ライフサイエンスコーパス: vascular permeability

1 disrupted BTB tight junctions and increased vascular permeability.

2 ung, skin, kidney and liver showed increased vascular permeability.

3 ium interaction with blood constituents, and vascular permeability.

4 othelial cells, thereby preventing excessive vascular permeability.

5 These effects correlated with decreased vascular permeability.

6 nulomas mature, they induce angiogenesis and vascular permeability.

7 hosphorylation of VE-cadherin, and increased vascular permeability.

8 diaphragm formation and maintenance of basal vascular permeability.

9 induced by sepsis and sustained increase in vascular permeability.

10 el role of MYLK-L-induced SOCE in increasing vascular permeability.

11 cs of endothelial junctions, thus permitting vascular permeability.

12 ty receptor for LTE4 that mediates cutaneous vascular permeability.

13 ing VEGF receptor 2 attenuates VEGFA-induced vascular permeability.

14 me protein regulates TGF-beta1-mediated lung vascular permeability.

15 lium and higher microvessel density increase vascular permeability.

16 te and sustained enhancement of cellular and vascular permeability.

17 very into treated tumor beds due to enhanced vascular permeability.

18 l cell mitogenesis, angiogenesis, as well as vascular permeability.

19 vating this pathway and in vivo in enhancing vascular permeability.

20 hich reduce retinal angiogenesis and retinal vascular permeability.

21 endothelial Pak2 deletion leads to increased vascular permeability.

22 hematocrit, and lung weight as a measure of vascular permeability.

23 s and the ID8 model directly correlates with vascular permeability.

24 nterstitial fluid pressure (IFP) by reducing vascular permeability.

25 lated PAH lungs without increasing pulmonary vascular permeability.

26 dothelial glycocalyx is a vital regulator of vascular permeability.

27 patients with thrombocytopenia and increased vascular permeability.

28 on PALD1 KD VECs demonstrated a recovery in vascular permeability.

29 kocyte recruitment is accompanied by reduced vascular permeability.

30 ted with increased bronchial vascularity and vascular permeability.

31 Mmp-10 and Nur77, and inhibits VEGF-induced vascular permeability.

32 pathway through which tight junctions limit vascular permeability.

33 uding angiopoietin 2 (ANG2), which increases vascular permeability.

34 ing along and between ECs is associated with vascular permeability.

35 n guinea pig skin, inhibits allergen-induced vascular permeability.

36 ion of JAM-A in mice significantly increased vascular permeability.

37 (N-WASP) in modulating P aeruginosa-induced vascular permeability.

38 angiotensin II to control vasodilatation and vascular permeability.

39 cluding rapid tumor targeting and high tumor vascular permeability.

40 neovessels lead to distinct changes in tumor vascular permeability.

41 re diabetic retinas contributes to increased vascular permeability.

42 prevented and reversed the tryptase-induced vascular permeability.

43 athophysiology of U-HAE increasing the basal vascular permeability.

44 mbers and integrity in the eye and increased vascular permeability.

45 metastasis, are accompanied by an increased vascular permeability.

46 l cell functions, including angiogenesis and vascular permeability.

47 h important outcomes in contexts of enhanced vascular permeability.

48 of VEGFR3 in the regulation of VEGF-induced vascular permeability.

49 may promote early atherogenesis by enhancing vascular permeability.

50 vascular proinflammatory responses including vascular permeability, adhesion and migration of leukocy

51 eed, alpha1AMPK exhibited heightened cardiac vascular permeability after lipopolysaccharide challenge

52 e tested the hypothesis that TRPC4 increases vascular permeability and alters the frequency of endoth

53 ght junction integrity, resulting in altered vascular permeability and an associated CNS inflammation

54 The authors show in turn how this affects vascular permeability and can ultimately improve the eff

55 ensing shear flow and eicosanoid modulators, vascular permeability and contractility at the inner ret

56 This effect was associated with increased vascular permeability and decreased vascular perfusion o

57 ed ALI, as a critical initiator of increased vascular permeability and early neutrophil infiltration.

58 Manifestations of such injury are increased vascular permeability and edema, endothelial dysfunction

59 LTD4 plus PGE2 potentiated vascular permeability and edema, gearing the system towa

60 or molecule perforin fully protected against vascular permeability and edema.

