent SchuS4 stra
165 Previous studies with the attenuated live vaccine strain (LVS) identified a role for the outer mem
166 of the F. tularensis subsp. holarctica live vaccine strain (LVS) in macrophages and epithelial cells
167 ntly available unlicensed F. tularensis live vaccine strain (LVS) is needed to protect against intent
168 protection, we created an F. tularensis live vaccine strain (LVS) mutant with a significantly increas
169 ined the transcriptional profile of the live vaccine strain (LVS) of F. tularensis grown in the FL83B
170 ificantly resistant to infection by the live vaccine strain (LVS) of F. tularensis Resistance is char
171 intradermal challenge of mice with the live vaccine strain (LVS) of F. tularensis, splenic IL-10 lev
176 First, inactivation of FTL_0325 from live vaccine strain (LVS) or FTT0831c from Schu S4 resulted i
177 macrophages infected with F. tularensis live vaccine strain (LVS) or the virulent SchuS4 strain are d
178 the lethality of primary F. tularensis live vaccine strain (LVS) pulmonary infection in mice that ar
179 rmal inoculation with the F. tularensis live vaccine strain (LVS) results in a robust Th1 response in
180 We employed Francisella tularensis live vaccine strain (LVS) to study mechanisms of protective i
182 though an attenuated strain, dubbed the live vaccine strain (LVS), is given to at-risk laboratory per
183 infection with a Francisella attenuated live vaccine strain (LVS), which is under study as a human va
186 Overall, the data suggest that the HSV-1 VC2 vaccine strain may be used as a viral vector for the vac
187 bition of PA-X expression in influenza virus vaccine strains may provide a novel way of safely attenu
188 siblings; the proband developed disseminated vaccine strain measles following routine immunization, w
192 However, as a result of antigenic drift, vaccine strains must be regularly updated to reflect cur
194 cobacterium tuberculosis with the attenuated vaccine strain Mycobacterium bovis bacillus Calmette-Gue
196 eport the development of a poliovirus type 2 vaccine strain (nOPV2) that is genetically more stable a
197 e observed that a newly generated Salmonella vaccine strain not only conferred superior protection co
200 egments of RSArrrr/16 group closely with the vaccine strain of BTV-16 (RSAvvvv/16) that was derived f
201 cine.IMPORTANCE The live-attenuated Candid#1 vaccine strain of Junin virus is used to protect against
202 ld-type mice cleared Candid 1 (JUNV C1), the vaccine strain of Junin virus, more rapidly than did TLR
203 glycoprotein of the Candid#1 live-attenuated vaccine strain of JUNV in MACV replication and its abili
204 to Mycobacterium avium paratuberculosis; the vaccine strain of M. bovis Bacillus Calmette-Guerin; and
205 ip between bat mumps virus (BMV) and the JL5 vaccine strain of mumps virus (MuVJL5), we rescued a chi
206 While sera from animals vaccinated with the vaccine strain of RPV showed cross-neutralizing ability
207 e markers in a single recombinant attenuated vaccine strain of Salmonella enterica serotype Typhimuri
208 virus infection against not only historical vaccine strains of H3N2 but also a set of cocirculating
211 rotected from rinderpest by inoculation with vaccine strains of the related morbillivirus, peste des
213 ABV expressing the attachment protein of CDV vaccine strain Onderstepoort succumbed to infection with
214 Salmonella may be useful as live attenuated vaccine strains or as vehicles for heterologous antigen
218 Using a dengue virus serotype 2 (DENV-2) vaccine strain (PDK53), we show that infection creates a
220 ns exposed to the egg-adapted 2016-2017 H3N2 vaccine strain poorly neutralize a glycosylated clade 3C
221 tigenic distances: the distances between the vaccine strain, pre-existing immunity, and the challenge
222 king studies demonstrated uptake of the Bp82 vaccine strain predominately by neutrophils in vaccine-d
224 glycoprotein-deletion variant of the SAD-B19 vaccine strain rabies virus (RABV) has been the reagent
225 lent vaccine candidates based on recombinant vaccine strain rabies virus particles, which concurrentl
226 ive PCR [RT-qPCR]) that can identify measles vaccine strains rapidly, with high throughput, and witho
