ライフサイエンスコーパス: vascular endothelium

1 ovel roles of MRTF-A/B in the homeostasis of vascular endothelium.

2 form of thrombomodulin that is shed from the vascular endothelium.

3 multidomain receptor primarily expressed by vascular endothelium.

4 ences expression of protein kinase N3 in the vascular endothelium.

5 localized at low nanomolar concentrations on vascular endothelium.

6 g to vessels and CNS infiltration at the CNS vascular endothelium.

7 egy of leukocytes to adhere and traverse the vascular endothelium.

8 or systemic activation of coagulation or the vascular endothelium.

9 a characteristic of pathologically activated vascular endothelium.

10 ne kidney grafts may depend on expression in vascular endothelium.

11 ; however, A/H antigens were not detected in vascular endothelium.

12 posed to nitric oxide (NO) released from the vascular endothelium.

13 uggesting a direct or indirect effect on the vascular endothelium.

14 dant specific binding sites at the pulmonary vascular endothelium.

15 especially as nitric oxide precursor in the vascular endothelium.

16 derm to specify somites instead of posterior vascular endothelium.

17 ence of sickle red blood cells (RBCs) to the vascular endothelium.

18 stitutive or inducible deletion of Epn1/2 in vascular endothelium.

19 more than 20 years as a prototype marker for vascular endothelium.

20 sential in regulating the development of the vascular endothelium.

21 ccumulated mainly intravascularly and at the vascular endothelium.

22 aggerated inflammatory response in pulmonary vascular endothelium.

23 tonella henselae in the chronically infected vascular endothelium.

24 s of caveolae at the luminal surface of lung vascular endothelium.

25 tate of chronic inflammation and damages the vascular endothelium.

26 itor populations that establish the coronary vascular endothelium.

27 sponsive/HIF target genes, especially in the vascular endothelium.

28 ransmigration using an in vitro model of the vascular endothelium.

29 roteins, mediates homophilic adhesion in the vascular endothelium.

30 es, where they are protected from therapy by vascular endothelium.

31 Ab to non-BM-derived cells such as pulmonary vascular endothelium.

32 est fatty streaks, DCs are found next to the vascular endothelium.

33 eactive oxygen species that damage pulmonary vascular endothelium.

34 human primary monocyte adhesion to activated vascular endothelium.

35 on layer forms on the luminal surface of the vascular endothelium.

36 utrophils interacted, promoting anchoring to vascular endothelium.

37 n assembly and directed cell movement in the vascular endothelium.

38 tor cells in cardiac mesoderm, distinct from vascular endothelium.

39 mediating interaction of leukocytes with the vascular endothelium.

40 exclusion properties found in the vertebrate vascular endothelium.

41 rescued barrier function in HKSA-challenged vascular endothelium.

42 podoplanin as specific markers for lymphatic vascular endothelium.

43 n sph/sph mice, suggesting activation of the vascular endothelium.

44 dditional receptors in the immune system and vascular endothelium.

45 e therefore studied Bmx signaling within the vascular endothelium.

46 studies show that monocytes may give rise to vascular endothelium.

47 ecifically and exclusively to the developing vascular endothelium.

48 the major end product of cyclooxygenase-2 in vascular endothelium.

49 tribute to the radiation response within the vascular endothelium.

50 itors are thought to derive from a subset of vascular endothelium.

51 paB alpha (I-kappaB alpha mt) selectively on vascular endothelium.

52 sition in a continuous linear pattern on the vascular endothelium.

53 duction of the vasodilator nitric oxide from vascular endothelium.

54 and injury with functional impairment of the vascular endothelium.

55 es themselves as well as with the underlying vascular endothelium.

56 ss does not depend on a breech in the limbal vascular endothelium.

57 ing in increased monocyte recruitment to the vascular endothelium.

58 nflammatory and anti-atherogenic molecule in vascular endothelium.

59 the retinal pigment epithelium (RPE), or the vascular endothelium.

60 ha (TNFalpha) to increase recruitment to the vascular endothelium.

61 expression also decreases with age in human vascular endothelium.

62 ly associated with better functioning of the vascular endothelium.

63 dium, atrioventricular cushions and coronary vascular endothelium.