61 Inflammatory signaling was associated with vascular permeability and endothelial activation, and re

62 ation after engraftment, partially impairing vascular permeability and glucose delivery to beta-cells

63 n along EC junctions, resulting in increased vascular permeability and HSPC egress.

64 Septic shock is characterized by increased vascular permeability and hypotension despite increased

65 likely cause increases in vascular dilation, vascular permeability and hypotension.

66 oxide in dengue is associated with increased vascular permeability and impaired homeostasis and may h

67 nockout mice grew faster and showed enhanced vascular permeability and increased angiogenesis as comp

68 Vascular permeability and inflammatory demyelination are

69 ded monocyte de-adhesion, thereby increasing vascular permeability and lesion formation, whereas soma

70 ung histology, lung cell proliferation, lung vascular permeability and lung gene expression profiling

71 tical illnesses is associated with increased vascular permeability and mortality.

72 In vivo vascular permeability and mouse models of passive system

73 Vascular permeability and neovascularization are implica

74 wever, the processes that underlie increased vascular permeability and pathological plasma leakage du

75 l cell (PEC) dysfunction including increased vascular permeability and perivascular inflammation asso

76 Vascular permeability and plasma leakage are immune-path

77 lts suggest that VEGF simultaneously induces vascular permeability and promotes responsiveness to nor

78 y a fundamental process in diabetes-mediated vascular permeability and provide translational rational

79 ports the notion that excessively decreasing vascular permeability and pruning/rarefaction after beva

80 ys an essential role in P aeruginosa-induced vascular permeability and pulmonary edema through the mo

81 sing RGD-coated stents results in diminished vascular permeability and reduced foam cell formation co

82 ather, cortactin deficiency caused decreased vascular permeability and reduced leukocyte infiltration

83 We demonstrate that increased vascular permeability and remodeling, after injury, can

84 t, to noninvasively monitor focal changes in vascular permeability and remodeling, after injury, in N

85 damage the endothelium leading to increased vascular permeability and remodeling.

86 ifying the pro-barrier mechanisms that block vascular permeability and restore the blood-retinal barr

87 newly synthesized lipid mediators that alter vascular permeability and smooth muscle tone.

88 Biweekly cyclophosphamide injection improved vascular permeability and structural abnormalities of en

89 ted stabilization of the ECs clearly reduced vascular permeability and suppressed alveolar hemorrhage

90 , an agent in clinical trials that increases vascular permeability and uptake of nanocarriers into tu

91 , stimulates vascular hypertrophy, increases vascular permeability and vascular inflammation (p65, ca

92 he stromal compartment, in the regulation of vascular permeability and vascular inflammation.

93 helial growth factor (VEGF) potently induces vascular permeability and vessel growth in the tumor mic

94 Denudation resulted in higher vascular permeability and vessel wall enhancement 7 days

95 lacking HIF2alpha in ECs had increased lung vascular permeability and water content, both of which w

96 ential process during leukocyte trafficking, vascular permeability, and angiogenesis.

97 f histones by inhibiting endothelial damage, vascular permeability, and coagulation activation, as re

98 e, improved tumour vessel perfusion, reduced vascular permeability, and consequently mitigated hypoxi

99 feration, migration, tubulogenesis, enhanced vascular permeability, and endothelial-to-mesenchymal tr

100 arget inflamed vasculature, locally increase vascular permeability, and extravasate across inflamed e

101 o WT mice increased LDL clearance, increased vascular permeability, and increased vascular deposition

102 of inflammatory cells in the lung, increased vascular permeability, and induced histologic ALI in nai

103 Left ventricular function, edema, vascular permeability, and inflammation were assessed in

104 otease inhibitor that regulates coagulation, vascular permeability, and inflammation, with beneficial

105 d its physiological properties, reducing its vascular permeability, and promoting a stabilized, quies

106 These isoforms have opposing actions on vascular permeability, angiogenesis, and vasodilatation.

107 gly resembling those of MS, early changes in vascular permeability are associated with perivascular i

108 Pathological changes in vascular permeability are driven by growth factors such

109 e mechanisms underlying P aeruginosa-induced vascular permeability are not well understood.

