ライフサイエンスコーパス: vascular remodeling

1 that alerts arterial macrophages to regulate vascular remodeling.

2 egions of disturbed flow, and flow-dependent vascular remodeling.

3 ance in the arterial wall and contributes to vascular remodeling.

4 ia in addition to basal cell hyperplasia and vascular remodeling.

5 henotypes can be altered during pathological vascular remodeling.

6 in persistent inflammation and pathological vascular remodeling.

7 ipating in pulmonary hypertension-associated vascular remodeling.

8 nal hematopoiesis, inflammation, and adverse vascular remodeling.

9 asoconstriction is correlated with pulmonary vascular remodeling.

10 ion and overactivation of Tie2 can result in vascular remodeling.

11 rrythmia, inhibited PAH-associated pulmonary vascular remodeling.

12 participant in blood pressure regulation and vascular remodeling.

13 perkinetic circulation, volume overload, and vascular remodeling.

14 CaMKIIdelta promotes VSM proliferation and vascular remodeling.

15 eutic targets for neointima formation during vascular remodeling.

16 PCSK6 as a key regulator of SMC function in vascular remodeling.

17 by aldosterone may mediate adverse pulmonary vascular remodeling.

18 mpairs re-endothelialization and accelerates vascular remodeling.

19 ibutes to impaired re-endothelialization and vascular remodeling.

20 y for Schistosoma-induced TGF-beta-dependent vascular remodeling.

21 zed by lung endothelial cell dysfunction and vascular remodeling.

22 icroRNA cluster, which is highly involved in vascular remodeling.

23 transcriptional network underlying lymphatic vascular remodeling.

24 Rbeta) known to be important in pathological vascular remodeling.

25 PMFs are key cells in hepatic vascular remodeling.

26 characterized by cellular proliferation and vascular remodeling.

27 e cells (SMC) is a key culprit of pathologic vascular remodeling.

28 mokine receptor CXCR7 in atherosclerosis and vascular remodeling.

29 e stress promote ROS1 activation and mediate vascular remodeling.

30 er, this strategy is limited by pathological vascular remodeling.

31 liferation, a major contributor to pulmonary vascular remodeling.

32 lopment of a functional microvasculature and vascular remodeling.

33 beyond BAS to other vasculopathies involving vascular remodeling.

34 ma formation but not for hypertension-driven vascular remodeling.

35 ignaling and then contribute to veins during vascular remodeling.

36 ased platelet activation, and less pulmonary vascular remodeling.

37 ignaling is necessary but not sufficient for vascular remodeling.

38 sociated with several human cancers and with vascular remodeling.

39 imulus for PASMC proliferation and pulmonary vascular remodeling.

40 ence of histological evidence of accentuated vascular remodeling.

41 critical role of mTOR signaling in pulmonary vascular remodeling.

42 ressive, usually fatal disease with abnormal vascular remodeling.

43 ting angiogenesis, but seems dispensable for vascular remodeling.

44 smooth muscle cells leading to (mal)adaptive vascular remodeling.

45 ause they produce growth factors that aid in vascular remodeling.

46 eatening disease, characterized by pulmonary vascular remodeling.

47 nd ER stress promote proliferative pulmonary vascular remodeling.

48 res the cardiac index, and reduces pulmonary vascular remodeling.

49 ty to apoptosis, a known driver of pulmonary vascular remodeling.

50 butes to endothelial apoptosis and pulmonary vascular remodeling.

51 ntricular hypertrophy, cardiac fibrosis, and vascular remodeling.

52 tase domain are significantly protected from vascular remodeling.

53 development and maintenance of pathological vascular remodeling.

54 Cutaneous leishmaniasis is characterized by vascular remodeling.

55 hypertension (PAH) progression and pulmonary vascular remodeling.

56 ctivates higher levels of TGF-beta1 to drive vascular remodeling.

57 ervention to limit atherogenesis and adverse vascular remodeling.

58 iology by targeting a modulator of pulmonary vascular remodeling.

59 by inflammation, leukocyte infiltration, and vascular remodeling.

60 on plays also a critical role in both PH and vascular remodeling.

61 sclerosis through increased inflammation and vascular remodeling.

62 urface thiol-redox control of thrombosis and vascular remodeling.

63 ysfunction, smooth muscle contractility, and vascular remodeling.

