ライフサイエンスコーパス: variant surface glycoprotein

1 , a marker for epimastigotes, and metacyclic variant surface glycoprotein.

2 of infective metacyclic forms expressing the variant surface glycoprotein.

3 ling endosomes, of pre-existing cell surface variant surface glycoprotein.

4 expressing normal mature GPI anchors on its variant surface glycoprotein.

5 ic switching while others stably express one variant surface glycoprotein?

6 NA sequences of the eight genes encoding the variant surface glycoprotein 117 (VSG) family.

7 is responsible for this release, transgenic variant surface glycoprotein 117 (VSG117) was expressed

8 nd surface proteomes, being dominated by the variant surface glycoprotein (African) or mucins (Americ

9 ct midgut stage, enabling rapid recycling of variant surface glycoprotein and antibody clearance from

10 its encoding the major cell surface antigens variant surface glycoprotein and procyclin.

11 ne pool is competent for transfer to nascent variant surface glycoprotein and represents 38% of glyco

12 nvariable regions of variable major protein, variant surface glycoprotein, and pilin, which are not a

13 munity, involving the switching of expressed variant surface glycoproteins by a stochastic and parasi

14 on of VSG genes that encode their protective variant surface glycoprotein coat.

15 expression of VSG genes that encode distinct Variant Surface Glycoprotein coats.

16 osphatidylinositol anchor of the trypanosome variant surface glycoprotein contains myristate as its s

17 In particular, the rapid switching of variant surface glycoproteins covering a large proportio

18 ortant for recombination of the subtelomeric variant surface glycoprotein during antigenic variation.

19 T. brucei results in derepression of silent variant surface glycoprotein ESs, as had previously been

20 nfection that is driven primarily by soluble variant surface glycoprotein exposure, and it may be tha

21 his influences the choice of a monocistronic variant surface glycoprotein expression site.

22 Secondly, knockdown of clathrin or the variant surface glycoprotein failed to perturb transcrip

23 of the bacterial aspartate receptor and the variant surface glycoprotein from Trypanosoma brucei.

24 In bloodstream-form trypanosomes, only one variant surface glycoprotein gene (VSG) expression site

25 at, isolated from the upstream region of the variant surface glycoprotein gene of Trypanosoma brucei,

26 n hosts by switching the expression of their variant surface glycoprotein genes (vsg).

27 alternating expression of telomere-proximal variant surface glycoprotein genes (vsgs), which is cont

28 m-specific epigenetic silencing of telomeric variant surface glycoprotein genes involved in antigenic

29 Transcription of telomere proximal variant surface glycoprotein genes is mono-allelic in bl

30 can trypanosome relies upon the silencing of variant surface glycoprotein genes that are found adjace

31 ed transcriptional switching of subtelomeric variant surface glycoprotein genes, continues to operate

32 depletion leads to deregulation of telomeric variant surface glycoprotein genes, linking the function

33 mmals and involves switches in expression of variant surface glycoprotein genes, which are co-transcr

34 anscribed by a different polymerase than the variant surface glycoprotein genes.

35 s to fine-tune transcription and splicing of variant surface glycoprotein genes.

36 lates with epigenetic silencing of telomeric variant surface glycoprotein genes.

37 ages stimulated with the trypanosome soluble variant surface glycoprotein in vitro and in macrophages

38 TbVps34 knockdown inhibits export of variant surface glycoprotein, indicating a function in e

39 interfering with the endocytic transport of variant surface glycoprotein is a highly desirable strat

40 somes, where the ratio of mRNAs for GP63 and variant surface glycoprotein is about 1:150.

41 nate trypanosome surface proteins, including variant surface glycoprotein, likely facilitating comple

42 somes are glycolipid A, the precursor of the variant surface glycoprotein membrane anchor, and glycol

43 lded from their hosts' defenses by a coat of variant surface glycoprotein molecules, each of which is

44 expresses only one of the unique metacyclic variant surface glycoprotein (mVSG) coat protein transcr

45 iable major protein of Borrelia hermsii, the variant surface glycoprotein of African trypanosomes, an

46 deposition of newly synthesized GPI-anchored variant surface glycoprotein on the cell surface.

47 n myristoylation of the enormous quantity of variant surface glycoprotein produced.

48 to maintain the cell density of its crucial variant surface glycoprotein protective coat.

49 isotopic sugar composition of the parasites variant surface glycoprotein synthesized in cells incuba

50 s, the parasite loses the 10(7) molecules of variant surface glycoprotein that formed its surface coa

51 re, we describe a protein complex sustaining variant surface glycoprotein (VSG) allelic exclusion and

52 e parasite's major cell-surface proteins-the variant surface glycoprotein (VSG) and procyclin.

53 by periodically switching the dense coat of variant surface glycoprotein (VSG) at the cell surface.

