ライフサイエンスコーパス: variegation

1 enhancer and a suppressor of position-effect variegation.

2 ochromatin phenomenon called position effect variegation.

3 region that protects against position effect variegation.

4 lation, suggests a model for position-effect variegation.

5 cing classically observed as position effect variegation.

6 gative thymocytes, but there was no apparent variegation.

7 dentified as a Suppressor of Position-Effect Variegation.

8 hat is probably analogous to position-effect variegation.

9 but clearly different from, position effect variegation.

10 the P0 protein in modifying position effect variegation.

11 cis, a hallmark of classical position-effect variegation.

12 h correlated in magnitude with the degree of variegation.

13 ition, Low weakly suppresses position effect variegation.

14 transformed hel+ behaves as a suppressor of variegation.

15 nt, chromosomal proteins and position effect variegation.

16 hromatin protein involved in position-effect variegation.

17 lassic genetic suppressor of position-effect variegation.

18 85 are strong suppressors of position effect variegation.

19 into VAR2 function and the mechanism of var2 variegation.

20 ains, as shown by monitoring position effect variegation.

21 is not the principle cause of hCD2 transgene variegation.

22 hat this resulted in the suppression of var2 variegation.

23 henotype associated with suppression of var2 variegation.

24 rganization in cis and trans position-effect variegation.

25 teristic for the green and yellow sectors of variegation.

26 of heterochromatin-mediated position effect variegation.

27 en-up, a known suppressor of position effect variegation.

28 hanism to explain nuclear gene-induced plant variegations.

29 heterozygous for mutations in Suppressor of variegation 205 [Su(var)205], a gene implicated in the c

30 heterozygous for a mutation in Suppressor of variegation 205, the gene that encodes the telomere-capp

31 tholog of Arabidopsis thaliana Suppressor Of Variegation 3 (SVR3) involved in plastid-nucleus signali

32 te a pivotal role for the SET {suppressor of variegation 3 to 9 [Su(var)3-9], enhancer of zeste [E(z)

33 The Enhancer of variegation 3-9 [E(var)3-9] gene was one of over a hundr

34 kdown screen identified SUVR4 {SUPPRESSOR OF VARIEGATION 3-9 [SU(VAR)3-9]-RELATED 4} as a histone H3

35 istone methyltransferase (HMT) suppressor of variegation 3-9 homolog 1 (SUV39H1) is required for the

36 the histone methyltransferase suppressor of variegation 3-9 homolog 1 (SUV39H1) selectively augments

37 Snail interacted with Suv39H1 (suppressor of variegation 3-9 homolog 1), a major methyltransferase re

38 N-methyltransferase SUV39H1 (suppression of variegation 3-9 homolog 1), resulting in heterochromatin

39 interaction between Smad5 and suppressor of variegation 3-9 homolog 2 (Suv39h2), a chromatin modifie

40 ne deacetylase 11 (HDAC11) and suppressor of variegation 3-9 homolog 2 (SUV39H2), key histone-modifyi

41 r of zeste homolog2 (EZH2) and suppressor of variegation 3-9 homolog1 (SUV39H1), which are two histon

42 display reduced expression of suppressor of variegation 3-9 homologs2, 4, and 9 and reduced DNA meth

43 Sirtuin 1 (SIRT1) and suppressor of variegation 3-9 homologue 1 (SUV39H1) are amongst the en

44 g (TGS) involve members of the suppressor of variegation 3-9-homologous (SUVH) group of putative hist

45 To address the mechanisms underlying variegation, a 30-kb genomic fragment containing a singl

46 Variegation, a common phenomenon in plants, can be the r

47 Plastid MSH1 depletion results in variegation, abiotic stress tolerance, variable growth r

48 bination of two modifiers of position effect variegation, adding an extra Y chromosome and increasing

49 previously established linkage between var2 variegation and chloroplast rRNA processing/chloroplast

50 generation and mechanisms of position-effect variegation and demonstrate the utility of rho-GFP as a

51 hat dLDH and L-2HG influence position effect variegation and DNA methylation, suggesting that this co

52 LCRs protect transgenes from position effect variegation and heterochromatinization and also promote

53 ne behaves as an enhancer of position-effect variegation and interacts genetically with mod(mdg4), wh

54 how chemical contrast between the sectors of variegation and quantitative changes as the ablation rea

55 hibitors of human plasmin (PLA) by iterative variegation and selection.