230 luenza vaccines mainly depends upon how well vaccine strains represent circulating viruses; mismatche
233 y, a genetic screen using the iglE-null live vaccine strain resulted in the identification of key reg
235 lasts and infected with B. abortus 2308, the vaccine strain S19, and attenuated mutants S19vjbR and B
236 e significantly lower than those against the vaccine strain Sabin-1, two genetically distinct WPV1s i
238 ainst either a panel of viruses representing vaccine strains selected by the World Health Organizatio
239 l approaches that may complement the current vaccine strain selection process, we selected antigenic
240 res of influenza virus fitness could improve vaccine strain selection through more accurate forecasts
241 he antigenic match of hemagglutinin (HA) for vaccine strain selection, and most vaccines rely on HA i
250 somewhat mitigated in combination with other vaccine strain-specific mutations, which might be compen
251 zing antibody) and/or stool excretion of the vaccine strain, stratified by HBGA status were determine
253 n=230; ranging from 29% to 65% for the three vaccine strains) than in the single-dose group (n=230; r
254 of two clones of VACV-IOC, a unique smallpox vaccine strain that contributed to smallpox eradication
255 , it has been a challenge to identify an RSV vaccine strain that has an optimal balance between atten
256 broad implications for rational selection of vaccine strains that do not contain prolines in antigeni
257 st the live attenuated West Nile virus (WNV) vaccine strain, the nonstructural (NS) 4B-P38G mutant.
258 ons, and for many live attenuated Salmonella vaccine strains, the acid tolerance response is unable t
260 . tularensis subsp. holarctica (type B) live vaccine strains, thereby demonstrating the vaccine poten
261 uberculosis from the Bacille-Calmette-Guerin vaccine strain, they currently lack the specificity to d
262 The first comparison of a live RNA viral vaccine strain to its wild-type parental strain by deep
264 le-genome sequencing of the M. gallisepticum vaccine strain ts-11 and several "ts-11-like" strains is
268 that can be used for screening and selecting vaccine strains using immunoinformatics tools and a huma
269 05) to Brucella vaccine protection efficacy: vaccine strain, vaccination host (mouse) strain, vaccina
270 number and proportion of HZ cases caused by vaccine-strain varicella zoster virus (VZV), assessed th
271 , the majority (78%) captured the infectious vaccine strain virus (CM244), while a smaller proportion
277 nization with a live attenuated Burkholderia vaccine strain was dependent primarily on generation of
278 17D-204 was observed, demonstrating that the vaccine strain was derived by discrete mutation of Asibi
279 either cryopreservation or cell culture, the vaccine strain was maintained for decades by sequential
280 sive drift away from the A/California/7/2009 vaccine strain was observed at both the nucleotide and a
281 istinguishable from that of the 181/clone 25 vaccine strain was obtained by the simultaneous expressi
282 atch to circulating viruses, except when the vaccine strain was unchanged from the prior season.
284 species barrier and to identify a candidate vaccine strain, we evaluated the in vitro and in vivo pr
285 , measles exposure and identification of the vaccine strain were helpful for public health decision-m
286 against the 2009 pandemic influenza A(H1N1) vaccine strain were significantly enhanced, compared wit
288 ns during this era, but the chosen wild-type vaccine strains were not able to elicit antibodies with
290 ttenuated herpes simplex virus 1 (HSV-1) VC2 vaccine strain, which has been shown to be unable to ent
291 cidence of HZ cases from reactivation of the vaccine strain, which in the long term will likely outnu
294 virus is critical for accurate selection of vaccine strains, which is important for effective preven
295 3) season's B/Wisconsin/01/2010-like clade 3 vaccine strain, while only 17% clustered with the curren
296 ce immunized with the auxotrophic Salmonella vaccine strain with the deletion mutation Delta(wza-wcaM
298 lly similar to the A/California/07/2009-like vaccine strain, with an adjusted VE of 71% (95% confiden
300 4 (DENV1 to DENV4) and the yellow fever 17D vaccine strain (YFV-17D) did not antagonize STAT5 phosph