64 ated versican fragment uniquely localized to vascular endothelium.

65 ESL mediates adhesion of T cells to inflamed vascular endothelium.

66 ligand for VLA-4), and leukocyte adhesion to vascular endothelium.

67 ntaining KATP channels are indeed present in vascular endothelium.

68 Estrogen exerts many effects on the vascular endothelium.

69 onses, and activation of coagulation and the vascular endothelium.

70 , patrol blood vessels by crawling along the vascular endothelium.

71 sitized erythrocytes without adhering to the vascular endothelium.

72 r hyaluronan (HA) with CD44, its receptor in vascular endothelium.

73 reflect inflammatory processes affecting the vascular endothelium.

74 ing the interaction of immune cells with the vascular endothelium.

75 mmune system and a transplanted graft is the vascular endothelium.

76 however, is known concerning its role in the vascular endothelium, a major regulator of blood pressur

77 Vascular endothelium activation and lymphocyte attractio

78 adhesion is triggered by the interaction of vascular endothelium adhesion molecules, such as ICAM-1,

79 not nontargeted counterparts, accumulated in vascular endothelium after intravenous injection, locali

80 or activity and suggest that statins protect vascular endothelium against the adverse effect of ox-LD

81 JAM3 is known to be present in vascular endothelium, although its roles in cerebral vas

82 stopathology suggest that AECAs activate the vascular endothelium, amplifying the alloimmune response

83 ver, K(ATP) channels are also located within vascular (endothelium and smooth muscle) and muscle (car

84 tain basal barrier properties in the retinal vascular endothelium and activation of the EPAC-Rap1 pat

85 operative versican proteolysis by ADAMTS9 in vascular endothelium and by ADAMTS20 in palate mesenchym

86 ents that include transmigration through the vascular endothelium and chemotaxis through the vicinal

87 hemistry demonstrated CD31/34 positivity for vascular endothelium and D2-40 negativity for lymphatic

88 kappaB signaling and leukocyte influx in the vascular endothelium and decreased lung injury and morta

89 rs; (iii) P-glycoprotein is expressed on the vascular endothelium and end-feet of vascular glia (form

90 f a factor promoting COUP-TFII expression in vascular endothelium and highlights a novel role for chr

91 adhesion molecule C (JAM-C) is expressed by vascular endothelium and human but not mouse B lymphocyt

92 tumor suppressor that is highly expressed in vascular endothelium and inflamed tissues, yet its role

93 Blood cell aggregation and adherence to vascular endothelium and inflammation play a central rol

94 revents patrolling monocyte migration on the vascular endothelium and interrupts MCMV dissemination t

95 tide that is synthesized and released by the vascular endothelium and is a marker of endothelial func

96 demonstrate the nonthrombotic nature of the vascular endothelium and its transition to a prothrombot

97 telets that expressed P-selectin attached to vascular endothelium and macrophages.

98 tion of chemotherapeutic drugs with both the vascular endothelium and monocytes.

99 dhesive interactions of neutrophils with the vascular endothelium and neutrophil extravasation.

100 A-Tg mice expressed A-antigen on vascular endothelium and other cells including erythrocy

101 they also exhibit enhanced cytoadherence to vascular endothelium and other healthy and infected RBCs

102 -cultured, a parallel channel lined by human vascular endothelium and perfused with culture medium, a

103 synthase uncoupling and oxidative stress in vascular endothelium and peripheral nerve.

104 We detected ELA expression in human vascular endothelium and plasma.

105 t hypoxia, complement/antibody deposition on vascular endothelium and promoted vascular perfusion by

106 vitro that mediates Th17 cell rolling on the vascular endothelium and recruitment in vivo.

107 megalovirus (CMV) infection directly targets vascular endothelium and smooth muscle and at older ages

108 n on human platelets that is also present on vascular endothelium and smooth muscle.

109 e selectively recovered from atherosclerotic vascular endothelium and subjacent tissues.

110 f p66shc expression that is operative in the vascular endothelium and suggest that this mechanism is

111 t sections demonstrated C3 deposition on the vascular endothelium and surrounding myocytes.

