ライフサイエンスコーパス: variably

1 ion (body mass relative to size) behave more variably.

2 nged consistently with fat fraction but more variably.

3 ereas its catalytic USP domain is positioned variably.

4 p3 also attenuated skin disease, albeit more variably.

5 l cells to which individual units contribute variably.

6 s consist of a copy of U6 RNA conjoined to a variably 5'-truncated L1, but how U6/L1 chimeras are for

7 owth response (EGR) binding site as the most variably accessible during Hofstenia regeneration.

8 ed by the effectiveness of adaptation to the variably acidic environment of the host stomach.

9 These compounds were synthesized from variably acylated glycopyranosyl azides and either 3- or

10 All bacterial lipoproteins share a variably acylated N-terminal cysteine residue.

11 ng pocket of the GTPase and are predicted to variably affect diverse aspects of RRAS2 biochemical beh

12 w that these tumor-mediated alterations also variably affect NK cell subsets.

13 BP1 mutations in patient-derived fibroblasts variably affect the amount of SSBP1 protein and alter mu

14 ion evaluation revealed that these mutations variably affect transcription, protein expression, prote

15 stigated at multiple locations in an aquifer variably affected by a large, wastewater-derived contami

16 c systems (high delta(15)N, low delta(18)O), variably affected by denitrification.

17 lpha1-M1 domain impaired GABA activation and variably affected etomidate sensitivity.

18 e a hormone response element-driven reporter variably affected the strength and polarity of these res

19 every case, whereas the entorhinal cortex is variably affected.

20 Protein glycosylation was variably affected.

21 ular ATP (eATP) is a signaling molecule that variably affects all cells of the immune system either d

22 In vivo inhibition of mAChRs variably affects CD4(+) T-cell subsets, and desiccating

23 therapy improves bradykinesia, but treatment variably affects the bradykinesia features and does not

24 K. brevis is variably allelopathic to multiple competitors, typically

25 es Sangiran 5 and Sangiran 6a, were formerly variably allocated to other taxa (Meganthropus palaeojav

26 mannopyranosyl residues (D-Rha4NFo) that are variably alpha(1-->2)- and alpha(1-->3)-linked.

27 greatly enhanced light sensitivity, mutants variably altered in Pfr-to-Pr thermal reversion and nucl

28 if protein was expressed over time, although variably, and these changes could not be linked to mutat

29 These issues were due, in part, to variably annotated 3' untranslated regions and thousands

30 lighted that regulatory definitions are only variably applicable and used at present.

31 likely cases, yet effective practices remain variably applied and lacking in sensitivity and specific

32 ical and pathological criteria, which may be variably applied.

33 ogic variants of Borrelia burgdorferi, known variably as "cyst forms" and "L-forms," are responsible

34 lyses demonstrated that hydroxamates can act variably as substrates for MPO and convert the enzyme to

35 Shigellosis can present variably as watery diarrhea alone or with dysentery, and

36 mogenic form of cardiomyopathy that has been variably associated with arrhythmogenic right ventricula

37 sive spastic paraparesis and polyneuropathy, variably associated with behavioral changes, cognitive i

38 Monoallelic deletions of 20p12 are variably associated with cleft palate, short stature, an

39 on, three polymorphisms in the GALC gene are variably associated with disease mutations and have unkn

40 itivity to ionizing irradiation (IR) and are variably associated with growth retardation, microcephal

41 l learning, and visuomotor coordination were variably associated with HVI, Crus I, Crus II, HVII B an

42 se in the context of immunodeficiency and is variably associated with liver damage.

43 Vascular anomalies are variably associated with overgrowth, skeletal anomalies,

44 mum in aerodynamic diameter (PM2.5) has been variably associated with preterm birth (PTB).

45 ized by a distinctive hindbrain malformation variably associated with retinal dystrophy and cystic ki

46 Household endotoxin levels have been variably associated with risk for asthma and atopy.

47 Polymorphisms in these genes have been variably associated with susceptibility to TB among diff

48 ant inheritance of thoracic aortic aneurysms variably associated with the bicuspid aortic valve was u

49 , and prenatal vitamin D deficiency has been variably associated with these disorders in offspring.

50 opsia, dysautonomia and dysarthria were also variably associated.

