ライフサイエンスコーパス: vascular development

1 suppress VEGFA expression to support normal vascular development.

2 receptor APLNR, is known to be important in vascular development.

3 n in pregnancy characteristics and childhood vascular development.

4 ation and signaling, potentially influencing vascular development.

5 cating that MCs mostly cover arteries during vascular development.

6 ut mice have previously implicated MAP3K3 in vascular development.

7 ental angiogenesis regulation in addition to vascular development.

8 while secondary vascular stem cells sustain vascular development.

9 levels, demonstrated a similar reduction in vascular development.

10 ein alpha-parvin (alpha-pv) is essential for vascular development.

11 f mice to study its role in angiogenesis and vascular development.

12 -PXY module and fine-tunes TDIF signaling in vascular development.

13 of endoreduplication, KAK may play a role in vascular development.

14 yonic lethality because of severe defects in vascular development.

15 t Mekk3 plays an intrinsic role in embryonic vascular development.

16 ming and extent of GPCR-mediated cardiac and vascular development.

17 ates angiogenic SLIT3-ROBO4 signaling during vascular development.

18 g the requirement of WNK1-OSR1 signaling for vascular development.

19 sting that BMPER may play a role in coronary vascular development.

20 not been specifically implicated in coronary vascular development.

21 al role for seryl-tRNA synthetase (SerRS) in vascular development.

22 of synaptic connectivity and is involved in vascular development.

23 Neurons have an important role in retinal vascular development.

24 bryonic lethality at E11 because of impaired vascular development.

25 rane receptors involved in axon guidance and vascular development.

26 il1-Dll4/Notch1 axis that controls embryonic vascular development.

27 ty between E11.5 and E12.5 due to defects in vascular development.

28 + cells in the kidney and its role in kidney vascular development.

29 en have been established to be regulators of vascular development.

30 aintaining normal mitochondrial function and vascular development.

31 th Norrin/Frizzled4 signaling to control CNS vascular development.

32 Capillaries expressed gene programs for vascular development.

33 mine if the oxidase activity was crucial for vascular development.

34 lead to the undesirable inhibition of normal vascular development.

35 of the most critical events during embryonic vascular development.

36 /RhoA-mediated pathway to promote vertebrate vascular development.

37 , functionally equivalent ligands of ALK1 in vascular development.

38 omolog (dcbld2) in zebrafish impaired normal vascular development.

39 are essential morphogens in angiogenesis and vascular development.

40 ions and directed cell rearrangements during vascular development.

41 that Nrf2 is increased and activated during vascular development.

42 tion, and their specification is crucial for vascular development.

43 essential function of glutaredoxin 2 during vascular development.

44 acts in part via Wnt5a to regulate pulmonary vascular development.

45 nal repression by microRNAs, to allow normal vascular development.

46 c cell signaling that is required for normal vascular development.

47 (SRF) is known to be important for embryonic vascular development.

48 icroRNAs contribute to its repression during vascular development.

49 d in the vascular tissues and regulate shoot vascular development.

50 s through vascular S1P receptors to regulate vascular development.

51 4 is dispensable for embryonic viability and vascular development.

52 y for monolignol polymerization during plant vascular development.

53 nd calcium oscillations in the regulation of vascular development.

54 scent vessels and arterial maturation during vascular development.

55 trin-4-induced biological effects related to vascular development.

56 the canonical Wnt pathway to control retinal vascular development.

57 cause appreciable defects in normal retinal vascular development.

58 transcription factor FoxC1 regulates corneal vascular development.

59 death receptors DR6 and TROY in CNS-specific vascular development.

60 sphorylation, Notch signalling and embryonic vascular development.

61 s high plasticity and cell type diversity in vascular development.

62 these cadherins play a nonredundant role in vascular development.

63 ta introduce LRP1 as a critical regulator of vascular development.

64 ine-binding proteins (G-proteins) in retinal vascular development.

65 ause its role has been implicated in retinal vascular development.

66 reveal a crucial role for GATA2 in lymphatic vascular development.

67 ment, as an important regulator of lymphatic vascular development.

68 n of proper lung epithelial, mesenchymal and vascular development.

69 suggested that maize ANT1 (ZmANT1) regulates vascular development.

70 as a novel regulator of mammalian lymphatic vascular development.

71 fection in early pregnancy impedes placental vascular development.

72 g and suggest that PLXND1 trafficking shapes vascular development.

73 genes that play essential roles in brain and vascular development.

74 o1 protein senses mechanical force to enable vascular development.