110 Inflammation and vascular permeability are thought to be major contributo

111 s to exit the circulation without increasing vascular permeability-are starting to be elucidated and

112 ibition of NRP2 was hypothesized to decrease vascular permeability as well.

113 lectrophysiology, impedance measurements and vascular permeability assays, we show that the transient

114 (gadofosveset) could quantify the changes in vascular permeability associated with atherosclerosis pr

115 ation of multiple sized tracers to determine vascular permeability at a resolution of nearly one micr

116 n albumin-binding probe to assess changes in vascular permeability at different stages of aneurysm gr

117 ukocyte diapedesis, but not the induction of vascular permeability, attenuates bleeding.

118 g injury (ALI) was associated with increased vascular permeability attributable to loss of the Src fa

119 y domain 1, contribute to maintenance of the vascular permeability barrier and to its re-establishmen

120 nerating thrombin which in turn can increase vascular permeability both directly, acting on endotheli

121 rast, VE-cadDEE/DEE mutants exhibited normal vascular permeability but displayed microvascular patter

122 howed a dose-dependent loss of LTE4-mediated vascular permeability, but not to LTC4 or LTD4, revealin

123 acerbate inflammation, RvD2 did not increase vascular permeability, but reduced neutrophil accumulati

124 ring high levels of bradykinin and increased vascular permeability, but the cellular mechanisms leadi

125 phorylation of VEGF receptor 2, promotion of vascular permeability by ANGPTL4 was independent of this

126 ce showing that hypoxic Muller cells promote vascular permeability by stabilizing hypoxia-inducible f

127 at sites of inflammation, sgC1qR can enhance vascular permeability by upregulation of B1R expression

128 Many of the signaling pathways promoting vascular permeability can also be triggered during disea

129 The realization that leukocyte traffic and vascular permeability can be regulated separately should

130 to explain how local tissue inflammation and vascular permeability can induce downstream pathological

131 stamine (which has a short primary effect on vascular permeability), can have severe secondary effect

132 cosal tissue, due to a temporary increase in vascular permeability caused by the release of vasoactiv

133 ated acute pulmonary damage through reducing vascular permeability changes and recruitment of neutrop

134 LPS-induced vascular permeability changes were reduced in EC-specifi

135 nflammatory response, resulting in increased vascular permeability, circulatory collapse, decreased c

136 ortant for the regulation of blood pressure, vascular permeability, clotting and transendothelial mig

137 e show that the developmental acquisition of vascular permeability coincides with differential expres

138 arization (cerebral blood volume [CBV]), and vascular permeability (contrast enhancement after gadoli

139 Increased retinal vascular permeability contributes to macular edema, a le

140 Increased vascular permeability contributes to many diseases, incl

141 ss is known about downstream mechanisms (ie, vascular permeability controlled by endothelial cells [E

142 More advanced aneurysms with higher vascular permeability demonstrated an increased uptake o

143 diet for 2 years were monitored for retinal vascular permeability, development of ME, and morphologi

144 gration and barrier function in a variety of vascular permeability disorders.

145 exhibit frequent haemorrhages and increased vascular permeability due to increased phosphorylation a

146 ort, high interstitial pressure and enhanced vascular permeability due to the presence of "leaky vess

147 Angioedema attacks result from increased vascular permeability due to the release of bradykinin f

148 recruitment to lungs and increases pulmonary vascular permeability during ALI.

149 se, tryptase, is consequential for promoting vascular permeability during DENV infection, through ind

150 ical trials, we link ANG-2/TIE2 signaling to vascular permeability during mycobacterial infection.

151 in inflammatory amplification and increased vascular permeability during severe forms of dengue.

152 observed in diseases associated with higher vascular permeability (e.g., systemic capillary leak syn

153 lipopolysaccharide-induced increases of lung vascular permeability, edema, and inflammatory cell infi

154 dify endothelial function in mouse models of vascular permeability, emphysema, primary tumour growth

155 terferon-gamma and mediate local increase in vascular permeability, enabling antibody access for vira

156 n myrobalan fruits can inhibit VEGFA induced vascular permeability, endothelial cell proliferation, m

157 nfocal intravital microscopy, we report that vascular permeability-enhancing stimuli caused a signifi

158 actor, was originally discovered as a potent vascular permeability factor (VPF), suggesting that othe

159 croglia/macrophage activation, and increased vascular permeability, features commonly associated with

160 lity during IAV infection and show decreased vascular permeability, fewer pulmonary neutrophils, and

161 infection, a finding confirmed by heightened vascular permeability following virus challenge.