112 monstrates that DDAH1 is highly expressed in vascular endothelium and that endothelial DDAH1 plays an

113 found that these ligands directly target the vascular endothelium and that the CNS uses the canonical

114 e of activation of the cytokine network, the vascular endothelium and the coagulation system, with th

115 integrins and their ligands expressed on the vascular endothelium and the extracellular matrix.

116 AM15 in prostate tumor cell interaction with vascular endothelium and the metastatic progression of h

117 denosine receptor disrupted scl(+) hemogenic vascular endothelium and the subsequent EHT process.

118 ular parameters for schizont adhesion to the vascular endothelium and to predict bond dynamics in the

119 he more adhesive SS2 cells interact with the vascular endothelium and trap ISC cells, resulting in va

120 --to the lining of the circulatory system or vascular endothelium and unchecked neutrophil transmigra

121 eolar lavage macrophages, airway epithelium, vascular endothelium, and airway smooth muscle.

122 uding pain), regulation of renal blood flow, vascular endothelium, and inflammatory responses.

123 lying cellular and molecular pathways of the vascular endothelium, and influencing fistula maturation

124 phron, kidney interstitial cell populations, vascular endothelium, and macrophages/monocytes.

125 vascular and airway smooth muscle, proximal vascular endothelium, and pericyte-like cells.

126 lateral line, osteoblast, dermal fibroblast, vascular endothelium, and resident blood.

127 re, we report expression of delta-catenin in vascular endothelium, and show that deletion of only one

128 e of activation of the cytokine network, the vascular endothelium, and the coagulation system in pati

129 ns in hemodynamic shear stress acting on the vascular endothelium are critical for adaptive arterial

130 essive mechanical forces experienced by lung vascular endothelium are known to lead to increased vasc

131 Microtubule (MT) dynamics in vascular endothelium are modulated by vasoactive mediato

132 Although endocardial and vascular endothelium are molecularly similar, endocardia

133 Critical functions of the vascular endothelium are regulated by changes in intrace

134 Thus, physical interactions with the vascular endothelium are required for OPC migration.

135 inflammatory response, thus pointing at the vascular endothelium as a therapeutic target for the man

136 The deposition of C4d on vascular endothelium as well as the coincident presence

137 39 transgene expression was localized to the vascular endothelium at baseline and did not affect tota

138 e adenosine receptor A2b is expressed in the vascular endothelium before HSPC emergence.

139 serum IgG indicating that in addition to the vascular endothelium, bone marrow-derived phagocytic cel

140 ng proepicardial cells give rise to coronary vascular endothelium both in vivo and in vitro.

141 tions between the coagulation system and the vascular endothelium, brain tissue, inflammatory mechani

142 t impaired rolling or sticking to lymph node vascular endothelium but rather decreased migration acro

143 esults suggest that SHS not only affects the vascular endothelium, but also the function of EPCs.

144 lls emerge from Drosha-deficient and control vascular endothelium, but Drosha (cKO)-derived hematopoi

145 OSA directly affects the vascular endothelium by promoting inflammation and oxida

146 tor of downstream NF-kappaB signaling in the vascular endothelium by targeting importin-alpha3, a pro

147 ith microRNA (miRNA) sequences controlled by vascular endothelium cadherin (VE-cad) to study the spec

148 antibody directed at an epitope of monomeric vascular endothelium cadherin that is expressed in tumor

149 l and physiopathologic evidences showed that vascular endothelium can be a target of GvHD in the earl

150 thelium demonstrates for the first time that vascular endothelium can be an important site to activel

151 Here we show that the permeability of vascular endothelium can be increased using an external

152 idly adheres to and penetrates the zebrafish vascular endothelium causing a dose- and time-dependent

153 The vascular endothelium continually senses and responds to

154 of this study was to determine whether human vascular endothelium could produce C4 in response to sti

155 Expressed in the vascular endothelium, cytochrome P450 (CYP) 2J2 is one o

156 ype of cells, the strong DDAH1 expression in vascular endothelium demonstrates for the first time tha

157 Among 11 DHHCs detected in vascular endothelium, DHHC21 is required for barrier res

158 ange of paradigm with the discovery that the vascular endothelium does not just respond to exogenous

159 rmeability and inflammatory responses of the vascular endothelium during endotoxemia.