75 (FGFR) signalling as a critical regulator of vascular development.

76 t important and complex signaling systems in vascular development.

77 mediate touch perception, proprioception and vascular development.

78 es, with absence of any detectable defect in vascular development.

79 ges expression of multiple genes involved in vascular development.

80 1b, are primarily expressed during embryonic vascular development.

81 sted KANK genes were co-opted for vertebrate vascular development.

82 ed GPCR crosstalk, which plays a key role in vascular development.

83 erscore the importance of the S1P pathway in vascular development.

84 aintaining normal mitochondrial function and vascular development.

85 T signaling and Sox17 to ensure normal brain vascular development.

86 mice displayed significantly delayed retinal vascular development, absence of deep layer retinal vess

87 lishing the venous identity during embryonic vascular development, also regulates the pathophysiologi

88 vity, protein metabolism, cell adhesion, and vascular development, among others.

89 ia probably plays an important role in plant vascular development and adaptation to land environments

90 ults in the profound impairment of postnatal vascular development and adult angiogenesis, lymphangiog

91 Here we show that it also regulates vascular development and adult angiogenesis.

92 Vascular development and angiogenesis initially depend o

93 nd Notch ligand, plays a fundamental role in vascular development and angiogenesis.

94 ignaling family, plays a fundamental role in vascular development and angiogenesis.

95 in-dependent transcription recapitulated the vascular development and barrier defects associated with

96 5) and LRP6 had redundant functions in brain vascular development and barrier maintenance; however, l

97 hat loss of NDST1 causes defective diaphragm vascular development and CDH and that heparan sulfate fa

98 n plays a crucial role in both physiological vascular development and common blinding diseases.

99 4 as a critical regulator of early lymphatic vascular development and demonstrate that mutations in t

100 ist regarding our understanding of pulmonary vascular development and disease in preterm infants at r

101 n Muller glia play distinct roles in retinal vascular development and disease, adding to a growing bo

102 different pathways in growth factor actions, vascular development and disease, and are worthy of furt

103 phatase-5 (DUSP5), and its role in embryonic vascular development and disease, we hypothesized that m

104 o summarize the emerging roles of lncRNAs in vascular development and disease.

105 now emerging as key regulators of mammalian vascular development and disease.

106 in endothelial cells is required for normal vascular development and embryonic viability.

107 nstream signals that play essential roles in vascular development and endothelial integrity, control

108 s with FZD4, a receptor important in retinal vascular development and frequently mutated in Norrie di

109 is an important regulator of uteroplacental vascular development and function and has been implicate

110 he molecular mechanisms underlying lymphatic vascular development and function are not well understoo

111 tch signaling pathway is required for normal vascular development and function, and genetic associati

112 shear forces have established roles in blood vascular development and function, but whether such forc

113 critical requirement for the Abl kinases in vascular development and function, which may have import

114 GF-A) is a master regulator of angiogenesis, vascular development and function.

115 terial-venous differentiation is crucial for vascular development and function.

116 ntrol GATA4 exercises over specialized liver vascular development and function.

117 However, VEGFA also regulates retinal vascular development and functions as a retinal neural s

118 They are important for vascular development and hematopoiesis, immune and infla

119 orm to uncover the molecular determinants of vascular development and heterogeneity and potentially r

120 broad implications for our understanding of vascular development and heterogeneity.

121 ries produced by blood flow is important for vascular development and homeostasis but can also initia

122 d support a critical role for VEGF-D in lung vascular development and homeostasis.

123 ATOH7, especially its importance in retinal vascular development and hyaloid regression.

124 analyses suggest that PVE1 functions during vascular development and in mediolateral and dorsiventra

125 xact contribution of these components in CNS vascular development and in specification of the blood-b

126 e secretome from differentiating ASCs in the vascular development and its integration with the bone t

127 a mutant rootstock results in restoration of vascular development and lateral root initiation.

128 r processes, particularly those that lead to vascular development and maintenance.

129 n of endothelial cell adhesion is central to vascular development and maintenance.

130 eceptor-1 (S1PR1) is essential for embryonic vascular development and maturation.

131 growth factor (VEGF)-dependent regulation of vascular development and metabolism, little is understoo

132 he KIF11 gene likely plays a role in retinal vascular development and mutations in this gene can lead

133 Notch signaling mediates embryonic vascular development and normal vascular remodeling; Not

134 the molecular characterization of lymphatic vascular development and our understanding of this vascu

135 -beta co-receptor, play an essential role in vascular development and pathological angiogenesis.