54 ucei depends upon switches in its protective Variant Surface Glycoprotein (VSG) coat by antigenic var

55 Variable subregions within the variant surface glycoprotein (VSG) coat displayed by Afr

56 ng T-independent B-cell response against the variant surface glycoprotein (VSG) coat expressed by try

57 ular eukaryote, which relies on a protective variant surface glycoprotein (VSG) coat for survival in

58 brucei relies on antigenic variation of its variant surface glycoprotein (VSG) coat for survival.

59 e response by repeatedly replacing its dense variant surface glycoprotein (VSG) coat from its large g

60 y expresses only 1 of thousands of different variant surface glycoprotein (VSG) coat genes.

61 A Variant Surface Glycoprotein (VSG) coat protects bloodst

62 eping Sickness, constantly changes its dense variant surface glycoprotein (VSG) coat to avoid elimina

63 tem through antigenic variation of its dense variant surface glycoprotein (VSG) coat, periodically 's

64 host immune system through replacement of a variant surface glycoprotein (VSG) coat.

65 st antibodies by periodically changing their variant surface glycoprotein (VSG) coat.

66 genic variation, a periodic switching of its variant surface glycoprotein (VSG) coat.

67 tigenic variation by periodic changes in its variant surface glycoprotein (VSG) coat.

68 sticated antigenic variation of a protective variant surface glycoprotein (VSG) coat.

69 Variant surface glycoprotein (VSG) coats bloodstream for

70 here it is protected by an essential coat of Variant Surface Glycoprotein (VSG) comprising approximat

71 The parasites' variant surface glycoprotein (VSG) enables them to evade

72 Changes in variant surface glycoprotein (Vsg) expression allow Tryp

73 has about twenty telomeric bloodstream form Variant Surface Glycoprotein (VSG) expression sites (BES

74 ranscription is altered at telomere-proximal variant surface glycoprotein (VSG) expression sites (ESs

75 gulation of the RNA polymerase I transcribed variant surface glycoprotein (VSG) expression sites (ESs

76 a unique subset of protein-coding genes-the variant surface glycoprotein (VSG) expression sites and

77 mis-regulation of telomere-proximal silenced variant surface glycoprotein (VSG) expression sites and

78 romosome inactivation, and also in monogenic variant surface glycoprotein (VSG) expression via VSG ex

79 antigenic variation system, mediated by the variant surface glycoprotein (VSG) family and fundamenta

80 e living in the human bloodstream, expresses variant surface glycoprotein (VSG) from 1 of 15 bloodstr

81 mulated PI-PLC cleavage of the GPI anchor of variant surface glycoprotein (VSG) from Trypanosoma bruc

82 e-I (pol-I) to transcribe just one telomeric variant surface glycoprotein (VSG) gene at a time, produ

83 some consists of a putative bloodstream-form variant surface glycoprotein (VSG) gene expression site

84 d from the metacyclic variant antigen type 4 variant surface glycoprotein (VSG) gene expression site,

85 hese features are reminiscent of a vestigial variant surface glycoprotein (VSG) gene expression site.

86 gulates RNA polymerase I (Pol I)-transcribed variant surface glycoprotein (VSG) gene expression sites

87 ukaryote, Trypanosoma brucei transcribes its variant surface glycoprotein (VSG) gene expression sites

88 also located within the silent subtelomeric variant surface glycoprotein (VSG) gene expression sites

89 ono-telomeric but switchable expression of a Variant Surface Glycoprotein (VSG) gene in a transcripti

90 he metacyclic variant antigen type 7 (MVAT7) variant surface glycoprotein (VSG) gene in bloodstream T

91 ation through DNA-repair processes involving Variant Surface Glycoprotein (VSG) gene rearrangements a

92 n initially implicated both ZC3H proteins in variant surface glycoprotein (VSG) gene silencing.

93 elic expression of one of about 20 telomeric variant surface glycoprotein (VSG) gene-expression sites

94 periodically switching the expression of its variant surface glycoprotein (VSG) genes (vsg) among an

95 chromosomes contain nontranscribed copies of variant surface glycoprotein (VSG) genes and are thought

96 lelic expression and reversible silencing of variant surface glycoprotein (VSG) genes found adjacent

97 Trypanosoma brucei expresses variant surface glycoprotein (VSG) genes in a strictly m

98 aintenance and transcriptional regulation of variant surface glycoprotein (VSG) genes in Trypanosoma

99 , relies on targeted recombination of silent Variant Surface Glycoprotein (VSG) genes into a speciali

100 ion in Trypanosoma brucei is used for moving variant surface glycoprotein (VSG) genes into expression

101 Allelic exclusion of variant surface glycoprotein (VSG) genes is essential fo

102 e, relies upon rearrangement of subtelomeric variant surface glycoprotein (VSG) genes to achieve anti

103 ubtelomeric arrays contain an archive of 806 variant surface glycoprotein (VSG) genes used by the par

104 elically expresses one of approximately 1500 variant surface glycoprotein (VSG) genes while multiplyi

105 African trypanosomes possess hundreds of variant surface glycoprotein (VSG) genes, but only one i

106 the evolution of a massive archive of silent Variant Surface Glycoprotein (VSG) genes, which are acti

107 by silent subtelomeres, housing thousands of Variant Surface Glycoprotein (VSG) genes.