160 attachment of circulating tumor cells to the vascular endothelium during metastasis.

161 We found Sdc1 expressed in the vascular endothelium during microvessel outgrowth from a

162 n of lymphocytes as they traffic through the vascular endothelium during the immune response.

163 hyperbaric (pressurized) oxygen (HBO) alter vascular endothelium dysfunction and modulate the host i

164 lveolar macrophages and was also detected in vascular endothelium (eg, lymphatics) and pleural mesoth

165 TNFalpha signaling in the vascular endothelium elicits multiple inflammatory respo

166 titutive exposure to disruptive strains, the vascular endothelium exhibits robust barrier function.

167 Although normal vascular endothelium expresses low levels of CXCR7, mark

168 The vascular endothelium forms the inner lining of blood ves

169 paring the transcriptional profiles of blood vascular endothelium from human invasive bladder cancer

170 Collagen XIII is absent in the vascular endothelium from normal renal cortex and abunda

171 efense and protects the developing pulmonary vascular endothelium from ongoing inflammatory injury.

172 novel mechanism by which metformin protects vascular endothelium from SFA-induced ectopic lipid accu

173 In the vascular endothelium, group IV phospholipase A(2)alpha (

174 size vessels can become occluded during anti-vascular endothelium growth factor (anti-VEGF) therapy,

175 gering expression of the angiogenic cytokine vascular endothelium growth factor (VEGF).

176 The Lama2(-/-) vascular endothelium had significant abnormalities, incl

177 However, it is not clear whether the vascular endothelium has a role in contributing osteopro

178 The vascular endothelium has been discovered in the past sev

179 t studies of control pathways regulating the vascular endothelium have illuminated how this single ce

180 e we show that in addition to activating the vascular endothelium, hemoglobin and heme excess alters

181 ating memory CD8(+) T cells that express the vascular endothelium-homing receptor CX3CR1 (fractalkine

182 CD57(+) CD4 T cells also express the vascular endothelium-homing receptor CX3CR1 and migrate

183 minitis, thrombocytopenia, and injury to the vascular endothelium, illustrating challenges yet to ove

184 study to show the expression of LPL from the vascular endothelium in chickens.

185 ta strongly support an important role of the vascular endothelium in determining whole-organ glucose

186 esponsible for the phenotypic changes to the vascular endothelium in inflammation, which allows fluid

187 herapy in endothelial cells as well as tumor vascular endothelium in lung cancer tumors in mice.

188 expressing beta(S) hemoglobin have activated vascular endothelium in multiple organs that exhibits en

189 tumor cells at the periphery and to CD31(+) vascular endothelium in the core.

190 and further support the central role of the vascular endothelium in the pathobiology of PAH.

191 equire these substrates, a major role of the vascular endothelium in the regulation of tissue metabol

192 ur evolving understanding of the role of the vascular endothelium in this process.

193 both SS RBC and murine leukocyte adhesion to vascular endothelium in vivo.

194 These data suggest that the vascular endothelium, in addition to the hematopoietic s

195 cadherin, which localizes adiponectin to the vascular endothelium, in the revascularization response

196 ate angiogenesis and contribute to repair of vascular endothelium, increase during pregnancy.

197 pe I extracellular membrane protein on brain vascular endothelium inducing platelet aggregation via t

198 Furthermore, overexpression of Bcl-2 in the vascular endothelium inhibited the diabetes-induced dege

199 d minimal hepatocyte, biliary epithelium and vascular endothelium injury during preservation and post

200 Adherens junctions are required for vascular endothelium integrity.

201 vels of reactive oxygen species (ROS) in the vascular endothelium is a common pathogenic pathway in m

202 Cancer cell adhesion to the vascular endothelium is a critical step of tumour metast

203 The vascular endothelium is a highly dynamic structure, and

204 phocytes across central nervous system (CNS) vascular endothelium is a key step in inflammatory demye

205 sion of indoleamine-2,3-dioxygenase (IDO) by vascular endothelium is a newly identified vasomotor-reg