56 hetic PATCs are resistant to position effect variegation and stochastic silencing in the germline.

57 rns similar to those seen in position-effect variegation and yet most inserts were in euchromatic loc

58 an array closer to heterochromatin enhanced variegation, and enhancement was reverted by recombinati

59 aging agents, suppression of position-effect variegation, and female sterility in which ovaries are u

60 Deletion of mutation of hel enhances white variegation, and this can be reversed by a transformed c

61 This variegation appears to be due to expression of the CHS a

62 erent Ly49 genes, and the sequences imposing variegation are located proximally to Ly49 genes.

63 Many variegations are caused by mutations in nuclear genes th

64 PEV revealed that it is not a suppressor of variegation, as concluded by other investigators.

65 insufficiency for E(var)3-9 enhances omegam4 variegation, as would be expected from increased heteroc

66 regulators using a GAL4Colon, two colonsGFP variegation assay.

67 model is proposed to explain the patterns of variegation associated with both "wild type" active Ac a

68 SC80 transgenes are subject to silencing and variegation at a high frequency.

69 is 1360 element contributes to HP1-dependent variegation at a pericentric insertion site, as demonstr

70 0 kinase act as enhancers of position-effect variegation at pericentric sites whereas the gain-of-fun

71 is variable (position effect and expression variegation) because retroviruses are highly susceptible

72 ts as a dominant enhancer of position effect variegation but in a more context-specific manner.

73 ne is non-centromeric and that the extent of variegation can be developmentally regulated.

74 t as dominant suppressors of position effect variegation, confirming a role in heterochromatin spread

75 lted in a decrease, increase or no effect on variegation depending upon the site of integration.

76 ABCD (Asymmetry, Border irregularity, Color variegation, Diameter >6 mm) acronym for the appraisal o

77 Therefore, Ly49 variegation does not require competition in cis between

78 the nuclear VAR2 locus of Arabidopsis cause variegation due to loss of a chloroplast thylakoid membr

79 ber of the positive regulatory/suppressor of variegation, enhancer of zeste, trithorax (PR/SET) domai

80 (Win) motif and the catalytic suppressor of variegation, enhancer of zeste, trithorax (SET) domain.

81 estigation, we report that the suppressor of variegation, enhancer of zeste, trithorax (SET) domains

82 Here we present that suppressor-of-variegation, enhancer-of-zeste, trithorax protein from B

83 12, and EED, in which the SET (suppressor of variegation-enhancer of zeste-trithorax) domain of EZH2

84 sgene with additional 3' sequences showed no variegation even when the latter integrated in centromer

85 sophila transgenes can cause heterochromatic variegation for transgene expression in a copy-number an

86 trans or by the spreading of position effect variegation from rearrangements having heterochromatic b

87 Extensive genetic and epigenetic variegation has been demonstrated in many malignancies.

88 elanogaster for modifiers of position-effect variegation have revealed the basis of much of our under

89 ological processes including position-effect variegation, heterochromatin formation and transcription

90 Additional key features (variegation, heterophylly) evolved in the most species-r

91 some lettuce cultivars exhibit dramatic red variegation; however, the genetic mechanisms underlying

92 vernalization in plants and position effect variegation in animals.

93 effectively prevents transgene silencing and variegation in cell lines, multipotent and pluripotent s

94 Similarities between position effect variegation in Drosophila and gene silencing in maize me

95 Otu1 and Usp5 induces strong position effect variegation in Drosophila eye following I-SceI-induced D

96 silencing, as exemplified by position effect variegation in Drosophila melanogaster and X-chromosome

97 Thus, like variegation in Drosophila, recruitment of mammalian HP1

98 wer temperatures, similar to position effect variegation in Drosophila.