51 ic regions, and sociopolitical settings, and variably associates with different risk factors, suggest

52 These extinctions have been variably attributed to the impacts of climate change and

53 B, with a trend for microglial activation to variably be above control.

54 -12 (IL-12), IL-23, IL-17A, and IL-17RA have variably beneficial effects in psoriasis, Crohn's diseas

55 itially highly restricted and then increases variably between individuals during larval development u

56 an genome (core genes plus genes distributed variably between strains) probably supported by an atypi

57 FAC modulation was able to successfully, yet variably, block evoked chemo-afferent responses.

58 ggest that seagrass populations will respond variably, but overall positively, to increasing CO(2) co

59 plasma, 1.07 +/- 0.66 min; n = 4), followed variably by either a prolonged terminal phase (blood hal

60 H NMR, UV-vis, and infrared spectroscopy and variably by elemental analysis, mass spectrometry, and X

61 manifestation of acute encephalopathy and is variably called acute brain failure, acute brain dysfunc

62 These two IFN-beta resistance mutations variably changed the sensitivity of CA binding to human

63 The senescence program is variably characterized by several non-exclusive markers,

64 ant phenotypic variation is progenitor cells variably choosing between two alternative fates during d

65 resented sequentially with two directions of variably coherent random dot patterns (40 degrees apart)

66 on, involving recruitment of pre-positioned, variably committed neurons into memory networks.

67 nantly of plants and terrestrial mammals and variably complemented with aquatic resources.

68 lected FeOx with variable aggregate size and variably composed FeOx-associated organic matter (OM) to

69 s (Phalacrocorax auritus) collected from six variably contaminated colonies.

70 permitted the geographical discrimination of variably contaminated herring gull eggs from the Great L

71 romising means to distinguish and prioritize variably contaminated sites.

72 e of avian hepatocytes to SPMD extracts from variably contaminated wetlands highlighted traditional P

73 he fact that distinct causes may coexist and variably contribute to exercise intolerance in patients

74 actor has homology to these two proteins and variably contributes to ionizing radiation-induced DSB r

75 Survival of memory B cells appears variably controlled by affinity for antigen, allowing a

76 The mature retrovirus capsid consists of a variably curved lattice of capsid protein (CA) hexamers

77 es, retroviral capsids are pleomorphic, with variably curved, closed fullerene shells composed of app

78 s of MR-proANP, NT-proBNP, and proBNP(1-108) variably declined after treatment; whereas CNP concentra

79 Available systemic therapies for CTCL may variably decrease tumor burden and improve quality of li

80 of GCG+ neurons did reduce food intake, and variably decreased hepatic glucose production, other GLP

81 of mammalian target of rapamycin (mTOR) have variably decreased or caused proteinuria and sclerosis i

82 finitions of bronchopulmonary dysplasia that variably define disease severity according to the level

83 HK variably defined as serum K>4.5, 5, or 5.5 mmol/L occurr

84 ICR was variably defined if any lesion with diameter stenosis (D

85 tent with this process, ELISAs incorporating variably deiminated HSP90 as substrate Ag indicate a dir

86 nes we identify two siblings and a singleton variably demonstrating severe neonatal anemia, membranop

87 il with increasing soil available N that was variably dependent on carbon (C) availability.

88 t of cultures of whole embryonic kidney with variably desulfated heparin compounds indicated a requir

89 Twenty-eight phenolic compounds were variably detected and quantitated through Orbitrap LC-MS

90 Mosaic variants of APC were variably detected in leukocyte DNA and/or non-neoplastic

91 gland lesions were composed predominantly of variably dilated, branching tubular structures with pseu

92 n both genes were deleted, ductal growth was variably diminished (likely due to variable Cre-recombin

93 Although PGM3 protein expression was variably diminished, impaired function was demonstrated

94 ial rapid coverage over the first 5 min; and variably diminishing adsorption thereafter (5-70 min).

95 direct an avatar's limb to distinct targets variably displayed on a screen.

96 ed at the primary tumor site, progressing to variably distant metastatic sites in a fairly predictabl

97 ults and an adolescent, in upper hollows and variably distributed down the slope, largely segregated

98 ometry to measure p53 and AID protein within variably divided blasts, qRT-PCR of p53 mRNA from cultur

99 -1 sequences in vivo, our findings support a variably dynamic process of shifting CTL clonality laggi

100 Available influenza vaccines are variably effective each season, are of limited scope at

101 We find pan-1(RNAi) is variably effective in knocking down PAN-1 protein and re

102 chemoembolization (TACE) is an important yet variably effective treatment for management of hepatic m

103 sired edits, but HDR has been reported to be variably efficient.