64 vascular endothelial growth factor-dependent vascular remodeling.

65 vasoregulation, hemostasis, thrombosis, and vascular remodeling.

66 embryos die at midgestation with defects in vascular remodeling, a process critically influenced by

67 Vasoconstrictive and vascular remodeling actions of endothelin (ET) 1 and ang

68 cells as critical adventitial progenitors in vascular remodeling after acute and during chronic injur

69 rotein E knockout mice significantly reduced vascular remodeling after acute induction of disturbed f

70 RB6-8C5 or 1A8 reduced neutrophil influx and vascular remodeling after infection by about 90%.

71 Similarly, vascular remodeling after infection was suppressed in Cx

72 Atherosclerosis and vascular remodeling after injury are driven by inflammat

73 We tested CaMKIIgamma function in vascular remodeling after injury.

74 ressing non-classical monocytes that support vascular remodeling after injury.

75 vivo investigation of neovascularization and vascular remodeling after ischemia or vessel injury, and

76 dings reveal the spatiotemporal evolution of vascular remodeling after stroke and demonstrate that a

77 ng the mechanisms of intimal hyperplasia and vascular remodeling, although their technical complexity

78 stromal microenvironment that contributes to vascular remodeling and aberrant tumor angiogenesis in t

79 hus, pre-patterned vascular networks enhance vascular remodeling and accelerate coronary perfusion, p

80 ed before triggering to identify plaques and vascular remodeling and after triggering to identify thr

81 tory phenotype, and their secretome promotes vascular remodeling and angiogenesis.

82 mmatory activation of the endothelium during vascular remodeling and atherosclerosis.

83 d EVs provides potential targets to modulate vascular remodeling and calcification in the context of

84 X2 expression histologically correlates with vascular remodeling and calcification.

85 lungs of patients with PAH, contributing to vascular remodeling and calcium-related biomineralizatio

86 st agent, and T1 mapping were used to assess vascular remodeling and calculate the plaque area and ve

87 ltrate small pulmonary arteries, and promote vascular remodeling and development of PH.

88 However, the vascular remodeling and dysfunction due to World Trade C

89 us H2S production predisposes the animals to vascular remodeling and early development of atheroscler

90 erial hypertension (PAH) is characterized by vascular remodeling and excessive proliferation of pulmo

91 5-deficient mice, a model that is linked to vascular remodeling and fibrosis.

92 molecular mechanism that promotes pulmonary vascular remodeling and fibrosis.

93 somes, have been identified as regulators of vascular remodeling and have promise as therapeutics for

94 enic proteins (BMPs) and blood flow regulate vascular remodeling and homeostasis.

95 the cell behaviors underlying each stage of vascular remodeling and identify a pathway required for

96 y or metformin treatment, reversed pulmonary vascular remodeling and improve PH due to LHD.

97 structure, attenuated PH, reduced pulmonary vascular remodeling and improved cardiac function.

98 Oral treatment with RVX208 reversed vascular remodeling and improved pulmonary hemodynamics

99 pathway in diseases characterized by adverse vascular remodeling and increased permeability.

100 MP-9 forms may help explain the constitutive vascular remodeling and infiltrative nature of these les

101 herein FOXO1-driven ANG2 expression promotes vascular remodeling and leakage.

102 oligomerization domain of angiopoietin-2 in vascular remodeling and lung metastasis and provides new

103 her, the major effects of EVE appeared to be vascular remodeling and maturation of functional blood v

104 ry arterial hypertension is characterized by vascular remodeling and neomuscularization.

105 trols PASMC survival to promote hypertrophic vascular remodeling and PAH.-

106 cally modified mouse model with obliterative vascular remodeling and pathophysiology recapitulating c

107 In these mice, vascular remodeling and PH severity were significantly r

108 signaling and reduced established pulmonary vascular remodeling and PH.

109 iR-210 were detectable in 2 rodent models of vascular remodeling and plaque rupture.