162 of LeTx-induced damage, including changes in vascular permeability, hepatic necrosis, and cellular ap

163 his phenomenon can be explained by increased vascular permeability immediately after NIR-PIT.

164 This phenomenon is explained by increased vascular permeability immediately after NIR-PIT.

165 , we investigated postnatal angiogenesis and vascular permeability in a DEP-1-deficient mouse.

166 e inhibition of MMP-9 decreased pathological vascular permeability in a murine model of diabetic reti

167 dition of exogenous SEMA3F protein inhibited vascular permeability in Balb/cJ mice, suggesting that t

168 Here we report increased colonic vascular permeability in CDI mice and elevated vascular

169 l roles for toxin-induced VEGF-A and colonic vascular permeability in CDI pathogenesis and may also p

170 BRB properties and correlates with increased vascular permeability in diabetic macular edema.

171 n restores BRB properties after VEGF-induced vascular permeability in diabetic rats or in animals int

172 tastatic cancer cells induces metastasis and vascular permeability in distant organs, whereas inhibit

173 no consensus that apoptosis is the basis of vascular permeability in human dengue infections, we sho

174 h increased CD31(+) aggregates and increased vascular permeability in inflamed mucosa compared with t

175 current knowledge on the nature of enhanced vascular permeability in multiple non-cancerous patholog

176 g probe may enable noninvasive assessment of vascular permeability in murine AAAs and prediction of r

177 ning of blood vessels and actively regulates vascular permeability in response to chemical and physic

178 all treatment protocols displayed decreased vascular permeability in response to OVA challenge after

179 anscriptional program that broadly regulates vascular permeability in response to progesterone.

180 in contrast to c-Src and Yes, which increase vascular permeability in response to stimuli, Lyn stabil

181 ssues, as well as in tumors, and exacerbated vascular permeability in response to VEGF, administered

182 signaling downstream of VEGFR2 pY949 limits vascular permeability in retinopathy induced by high oxy

183 ogether, these data support a role for islet vascular permeability in shaping beta-cell adaptive resp

184 Increased vascular permeability in the allograft has been identifi

185 Vascular permeability in the lungs was assessed by accum

186 xcessive glutamate release lead to increased vascular permeability in the rat cerebral cortex, throug

187 UUO enhanced vascular permeability in the renal interstitium, and ATX

188 mechanical and chemical stimuli and regulate vascular permeability in the retina is unknown.

189 therapeutics at the tumor site by modifying vascular permeability in the tumor to increase the thera

190 ration was also impaired, reflecting reduced vascular permeability in the tumors or a possible cell a

191 specific deletion of PR blocks physiological vascular permeability in the uterus, whereas misexpressi

192 NGR-hTNF selectively increased vascular permeability in tumoral/peritumoral areas, with

193 cated that the mechanisms of MMP-1-dependent vascular permeability in tumors involve endothelial PAR1

194 FTY720-phosphate, on variables of pulmonary vascular permeability in vitro and alveolar-capillary pe

195 ial Ca(2+) signals mediated by TRPC4 enhance vascular permeability in vitro, but the contribution of

196 The absence of Eps8 also increases vascular permeability in vivo, but did not induce other

197 vessel regeneration and reduce VEGF-induced vascular permeability in vivo.

198 f AMP-activated protein kinase activation on vascular permeability in vivo.

199 LL-N-MYLK mutant in Mylk-L(-/-) mice rescued vascular permeability increase in response to endotoxin,

200 Excess vascular permeability, increased number of AC and PL, va

201 able tumor responses to FUS include enhanced vascular permeability, increased T cell infiltration, an

202 n patients with a maximum value of pulmonary vascular permeability index >3.8 and 37% in the group wi

203 the group with a maximum value of pulmonary vascular permeability index </= 3.8 (p < 0.0001).

