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1 nsive investigation of which of the about 60 var gene-encoded PfEMP1 variants per parasite genome can
5 of a domain cassette (DC) present in group A var genes from six genetically distinct P. falciparum pa
6 SIS) pathway in the C. neoformans serotype A var. grubii lineage, in which tandem transgene arrays tr
8 ntrons are associated with the single active var gene at the time in the cell cycle when the single v
9 eic acid molecules down-regulated the active var gene, erased the epigenetic memory, and induced expr
13 es of the Mexican avocado race, P. americana var. drymifolia, and the most commercially popular hybri
14 nd elephant garlic (EG) (Allium ampeloprasum var. holmense) collected from the Val di Chiana area (Tu
15 CR using a set of 42 primer pairs amplifying var subtype-specific loci covering most var/PfEMP1 subty
16 properties of IE collected on admission, and var gene transcription using quantitative polymerase cha
17 the presence of two hybrid classes, F1s and var. incana backcrosses, as would be expected on a relat
19 pertoire structure matters for the antigenic var diversity of the parasite population remaining after
20 60 degrees C and 2m/s, CD sample) on apple (var. Granny Smith) behavior during in vitro gastric dige
21 ated expression of both virulence-associated var genes and PfAP2-g, a transcription factor controllin
22 olate MUT4330 of Penicillium aurantiogriseum var. viridicatum which harbors six virus species, some h
24 ic class A LPAT2s and a cDNA from C. avigera var. pulcherrima (CpuLPATB) encoding a microsomal, seed-
25 ea viscosissima (CvLPAT2) and Cuphea avigera var. pulcherrima (CpuLPAT2a) encoding microsomal, seed-s
27 pers (Capsicum annuum), chards (Betavulgaris var. cicla), artichokes (Cynarascholymus)) and fruits (R
29 from extensive ectopic recombination between var genes during mitotic replication; however, the molec
30 -exclusive transcriptional switching between var genes allows parasites to escape host antibodies.
31 arborescent forests (Cystoseira brachycarpa var. balearica) versus an alternate state: bushland (Dic
32 xemplified by the variant gene family called var, which encodes the major surface antigen displayed o
34 offea arabica (Arabica) and Coffea canephora var. robusta (Robusta) commercial stocks in each step of
35 15 different cultivars of chillies (Capsicum var.) grown in temperate climate Denmark and determined
37 rts of the direct detection of H. capsulatum var. farciminosum in equine blood and at high frequency
38 s with suspected cases of EZL, H. capsulatum var. farciminosum was confirmed by extraction of DNA fro
41 ninomicin producer Micromonospora carbonacea var. aurantiaca, we discovered previously uncharacterize
42 choke and cultivated cardoon (C. cardunculus var. altilis) parental genotypes and low-coverage (0.5 t
44 berry, impregnated with Lactobacillus casei var. rhamnosus and dehydrated by different methods: free
46 ate time point, 9 subtelomeric and 8 central var genes were transcribed at the same levels in almost
47 ranscribed the same subtelomeric and central var genes, except for var2csa CONCLUSIONS: The duration
48 ading to the generation of multiple chimeric var genes, a process that can greatly accelerate the gen
52 ples, namely cultivated and wild M. communis var. melanocarpa DC, characterized by red/purple berries
53 We sequenced the genome of Ananas comosus var. bracteatus CB5 and assembled 513 Mb into 25 chromos
54 ted with severe disease outcome, we compared var transcript levels in parasites from 88 children with
56 res can erode lodgepole pine (Pinus contorta var. latifolia) forest resilience via increased burn sev
57 le host tree [lodgepole pine (Pinus contorta var. latifolia)] was not directly affected by prefire ou
59 tein 1) family that bind EPCR, including DC8 var genes that have previously been linked to severe ped
61 . vulgaris and in aerial parts of A. dioicus var. aethusifolius (H.Lev.) H.Hara [Syn.: Aruncus aethus
62 noids in different organs of Aruncus dioicus var. vulgaris and in aerial parts of A. dioicus var. aet
64 ation, we also find evidence of multi-domain var structure and synteny in Plasmodium gaboni, one of t
66 var. Delica and Cucurbita moschata Duchesne var. Butternut) up to 2 months of refrigerated storage.