110 Implication of RUNX2 in PAH-related vascular remodeling and presence of calcified lesions in

111 Here we report the role of NLRC5 on vascular remodeling and provide a better understanding o

112 e effects of the fucoidan/P-selectin axis on vascular remodeling and pulmonary hypertension (PH) afte

113 cp2KO mice spontaneously developed pulmonary vascular remodeling and pulmonary hypertension and exhib

114 deletion of HIF-1alpha attenuated pulmonary vascular remodeling and pulmonary hypertension in chroni

115 ha in smooth muscle contributes to pulmonary vascular remodeling and pulmonary hypertension in chroni

116 t EP3 activation facilitates hypoxia-induced vascular remodeling and pulmonary hypertension in mice a

117 The pulmonary vascular remodeling and pulmonary hypertension were depe

118 soconstriction and chronic hypoxia can cause vascular remodeling and pulmonary hypertension, conflict

119 of autoantibodies into rats caused pulmonary vascular remodeling and pulmonary hypertension.

120 igration are postulated to have roles during vascular remodeling and regression, the contribution of

121 ibody and P-selectin-deficient mice improved vascular remodeling and restored RV function.

122 poxia-induced PH in mice, reducing pulmonary vascular remodeling and restoring RV function.

123 rtension (PAH) is characterized by pulmonary vascular remodeling and right heart failure.

124 ti-Gremlin 1 antibody also reduced pulmonary vascular remodeling and right ventricular hypertrophy in

125 eptor type 2 (BMPR2) signaling, and reversed vascular remodeling and right-heart hypertrophy in vivo.

126 ective contributions to the initial stage of vascular remodeling and sprouting lymphangiogenesis were

127 postnatal retinal vessels leads to aberrant vascular remodeling and sprouting, as well as markedly r

128 hances post-stroke angiogenesis by promoting vascular remodeling and stimulating the generation of ne

129 s novel targets, RhoB and MLC2, resulting in vascular remodeling and the development of PAH.

130 Therefore, the reduction of vascular remodeling and the up-regulation of Kallikrein-

131 nsufficient trophoblast invasion, inadequate vascular remodeling, and a loss of immunologic homeostas

132 gh, contribute to lung fibrosis, maladaptive vascular remodeling, and allergic asthma.

133 is characterized by inflammation, pulmonary vascular remodeling, and angio-obliteration leading to e

134 ions in bioavailable nitric oxide, increased vascular remodeling, and associated increases in vascula

135 embryonic organ development, hematopoiesis, vascular remodeling, and atherogenesis.

136 rp5/6 pathway is essential for angiogenesis, vascular remodeling, and barrier maturation, how these d

137 cts of imatinib (100 mg/kg) on hemodynamics, vascular remodeling, and downstream molecular signatures

138 nt role in VSMC migration and injury-induced vascular remodeling, and implicate PLD2 as a candidate t

139 lol in improving cardiac function, pulmonary vascular remodeling, and inflammation of rats with monoc

140 ontaneously developed PAH, adverse pulmonary vascular remodeling, and inflammation, with elevated lev

141 Serum, lung and liver cytokine, pulmonary vascular remodeling, and liver histology were assessed.

142 gen delivery, by regulating angiogenesis and vascular remodeling, and oxygen utilization, by regulati

143 S is associated with plaque burden, positive vascular remodeling, and plaque disruption in a rabbit m

144 m the effects of hypoxia on the right heart, vascular remodeling, and raised serum endothelin 1 level

145 icits pulmonary dilation, prevents pulmonary vascular remodeling, and reduces the right ventricular h

146 improving endothelial dysfunction, pulmonary vascular remodeling, and right heart function.

147 eased right ventricular pressures, pulmonary vascular remodeling, and right ventricular hypertrophy.

148 rized by elevated pulmonary artery pressure, vascular remodeling, and ultimately right ventricular he

149 PH, cardiac function, vascular remodeling, and valve structure were assessed b

150 pmental and tumor angiogenesis, inflammatory vascular remodeling, and vessel leakage.

151 is highly active in extracellular matrix and vascular remodeling, angiogenesis, and tumor progression

152 Angiogenesis and vascular remodeling are complementary, innate responses

153 er fibrosis expanding from portal tracts and vascular remodeling are determinant factors in the progr

154 Angiogenesis and vascular remodeling are essential for the establishment

155 Although the cues governing vascular remodeling are not fully understood, target-der

156 inflammation, water and salt retention, and vascular remodeling, are mediated via its type 1 (AT1) r

157 d pericyte coverage contributes to pulmonary vascular remodeling as a source of smooth muscle-like ce

