ライフサイエンスコーパス: valyl-tRNA

1 ransient overexpression of editing-defective valyl-tRNA synthetase (ValRS(ED)) activated DNA break-re

2 actions between Escherichia coli tRNAVal and valyl-tRNA synthetase (ValRS) by enzymatic footprinting

3 mologs isoleucyl-tRNA synthetase (IleRS) and valyl-tRNA synthetase (ValRS) deacylate Val-tRNA(Ile) an

4 Valyl-tRNA synthetase (ValRS) has difficulty differentia

5 Valyl-tRNA synthetase (ValRS) has difficulty discriminat

6 uRS), isoleucyl-tRNA synthetase (IleRS), and valyl-tRNA synthetase (ValRS) have evolved a discrete ed

7 uRS), isoleucyl-tRNA synthetase (IleRS), and valyl-tRNA synthetase (ValRS) share a common insertion,

8 n Escherichia coli tRNAValfor recognition by valyl-tRNA synthetase (ValRS), nucleotides in the accept

9 g that diminish the proofreading activity of valyl-tRNA synthetase (ValRS).

10 wo previously reported biallelic variants in valyl-tRNA synthetase (VARS) in ten patients with a deve

11 Valyl-tRNA synthetase catalyzes aminoacylations of CoA-S

12 NMR also shows that formation of the tRNAVal-valyl-tRNA synthetase complex does not disrupt the first

13 Valyl-tRNA synthetase does not edit wild-type tRNA(Val)(

14 the homologous isoleucyl-tRNA synthetase and valyl-tRNA synthetase editing active sites, play a centr

15 in the 5' untranslated region of a putative valyl-tRNA synthetase gene, valRS.

16 tive peptide 1; CP1 domain), LeuRS resembles valyl-tRNA synthetase in its reliance on post-transfer e

17 pecificity nor interaction specifically with valyl-tRNA synthetase is crucial.

18 Valyl-tRNA synthetase is unable to hydrolytically deacyl

19 l-tRNA synthetase misactivates valine, while valyl-tRNA synthetase misactivates threonine.

20 es, are abolished in a temperature-sensitive valyl-tRNA synthetase mutant (un-3(ts)) that has high le

21 Valyl-tRNA synthetase specifically protects the anticodo

22 hing the identity of the human mitochondrial valyl-tRNA synthetase then inducing its overexpression i

23 Valyl-tRNA synthetase, a close homolog of isoleucyl-tRNA

24 tic analyses of beta-tubulin, chaperonin 60, valyl-tRNA synthetase, and EF-1alpha, suggests a sister-

25 or analyses of isoleucyl-tRNA synthetase and valyl-tRNA synthetase, these experiments provide the bas

26 crimination were functionally independent in valyl-tRNA synthetase.

27 case of inner mitochondrial membrane 50, and valyl-tRNA synthetase.

28 mportant for proper recognition of tRNAValby valyl-tRNA synthetase.19F NMR also shows that formation

29 d thereby identified a segment of the enzyme valyl-tRNA-synthetase (ValRS).

30 the evolutionary-related IleRS, leucyl- and valyl-tRNA synthetases (I/L/VRSs), all efficiently hydro

31 For isoleucyl- (IleRS) and valyl-tRNA synthetases (ValRS), reactions that hydrolyze

32 in all known LeuRSs and also isoleucyl- and valyl-tRNA synthetases.