ライフサイエンスコーパス: ventral midline

1 low a complex trajectory once they cross the ventral midline.

2 all three Slit homologs are expressed at the ventral midline.

3 late, a specialized structure located at the ventral midline.

4 ntil they fuse into a single ganglion at the ventral midline.

5 arcuate territories arrayed bilateral to the ventral midline.

6 e members of a population with somata at the ventral midline.

7 orsal mesocardial regions around the foregut ventral midline.

8 myosin 2 depending on the distance from the ventral midline.

9 tion of longitudinal axon projections at the ventral midline.

10 C), in attracting the leading process to the ventral midline.

11 ion to prevent aberrant axon crossing at the ventral midline.

12 s in an expansion of the neural plate to the ventral midline.

13 ntral nervous system, including cells of the ventral midline.

14 evelopment of ventral cell fates outside the ventral midline.

15 bryos have two partial retinas joined in the ventral midline.

16 her the edges of the hypodermal sheet at the ventral midline.

17 nchial arches and unpaired cartilages in the ventral midline.

18 he embryo and coalesce along the prospective ventral midline.

19 ted in myocardial cells before fusion at the ventral midline.

20 are guided by several cues secreted from the ventral midline.

21 umn, but then migrated tangentially into the ventral midline.

22 differentiation, as they failed to reach the ventral midline.

23 CSF to underlying neural circuits along the ventral midline.

24 ateral heart progenitors fail to fuse at the ventral midline.

25 ns across the floor plate at the spinal cord ventral midline.

26 retinal axons that would normally cross the ventral midline.

27 ast substrate and subsequent adhesion at the ventral midline.

28 missural axons project toward and across the ventral midline.

29 nd failure of epidermal sheet sealing at the ventral midline.

30 ower axons from inappropriately crossing the ventral midline.

31 murine fetal skin, converging on dorsal and ventral midlines.

32 surface of the embryo towards the dorsal and ventral midlines.

33 re either absent or appear aberrantly at the ventral midline after cyclopamine treatment, while dorsa

34 may thus act to refine the patterning of the ventral midline along the rostrocaudal axis.

35 n depends on high levels of myosin along the ventral midline, although the basis for this localizatio

36 eam along the anterior-posterior axis at the ventral midline and contribute to multiple gut tissues.

37 One set remains at the ventral midline and forms the posterior-ventral infundib

38 ons tipped with large growth cones cross the ventral midline and immediately make a right angle turn.

39 te repulsive axon guidance at the Drosophila ventral midline and in the vertebrate spinal cord.

40 EGFR is activated in the ventral midline and neurogenic ectoderm by the Spitz lig

41 Retinal axons normally cross at the ventral midline and project to the contralateral tectum.

42 oligodendrocyte precursors originate at the ventral midline and subsequently migrate to the white ma

43 ructures during embryogenesis, including the ventral midline and the boundary of the salivary gland p

44 n this study, we examine the function of the ventral midline and the midline-associated gene single-m

45 the proper guidance of the axons across the ventral midline and their subsequent rostral turn into t

46 l neuron populations extend axons across the ventral midline and through the ventral white matter alo

47 leted in colorectal cancer), axons cross the ventral midline, and many turn to grow longitudinally on

48 nd phenotypic transition on their way to the ventral midline, and that this transition is driven in r

49 rimarily by axon fibers that grow across the ventral midline, and then away on the other side to thei

50 Historically, ventral midline approaches have been considered technica

51 hat genes involved in axon patterning at the ventral midline are functionally conserved across phylog

52 type in which structures in the anterior and ventral midline are reduced or lost; additionally, we de

53 ge there are 11 Pn.p hypodermal cells in the ventral midline arrayed along the anterior-posterior axi

54 CST-depleted embryos, cardiomyocytes at the ventral midline arrest and are maintained as cardiac pro

55 ocyte precursors failed to disperse from the ventral midline as a consequence of a lack of polarizati

56 rentiation of midline glia, we have used the ventral midline as a model system to study SOX gene func

57 it the eye, enter the optic stalk, cross the ventral midline at the optic chiasm, and terminate in th

58 uidance information for a specific subset of ventral midline axons.