158 Sac/Val reduces pulmonary pressures, vascular remodeling, as well as RV hypertrophy in a rat

159 elta 71 Rats exhibited progressive pulmonary vascular remodeling associated with a proproliferative p

160 erial hypertension (PAH) is characterized by vascular remodeling associated with obliteration of pulm

161 g processes are involved in the inflammatory vascular remodeling associated with the resolution of DV

162 ic arch variations noted during normal rapid vascular remodeling at stage 21 identify a temporal wind

163 ophysiology, with cellular proliferation and vascular remodeling being the key pathogenic events alon

164 ecular explanation behind the alterations in vascular remodeling, biomechanical properties, and aneur

165 moting pulmonary vasodilation and inhibiting vascular remodeling but are degraded by neprilysin.

166 actor (VEGF) are both capable of stimulating vascular remodeling, but the resulting blood vessel netw

167 n HF, PH is associated with global pulmonary vascular remodeling, but the severity of PH correlates m

168 , under pathogen-free conditions, ANG2 drove vascular remodeling by acting as an agonist, promoting h

169 Our study demonstrates that NLRC5 regulates vascular remodeling by directly inhibiting SMC dysfuncti

170 A20 protects against pathologic vascular remodeling by inhibiting the inflammatory trans

171 The time course of vascular remodeling coincided with the influx of neutrop

172 During vascular remodeling, colocalization of Notch2 and p27(ki

173 e in AAA formation, aortic inflammation, and vascular remodeling compared to elastase-treated WT mice

174 c interstitial pneumonia and major pulmonary vascular remodeling.Conclusions: PH-NF1 is characterized

175 Vascular remodeling consisted of both luminal enlargemen

176 surrounding the infarct, but whether and how vascular remodeling contributes to recovery are unclear.

177 e lesion, but whether and how the process of vascular remodeling contributes to recovery of behaviora

178 -beta in extracellular matrix production and vascular remodeling, coupled with increased TGF-beta exp

179 how that factors found in young blood induce vascular remodeling, culminating in increased neurogenes

180 Pulmonary arterial hypertension (PAH) is a vascular remodeling disease with limited therapeutic opt

181 of nitrite anion therapy for ischemic tissue vascular remodeling during diabetes remain unknown.

182 ANG2 drove vascular remodeling during Mycoplasma pulmonis infection

183 oup first reported that RGS5 is important in vascular remodeling during tumor angiogenesis.

184 ammation in vessels, leading to pathological vascular remodeling during VZV vasculopathy and persiste

185 owth and angiogenesis and displayed a marked vascular remodeling effect, leading to normalized microv

186 en the transpulmonary gradient and pulmonary vascular remodeling existed, with numerically stronger a

187 rophoblasts, STBs) and invasion and maternal vascular remodeling (extravillous trophoblasts, EVTs).

188 Therefore, our findings support that vascular remodeling facilitates behavioral recovery afte

189 migration to the perivascular space and that vascular remodeling following arterial occlusion occurs

190 ay act as a risk factor contributing to lung vascular remodeling following endothelial cell injury.

191 signaling is a promising strategy to reverse vascular remodeling for treatment of severe PAH.

192 ntribute to the process of hypoxic pulmonary vascular remodeling; however, the specific role of pulmo

193 lar development and the pathogenic events of vascular remodeling i.e. restenosis.

194 isruption of the Gal1-N-glycan axis promoted vascular remodeling, immune cell influx and tumor growth

195 udies will evaluate whether exercise-induced vascular remodeling improves gemcitabine or other chemot

196 phosphatase activity substantially reverses vascular remodeling in a rat model of angio-obliterative

197 We present a novel approach to characterize vascular remodeling in adult mice using Adipo-Clear in c

198 Despite clinical and histologic vascular remodeling in all patients with PH-COPD and PH-

199 nsiveness in vitro, and attenuated occlusive vascular remodeling in chronically hypoxic Sugen5416-tre

200 linking hyperglycemia, hypercoagulation, and vascular remodeling in diabetes mellitus.

201 ay a role in the development of pathological vascular remodeling in diabetic retinopathy.

202 killer T (NKT) cells play a critical role in vascular remodeling in different physiological and patho

203 accumulation of pro-angiogenic monocytes and vascular remodeling in experimental hepatopulmonary synd

204 mproved survival, RV function, and pulmonary vascular remodeling in experimental PH.