99 d role of this DNA repeat in position effect variegation in facio- scapulohumeral muscular dystrophy

100 determinants of this pattern--recognized by variegation in females but not in males--have been descr

101 cle and is misregulated by TPE-OLD-dependent variegation in FSHD myoblasts.

102 atment efficacies will reflect the molecular variegation in individual tumors.

103 d in diverse systems such as position effect variegation in insects, silencing near yeast telomeres,

104 Collectively, these data suggest that variegation in levels of transgene expression are due to

105 or the origin and inheritance of green-white variegation in nature.

106 previously been shown to enhance expression variegation in petunia and tobacco and to carry a hot sp

107 istinguished from common melanocytic nevi by variegation in pigmentation and clinical appearance, as

108 disturbed phyllotaxis, fasciated stems, and variegation in plants), inhibit its growth, development,

109 endent regulation of domain size and memory, variegation in the absence of antagonists, and coexisten

110 Suppression of variegation in the first line, TAG-FN, was caused by dis

111 sed cloning revealed that the suppression of variegation in this line is due to a splice site mutatio

112 model is presented to explain the pattern of variegation in var2 in which AtFtsH8 provides a compensa

113 lation levels and suppresses position-effect variegation in various Drosophila tissues.

114 Our data suggest a model of variegation in which the IM protein functions early in c

115 z)12, a strong suppressor of position effect variegation, in PRC2 suggests that PRC2 may play a wides

116 ely affected by modifiers of position effect variegation including the Y chromosome, Su(var)205(2), p

117 The proportion of clones displaying marked variegation increased with progressive deletion.

118 utations in HP2 can suppress position effect variegation, indicating a role in gene silencing and het

119 hila PR-Set7 that suppresses position effect variegation, indicating that PR-Set7 indeed functions in

120 stwl mutants acted as Suppressors of variegation, indicating that stwl normally acts in chrom

121 otein, suggesting that the mechanism of var2 variegation involves the action of a redundant activity

122 Variegation is a common feature of gene silencing phenom

123 Embedded in this variegation is a spatial axis of shared multimodal chang

124 these data suggest that screening for yellow variegation is a very efficient method for recovering ce

125 of the AE1 promoter and that position effect variegation is associated with RNA transcription from th

126 ples are described in which a lesion causing variegation is capable of silencing the white transgene

127 Leaf variegation is expressed only in homozygous recessive pl

128 cterization of 004-003, a line in which var2 variegation is suppressed.

129 We have identified a new enhancer of variegation locus, Dmrnahel (hel).

130 Position effect variegation may be considered an abnormal manifestation

131 s found to display reciprocal dose-dependent variegation modifier phenotypes, similar to those for mu

132 ity described here underlies position effect variegation, molds the structure of polytene chromosomes

133 The Arabidopsis var2 variegation mutant defines a nuclear gene for a chloropl

134 The immutans (im) variegation mutant of Arabidopsis (Arabidopsis thaliana)

135 The immutans (im) variegation mutant of Arabidopsis defines the gene for P

136 The immutans (im) variegation mutant of Arabidopsis has green and white le

137 The immutans (im) variegation mutant of Arabidopsis thaliana is caused by

138 In this article, we show that the var1 variegation mutant, which is defective in AtFtsH5, has a

139 d plants and white sectors from the immutans variegation mutant.

140 Nuclear gene-induced variegation mutants provide a powerful system to dissect

141 The immutans (im) variegation mutation of Arabidopsis is nuclear and reces

142 We propose that variegation occurs because heterochromatin inhibits the

143 In addition, white transgene arrays cause variegation of a nearby gene in cis, a hallmark of class

144 exhibits a dosage-dependent modification of variegation of a yellow reporter transgene, indicating a

145 n, we show that Kat2a loss results in global variegation of cell identity and accumulation of preleuk

146 nic dystrophy and Friedreich's ataxia confer variegation of expression on a linked transgene in mice.