104 cose levels following glucose challenge, and variably elevated insulin and C-peptide levels in the no

105 tarting at 3 or 10 wk of age still contained variably elevated leukocytic infiltrates in their islets

106 uctural analysis reveal that individual VHHs variably employ divergent antigen-binding regions to bin

107 heterogeneous set of cortical atrophy sites variably encompassing temporoparietal components of Wern

108 ncogenic hotspots of RAS genes and conferred variably enhanced RRAS function and stimulus-dependent M

109 ese results show that oculomotor information variably enhances auditory spatial resolution even when

110 Use of different HFpEF classifications variably enriches for future cardiovascular events, but

111 s respond selectively to bile acids that are variably excreted in male and female mouse faeces, and o

112 cellular pathology relating to 3 individuals variably exhibiting the core features of the SAVI phenot

113 uding diffuse large B-cell lymphoma (DLBCL), variably express CD30.

114 ative erythrocyte receptors for invasion and variably express cognate ligands encoded by the erythroc

115 Human and murine platelets (PLTs) variably express toll-like receptors (TLRs), which link

116 miR-30 family members were both robustly and variably expressed across functionally distinct cell typ

117 blished glioblastoma subtype classifiers are variably expressed across individual cells within a tumo

118 Mutations in LMNA are variably expressed and may cause cardiomyopathy, atriove

119 The chimeric proteins were variably expressed at the cell surface.

120 Four variants of IgA proteases are variably expressed by H. influenzae during infection of

121 D4(+), CD8(+), and CD4(-)CD8(-) subsets, and variably expressed CD56, CD161, HLA-DR, and NKG2D but ne

122 The protein was nuclear and variably expressed during the cell cycle, maximally duri

123 The most variably expressed genes between sites were involved in

124 malian gene neighborhoods contain highly and variably expressed genes.

125 cytosolic enzyme, abundant in the liver and variably expressed in mammalian tissues.

126 TLRs and TLR-related proteins were variably expressed in melanoma cell lines, with 42% expr

127 tyl, and Neu5Gc modifications are widely but variably expressed in mouse tissues, with the highest le

128 ly, genes related to the cell cycle are more variably expressed in the 2i and a2i conditions.

129 ns in PSTPIP1 are incompletely penetrant and variably expressed in the PAPA syndrome.

130 Phase variably expressed N(6)-adenine DNA methyltransferases (

131 CD33 is variably expressed on acute myeloid leukemia (AML) blast

132 s of a three-generation family exhibited the variably expressed phenotype, three of whom manifested C

133 ong non-coding RNAs, malat-1 and CRNDE to be variably expressed.

134 Vitreoretinal fellows perform variably few pneumatic retinopexies but have outcomes co

135 epending on local constraints, this fragment variably formed new domains, partitioned existing ones,

136 The few variably fractionated syntenic genes that were identifie

137 ged by postdecomposition inundation, and the variably fragmentary remains of at least two individuals

138 For this, we synthesize variably functionalized magnetic iron oxide nanoparticle

139 mplications (excluding mortality), which are variably grouped in published analyses using ACS NSQIP d

140 not reported for nearly 30% of outcomes and variably handled in contemporary HF meta-analyses.

141 eloped for the proteomic characterization of variably-heated milk products, highlighting their limits

142 inated action of a receptor-binding protein (variably HN, H, or G) and a more conserved metastable fu

143 These structures are variably homologized with jointed appendages of the seco

144 ermodynamic ramifications of the exposure of variably hydrated Ca-rich montmorillonites to supercriti

145 Reactions involving variably hydrated super critical CO(2) (scCO(2)) and a N

146 n Paleocene adapisoriculids, which have been variably identified as stem euarchontans, stem primates,

147 ch iteratively stitches together a number of variably illuminated, low-resolution intensity images in

148 increase activation of the MAPK cascade and variably impact cell morphology and cytoskeletal rearran

149 in floc compared to bed sediments across six variably impacted aquatic ecosystems.