204 dexed to predicted body weight and pulmonary vascular permeability index are two promising early mark

205 dexed to predicted body weight and pulmonary vascular permeability index as predictive markers of cli

206 Pulmonary vascular permeability index discriminated acute respirat

207 Pulmonary vascular permeability index effectively discriminated po

208 dexed to predicted body weight and pulmonary vascular permeability index measurements were obtained i

209 dexed to predicted body weight and pulmonary vascular permeability index measurements.

210 extravascular lung water index and pulmonary vascular permeability index recorded during the acute re

211 dexed to predicted body weight and pulmonary vascular permeability index were obtained within 2 hours

212 dexed to predicted body weight and pulmonary vascular permeability index would identify patients at r

213 g water index and maximum value of pulmonary vascular permeability index, respectively) were signific

214 ng water index or maximum value of pulmonary vascular permeability index, Simplified Acute Physiology

215 extravascular lung water index and pulmonary vascular permeability index, which can be measured by tr

216 4], p = 0.001 for maximum value of pulmonary vascular permeability index, Wilcoxon's test).

217 brane VE-cadherin in ECs and in mice, blocks vascular permeability induced by ischaemia-reperfusion (

218 361F mutant in ECs prevented the increase in vascular permeability induced by the thrombin receptor,

219 naling in the vasculature leads to increased vascular permeability, inflammation, and endothelial cel

220 we found increased leukocyte recruitment and vascular permeability/inflammation in sdc-1 knock-out mi

221 Increased vascular permeability is a fundamental characteristic of

222 Increased vascular permeability is a hallmark of inflammation.

223 Vascular permeability is a hallmark of several disease s

224 It has long been taught that increased vascular permeability is a natural consequence of inflam

225 Pulmonary edema associated with increased vascular permeability is a severe complication of Pseudo

226 Vascular permeability is frequently associated with infl

227 Vascular permeability is modulated by several factors, i

228 enhanced T1-weighted MRI, we determined that vascular permeability is not homogeneous but rather conf

229 A hallmark of inflammation, increased vascular permeability, is induced in endothelial cells b

230 at OMVs from P. gingivalis mediate increased vascular permeability, leading to a diseased phenotype b

231 uces biomechanical effects that increase the vascular permeability, leading to a locally enhanced ext

232 nse, and examined ear swelling, SK activity, vascular permeability, leukocyte recruitment, and produc

233 l injections of exogenous PK induced retinal vascular permeability, leukostasis, and retinal hemorrha

234 DSS is plasma leakage that leads to enhanced vascular permeability, likely due to a cytokine storm.

235 coagulopathy, proinflammatory cytokines, and vascular permeability, may serve as a receptor for Plasm

236 Vascular permeability measured by Evans blue extravasati

237 Pulmonary vascular resistance and vascular permeability measured in isolated perfused lung

238 We investigated whether vascular permeability measured in vivo by magnetic reson

239 We observed that VEGF regulates vascular permeability, monocyte infiltration, and scar-a

240 However, relative vascular permeabilities of the different nasal mucosal s

241 ute ocular inflammation, dilation, increased vascular permeability of choroidal vessels, and SRDs.

242 Glycyrrhizin also improved vascular permeability of endothelial cell-specific Fli1-

243 ration of renal fibroblasts and enhances the vascular permeability of endothelial monolayers.

244 nt with methlut significantly decreases skin vascular permeability of Evans blue dye in mice passivel

245 These findings indicate that ultrahigh vascular permeability of renal clearable nanocarriers ca

246 promote microvascular leakage, the impact of vascular permeability on neutrophil trafficking is unkno

247 ssociated with indirect markers of increased vascular permeability, organ dysfunction, mortality, and

248 dexed to predicted body weight and pulmonary vascular permeability patient-important with important o

249 le tumor targeting, we found their different vascular permeability played an even more important role

250 Inhibition of NO production reduced vascular permeability, preserved normal hematopoietic st

251 ed-enhanced MRI were used as measurements of vascular permeability (R1) and remodeling (vessel wall e

252 alyzed in immunohistochemical, morphometric, vascular permeability, real-time polymerase chain reacti

253 lar integrity and homeostasis, by regulating vascular permeability, regulating mechanotransduction, a

254 y in RGD-coated stents resulted in decreased vascular permeability relative to DES, which was further

255 Sustained amelioration of retinal vascular permeability (RVP) was demonstrated using a bes

256 dentifying areas with variable perfusion and vascular permeability, since individual tumor habitats v

257 NGR-hTNF enhanced vascular permeability specifically in tumoral/peritumora

258 lume and is influenced by agents that affect vascular permeability, such as antiangiogenic therapies.