59 entral nerve cord neurons do not respect the ventral midline boundary and cross over to the contralat

60 ), however, the gene is not expressed in the ventral midline but in the median area of the ventral ne

61 ively in the context of axon guidance at the ventral midline but not in other cellular contexts, ther

62 end filopodia and appeared to seal along the ventral midline by coordinated changes in cell shape, su

63 nism that VZ-derived Ntn1 directs CAs to the ventral midline by its local actions.

64 yogenesis requires secreted signals from the ventral midline carried by Hedgehog (Hh) proteins.

65 ate from the underlying endoderm, creating a ventral midline cavity that provides a physical space fo

66 nd the subsequent progressive opening of the ventral midline cavity.

67 In insects and crustaceans, ventral midline cells are present that subdivide the CNS

68 neural tissue prevents the rostralization of ventral midline cells by prechordal mesoderm.

69 expression of MEF2 in the epidermis and the ventral midline cells in embryos activates the expressio

70 To address the requirement for ventral midline cells in providing cues to commissural a

71 This finding indicates a critical role for ventral midline cells in regulating the rostral polarity

72 Ventral midline cells in the neural tube form floorplate

73 Ventral midline cells in the neural tube have distinct p

74 The cyclops b16 mutation deletes ventral midline cells in the neural tube, and leads to a

75 og (SHH) secreted from the notochord whereas ventral midline cells of the rostral diencephalon (RDVM

76 emonstrate that rhombomere-specific cues and ventral midline cells play important roles in the develo

77 eded for the survival and differentiation of ventral midline cells.

78 dibulum derives from two subsets of anterior ventral midline cells.

79 cance of VBW myofibroblasts in orchestrating ventral midline closure by mediating the response to the

80 are expressed in bilateral strips along the ventral midline, corresponding with the developing ventr

81 ither DTrc8 or DVhl resulted in an identical ventral midline defect.

82 utants, suggesting that they require another ventral midline-derived signal.

83 tor single-minded is the master regulator of ventral midline development and homology has been sugges

84 In the absence of Shh function, ventral midline development is perturbed resulting in ho

85 log, single-minded, is a master regulator of ventral midline development.

86 as expressed in this domain and recruited to ventral midline development.

87 Here we show that At-sim is not required for ventral midline development.

88 rential trajectory to the floor plate at the ventral midline directed by secreted proteins of the net

89 caudal CNS, guidance about the hypothalamic ventral midline does not require midline expression of n

90 The elongating ventral midline endoderm delimits the right and left sid

91 ngle midline heart tube, we propose that the ventral midline endoderm is ideally situated to function

92 We show that the ventral midline endoderm of the foregut is generated dir

93 and heart development may be influenced by a ventral midline endodermal cell population.

94 The rhombic lip and ventral midline express Slit2 and both early and late mi

95 commissural axons from dorsal spinal cord to ventral midline floor plate (FP). FP cells produce a che

96 stem-like progenitors for mDNs reside at the ventral midline floor plate, a region that also serves a

97 arrow stripe of two or three cells along the ventral midline, followed by progressive expansions into

98 s typically extend simultaneously toward the ventral midline following discrete paths with separation

99 The endodermal cells extend caudally in the ventral midline from the prechordal plate during develop

100 Netrin-1 (Ntn1) emanating from the ventral midline has been thought to act as a long-range

101 The Drosophila ventral midline has proven to be a useful model for unde

102 dorsal side around the embryo to meet at the ventral midline in a process known as ventral enclosure.

103 whose projections are directed away from the ventral midline in both WT and Gli2(-/-) embryos, althou

104 that Netrin has a conserved function in the ventral midline in commissural axon guidance.

105 find that commissural axons projected to the ventral midline in Gli2(-/-) embryos.

106 ila has led to a more restricted role of the ventral midline in patterning the DV axis of these insec

107 es to an oblate spheroid with a straightened ventral midline in the mature form can be accounted for

108 for the guidance of commissural axons to the ventral midline in the mouse spinal cord.

109 growth cones to mediate this process at the ventral midline in the vertebrate spinal cord.

110 xtended caudally and others rostrally at the ventral midline, in contrast to normal embryos in which

111 in the ventral neuroectoderm adjacent to the ventral midline, in the dorsoventral patterning of the n

112 -CAM are specialized glial formations in the ventral midline, including the floor plate in the spinal

113 null larvae, SDQR migrations are towards the ventral midline, indicating a response to other guidance

114 uroepithelium of the dorsal hindbrain to the ventral midline involves the extension of long (>1 mm) l

115 The ventral midline is a prominent structure in vertebrate a

116 The ventral midline is a source of signals that pattern the

117 the honeybee, Apis mellifera (A. mel.), the ventral midline is broad and encompasses 5-6 cells.