205 inflammation may trigger the development of vascular remodeling in group 2 PH.

206 We conclude that the pathogenesis of vascular remodeling in hypoxic PH involves an early comp

207 y pathophysiological components of pulmonary vascular remodeling in idiopathic pulmonary arterial hyp

208 here was a significant increase in pulmonary vascular remodeling in infected mice.

209 Stem cells are thought to enhance vascular remodeling in ischemic tissue in part through p

210 f TGFbeta1-mediated mechanisms that regulate vascular remodeling in mice and clinical PAH and PPARgam

211 ellular domain, exacerbated PH and pulmonary vascular remodeling in mice treated with hypoxia versus

212 right ventricular hypertrophy and pulmonary vascular remodeling in monocrotaline-exposed rats.

213 inhibitor-1, and mitigated PH and pulmonary vascular remodeling in monocrotaline-treated rats, SU541

214 Increased VEGF expression promoted islet vascular remodeling in NOD mice, and inhibition of VEGFR

215 time-course of the development of pulmonary vascular remodeling in PAH rats.

216 urvive and proliferate, thus contributing to vascular remodeling in PAH.

217 rm shear profiles that are critical loci for vascular remodeling in PAH.

218 macrophage activation as the sole driver of vascular remodeling in PH, and uncover a cross-talk betw

219 eceptor interaction enable discrimination of vascular remodeling in PH-IPF or PH-COPD.

220 key pathophysiologic components of pulmonary vascular remodeling in pulmonary arterial hypertension (

221 e dysregulation has been linked to occlusive vascular remodeling in pulmonary arterial hypertension (

222 yperaldosteronism correlates positively with vascular remodeling in pulmonary arterial hypertension,

223 h muscle cells (PASMCs) is key to pathologic vascular remodeling in pulmonary hypertension (PH).

224 contribution during chronic hypoxia-induced vascular remodeling in Pw1(nLacZ+/-) mouse expressing be

225 ries, and reversed hypoxia-induced pulmonary vascular remodeling in rats.

226 Adaptive vascular remodeling in response to arterial occlusion ta

227 ysiological role for CNP in angiogenesis and vascular remodeling in response to ischemia and provide

228 e a central role for CNP in angiogenesis and vascular remodeling in response to ischemia.

229 raphic investigation suggests that pulmonary vascular remodeling in smokers is characterized by dista

230 wth factor (VEGF) plays an important role in vascular remodeling in the asthmatic airways.

231 d pulmonary hypertension and the concomitant vascular remodeling in the lung.

232 loid-specific conditional deletion of FAK on vascular remodeling in the mouse femoral arterial ligati

233 16 injection reduced pulmonary pressures and vascular remodeling in the PH-HFpEF model with robust ac

234 is a serious lung condition characterized by vascular remodeling in the precapillary pulmonary arteri

235 st agent enables more accurate assessment of vascular remodeling in the prediction of vulnerable plaq

236 termine whether neutrophils are required for vascular remodeling in the respiratory tract by using My

237 erapy effectively stimulates ischemic tissue vascular remodeling in the setting of metabolic dysfunct

238 t to HSS and if the shear defect partakes in vascular remodeling in vivo.

239 esponses to flow in vitro and flow-dependent vascular remodeling in vivo.

240 is a fatal disease characterized by profound vascular remodeling in which pulmonary arteries narrow b

241 ntaneous severe PAH with extensive pulmonary vascular remodeling, including vascular occlusion and pl

242 or alpha, stimuli implicated in pathological vascular remodeling, increase Adamts-1 expression in end

243 dly expand into primitive plexi that undergo vascular remodeling into circulatory networks, requiring

244 Vascular remodeling is a feature of sustained inflammati

245 Following transplantation, appropriate vascular remodeling is crucial to ensure the survival an

246 Vascular remodeling is essential for tissue repair and i

247 VEGF in modulation of tumor angiogenesis and vascular remodeling is less understood.

248 s-1 upregulation by inducers of pathological vascular remodeling is mediated by specific signal trans

249 Vascular remodeling is promoted by the survival and prol

250 This vascular remodeling is reversible, and hydrogen sulfide

251 In pulmonary hypertension vascular remodeling leads to narrowing of distal pulmona

252 factor play important roles in angiogenesis, vascular remodeling, local tumor growth, and metastatic

253 This suggests that tumor vascular remodeling may redirect the organism-wide signa

254 essels regress, identifies these proteins as vascular remodeling molecules crucial for angioplasticit

255 isorder in which endothelial dysfunction and vascular remodeling obstruct small pulmonary arteries, r

256 so demonstrate for the first time that tumor vascular remodeling occurs in association with exercise

257 sel for 18 d is demonstrated while occlusive vascular remodeling occurs.

