ライフサイエンスコーパス: valyl

1 S*,R*)-N-[[2-[N-(2-amino-3-mercaptopropyl)-L-valyl]-1,2,3,4- tetrahydro-3-isoquinolinyl]carbonyl]-L-m

2 trahydro-2-[N-[2-(1H-imidazol-4-yl)ethyl] -L-valyl]-3-isoquinolinyl]carbonyl]-L-methionine ([imidazol

3 A synthetase misactivates valine (to produce valyl adenylate or Val-tRNA(Ile)) at its active site.

4 imed complex processively edits misactivated valyl-adenylate via the pretransfer route.

5 d 7 because benzyloxycarbonyl-valyl-aspartyl-valyl-alanyl-aspartic acid fluoromethyl ketone (Z-VDVAD-

6 the potent antiapoptotic agent carbobenzoxy-valyl-alanyl-aspartyl(beta-methyl ester)-fluoromethyl ke

7 with the pancaspase inhibitor carbobenzoxyl-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone befo

8 nd SuVP reagents are the same except for the valyl and aspartyl groups which provide a distinctive ch

9 Thus, isoleucyl-, valyl-, and lysyl-tRNA synthetases behave as aminoacyl-S

10 spase inhibitor) or acetyl-aspartyl-glutamyl-valyl-aspart-1-aldehyde (a relatively selective caspase-

11 aspase 2, 3, and 7 because benzyloxycarbonyl-valyl-aspartyl-valyl-alanyl-aspartic acid fluoromethyl k

12 the 5'-glycyl ester of acyclovir, and the 5'-valyl ester of zidovudine (AZT), was purified from Caco-

13 Valacyclovir is the 5'-valyl ester prodrug of acyclovir, an effective anti-herp

14 by treatment with N-benzyloxycarbonyl-leucyl-valyl-glycine diazomethyl ketone lacked the 66-kDa gelat

15 with the subsequent mole fractions of [14C] valyl groups that could be covalently transferred to the

16 el-breathing motions in all systems except l-valyl-l-alanine.

17 e substrates, acetyl-L-aspartic-L-glutamic-L-valyl-L-aspartic acid 4-methyl-7-aminocoumarin or acetyl

18 In contrast, acetyl-L-tyrosyl-L-valyl-L-aspartic acid 4-methyl-7-aminocoumarin was resis

19 l cleavage of acetyl-L-aspartic-L-glutamic-L-valyl-L-aspartic acid 4-methyl-7-aminocoumarin within 6

20 methyl-7-aminocoumarin or acetyl-L-tyrosyl-L-valyl-L-aspartic acid 4-methyl-7-aminocoumarin.

21 d FMOC-l-valine, and a dipeptide, N-acetyl-l-valyl-l-leucine (N-Ac-VL), were studied via one- and two

22 scent peptide N-succinyl-L-leucyl-L-leucyl-L-valyl-L-tyrosine-7-amido-4- methylcoumarin or the microt

23 ent substrate N-succinyl-L-leucyl-L-leucyl-L-valyl-L-tyrosine-7-amido-4-methylcouma rin, as well as t

24 phenylalanyl-lysine-fluorescein and N-formyl-valyl-leucyl-phenylalanyl-lysine-fluorescein to the N-fo

25 Truncation of the last two residues (valyl-lysine) from the C terminus is sufficient to creat

26 fied tRNA transcripts of four specificities (valyl, methionyl, alanyl, and phenylalanyl) from higher

27 t of the hydrolysis of P5, N,N-dimethylvalyl-valyl-N-methylvalyl-proline (P4), had little activity as

28 lularly, with formation of N,N-dimethylvalyl-valyl-N-methylvalyl-prolyl-proline (P5), a pentapeptide

29 n by using a pan-caspase inhibitor, quinolyl-valyl-O-methylaspartyl-[-2,6-difluorophenoxy]-methyl ket

30 s shows that this use of a chirally resolved valyl phosphonate results in selection of much more pote

31 experiment, a single-enantiomer form of the valyl phosphonate was used rather than a racemic mixture

32 yl-proline (SuDP), disuccinimidyl-succinamyl-valyl-proline (SuVP) was synthesized.

33 lecular weight MyD88 mimic, hydrocinnamoyl-l-valyl pyrrolidine (compound 4a), modeled on a tripeptide

34 y suggests a multistep mechanism including a valyl radical intermediate.

35 ransient overexpression of editing-defective valyl-tRNA synthetase (ValRS(ED)) activated DNA break-re

36 actions between Escherichia coli tRNAVal and valyl-tRNA synthetase (ValRS) by enzymatic footprinting

37 mologs isoleucyl-tRNA synthetase (IleRS) and valyl-tRNA synthetase (ValRS) deacylate Val-tRNA(Ile) an

38 Valyl-tRNA synthetase (ValRS) has difficulty differentia

39 Valyl-tRNA synthetase (ValRS) has difficulty discriminat

40 uRS), isoleucyl-tRNA synthetase (IleRS), and valyl-tRNA synthetase (ValRS) have evolved a discrete ed

41 uRS), isoleucyl-tRNA synthetase (IleRS), and valyl-tRNA synthetase (ValRS) share a common insertion,

42 n Escherichia coli tRNAValfor recognition by valyl-tRNA synthetase (ValRS), nucleotides in the accept

43 g that diminish the proofreading activity of valyl-tRNA synthetase (ValRS).

44 wo previously reported biallelic variants in valyl-tRNA synthetase (VARS) in ten patients with a deve

45 Valyl-tRNA synthetase catalyzes aminoacylations of CoA-S

46 NMR also shows that formation of the tRNAVal-valyl-tRNA synthetase complex does not disrupt the first

47 Valyl-tRNA synthetase does not edit wild-type tRNA(Val)(

48 the homologous isoleucyl-tRNA synthetase and valyl-tRNA synthetase editing active sites, play a centr

49 in the 5' untranslated region of a putative valyl-tRNA synthetase gene, valRS.

50 tive peptide 1; CP1 domain), LeuRS resembles valyl-tRNA synthetase in its reliance on post-transfer e

51 pecificity nor interaction specifically with valyl-tRNA synthetase is crucial.

52 Valyl-tRNA synthetase is unable to hydrolytically deacyl

53 l-tRNA synthetase misactivates valine, while valyl-tRNA synthetase misactivates threonine.

54 es, are abolished in a temperature-sensitive valyl-tRNA synthetase mutant (un-3(ts)) that has high le

55 Valyl-tRNA synthetase specifically protects the anticodo

56 hing the identity of the human mitochondrial valyl-tRNA synthetase then inducing its overexpression i

57 Valyl-tRNA synthetase, a close homolog of isoleucyl-tRNA

58 tic analyses of beta-tubulin, chaperonin 60, valyl-tRNA synthetase, and EF-1alpha, suggests a sister-

59 or analyses of isoleucyl-tRNA synthetase and valyl-tRNA synthetase, these experiments provide the bas

60 crimination were functionally independent in valyl-tRNA synthetase.

61 case of inner mitochondrial membrane 50, and valyl-tRNA synthetase.

62 mportant for proper recognition of tRNAValby valyl-tRNA synthetase.19F NMR also shows that formation

63 the evolutionary-related IleRS, leucyl- and valyl-tRNA synthetases (I/L/VRSs), all efficiently hydro

64 For isoleucyl- (IleRS) and valyl-tRNA synthetases (ValRS), reactions that hydrolyze

65 in all known LeuRSs and also isoleucyl- and valyl-tRNA synthetases.

66 d thereby identified a segment of the enzyme valyl-tRNA-synthetase (ValRS).