136 nses to fluid shear stress are essential for vascular development and physiology, and determine the f

137 1-phosphate (S1P) signaling is essential for vascular development and postnatal vascular homeostasis.

138 lnutrition specifically impacts fetal kidney vascular development and prevents full functionality of

139 recent contributions to the understanding of vascular development and remodelling.

140 Thus, abnormal vascular development and resulting hypoxia may contribut

141 that are believed to play important roles in vascular development and stability.

142 well as their basis in general mechanisms of vascular development and stability.

143 ical role in a number of processes including vascular development and stabilization, lymphocyte migra

144 d molecular signals contributing to abnormal vascular development and subsequent identification of no

145 ith the usual role of flow directionality in vascular development and suggests that the full spatial

146 helial Notch signaling is critical for early vascular development and survival.

147 ngineered vessels and play a crucial role in vascular development and the pathogenic events of vascul

148 s a matricellular protein involved in normal vascular development and tissue repair.

149 xpressed, matricellular protein required for vascular development and tissue repair.

150 though Twist1 also plays a role in embryonic vascular development and tumor angiogenesis, the molecul

151 by regulating endothelial genes critical for vascular development and vascular endothelial growth fac

152 ing transcription factor that contributes to vascular development, and has been implicated in coronar

153 es such as adaptive immune cell trafficking, vascular development, and homeostasis.

154 as lymphocyte trafficking, cardiac function, vascular development, and inflammation.

155 trafficking, organization of immune organs, vascular development, and neuroinflammation.

156 ial ligand for endothelial Alk1 in embryonic vascular development, and provide evidence that circulat

157 cell (SMC) differentiation is essential for vascular development, and TGF-beta signaling plays a cri

158 The VEGF-A isoforms play a crucial role in vascular development, and the VEGF signaling pathway is

159 the major approaches used in studying plant vascular development, and we cover the mechanisms and ge

160 vitro models for the investigation of renal vascular development are limited.

161 ower root diameter, indehiscent anthers, and vascular development arrest with lack of lignification.

162 cerebellar cell types and implicate abnormal vascular development as a mechanism for cerebellar malfo

163 e demonstrate that YAP/TAZ are essential for vascular development as endothelium-specific deletion of

164 iogenesis, is a central process in embryonic vascular development as well as in adult tissues.

165 overexpression in the early embryo inhibits vascular development at midgestation, but Edn2 overexpre

166 ion of these pathways evolved to orchestrate vascular development but also drives atherosclerosis in

167 ion in newborn mice not only blocked retinal vascular development but also suppressed astrocytic diff

168 Integrin alpha5beta1 is essential for vascular development but it remains unclear precisely wh

169 ephrinB2 are known key regulators of retinal vascular development, but due to their capacity for bidi

170 A lack of opticin does not influence vascular development, but opticin is antiangiogenic and

171 gnaling specifies arterial fate during early vascular development by inducing the transcription of De

172 thelin-2 (Edn2) in the mouse retina perturbs vascular development by inhibiting endothelial cell migr

173 eal that EC Map4k4 is critical for lymphatic vascular development by regulating EC quiescence and lym

174 tch1-Delta-like 4 (Dll4) signalling controls vascular development by regulating endothelial cell (EC)

175 n regulating secondary wall formation during vascular development by tissue- or cell-specific modulat

176 s Review, we will discuss how the process of vascular development can be used to guide approaches to

177 zed that somatic mosaic mutations disrupting vascular development cause both the Sturge-Weber syndrom

178 d the developmental deformities and impaired vascular development caused by ERSE.

179 specific cox10 ablation results in deficient vascular development causing embryonic lethality.

180 tion, bone/joint formation, axonal guidance, vascular development, cell proliferation and cell moveme

181 not single knockout mice displayed dramatic vascular development defects.

182 Thus, the essential function of SerRS in vascular development depends on UNE-S.

183 During CNS vascular development, doppel interacts with receptor tyr

184 -2 function is required for proper lymphatic vascular development during embryogenesis.

185 ght an essential role of mammalian Piezo1 in vascular development during embryonic development.

186 and highlight potential mechanisms involving vascular development, endothelial function and calcium h

187 in vivo monitoring of hemodynamic status and vascular development, especially in the brain.

188 provides new insights into the mechanisms of vascular development, function, and dysfunction.

189 logical responses, the involvement of EVs in vascular development, growth, and maturation has been wi

190 Our understanding of the process of vascular development has gained significant refinement i

191 rphogenesis, but how NRP1 functions to guide vascular development has not been completely elucidated.