67 cond promoter within an intron found in each var gene is required for silencing and counting of var g
68 analysis revealed that DC6- and DC8-encoding var transcripts in combination with high parasite biomas
71 pecific members of the Plasmodium falciparum var gene/PfEMP1 (P. falciparum erythrocyte membrane prot
72 g shoots of Aruncus dioicus (Walter) Fernald var. vulgaris (Maxim.) H.Hara (Rosaceae), collected from
74 ong noncoding RNAs (lncRNAs) initiating from var introns are associated with the single active var ge
78 lta(18) O series of Smith fir (Abies georgei var. smithii) on the southeastern Tibetan Plateau, and u
79 (Raphanus sativus), celery (Apium graveolens var. dulce), tomato (Lycopersicon lycopersicum), and sug
80 pis alba) and celery roots (Apium graveolens var. rapaceum), celery stalks (A. g. var. dulce) and lea
81 (Ulva lactuca (UL) or Sargassum hemiphyllum var. chinense (SHC)) on the distribution and metabolites
84 tigene families, including the hypervariable var genes, is broadly conserved, but P. falciparum has a
87 od for analyzing evolutionary constraints in var genes, and is also flexible enough to be easily appl
88 ts and genome-wide recombination hotspots in var genes, we show that during the parasite's sexual sta
92 switching is mediated by clonal variation in var expression, and recent in vitro studies have demonst
93 ular mass (LMM) extract of Cichorium intybus var. silvestre (red chicory) has been shown to inhibit v
94 cted from several types of Cichorium intybus var. silvestre salads ("Chioggia", "Treviso", "Treviso t
95 ble riparian forms on other Pacific Islands, var. newellii appears to represent parallel incipient ec
96 ges, ectopic recombination between isogenous var paralogs occurs near low folding free energy DNA 50-
97 extract of immature kumquat (Citrus japonica var. margarita) were identified and quantified (mg/100g
101 nt study, curly endive (Cichorium endivia L. var. crispum) and escarole (Cichorium endivia L. var. la
102 crispum) and escarole (Cichorium endivia L. var. latifolium) accessions were investigated for their
105 by inoculating adlay (Cois lachrymal-jobi L. var. ma-yuen Stapf) with Monascus purpureus may protect
106 of two pumpkin species (Cucurbita maxima L. var. Delica and Cucurbita moschata Duchesne var. Buttern
108 oids found in broccoli (Brassica oleracea L. var. italica), carrot (Daucus carota), corn (Zea mays),
109 ee plants, viz. rapa L., Raphanus sativus L. var. and Eruca sativa Mill., were analyzed with this met
110 quantified in the pod of Raphanus sativus L. var. caudatus Alef extracts (2253.05+/-246.18 and 111.94
111 ronomic trait of durum (Triticum turgidum L. var. durum) and bread (Triticum aestivum L.) wheat that
112 Herein, flowers of Bauhinia variegata L. var. candida alba Buch.-Ham were submitted to electron b
113 -quality ethanol/water for Vitis vinifera L. var. 'Viosinho' (white variety), and 23.4 min, 84.2 degr
117 tracted from the resin of Pistacia lentiscus var. chia and comparatively investigated their effects o
118 ntial of polyphenols extracted from lettuce (var. Maravilla de Verano), in J774A.1 macrophages stimul
119 egulated genes were a subset of group A-like var genes (HB3var3, 3D7_PFD0020c, ITvar7, and ITvar19) t
120 itter melons (WBM; Momordica charantia Linn. var. abbreviata Ser.) on Propionibacterium acnes-induced
121 composed of S. lycopersicum, S. lycopersicum var cerasiforme, and Solanum pimpinellifolium to map loc
125 interior Douglas-fir (Pseudotsuga menziesii var. glauca) from multiple populations were grown in mul
126 of coast Douglas-fir (Pseudotsuga menziesii var. menziesii) growing at three test sites with distinc
127 of coast Douglas-fir (Pseudotsuga menziesii var. menziesii) to test the hypotheses: (i) cool-tempera
131 ersity of its highly antigenic and multicopy var genes preclude such clear clustering in endemic regi
136 ients infected with strains of C. neoformans var. grubii with identical genotypes exhibited >/=4-fold