206 The vascular endothelium is a particularly important target

207 During the immune response the vascular endothelium is constantly perturbed by biologic

208 The vascular endothelium is critical for induction of approp

209 ouse brain, pericyte investment of the tumor vascular endothelium is reduced, causing deficiencies in

210 tumour immune response and its expression on vascular endothelium is responsible for life threatening

211 The vascular endothelium is the continuous single-cell linin

212 context of cardiovascular disease (CVD), the vascular endothelium is the layer of initiation for the

213 expressed in nonphagocytic cells, including vascular endothelium, is localized to the endoplasmic re

214 nent, where neutrophil interactions with the vascular endothelium lead to barrier dysfunction and inc

215 duction in BMDACs enhances their adhesion to vascular endothelium, leading to synergistic effects of

216 Gremlin 1 released from the vascular endothelium may inhibit endogenous bone morphog

217 hat previously overlooked involvement of the vascular endothelium may provide a more complete picture

218 Selectins on activated vascular endothelium mediate inflammation by binding to

219 infected erythrocytes (IE) to adhere to the vascular endothelium, mediated by P. falciparum erythroc

220 ate arrest of circulating tumor cells at the vascular endothelium, melanoma cell attachment to endoth

221 f muscle contraction, can acutely render the vascular endothelium more insulin-responsive.

222 and add to the perturbation of the maternal vascular endothelium, normally attributed to non-membran

223 y arterial hypertension and in the pulmonary vascular endothelium of 3 rat models of pulmonary hypert

224 we conditionally deleted this receptor from vascular endothelium of adult mice, generating CXCR7(Del

225 nce CPATAERPC) that selectively binds to the vascular endothelium of brown adipose tissue, but not of

226 hypothesized that antibody targeting of the vascular endothelium of glioblastoma with cytotoxic shor

227 , we show that it is highly expressed in the vascular endothelium of human cancers and in a banded pa

228 asite-infected red blood cells (irbc) to the vascular endothelium of organs plays a key role in the p

229 human B-domain deleted FVIII (hFVIII) in the vascular endothelium of otherwise FVIII-deficient mice r

230 nction and inflammation occur in vivo in the vascular endothelium of patients with OSA.

231 The vascular endothelium of proliferating intrarenal vessels

232 alcium (Ca(2+)) signals ("sparklets") in the vascular endothelium of resistance arteries that represe

233 , but not C4, is expressed in the stroma and vascular endothelium of several human malignant tumours.

234 In addition to its expression in the vascular endothelium of several organs, we found FcRn to

235 nduced astrocyte loss and at the fenestrated vascular endothelium of the area postrema.

236 nism by which they initiate contact with the vascular endothelium of the blood brain barrier (BBB) is

237 thy is mediated by leukocyte adhesion to the vascular endothelium of the diabetic retina, which resul

238 tic stem and progenitor cells arise from the vascular endothelium of the dorsal aorta and subsequentl

239 rogenitor cells are generated first from the vascular endothelium of the dorsal aorta and then the fe

240 that impairment of TGF-beta signaling in the vascular endothelium of the eye is sufficient to trigger

241 ormal adhesion of circulating blood cells to vascular endothelium of the microcirculation.

242 Vascular endothelium offers a variety of therapeutic tar

243 The synthetic endothelial ECM and vascular endothelium on it may help us enter in a new ph

244 oreactor to culture pulmonary epithelium and vascular endothelium on the acellular lung matrix.

245 ing, neutrophils migrate along the activated vascular endothelium on which ligands, including interce

246 The vascular endothelium operates in a highly polarized envi

247 ese circulating cells as engrafting cells in vascular endothelium or as promoters of tumor growth.