150 Workplace interventions variably improve MVPA levels and related cardiometabolic

151 cerebellum, the labeled terminals were found variably in all of the cerebellar nuclei.

152 several forms of endocytosis may contribute variably in different conditions.

153 ons in the other 3D-structure nodes and more variably in other parts of ventral visual cortex.

154 KSHV vDNA was detectable in tumors but variably in plasma and peripheral blood mononuclear cell

155 Proliferative retinopathy can present variably in VKH patients and indicates persistent inflam

156 lacks a solid anatomic basis and results in variably inaccurate measurements for 2 reasons.

157 ral stenosis or mechanical heart valves, but variably included patients with other VHD and valve surg

158 Previous studies of resident attrition have variably included preliminary residents and likely overe

159 The OpBR mutant phenotype variably includes bone expansion and fusion, Op duplicat

160 y maximal electroshock (MES) or pilocarpine, variably including electroencephalography, electrocardio

161 s variability correlated in blastocysts with variably increased 5mC/5hmC in gene bodies and repetitiv

162 n (MCD) and Nystatin) and Ang II stimulation variably increased O(2)(-) generation and phosphorylatio

163 Roasting variably increased the a* value, antioxidant activity, p

164 nistic" insights by creating gene lists with variably increased/decreased expression compared with st

165 The existing evidence, however, variably indicates that M1 is under-activated with movem

166 ng in the adventitia/perivascular tissue and variably inflaming/damaging the wall during progression

167 Mechanical confinement can variably influence cell migration behaviors, and it is p

168 idual protein and chemical contaminants that variably inhibit Taq polymerase and primer annealing.

169 accination serum from naive subjects but was variably inhibited by serum from preimmune subjects.

170 eterogeneous non-Hodgkin's lymphoma that may variably involve the skin, lymph nodes, and peripheral b

171 mechanism and that this activation mechanism variably involves DUOX1 and NOX2.

172 ctivity, we documented both consistently and variably labeled CNS structures across individuals.

173 ST131 isolates; representative isolates were variably lethal in a mouse subcutaneous sepsis model.

174 Mesophyll conductance significantly, and variably, limits photosynthesis but we currently have no

175 Multiple small human genetic studies have variably linked single nucleotide polymorphisms in these

176 Her stools were variably loose.

177 erived from the central nervous system (CNS) variably lose their unique barrier properties during in

178 al ions in the affected individuals revealed variably low levels of Mn and Zn in blood and elevated l

179 Synechocystis Most active site substitutions variably lowered maximal catalytic activity without mark

180 Transcripts expressed in cell lines variably matched transcripts selectively expressed in na

181 Extending this, variably methylated genic CGs in maize and Brachypodium

182 About half of the variably methylated IAP LTRs tend to be hypomethylated i

183 Using a repertoire of murine variably methylated intracisternal A-particle (VM-IAP) e

184 type on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent coho

185 e highly variable across individuals, termed variably methylated regions (VMRs), against a backdrop o

186 the C alleles at rs143383 and rs143384 were variably methylated, and treatment of a heterozygous cel

187 d estimate that >6.7% of the mouse genome is variably methylated.

188 ors (PIs) prescribed to HIV-infected persons variably modulate cathepsin activities in human APCs, de

189 Thus, TRPV1 is variably N-glycosylated and glycosylation is a key deter

190 The complex was variably named the mitochondrial contact site complex, m

191 e A reductase inhibitors (statins) have been variably noted to affect hepatitis C virus (HCV) treatme

192 Here, we have identified a variably occupied CTCF site in the Drosophila Ultrabitho

193 This indicates that variably open DHS sites are often occupied by rotational

194 ggest a possible link between this phase and variably oxidized ferropericlase that is commonly trappe

195 collagen binding and ADAMTS13 cleavage) were variably oxidized, one completely.

196 are the cell cycle inhibitors, pRb, p57, and variably, p21: none of the cyclins or cdks necessary to

197 volves the conversion of recently discovered variably participating neurons to reliable status.