138 rotype AA) and of hybrids with C. neoformans var. neoformans (serotype AD) such aneuploidies have res
141 ated by the modular genetic architectures of var genes that encode varying numbers of antigenic domai
143 ne is required for silencing and counting of var genes by the mechanism that controls mutually exclus
144 cture, significant for the high diversity of var genes that compose it at a local level, supports the
145 sequencing the conserved DBLalpha domain of var genes from six sentinel sites in Uganda we found tha
146 Deep sampling of the DBLalpha domain of var genes in the local population of Bakoumba, West Afri
148 lencing and mutually exclusive expression of var genes is regulated by the precise arrangement of ins
149 ined in detail the patterns of expression of var in a well-characterized sample of parasites from Ken
155 we investigated the transcription pattern of var genes by real-time polymerase chain reaction, the ex
156 nic variation depends on tight regulation of var gene expression, ensuring that only a single var gen
157 subset of coexisting dominant repertoires of var genes whose degree of antigenic overlap depends on t
158 hal of human malaria parasites, switching of var gene expression results in alternating expression of
159 to obtain bioactive compounds of B. oleracea var capitata showed to be a promising alternative to con
160 rd (Brassica nigra) and collard (B. oleracea var. acephala) and the effects of leaf nitrogen and gluc
161 d bioactive compounds from Brassica oleracea var capitata using supercritical CO2 and evaluated the a
162 Diets rich in broccoli (Brassica oleracea var italica) have been associated with maintenance of ca
163 ant (white cabbage cabbage Brassica oleracea var. capitata f. alba cv. Castello L.) with and without
164 phanus sativus L. (tuber), Brassica oleracea var. capitata L. (leaf), and Bixa orellana L. (seed) had
167 rassicaceae (Eruca sativa, Brassica oleracea var. sabauda) were stored in air and under a modified at
170 vels across the Laverania subgenus, based on var-like sequences from eight single-species and three m
171 entii followed by V. opulus P3 and V. opulus var. americanum possessed the highest antioxidant capaci
172 neral, the study demonstrated that V. opulus var. sargentii followed by V. opulus P3 and V. opulus va
174 catechin (the main antioxidants in V. opulus var. sargentii) contributed to 40% and 23% of the total
175 dy the effects of Citrus grandis (L.) Osbeck var. tomentosa hort. fruit extract on the energy metabol
178 d resistance against Phytophthora parasitica var. nicotianae, Alternaria alternata var. nicotianae an
179 ss for the activation of a single particular var gene that involves AP2 transcription factors and lnc
182 tetraploid Vigna species (V. reflexo-pilosa var. glabra) provides genomic evidence of a recent allop
183 ls of 'Hort16A' (Actinidia chinensis Planch. var chinensis) kiwifruit were examined and the changes i
184 ree larch species - L. decidua, L. potaninii var. chinensis (complete genome 122,492 bp), and L. occi
185 A) that has previously been shown to promote var gene transcription during the intraerythrocytic cycl
186 he methanol extract of Centaurea pulcherrima var. pulcherrima showed the superior free radical scaven
187 arotenoid ester composition of lucuma pulps (var. Molina and Beltran) and assess their bioaccessibili
188 l SES (var(SES) = 0.002), daily air quality (var(AQI) = 0.0004), and average temperature (var(temp) =
192 isense lncRNAs play a key role in regulating var gene activation and mutually exclusive expression.
195 The single island-endemic form, riparian var. newellii, showed especially strong differentiation
197 persicum), and sugar snap pea (Pisum sativum var. macrocarpon) from an industrially impacted biosolid
198 o cucumber taxa, and suggest that C. sativus var. hardwickii is the progenitor of cultivated cucumber
203 ve oxygen species, highest in PTEN(mut+)/SDH(var+) cells, correlating with apoptosis resistance.