118 results indicate that Shh signaling from the ventral midline is essential for regulating brain morpho

119 c cells derive from the rostral diencephalic ventral midline, lie above the prechordal mesendoderm an

120 ow and temporally pulsed BMP activity at the ventral midline/median hinge point (MHP).

121 tenance of neural and epidermal cells of the ventral midline (mesectoderm and ventromedial ectoderm).

122 After reaching the ventral midline, most commissural axons remained cluster

123 In the Caenorhabditis elegans embryo, some ventral midline motoneurons extend a process circumferen

124 s appear to be specified initially as caudal ventral midline neurectodermal cells and to acquire RDVM

125 ft-oriented, cilia-generated flow within the ventral, midline node [11, 12].

126 neuron, PVT, whose axon is located along the ventral midline of C. elegans.

127 ng gastrulation and early somitogenesis, the ventral midline of the central nervous system (CNS) toge

128 directs transgene reporter expression to the ventral midline of the CNS and notochord in a Shh-like m

129 The establishment of the floor plate at the ventral midline of the CNS is dependent on an inductive

130 lized cells are established along the dorsal-ventral midline of the developing eye by Notch-mediated

131 relative position of the optic chiasm at the ventral midline of the developing hypothalamus.

132 pathfinding commissural axons located at the ventral midline of the developing mouse spinal cord.

133 pulation of epithelial cells that lie at the ventral midline of the developing neural tube, whereas t

134 -associated protein that is expressed at the ventral midline of the developing vertebrate central ner

135 A suction-cup hydrophone placed on the ventral midline of the dolphin produced a continuous hea

136 We show that traumatic injury to the ventral midline of the embryonic Drosophila CNS activate

137 The ventral midline of the nervous system is an important ch

138 Commissural axons cross the ventral midline of the neural tube in a Slit-dependent m

139 th chick and mouse Foxj1 is expressed in the ventral midline of the neural tube in cells that make up

140 Induction of the floor plate at the ventral midline of the neural tube is one of the earlies

141 or this activity, the axial mesoderm and the ventral midline of the neural tube, is regulated along t

142 3 is expressed prominently at the dorsal and ventral midline of the neural tube, particularly in the

143 The axial midline mesoderm and the ventral midline of the neural tube, the floor plate, sha

144 mp2 and Bmp7 are abnormally expressed in the ventral midline of the neural tube.

145 chiasm, intermediate targets located at the ventral midline of the spinal cord and diencephalon in t

146 along the anteroposterior axis including the ventral midline of the spinal cord, hindbrain, rostral m

147 vigate toward and across the floorplate, the ventral midline of the spinal cord.

148 The sternum bone lies at the ventral midline of the thorax where it provides a critic

149 (Shh) plays an integral role in forming the ventral midline of the vertebrate central nervous system

150 erotonergic (5-HT) neurons develop along the ventral midline of the vertebrate hindbrain.

151 motropic guidance cues, in particular in the ventral midline of vertebrates and invertebrates.

152 zer regions that extend along the dorsal and ventral midlines of the entire neuraxis, whereas anterop

153 is crucial for ensuring that they cross the ventral midline only once.

154 in the compound mutant, but not those at the ventral midline or the non-segmented muscles of the limb

155 The floor plate, an essential ventral midline organizing center that produces the morp

156 growth, the establishment of both dorsal and ventral midline patterning and the generation of specifi

157 nd one-eyed-pinhead, cyclops is required for ventral midline patterning of the embryonic central nerv

158 Remarkably, we found that Ph-sim and the ventral midline play a central role in establishing prop

159 Subsequently, the ventral midline plays a more restricted role in DV patte

160 Our fate mapping studies reveal that this ventral midline population of cardiomyocytes ultimately

161 Casz1 is required for Xenopus heart ventral midline progenitor cell differentiation.

162 t target of Six3 in the rostral diencephalon ventral midline (RDVM).

163 e Twi-only mode of regulation--and the broad ventral midline--represents the ancestral form of CNS pa

164 domain of the ventral neuroepithelium by the ventral midline signal Sonic hedgehog (Shh).

