ライフサイエンスコーパス: ventral neural tube

1 Neurog1-like expression specifically in the ventral neural tube.

2 o form muscle fibers as well as cells of the ventral neural tube.

3 forming a dynamic, punctate gradient in the ventral neural tube.

4 CL and the transcription factor Olig2 in the ventral neural tube.

5 pressed by mesenchymal cells surrounding the ventral neural tube.

6 overlaps with Gli1 activator function in the ventral neural tube.

7 ity of the ngn2 enhancer specifically in the ventral neural tube.

8 fate acquisition and diversification in the ventral neural tube.

9 ls located at different positions within the ventral neural tube.

10 nitor cell identity and neuronal fate in the ventral neural tube.

11 eted by mesodermal cell types that flank the ventral neural tube.

12 ence for a gradient of endogenous Shh in the ventral neural tube.

13 ibute to the patterning of cell types in the ventral neural tube.

14 ertebrate embryogenesis in the notochord and ventral neural tube.

15 ry signals produced by the lateral plate and ventral neural tube.

16 l specification of neural progenitors in the ventral neural tube, a process known to require a gradie

17 ose-dependent loss of cell identities in the ventral neural tube and facial and skeletal defects, als

18 ramework to understand the patterning of the ventral neural tube and is permitting molecular analyses

19 yo, patched is initially detected within the ventral neural tube and later in the somites and limb bu

20 expressed by motor neuron progenitors in the ventral neural tube and that treatment of ventral neural

21 The ventral neural tube and the notochord function to promot

22 ections of Shh, which is expressed along the ventral neural tube, and FGF8, which is locally produced

23 then most prominently in the primitive node, ventral neural tube, and intermediate and lateral plate

24 enitor gene is specifically expressed in the ventral neural tube, and its activity is required for mo

25 point to an important role for Sulf1 in the ventral neural tube, and suggests a mechanism whereby Su

26 on gradient of Shh is thought to pattern the ventral neural tube, and these ventral cell types are ab

27 midbrain, hindbrain, trigeminal ganglia, and ventral-neural tube appear redundant and are spread both

28 Furthermore, Neurog1 progenitor cells in the ventral neural tube are largely fated to interneuron lin

29 tuberal progenitors develops in the anterior-ventral neural tube as a wave of neuroepithelial-derived

30 Using Sonic hedgehog (Shh) patterning of the ventral neural tube as an example, we show that the fram

31 receptor family members were detected in the ventral neural tube at approximately the time of initial

32 the differentiation of motor neurons in the ventral neural tube, but the intervening steps are poorl

33 g signaling pathway organizes the developing ventral neural tube by establishing distinct neural prog

34 naling controls cell fates in the developing ventral neural tube by regulating the patterned expressi

35 Cell types normally induced in the ventral neural tube by Shh are either absent or appear a

36 rocyte progenitor cells are induced from the ventral neural tube by the Sonic hedgehog (Shh) signal.

37 At E11.5 p.c., motor neurons in the ventral neural tube clearly express the marker transgene

38 Central to the understanding of ventral neural tube development is how Shh transcription

39 gated a possible involvement of this gene in ventral neural tube development.

40 In contrast to dorsal neural tube, pieces of ventral neural tube, dorsal ectoderm or neural crest cel

41 ed from glial precursors that arise from the ventral neural tube early in development.

42 he ventral neural tube and that treatment of ventral neural tube explants with the trkB ligand Brain-

43 Some of the labeled cells within the ventral neural tube expressed FP-1, characteristic of fl

44 and for normal expression of Nodal, and the ventral neural tube fails to express Shh, Foxa2 and Ebaf

45 ns are generated at defined positions in the ventral neural tube in response to a gradient of Sonic H

46 enon in the context of the patterning of the ventral neural tube in response to a gradient of the mor

47 equirement for Sonic Hh in patterning of the ventral neural tube in vertebrates.

48 The partitioning of the ventral neural tube into five distinct neuronal progenit

49 During normal development the ventral neural tube is competent to develop oligodendroc

50 The identity of distinct cell types in the ventral neural tube is generally believed to be specifie

51 Cell pattern in the ventral neural tube is organized by Sonic hedgehog (Shh)

52 e deficiencies in the dorsal mesendoderm and ventral neural tube, leading to neural defects and cyclo

53 xpressed Shh-N, leading to the activation of ventral neural tube markers such as Ptc, HNF-3beta, and

54 pathways expressed the HNK-1 epitope, but no ventral neural tube markers.

55 Cells labeled in the ventral neural tube migrate in association with the vagu

56 In the ventral neural tube, motor neuron and interneuron genera

57 Indeed, dorsal and ventral neural tube, notochord, ectoderm and neural cres

58 Less activity was found in the ventral neural tube, notochord, ectoderm, and lateral pl

59 e dorsal neural tube (via BMP and Wnts), the ventral neural tube/notochord (via Shh) and the somite i

60 s disrupted, as evidenced by abnormal dorsal-ventral neural tube patterning and diminished expression

61 se results bear significance on the model of ventral neural tube patterning as they suggest a dual ro

62 mark HH loss-of-function phenotypes (HPE and ventral neural tube patterning defects) in Cdon mutant m

63 Arl13b(hnn) mutants have abnormal ventral neural tube patterning due to disrupted Shh sign

64 or mesoderm in spt(-);ntl(-) embryos, dorsal-ventral neural tube patterning is relatively normal, wit

65 However, their roles in ventral neural tube patterning, in particular motor neur

66 Applied to a stem cell system that models ventral neural tube patterning, we recover a family of m

67 perinatal lethality and SHH-related abnormal ventral neural tube phenotypes.

68 on of Hedgehog signaling, which patterns the ventral neural tube, produced a two-fold increase in the

69 Motor neurons in the ventral neural tube project axons specifically to their

70 nd CaP, occupy distinct locations within the ventral neural tube relative to overlying somites, expre

71 In the ventral neural tube, Sonic hedgehog (Shh) acts as a grad

72 In the ventral neural tube, sonic hedgehog (Shh) signaling, tog

73 Strikingly, PRDM13 also ensures a battery of ventral neural tube specification genes such as Olig1, O

74 ryos lacking Shh express Lpp1 throughout the ventral neural tube, suggesting negative regulation of L

75 or identity and neuronal fate throughout the ventral neural tube, supporting a gradient mechanism whe

76 different progenitor cell populations in the ventral neural tube that are defined by the expression o

77 flect different sources of Shh, one from the ventral neural tube that controls trabecular morphogenes

78 dbrain, the midbrain-hindbrain boundary, the ventral neural tube, the developing eye, and the apical

79 c midline structures - the floorplate in the ventral neural tube, the notochord and the dorsal endode

80 ification of distinct cell identities in the ventral neural tube through a Gli-mediated (Gli1-3) tran

81 pation by tungsten needle, and the remaining ventral neural tube was labeled with DiI to examine any

82 s sufficient to drive lacZ expression in the ventral neural tube, whereas a 1.0-kb fragment located 3

83 ds the domain of Brn-3.0 expression into the ventral neural tube, while ectopic grafts of notochord t