108 oallelically expresses one of more than 1000 Variant Surface Glycoprotein (VSG) genes.

109 lencing of a repository of telomere-adjacent variant surface glycoprotein (VSG) genes.

110 nsport and secretion of wild-type and mutant variant surface glycoprotein (VSG) is characterized.

111 sitol (GPI) anchor of the Trypanosoma brucei variant surface glycoprotein (VSG) is unique in having e

112 m of antigenic variation in parasites is the variant surface glycoprotein (VSG) of African trypanosom

113 The variant surface glycoprotein (VSG) of African trypanosom

114 Th1 cell responses to the variant surface glycoprotein (VSG) of African trypanosom

115 The variant surface glycoprotein (VSG) of bloodstream form T

116 The coat consists of ten million copies of variant surface glycoprotein (VSG) that is expressed fro

117 regularly switches its major surface antigen variant surface glycoprotein (VSG) to evade mammalian ho

118 ed that trypanosome strains that express the variant surface glycoprotein (VSG) VSGsur possess height

119 nses and B-cell responses to the trypanosome variant surface glycoprotein (VSG) was measured.

120 e bloodstream stage surface coat composed of variant surface glycoprotein (VSG) with a new coat compo

121 ly synthesized secretory proteins, including variant surface glycoprotein (VSG), confirming its role

122 loodstream, African trypanosomes express the variant surface glycoprotein (VSG), continual switching

123 s evade immune destruction by changing their variant surface glycoprotein (VSG), encoded in a telomer

124 by expressing its major surface antigen, the Variant Surface Glycoprotein (VSG), in a monoallelic man

125 anchor substituents associated with the shed variant surface glycoprotein (VSG), plus the host-activa

126 rucei relies on RNA Pol I for expressing the variant surface glycoprotein (VSG), the key protein in a

127 s covered by a densely packed coat formed of variant surface glycoprotein (VSG), which counteracts th

128 The role of variant surface glycoprotein (VSG)-specific Th cell resp

129 panosomes engineered to express GPI-anchored variant surface glycoprotein (VSG).

130 Acylated GPI-PLC was active against variant surface glycoprotein (VSG).

131 mune system is a dense coat that comprises a variant surface glycoprotein (VSG).

132 a single type of glycoprotein molecule, the variant surface glycoprotein (VSG).

133 versity in the parasite's major antigen, the variant surface glycoprotein (VSG).

134 d is densely covered with highly immunogenic Variant Surface Glycoprotein (VSG).

135 dstream through antigenic variation of their Variant Surface Glycoprotein (VSG).

136 ularly changing their antigenic coat made of variant surface glycoprotein (VSG).

137 ted by a densely packed surface monolayer of variant surface glycoprotein (VSG).

138 by switching their dense protective coat of Variant Surface Glycoprotein (VSG).

139 t immune response by frequently changing its variant surface glycoprotein (VSG).

140 y RAD51-directed homologous recombination of Variant Surface Glycoproteins (VSG) genes, most of which

141 prevention due to antigenic variation of the Variant Surface Glycoproteins (VSG) that coat parasites

142 ing by periodically replacing a monolayer of variant surface glycoproteins (VSG) that covers its cell

143 h house the major antigenic determinant (the Variant Surface Glycoprotein, VSG gene) as well as TbORC

144 Similarly, defective glycosylation of the variant surface glycoprotein (VSG221) as well as the lys

145 Trypanosoma brucei switches between variant surface glycoproteins (VSGs) allowing immune esc

146 ation, the sequential expression of distinct variant surface glycoproteins (VSGs) at extremely high d

147 sequentially expressing genes for different variant surface glycoproteins (VSGs) from telomere-linke

148 n addition to derepression of genes encoding variant surface glycoproteins (VSGs) located in subtelom

149 ification of surface-exposed epitopes on the variant surface glycoproteins (VSGs) of African trypanos

150 trypanosomes abundantly express GPI-anchored variant surface glycoproteins (VSGs) on their cell surfa

151 The GPI anchors of Trypanosoma brucei variant surface glycoproteins (VSGs) undergo rounds of i

152 , with an enrichment in transcripts encoding variant surface glycoproteins (VSGs).

153 asites express a homogeneous surface coat of variant surface glycoproteins (VSGs).

154 chieved by periodically expressing different variant surface glycoproteins (VSGs).

155 acity to encode >1000 antigenically distinct variant surface glycoproteins (VSGs).

156 coprotein of bloodstream-form T. brucei, the variant surface glycoprotein, was unaffected in the TbGT