258 Vascular remodeling of donor, PH-COPD, and PH-IPF pulmon

259 PDE1 inhibition suppressed vascular remodeling of human saphenous vein explants ex

260 f cases, patients with PH due to LHD display vascular remodeling of pulmonary arteries (PAs) associat

261 IUGR is associated with vascular remodeling of the stem villus arteries.

262 rombus resolution by increasing inflammatory vascular remodeling of venous thrombi in vivo, and the p

263 and activated PI3K signaling, whereas during vascular remodeling, pericytes upregulate genes involved

264 estigate the role of the magnitude of ESS on vascular remodeling, plaque burden, and disruption using

265 During this vascular remodeling process, primordial endothelial cell

266 Pulmonary hypertension and pulmonary vascular remodeling (PVR) are common in many lung diseas

267 y pressure, vascular resistance, and limited vascular remodeling quantified by histology.

268 ion of transcriptional programs relevant for vascular remodeling, reestablishment of peri-infarct blo

269 However, the mechanisms of obliterative vascular remodeling remain elusive; hence, current thera

270 Yet, mechanisms underlying vascular remodeling remain poorly established.

271 However, the role of NLRC5 in vascular remodeling remains unknown.

272 gfrbeta, which effect ultimately fosters the vascular remodeling required for normal vision in the mo

273 JNK3-Foxo3a-Egr1/Creb1 axis coordinates the vascular remodeling response in peripheral ischemia.

274 The vascular remodeling responsible for pulmonary arterial h

275 ERCA2a) decreased pulmonary artery pressure, vascular remodeling, right ventricular hypertrophy, and

276 Pulmonary vascular remodeling severity was associated with reducti

277 al administration of TNFalpha did not induce vascular remodeling similar to that seen in infection.

278 standing of the regulation of vasomotion and vascular remodeling that have led to "reverse-remodeling

279 ildren conceived by ART manifest cardiac and vascular remodeling that is present in fetal life and pe

280 ole in several biological systems, including vascular remodeling that occurs following percutaneous t

281 ely modulate tumor growth, angiogenesis, and vascular remodeling through a VEGF-dependent mechanism.

282 signaling and demonstrate that LCCBs promote vascular remodeling through STIM-mediated activation of

283 ly modulates tumor growth, angiogenesis, and vascular remodeling through VEGF-dependent spatiotempora

284 increases in WSS are followed by a period of vascular remodeling to restore normative hemodynamic loa

285 cal links between endothelin-1 and pulmonary vascular remodeling, to our knowledge, the association b

286 predisposes to thrombotic and proliferative vascular remodeling, to which thrombin contributes via a

287 possibly contributing to occlusive pulmonary vascular remodeling triggered by EC apoptosis.

288 Vascular remodeling under conditions of growth or exerci

289 Fibroblasts (FBs) are involved in vascular remodeling, under physiological and pathologica

290 ith right ventricular dysfunction, pulmonary vascular remodeling was not more severe.

291 ciated pulmonary hypertension, we found that vascular remodeling was not responsible for observed inc

292 mportant roles in regulating ischemic muscle vascular remodeling, we examined the role of VEGF(165)b

293 damage, microcirculation, regeneration, and vascular remodeling were evaluated at postoperative days

294 induced pulmonary hypertension and pulmonary vascular remodeling were not or only slightly affected b

295 The hemodynamic and pulmonary vascular remodeling were reversed by iron replacement (f

296 ling in c-KitbetaTg mice induced substantial vascular remodeling, which resulted in increased islet i

297 ular resistance, RV afterload, and pulmonary vascular remodeling, which was associated with reduced l

298 the molecular cues regulating each stage of vascular remodeling will open new avenues for therapeuti

299 IDD rats exhibited profound pulmonary vascular remodeling with prominent muscularization, medi

300 ng the role of the mTOR pathway in pulmonary vascular remodeling, with a specific focus on the hypoxi