ライフサイエンスコーパス: ventral pallidum

1 0 increased extracellular GABA levels in the ventral pallidum.

2 ), rostromedial lateral globus pallidus, and ventral pallidum.

3 days withdrawal in the nucleus accumbens and ventral pallidum.

4 mbic projections of the NAcc, such as to the ventral pallidum.

5 at involves the glutamatergic neurons of the ventral pallidum.

6 halin immunoreactivity, both markers for the ventral pallidum.

7 l but not into the core, dorsal striatum, or ventral pallidum.

8 men, bed nucleus of the stria terminalis, or ventral pallidum.

9 t projections from the nucleus accumbens and ventral pallidum.

10 blocking the motor response by DAMGO in the ventral pallidum.

11 us accumbens, globus pallidus and the medial ventral pallidum.

12 the dorsolateral part of the subcommissural ventral pallidum.

13 tate identification of subterritories in the ventral pallidum.

14 ucleus, and from SOM-positive neurons in the ventral pallidum.

15 associated with MDD PRS in the amygdala and ventral pallidum.

16 d transcription in the efferent nucleus, the ventral pallidum.

17 halic D1-MSN afferents collateralized to the ventral pallidum.

18 the mid-insula and the ventral striatum and ventral pallidum.

19 ctively lost in D2, but not D1 inputs to the ventral pallidum.

20 ced reinstatement of cocaine seeking via the ventral pallidum.

21 orsal-lateral BF, in regions occupied by the ventral pallidum.

22 als from iMSNs than their projections to the ventral pallidum.

23 o mouse nucleus accumbens projections to the ventral pallidum.

24 spot circuits in nucleus accumbens (NAc) and ventral pallidum.

25 on the dorsal striatum, prelimbic cortex, or ventral pallidum.

26 his manner, with both cell types innervating ventral pallidum.

27 ther vector functioned when infused into the ventral pallidum.

28 circuits involving the nucleus accumbens and ventral pallidum.

29 coded in neural signals coursing through the ventral pallidum.

30 and in the globus pallidus (+9%; p=0.06) and ventral pallidum (+11%; p=0.1), whereas binding was slig

31 ll (77 and 83% of control, respectively) and ventral pallidum (82% of control) as well as in the caud

32 gions (limbic striatum, globus pallidus, and ventral pallidum (9-14%; p < 0.04) in humans and Islands

33 A ventral pallidum, a basal cholinergic cell group, and me

34 Here we reveal synaptic properties in the ventral pallidum, a central hub of reward circuits, that

35 ver pressing by cocaine was blocked by intra-ventral pallidum administration of the mu receptor antag

36 a majority of the neurons that innervate the ventral pallidum also collateralize to the ventral mesen

37 he stimulation of mu-opioid receptors in the ventral pallidum also elicits motor activation, and this

38 nsmission in the rostral anterior cingulate, ventral pallidum, amygdala, and inferior temporal cortex

39 teral cluster spanning the ventral striatum, ventral pallidum, amygdala, midbrain, and orbitofrontal

40 left dlPFC functional connectivity with the ventral pallidum, an AVP receptor-rich region previously

41 al band nuclei), lateral VTA and medial SNC (ventral pallidum and anterior half of substantia innomin

42 in other brain regions studied (hippocampus, ventral pallidum and cerebellum), or of the effects of c

43 (2020) dissect the function of the enigmatic ventral pallidum and elegantly demonstrate positive and

44 By contrast, damage to sites in the ventral pallidum and globus pallidus impaired grooming a

45 and monosynaptic inhibitory currents in the ventral pallidum and lateral habenula, though the net ef

46 n (BF) inputs to LHb, primarily arising from ventral pallidum and nucleus accumbens shell (VP/NAcs).

47 the ventromedial part of the subcommissural ventral pallidum and pallidal parts of the olfactory tub

48 d PHA-L-labeled presynaptic terminals in the ventral pallidum and substantia innominata were found to

49 Neurons in the ventral pallidum and substantia innominata were recorded

50 ced response in the DRD3-rich regions of the ventral pallidum and substantia nigra.