248 eptor with counter-adhesion molecules on the vascular endothelium or extracellular matrix and lead to

249 e adhesion of infected erythrocytes (IEs) to vascular endothelium or placenta is the key event in the

250 lature, but whether the channel localizes to vascular endothelium or smooth muscle is controversial a

251 Activation of the vascular endothelium (plasma von Willebrand levels) and

252 The vascular endothelium plays a critical role in vascular h

253 R1 expressed on aortic and limb arterial pig vascular endothelium plays a role in binding and phagocy

254 Cell rolling on the vascular endothelium plays an important role in traffick

255 The vascular endothelium presents a major transport barrier

256 The surface proteins in the bone marrow vascular endothelium provide docking sites for targeted

257 Vascular endothelium provides a selective barrier betwee

258 how that Galpha(i) signaling pathways in the vascular endothelium regulate a critical step required f

259 Fluid shear stress due to blood flow on the vascular endothelium regulates blood vessel development,

260 his delicate coating of cells, including the vascular endothelium, regulates permeability, leukocyte

261 tro models of physiological and pathological vascular endothelium remains a fundamental challenge in

262 investigate how the hypoxia response of the vascular endothelium remodels the lung pre-metastatic ni

263 sduction in several cell types including the vascular endothelium, renal tubular cells and erythrocyt

264 Inhibition of leukocyte adhesion to the vascular endothelium represents a novel and important ap

265 The vascular endothelium responds to damage through activati

266 Dengue virus causes leakage of the vascular endothelium, resulting in dengue hemorrhagic fe

267 Murine tumor vessels that lack S1PR1 in the vascular endothelium (S1pr1 ECKO) show excessive vascula

268 ndothelium; the hematopoietic system and the vascular endothelium share a common embryonic origin; in

269 Here we report that vascular endothelium-specific deletion of mouse Drosha (

270 e 1 (DNMT1) and a global hypermethylation in vascular endothelium subjected to disturbed flow.

271 nonuclear cells prevents activation of human vascular endothelium, suggesting a potential role of the

272 gene signatures of mesoderm, trophoblast and vascular endothelium, suggesting correspondence to gastr

273 the expression of adhesion molecules on the vascular endothelium that bind to ligands on circulating

274 coculture of proximal tubule epithelium and vascular endothelium that exhibits active reabsorption v

275 uncover a novel nutrient-sensing role of the vascular endothelium that instigates postprandial VAT in

276 Although our study focuses on the vascular endothelium, the findings are likely to be broa

277 e facts: atherosclerosis is a disease of the vascular endothelium; the hematopoietic system and the v

278 Plasmodium falciparum (iRBCs) adhere to the vascular endothelium through adhesive protrusions called

279 nical Wnt pathway at two different levels in vascular endothelium: through transcriptional regulation

280 across the blood-brain barrier and the gut's vascular endothelium thus compromising immune surveillan

281 thesis that elevated shear stress causes the vascular endothelium to become more insulin-responsive a

282 gnaling in both types of mice stimulates the vascular endothelium to contribute osteoprogenitor cells

283 function and that LPC impacts on the retinal vascular endothelium to induce vasopermeability via VEGF

284 by which rapamycin modulates the ability of vascular endothelium to mediate inflammation and identif

285 ole played by genetic variants acting in the vascular endothelium to modulate inter-individual risk i

286 fluence leukocyte recruitment, it primes the vascular endothelium to mount a more intense response wh

287 gated the ability of overexpressing Bcl-2 in vascular endothelium to protect against early stages of

288 AT1 activation in innate immune responses of vascular endothelium to R. conorii infection.

289 LSTc was instead found on microglia and vascular endothelium, to which virus bound abundantly.

290 impeded HCC migration and their adhesion to vascular endothelium, two critical processes in hematoge

291 ributing to the proinflammatory responses of vascular endothelium under OSS.

292 nal antioxidant intervention targeted to the vascular endothelium using PEG-liposomes loaded with EUK

293 In vascular endothelium VEGF signals through two receptor-t

294 tissues was linked to the activation of the vascular endothelium via one or more Galpha(i)-coupled r

295 Likewise, CD59 expression on vascular endothelium was significantly higher in atheror

296 It also has antiproliferative effects on vascular endothelium when used to coat coronary artery s

297 d receptor gamma (PPARgamma) is expressed in vascular endothelium where it exerts anti-inflammatory a

298 trate that NPP4 is present on the surface of vascular endothelium, where it hydrolyzes Ap3A into AMP

299 ges on the ability of the cells to adhere to vascular endothelium with sufficient strength to overcom

300 ced IP is associated with injury to the lung vascular endothelium, with decreased TJ and PPAR-gamma e