198 mic lupus erythematosus (SLE) kidneys have a variably patterned and often extensive infiltrate of pre

199 n vivo Embryos lacking this enhancer display variably penetrant defects in anterior-posterior axis or

200 Arrhythmogenic cardiomyopathy (ACM) is a variably penetrant disease increasingly identified in yo

201 ssion of autosomal genes as well as into the variably penetrant pathophysiological spectrum of phenot

202 genetic variants are currently thought to be variably penetrant, we hypothesise that when disorders e

203 Residents variably perform a purposeful pause ("time-out") when in

204 p53 loss) in murine melanocytes, we observed variably pigmented and highly metastatic melanoma with 1

205 a was a flat, irregularly shaped lesion with variably pigmented and irregularly distributed globules

206 , we examined the follicular melanin unit in variably pigmented follicles from the aging human scalp

207 h two minima, sigma(u)* and pai(u), that are variably populated at room temperature.

208 Serum IgA1 responses were variably positive, and individuals were rarely positive

209 The tradition of consanguinity, variably practiced in the Persian Gulf region, North Afr

210 Wealth and disease severity were variably predictive of blood culture-confirmed enteric f

211 resence of axonal loss, axonal spheroids and variably present pigmented macrophages on pathological e

212 is a clonal disorder of mast cells that may variably present with characteristic skin lesions, episo

213 dal dysfunction and/or peripheral neuropathy variably present), who are clinically indistinguishable

214 iegated aneuploidy (MVA) syndrome, were more variably present.

215 asticity, dystonia, tremor and migraine were variably present; cognitive impairment was severe in ear

216 normal counterparts, cancer cell glycans are variably produced and often structurally distinct, servi

217 gehog/Smoothened (Hh/Smo) signaling has been variably proposed to stimulate overall fin regenerative

218 This means that five cases of variably protease-sensitive prionopathy have been identi

219 Variably protease-sensitive prionopathy is a newly descr

220 man prion diseases, these data indicate that variably protease-sensitive prionopathy is a rare phenot

221 nt prion protein fragment that characterizes variably protease-sensitive prionopathy is detectable at

222 Two cases that conform to the variably protease-sensitive prionopathy phenotype have b

223 linical grounds, and one was a known case of variably protease-sensitive prionopathy previously repor

224 To determine the incidence and phenotype of variably protease-sensitive prionopathy within a single

225 bstitution of the original designation with "variably protease-sensitive prionopathy" (VPSPr).

226 e-resistant prion protein that characterizes variably protease-sensitive prionopathy, followed by neu

227 e found in certain brain regions of cases of variably protease-sensitive prionopathy, indicating mole

228 med biochemically and neuropathologically as variably protease-sensitive prionopathy.

229 chemically, yielding four candidate cases of variably protease-sensitive prionopathy.

230 ever, the alignment among the bands of these variably quantum confined materials remains a controvers

231 We found that BRD2, BRD3, and BRD4 were variably recruited to GATA1-regulated genes, with BRD3 b

232 h in vitro, both BHLF1 (-) viruses exhibited variably reduced immortalization potential relative to t

233 KDSR enzymatic activity was variably reduced in all patients, resulting in defective

234 Biochemical analyses documented variably reduced levels of TBCD, indicating relative ins

235 plagued by substantial initial dysfunction, variably referred to as slow or delayed graft function,

236 explains how another (p)ppGpp target GMK is variably regulated across species.

237 Hippocampal volume reduction was variably related to Abeta deposition.

238 Exercise-induced metabolite changes were variably related to the amount of exercise performed (pe

239 Although perinatal ILC2s were variably replaced across tissues with age, the dramatic

240 s in which the 6-deoxy-l-talose residues are variably replaced with O-acetyl and O-methyl modificatio

241 ell as liver enzyme abnormalities, have been variably reported in patients with coronavirus disease 2

242 Other outcomes were heterogeneous and variably reported, but no study showed an increase in ad

243 87 genes conserved in all strains, and 1,860 variably represented genes.

244 d-chaining rules to take information that is variably represented in source databases and integrating

245 ity and specificity, but IFA is impractical, variably reproducible, and cumbersome for large epidemio

246 Colonies arising with Sendai were variably reprogrammed (10%-80% TRA-1-60(+)), with variab

247 s leads to an innate immune response that is variably responsive to challenges across the circadian d

248 Three-dimensional variably saturated flow and multicomponent biogeochemica

249 ide range of other multisystem features were variably seen, including dysmorphism, skeletal abnormali

250 ructurally conserved DNA-binding domains, is variably sensitive to methylation of their target genes.