147 e far less susceptible to position-dependent variegation of expression than are the Mo-MuLV-based vec

148 Variegation of expression was observed in founders but p

149 guises the fundamental features of subclonal variegation of genetic lesions and of clonal phylogeny.

150 e normal physiology of GCs involves regional variegation of hypoxia, and HIF-dependent oxygen sensing

151 This variegation of IDP change underlines the limitations of

152 and signaling networks in DCs that guide the variegation of immune responses.

153 Variegation of lt was induced in the adult eye, larval s

154 The pattern of aleurone variegation of maize kernels carrying Ac and bz-m2(DI) a

155 Position effect variegation of most Drosophila melanogaster genes, inclu

156 ed for silencing, we propose that epigenetic variegation of telomeric gene expression is due to the b

157 nsitivity of the phenotypic landscape to the variegation of the genotypic landscape suggests that the

158 development, with its disruption leading to variegation of the plant.

159 satellites of Drosophila show repression and variegation of the reporter gene.

160 Position-effect variegation of the w(m4h) allele and different variegati

161 In Drosophila melanogaster, position-effect variegation of the white gene has been a useful phenomen

162 telomere-associated sequences (TAS) and that variegation of these genes is the result of competition

163 The lesions that cause variegation of white minimally disrupt the linear order

164 Rearrangements that lack the array enhanced variegation of white on a homologue bearing the array.

165 In this study, we cloned the causal gene for variegation on lettuce leaves and elucidated the underly

166 sion of nearby marker genes (position-effect variegation or silencing).

167 inactivation associated with position-effect variegation or X chromosome inactivation.

168 relied on mosaic silencing (position-effect variegation, or PEV) of the yellow gene present in the t

169 nation for such phenomena as position-effect variegation (PEV) and control of segment determination a

170 Heterochromatic position-effect variegation (PEV) describes the mosaic phenotype of a eu

171 Position-effect variegation (PEV) describes the stochastic transcription

172 Position effect variegation (PEV) in Drosophila results from new juxtapo

173 ould be similar to a loss of position-effect variegation (PEV) in Drosophila.

174 s required for prevention of position effect variegation (PEV) in transgenic mice.

175 terozygotes display enhanced position effect variegation (PEV) indicative of the broad role of GAF in

176 Position effect variegation (PEV) is the clonal inactivation of euchroma

177 The classical phenomenon of position-effect variegation (PEV) is the mosaic expression that occurs w

178 Position effect variegation (PEV) occurs when a gene is located abnormal

179 romatin-induced silencing or position-effect variegation (PEV) of a reporter gene has provided insigh

180 7) dramatically increase the position effect variegation (PEV) of a yellow(+) body-color gene located

181 BID expression also enhances position-effect variegation (PEV) of the w(m4h) allele and a yellow tran

182 se are strong suppressors of position effect variegation (PEV) of the wm4 allele and that lack of JIL

183 out of 13 JmjC genes modify position effect variegation (PEV) phenotypes, consistent with their ascr

184 Position-effect variegation (PEV) results from the juxtaposition of euch

185 sion, such as is observed in position effect variegation (PEV) when the Drosophila melanogaster white

186 nogaster chromosomes exhibit position effect variegation (PEV), a mosaic silencing characteristic of

187 matic gene, which results in position-effect variegation (PEV), also causes the aberrant association

188 ing rRNA gene transcription, position-effect variegation (PEV), and the link among rDNA copy number,

189 calized protein required for position effect variegation (PEV), colocalized with DmORC2 at these site

190 and recessive suppressors of position-effect variegation (PEV), indicating that, as in yeast, dSir2 i

191 nd regulates heterochromatin position-effect variegation (PEV), organization of repetitive DNAs, and

192 ding of aneuploid syndromes, position-effect variegation (PEV), quantitative traits, and dosage compe

193 n of roX function suppresses position effect variegation (PEV), revealing functional alteration in he

194 dhtt acts as a suppressor of position-effect variegation (PEV), suggesting that it influences chromat

195 mutations in His2Av suppress position effect variegation (PEV), suggesting that this histone variant

196 eterochromatin can result in position effect variegation (PEV), the variable expression of heterochro

197 his contrasts with classical position effect variegation (PEV), where a given gene is either active o

198 n Drosophila melanogaster by position effect variegation (PEV).