206 the domain architectures of fully sequenced var gene repertoires we reveal a significant, non-random
207 onmental factors such as zip-code-level SES (var(SES) = 0.002), daily air quality (var(AQI) = 0.0004)
209 GS parasites in this cluster express similar var genes, more than would be expected by chance in the
212 ) differed from the cultivars of C. sinensis var. sinensis, with higher levels of theobromine, (+)-ca
213 ) differed from the cultivars of C. sinensis var. sinensis, with higher levels of theobromine, (+)-ca
214 The effect of infection of Citrus sinensis (var. Navelina) fruits with Penicillium digitatum was stu
215 Individual parasites express only a single var gene at a time, maintaining the remaining var genes
216 gene expression, ensuring that only a single var gene is expressed at a time while the rest of the fa
217 After infection of mosquitoes, a single var gene is selected for expression in the oocyst, and t
219 ny evidence of a selective sweep of specific var genes or clonal epidemic structure related to the in
220 species (Bengalese finches, Lonchura striata var. domestica) greatly reduced the magnitude of vocal l
221 dback in Bengalese finches (Lonchura striata var. domestica) to create sensory errors during vocal ge
226 ly occupy the co-factor binding site of a Su(var)3-9, enhancer of a zeste, trithorax (SET) domain con
227 a chimeric fusion protein consisting of a su(var)3-9, enhancer-of-zeste and trithorax (SET) histone m
229 an ectopic site leads to Piwi, HP1a, and Su(var)3-9 recruitment to the site as well as H3K9me2/3 enr
230 expression levels of mod(mdg4) as well as Su(var)205; the latter gene codes for heterochromatin prote
231 a set of conserved genes is repressed by Su(var)2-10/SetDB1-induced H3K9 trimethylation, ensuring ti
234 -like protein SUMO and the SUMO E3 ligase Su(var)2-10 are required for piRNA-guided deposition of rep
235 mark depends on SUMO and the SUMO ligase Su(var)2-10, which recruits the histone methyltransferase c
236 ecific histone H3 Lys-9 methyltransferase Su(var)3-9, the H1 C-terminal domain makes important contri
239 t the requirement for wild-type dosage of Su(var)205 and mod(mdg4) in enabling naturally occurring Y-
241 ucture, including overexpression of Sir2, Su(var)3-9, and Dicer-2, as well as decreased expression of
242 potent orthosteric inhibitors of specific Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain methy
244 k of heterochromatin, is deposited by the Su(var)3-9 family of proteins; however, the mechanism by wh
245 ti-silencing function for a member of the Su(var)3-9 family that has previously been associated with
249 ion of embryonic ectoderm development or Su-(var)3-9; E(z); Trithorax (set)-7, encoding components of
250 a Polycomb repressive complex 2 (PRC2)--[Su-(var)3-9; E(z); Trithorax] (SET)-7, embryonic ectoderm de
255 var(AQI) = 0.0004), and average temperature (var(temp) = 0.001) overall, as well as for individual ph
256 Here we use network analysis to show that var architecture and mosaicism are conserved at multiple
264 DBL1alpha domain primers to characterize the var genes expressed by CGS parasites after short-term in
265 he loss of PFB0080c markedly compromises the var gene switching process, leading to a marked reductio
266 ion therefore shapes the organization of the var diversity into parasite genomes, leaving a persisten
267 ually exclusive expression of members of the var multi-gene family and appears to follow a non-random
270 binding phenotype and the selection of three var genes, including two that encode the tandem domain c
276 ars 4,5,12:i:-, Typhimurium, and Typhimurium var. 5- were frequently not classified correctly, which
277 chitecture and sequence diversity underlying var-mediated host-parasite interactions evolved before t
282 CGS parasites show upregulation of UpsA var genes and 2-cysteine-containing PfEMP-1 molecules an
283 is a major variant surface antigen, we used var Ups quantitative reverse transcription-PCR (qRT-PCR)
285 sted significant between-country variations (var=0.19, p=0.002) and between-hospital variations (var=
286 9, p=0.002) and between-hospital variations (var=0.43, p<0.0001) in the individual risk of in-hospita
287 lted in a set of autotetraploid S. viminalis var. Energo genotypes (polyploid Energo [PP-E]; 2n = 4x
288 olite of the ascomycete Chloridium virescens var. chlamydosporum, was synthesized in 16 linear steps
291 itexin-2-O-xyloside (XVX) from Beta vulgaris var. (BVc) seeds, betaxanthin (R1) and betacyanin (R2) f
292 betacyanin (R2) fractions from Beta vulgaris var. (BVr) roots were combined and tested for cytotoxici
293 itexin-2-O-xyloside (XVX) from Beta vulgaris var. cicla L. (BVc) seeds, betaxanthin (R1) and betacyan
294 betacyanin (R2) fractions from Beta vulgaris var. rubra L. (BVr) roots were combined and tested for c
296 exhibits virtually limitless diversity when var gene repertoires from different parasite isolates ar
297 les (i.e., groups) of parasite genomes whose var gene combinations are more similar within than betwe
299 on volcanically active Hawai'i Island, with var. glaberrima also extending to higher elevations and