259 cells require HIF--but not VEGF--to promote vascular permeability, suggesting that other HIF-depende

260 etes, including microaneurysms and increased vascular permeability, suggesting that pericyte cell los

261 gradation products are capable of modulating vascular permeability, suggesting that these fragments a

262 at 3 months' diabetes duration and included vascular permeability, superoxide production, leukotrien

263 a mild fever to a severe, potentially fatal vascular permeability syndrome.

264 Concurrently with the initiation of vascular permeability, T2-weighted MRI revealed edema an

265 that low-density GS-AgNPs showed much higher vascular permeability than GS-AuNPs and can rapidly pene

266 EH inhibitor prevented the pericyte loss and vascular permeability that are characteristic of non-pro

267 herapies are needed to reverse the increased vascular permeability that characterizes acute inflammat

268 Dengue can cause increased vascular permeability that may lead to hypovolemic shock

269 Here, we show that the physiological vascular permeability that precedes implantation is dire

270 g solid tumors has been reported to increase vascular permeability, the mechanism of this process rem

271 ey role for the RhoA signalling circuitry in vascular permeability, thereby identifying novel pharmac

272 ) are proinflammatory mediators that enhance vascular permeability through distinct receptors (CysLTR

273 n activator (uPA) regulates angiogenesis and vascular permeability through proteolytic degradation of

274 microvasculature, the VI-V fragment promoted vascular permeability through the uncoordinated 5B (UNC5

275 s, the eGC is damaged, resulting in enhanced vascular permeability, tissue edema, augmented leukocyte

276 ing water supplied by ATO) exhibited greater vascular permeability to Evans blue dye and fluorescein

277 sm for the bidirectional modulation of brain vascular permeability toward increased drug delivery and

278 eactive oxygen species (ROS) and exacerbates vascular permeability triggered by several inflammatory

279 rowth (associated with PDGF-BB delivery) and vascular permeability (triggered by VEGF-A).

280 ency led to decreased levels of intratumoral vascular permeability, tumor cell intravasation, and met

281 at 3 and 12 weeks, to quantify plaque area, vascular permeability, vasodilation, and stiffness and p

282 Targeting granuloma-induced vascular permeability via vascular endothelial-protein t

283 VEGF) is the main driver of angiogenesis and vascular permeability via VEGF receptor 2 (VEGFR2), wher

284 ted by immunostaining with isolectin B4, and vascular permeability was analyzed by fluorescein angiog

285 Moreover, VEGF-induced vascular permeability was decreased by 30% in Esm1(KO) m

286 imately 70-fold (FITC-lectin binding), tumor vascular permeability was enhanced by more than 30% (dyn

287 tro, protease-activated receptor-2-dependent vascular permeability was induced by pooled mature trypt

288 NADPH oxidase, respectively), but increased vascular permeability was not significantly affected.

289 Vascular permeability was not significantly altered in M

290 Because increased vascular permeability was observed early in the disease

291 dema attributable to ischemic stroke-induced vascular permeability was reduced by 50% in the absence

292 VEGF-mediated in vivo vascular permeability was significantly attenuated in PT

293 Vascular permeability was twofold greater in inflamed bl

294 e caveolae regulate endothelial function and vascular permeability, we hypothesized that defects in c

295 ps in VEGFA/VEGF receptor 2 (VEGFR2)-induced vascular permeability, we show that targeting signaling

296 ie-2, pericyte/endothelial (EC) coverage and vascular permeability were assessed.

297 matory cytokines in the CNS and induction of vascular permeability were reduced.

298 ng a role in angiogenesis, inflammation, and vascular permeability, which might be of potential inter

299 the blood-brain barrier (BBB) via increased vascular permeability, with the magnitude of changes dep

300 ADH-1 increased vascular permeability without effecting tumor interstiti