199 lenced-a phenomenon known as position effect variegation (PEV).

200 ite dependent, and resembles position-effect variegation (PEV).

201 d counterbalancing effect on position-effect variegation (PEV).

202 three distinct loci showing position-effect variegation (PEV).

203 trong dominant suppressor of position effect variegation (PEV).

204 urvival and does not control position-effect variegation (PEV).

205 also found that whereas var2 displays a leaf variegation phenotype at 22 degrees C, it has a pronounc

206 The spontaneous mutation gpa1.a caused a variegation phenotype of the leaf, dwarfed growth, reduc

207 r2-4 (a putative null allele) normalizes the variegation phenotype of the mutant and restores the two

208 The variegation phenotype of var1 (as well as var2, which is

209 cal library and employing the same iterative variegation procedures used to obtain PLA inhibitors.

210 Su(var)3-9 and Su(var)2-5 on position-effect variegation, providing evidence that a finely tuned bala

211 ever, the genetic mechanisms underlying this variegation remain unknown.

212 AtFtsH2/VAR2, normalizes the pattern of var1 variegation, restoring a nonvariegated phenotype.

213 r of Drosophila melanogaster correlates with variegation (silencing).

214 With position-effect variegation, similar responses were found as with gene e

215 igmatic in vivo function, as a Suppressor of Variegation [Su(var)] that is crucial to global heteroch

216 l assays of boundary activity and epigenetic variegation suggest that Nup2p and the Ran guanylyl-nucl

217 Studies of position effect variegation suggest that promoters of heterochromatic ge

218 alleles of dLsd1 suppress positional-effect variegation, suggesting a disruption of the balance betw

219 also acts as a suppressor of position effect variegation, suggesting that a possible function of Rga

220 Nap-1 are shown to suppress position effect variegation, suggesting that Nap-1 functions to help to

221 re recently shown to perturb position effect variegation, suggesting that the role of SIR2 in epigene

222 ified a novel promoter mechanism controlling variegation through inconsistent levels of methylation a

223 We have generated suppressors of var2 variegation to gain insight into factors and pathways th

224 Current models attribute variegation to the establishment of a heritable silent s

225 odel that may explain phenomena ranging from variegation to the neural restriction of Rett syndrome.

226 ion must strike a balance between sufficient variegation to thoroughly sample alternative functionali

227 Telomere-associated position-effect variegation (TPEV) in budding yeast has been used as a m

228 attenuated through telomere position-effect variegation (TPEV).

229 itable epigenetic trends leading to cellular variegation, trends endemic in a cell population based o

230 levels of expression and increased levels of variegation, upon maternal transmission; and this correl

231 two ilarvirus coat proteins, TSV and citrus variegation virus, is identified and also shown to conta

232 Genetic analyses showed that the variegation was always associated with the transposase c

233 In the second line (TAG-IE), suppression of variegation was caused by a lesion in SVR2, the gene for

234 Notably, triplet-repeat-associated variegation was not restricted to classical heterochroma

235 Consistent with this hypothesis, var2 variegation was repressed by chemical inhibitors of chlo

236 To study the mechanisms that cause variegation, we designed a transgene that we expected to

237 gene, SUP4-o, is subject to position effect variegation when located near a telomere and that this s

238 II (RNAP II) are subject to position effect variegation when located near yeast telomeres.

239 ased (but did not alleviate) position effect variegation within the expressing cell types.

240 NAs (piwi-interacting RNAs), position effect variegation, X-chromosome inactivation, parental imprint

241 ic phenomena, which contribute to phenotypic variegation, zygotic genome activation and nucleolar dom