192 erization of an endogenous role for VEGFD in vascular development has remained elusive.

193 iogenesis and vessel wall integrity), FOXC2 (vascular development), hemochromatosis (involved in veno

194 minant-negative PKA in mice led to perturbed vascular development, hemorrhage and embryonic lethality

195 at microRNAs (miRNAs) play a pivotal role in vascular development, homeostasis and a variety of disea

196 Forces play diverse roles in vascular development, homeostasis and disease.

197 ch signaling pathway (Notch) is essential to vascular development, homeostasis, and sprouting angioge

198 TGF-beta is essential for vascular development; however, excess TGF-beta signaling

199 rtant yet little understood aspects of brain vascular development, implicating for the first time a f

200 cytokine biosynthesis, and angiogenesis and vascular development in (adjusted P<0.1).

201 ient SEMA3-NRP1 signaling on fetal pulmonary vascular development in a mouse model.

202 interactions regulate neonatal white matter vascular development in a Wnt-dependent manner and furth

203 ation and generated the critical function in vascular development in Arabidopsis In summary, our resu

204 ermline Vegfr-1(-/-) embryos die of abnormal vascular development in association with excessive endot

205 n the mammalian retina is a paradigm for CNS vascular development in general, and its study is reveal

206 lant secondary cell walls forms the basis of vascular development in land plants, with xylem tissues

207 reported lack of yolk-sac hematopoiesis and vascular development in Ldb1(-/-) mouse result from a de

208 d in vivo application of GW9662 also reduced vascular development in Matrigel plugs.

209 Many genes associated with vascular development in other species show enriched expr

210 g adequate comparison of normal and abnormal vascular development in pregnancy disease.

211 RPE and iris development, ocular growth and vascular development in the anterior chamber, whereas Vh

212 ERSE (5%) also impaired vascular development in the brain.

213 Itgb8) have been shown to result in abnormal vascular development in the CNS, including prenatal and

214 l NOTCH ligand, due to its essential role in vascular development in the context of cardiovascular fe

215 receptor of SLIT3, aggravated the defect in vascular development in the diaphragm and CDH.

216 urine endothelium (Ndst1ECKO mice) disrupted vascular development in the diaphragm, which led to hypo

217 r of angiogenic sprouting and is involved in vascular development in the embryo.

218 e in utero during early gestation for normal vascular development in the eye.

219 nd pro-angiogenic miR-130a affect airway and vascular development in the fetal lungs.

220 Vascular development in the mammalian retina is a paradi

221 gated the hypothesis that opticin influences vascular development in the posterior segment of the eye

222 )-dependent retinal light responses regulate vascular development in the postnatal eye.

223 leiotropic abnormalities, including impaired vascular development in the yolk sac (YS).

224 n of angiogenesis, a direct role for TARS in vascular development in the zebrafish could be demonstra

225 Vascular development in UBR4-deficient YS normally advan

226 of FRG1 protein is critical for muscular and vascular development in vertebrates; however, its precis

227 However, their role on vSMCs during vascular development in vivo remains unclear.

228 To establish the involvement of Tks4 in vascular development in vivo, we show that loss of Tks4

229 of Elmo1 and Dock180 in human ECs and during vascular development in zebrafish embryos.

230 es endothelial migration, tube formation and vascular development in zebrafish that is, CLEC14A regul

231 and s1pr2 function cooperatively to regulate vascular development in zebrafish.

232 Normal vascular development includes the formation and specific

233 azoans and is required for many processes in vascular development, including arterial-venous differen

234 ent that influences several aspects of plant vascular development, including cell division in the vas

235 expression of endothelial genes critical for vascular development, including vascular endothelial gro

236 Vascular development is a complex process regulated by d

237 tic proteins (BMPs) and their antagonists in vascular development is increasingly being recognized.

238 idence that demonstrates a role for ENOX1 in vascular development is lacking.