165 EGF signaling along the ventral midline specifies the salivary duct fate for cel

166 secondary heart field (SHF), located in the ventral midline splanchnic mesenchyme, which provides ad

167 the region of the developing optic chiasm, a ventral midline structure in which retinal ganglion cell

168 A originate from the midbrain floor plate, a ventral midline structure that is operationally defined

169 ovide evidence that Hedgehog signalling from ventral midline structures acts directly on the zebrafis

170 In zebrafish, Hedgehog (Hh) signalling from ventral midline structures is necessary and sufficient t

171 hanisms that achieve alignment of dorsal and ventral midline structures remain a poorly understood as

172 eir requirement for EGFR signaling, head and ventral midline structures share several morphogenetic a

173 the human forebrain and the establishment of ventral midline structures.

174 cyclopia (a single midline eye), and loss of ventral midline structures.

175 t primarily affects the formation of diverse ventral midline structures.

176 ropod groups raises the question whether the ventral midline system is conserved in this phylum.

177 l ovariectomy in rodents, very few address a ventral midline technique, and none are specific to the

178 STATEMENT Growing evidence suggest that the ventral midline thalamic nuclei (reuniens and rhomboid)

179 n of our understanding of the involvement of ventral midline thalamic nuclei in cognitive processes:

180 firing in both lateral entorhinal cortex and ventral midline thalamic nuclei of neonatal rats.

181 cal for spatial working memory (SWM) and the ventral midline thalamic reuniens and rhomboid nuclei (R

182 reuniens and rhomboid (Re/Rh) nuclei of the ventral midline thalamus abolished only the SWM-specific

183 euniens (Re) and rhomboid (Rh) nuclei of the ventral midline thalamus are reciprocally connected with

184 fied distinct roles of entorhinal cortex and ventral midline thalamus for the functional development

185 The nucleus reuniens (Re) of the ventral midline thalamus is anatomically connected with

186 The ventral midline thalamus is positioned to exert signific

187 synchrony and optogenetic activation of the ventral midline thalamus primarily entrained prefrontal

188 s (as the spatial memory substrate), and the ventral midline thalamus, and therein the ReRh (as the c

189 activation by directed interactions with the ventral midline thalamus.

190 f Shh expression in the rostral diencephalon ventral midline, the alobar phenotype is caused by downr

191 the equator of the embryo and approaches the ventral midline, the remainder of the leading edge becom

192 orsal neural tube but its role in patterning ventral midline tissue has not been rigorously assessed.

193 tes the ability of cells to incorporate into ventral midline tissue, and within this tissue, antagoni

194 velop in the absence of surface ectoderm and ventral midline tissue, suggesting that the Brn-3.0 phen

195 aded levels of Shh signaling, emanating from ventral midline tissues.

196 - procardiomyocytes failed to migrate to the ventral midline to form a linear heart tube and instead

197 elds migrate and fuse anteriomedially in the ventral midline to form the first segment of the straigh

198 odents, most RGC growth cones then cross the ventral midline to join the contralateral optic tract; t

199 us system (CNS)-organizing activity from the ventral midline to the neurogenic ectoderm.

200 ursors have previously been localized to the ventral midline, two papers in this issue of Neuron (Cai

201 m the anterior lateral plate mesoderm to the ventral midline, undergoing a mesenchymal-to-epithelial

202 genitors then merge into a heart tube at the ventral midline (vertebrates) or the dorsal midline (Dro

203 yos, most spinal commissural axons cross the ventral midline (VM) and project either alongside or sig

204 or plate (FP), an intermediate target at the ventral midline (VM) of the spinal cord.

205 is localized to the floor plate (FP) at the ventral midline (VM), ephrin-B1 and ephrin-B2 are expres

206 rprisingly, the neurogenic ectoderm, not the ventral midline, was found to be the dominant source of

207 encephalic structures but is absent from the ventral midline where the optic chiasm forms.

208 from the lateral region of the embryo to the ventral midline, where it fuses to form the primitive he

209 , they migrate laterally and then toward the ventral midline, where they form the heart.

210 progenitor pools are brought together at the ventral midline, where they form the paired genital swel

211 the source of netrin1 directing axons to the ventral midline, while local VZ-supplied netrin1 is requ