251 ental inoculation, 9 (90%) group I dogs were variably seroreactive to one or more of six specific imm

252 enetic background and environmental factors, variably shift the probabilities of phenotypes along a p

253 during laparoscopic partial nephrectomy has variably shown increased intraoperative blood loss when

254 hic lesions with a small hyperpigmented rim, variably sized and predominantly located along the arcad

255 of a linear chromosome and a large number of variably sized linear and circular plasmids.

256 arged, uncharged but polar, hydrophobic, and variably sized primary amines.

257 eep sequencing libraries from small RNAs and variably sized RNA fragments obtained from ribonucleopro

258 ustering methods in 21 tumor types to detect variably sized significantly mutated regions (SMRs).

259 tors but concluded that wild-type MxA formed variably sized spherical or irregular bodies, filaments,

260 ) condensates in the cytoplasm consisting of variably sized spherical or irregular bodies, filaments,

261 ical findings included pleomorphic, small or variably sized yeast-like cells, with single or multiple

262 The underlying chronic strokes were variably sized, predominantly affected white matter trac

263 rkably, the remaining motifs are composed of variably-spaced half-sites (12%) or 'emergent' sites (16

264 s) rising from the deep vascular complex and variably spanning the outer retinal layers and eventuall

265 AMP binds to the HCN channel C terminus and variably stabilizes its open state.

266 structure as a proxy for the distribution of variably sticky information in a population.

267 mia (CLL) is a tumor of circulating B cells, variably stimulated and anergized following exposure to

268 Method development and results for variably substituted aryl acetonitriles and aldehydes in

269 rformed a computational study on a series of variably substituted trans-polyacetylenes, polyynes, and

270 pools in forests have been inconsistent and variably successful in the past.

271 pools in forests have been inconsistent and variably successful in the past.

272 s trials with antiretroviral drugs have been variably successful.

273 Furthermore, analysis of a minilibrary of variably sulfated derivatives of Escherichia coli K5 pol

274 , lapB (also known as yciM), ftsH, and lpxC, variably suppressed the defects in OM integrity, rifampi

275 coded on the X chromosome, in 5 males with a variably syndromic, normocytic CSA.

276 ers because the T3SS pilus must grow through variably thick plant cell walls before contacting the ho

277 Ranging from 0 to 47 months after surgery, a variably thick retrocorneal fibrous membrane was observe

278 or by existing approaches to modularity that variably threshold, binarize, or arbitrarily weight thes

279 this emergence to be a sudden, coherent and variably-timed ensemble transition that reliably precede

280 ion, and beta-cell apoptosis, which interact variably to cause the different diabetes syndromes.

281 st even after smoking cessation and responds variably to corticosteroids.

282 Results: Individual patients responded variably to first- and second-line treatments.

283 ecombinant subdomains, except for SD2, bound variably to human erythrocytes, with constructs containi

284 CD20-expressing T cells respond variably to immunomodulatory treatments given to MS pati

285 Concomitant fundoplication is used variably to prevent complications of gastroesophageal re

286 ith heterogeneous symptomatology and respond variably to therapeutic interventions.

287 the lipid-facing regions of TM3 and TM4 were variably tolerant.

288 components of both pathogens and self, which variably trigger endocytic, phagocytic, proinflammatory,

289 ted blockage of development and reintroduced variably truncated fragments of the pxr region to test f

290 sthyretin cardiac amyloidosis diagnosis have variably used 1- and 3-hour imaging time points.

291 in refractory pediatric acute asthma, it is variably used because of invasiveness and safety concern

292 = 3, >/= 4, or >/= 5 abnormalities have been variably used for its definition.

293 eural dynamics underlying the maintenance of variably visible stimuli using magnetoencephalography.

294 The variably weighted Odum dissimilarity (DwOdum) allows for

295 ing with forsterite (Mg(2)SiO(4)) exposed to variably wet supercritical CO(2) (scCO(2)).

296 Tissue stiffness correlated variably with cell number density, oligodendrocyte inter

297 threatening ventricular arrhythmias combined variably with epilepsy and delayed neurodevelopment.

298 However, these antibodies react variably with parvalbumin from different fish species.

299 ens reacted with S. mansoni egg antigens and variably with schistosome cercarial and worm antigens.

300 tionship, high-volume operators were defined variably, with annual PCIs ranging from >11 to >270, wit