239 Abnormal vascular development is likely to be responsible for the

240 ted IOP, demonstrating that anterior chamber vascular development is sensitive to Tek gene dosage and

241 A key cell type that regulates retinal vascular development is the astrocyte.

242 gh the function of VEGF-NRP1 interactions in vascular development is well described, the importance o

243 ase occurs during a critical period of brain vascular development, is characterized by glomeruloid va

244 encoded by NDP, has a well-described role in vascular development, its function in human tumorigenesi

245 sence of NG2(+) glia drastically affects the vascular development leading to severe reduction of rami

246 ve been recently described to play a role in vascular development, lineage commitment, and in mesoder

247 st that Etv2 is dynamically regulated during vascular development, little is known about the mechanis

248 are affected, S1P signaling is essential for vascular development, neurogenesis, and lymphocyte traff

249 ad range of investigations of mural cells in vascular development, neurovascular coupling and neuropa

250 ma amino butyric acid (GABA) on neuronal and vascular development of HPA axis regions, such as the pa

251 Vascular development of the central nervous system and b

252 r1 and s1pr2 is suppressed, severely reduced vascular development of the intersegmental vessels was o

253 retina, which include supporting neural and vascular development of the premature infant and retina.

254 differentiation of retinal pericytes during vascular development of the retina.

255 IVNV without affecting physiological retinal vascular development or overall pup growth.

256 ut adversely affecting physiological retinal vascular development or pup weight gain.

257 ulating effects of Vegf during early retinal vascular development, our data suggest a modest involvem

258 Etv2 gene ceases at midgestation; therefore, vascular development past this stage must continue indep

259 During vascular development, physical forces originating from a

260 HTS data with the cell-agent based model of vascular development predicted adverse effects of a refe

261 cuticle formation and epidermal patterning, vascular development, programmed cell death, organ absci

262 Glomerular vascular development progressed through intermediate sta

263 increased apical meristem life, and altered vascular development relative to the null controls.

264 ectors that modulate Notch signalling during vascular development remain largely undefined.

265 1/Dock180 regulates endothelial function and vascular development remained elusive.

266 Blood flow plays crucial roles in vascular development, remodeling and homeostasis, but th

267 e kinase 1 (ALK1) plays an important role in vascular development, remodeling, and pathologic angioge

268 During vascular development, seryl-tRNA synthetase (SerRS) regu

269 at endothelial PKA activity is essential for vascular development, specifically regulating the transi

270 n between astrocyte distribution and retinal vascular development, the factors that guide astrocytes

271 Despite its functional importance in vascular development, the physiological ligand or ligand

272 eta) is known to regulate various aspects of vascular development, the signaling mechanism of TGF-bet

273 indicate that the DGCR8 gene is required for vascular development through the regulation of VSMC prol

274 angiogenesis and promote physiologic retinal vascular development, toxicity from broad and targeted i

275 in decidualization that resulted in abnormal vascular development, trophoblast defects, and a deficie

276 120) and VE-cadherin (VE-cad) endocytosis in vascular development using mouse mutants that exhibit in

277 of the most recent experimental advances in vascular development using the mouse as a model organism

278 ve analysis in embryonic and adult models of vascular development, using intravascular injection of a

279 or any other source of S1P was essential for vascular development, vascular integrity, or hemostasis/

280 eptors is dynamically regulated and controls vascular development, vessel stability and immune cell t

281 ulation is a critical regulator of lymphatic vascular development via activation of Wnt/beta-catenin

282 ophospholipid S1P, which regulates embryonic vascular development via its receptors.

283 acid (RA) as an important regulator of brain vascular development via non-cell-autonomous and cell-au

284 Moreover, when gut vascular development was impaired, either genetically in

285 Its role in vascular development was validated in zebrafish embryos

286 ck (HS)-induced RCD, but not reproductive or vascular development, was found to involve a ferroptosis

287 d that neuropilin 2 (NRP2), a key factor for vascular development, was significantly downregulated du

288 hip of migrating ENCC, ENS formation and gut vascular development we combined fate-mapping of ENCC wi

289 genic mouse models for the study of coronary vascular development, we show that extracardiac septum t

290 giopoietin signaling pathways, which mediate vascular development, were downregulated from early stag

291 lish a new role for Notch signaling in brain vascular development whereby Notch3 signaling promotes e

292 e macrophages in the very early phase of CNS vascular development, which in turn are recruited from s

293 y (FEVR) is characterized by delayed retinal vascular development, which promotes hypoxia-induced pat

294 er, VEGF is also required for normal retinal vascular development, which raises concerns about inhibi

295 e found that Col4a1 mutations cause abnormal vascular development, which triggers small-vessel diseas

296 tion of candidate regulators acting early in vascular development will be essential for further progr

297 Gall formation also perturbed vascular development with a significant reduction in xyl

298 pression are highly dynamic during zebrafish vascular development, with both apparent during early so

299 gh the importance of neuronal progenitors in vascular development within the CNS is well recognized,

300 enriched in transcripts for innate immunity, vascular development, WNT signaling pathway, and cell mi