51 xtrapyramidal nuclei, such as the globus and ventral pallidum and the substantia nigra, pars reticula

52 s accumbens (NAc) include projections to the ventral pallidum and the ventral tegmental area and subt

53 Ns that primarily project and connect to the ventral pallidum and to a lesser extent the ventral midb

54 he D1-expressing neurons project to both the ventral pallidum and ventral mesencephalon, and we found

55 ns D1-MSNs largely collateralize to both the ventral pallidum and ventral mesencephalon, only D1-MSN

56 ic projections from the nucleus accumbens to ventral pallidum and ventral tegmental area (VTA) are in

57 ampus, nucleus accumbens, prefrontal cortex, ventral pallidum and ventral tegmentum, and more intense

58 cell types send GABAergic projections to the ventral pallidum and were found to differentially promot

59 in a number of limbic (nucleus accumbens and ventral pallidum) and cortical (medial/ventral orbital a

60 nsmission in the rostral anterior cingulate, ventral pallidum, and amygdala was correlated with the i

61 halamus, rostral pallium, nucleus accumbens, ventral pallidum, and bed nucleus of the stria terminali

62 ide substantial GABAergic innervation to the ventral pallidum, and chemogenetic inhibition of ventral

63 en specific neurons in nucleus accumbens and ventral pallidum, and how these changes are associated w

64 ntal cortex, including the ventral striatum, ventral pallidum, and mediodorsal thalamus, the amygdala

65 conditioning (through the ventral striatum, ventral pallidum, and PPTN) and the other to adaptively

66 ia terminalis, paraventricular hypothalamus, ventral pallidum, and prefrontal cortex.

67 ioral function for D1-MSN innervation of the ventral pallidum, and suggest that losing LTDGABA in D2-

68 ion in ventral tegmentum, nucleus accumbens, ventral pallidum, and the orbitofrontal prefrontal corte

69 iated with reduced extracellular GABA in the ventral pallidum, and the reduction in GABA was also pre

70 een in both pallidal segments, including the ventral pallidum, and the subthalamic nucleus, consisten

71 rfacing with projections to the striatum and ventral pallidum, and these SC projections excite DA and

72 minata, bed nucleus of the stria terminalis, ventral pallidum, and ventrolateral globus pallidus.

73 anterior and posterior basolateral amygdala; ventral pallidum; and periaqueductal gray.

74 Also, compound 13 injected into the rat ventral pallidum antagonized the locomotor activity elic

75 the dorsolateral part of the subcommissural ventral pallidum, anterograde labeling was weak in the m

76 In addition, following injections into the ventral pallidum, anterogradely transported biotinylated

77 bed nucleus of the stria terminalis, medial ventral pallidum, arcuate nucleus, and ventral tegmental

78 e nucleus accumbens core to the dorsolateral ventral pallidum are necessary for drug-conditioned cues

79 Astrocytes in the ventral pallidum are situated perisynaptically and regul

80 Afferents to the ventral pallidum arise from both D1- and D2-MSNs, wherea

81 brain particularly the nucleus accumbens and ventral pallidum as well as actions within the ascending

82 o sadness-induced mu-opioid activation (left ventral pallidum, bilateral anterior cingulate cortices,

83 g pairing in the right nucleus accumbens and ventral pallidum but not in other areas.

84 with clozapine-N-oxide administered into the ventral pallidum, but not into the ventral mesencephalon

85 VTA (by baclofen) or GABAA receptors in the ventral pallidum (by muscimol) inhibit the motor respons

86 rminals in the pallidum (globus pallidus and ventral pallidum) can be modulated by locally applied op

87 umbens, bed nucleus of the stria terminalis, ventral pallidum, central nucleus of the amygdala, and c

88 proximately 70% of D1-MSNs projecting to the ventral pallidum collateralized to the ventral mesenceph

89 awal from cocaine.SIGNIFICANCE STATEMENT The ventral pallidum consists mainly of GABAergic reward-pro

90 D1- versus D2-MSN GABAergic synapses in the ventral pallidum could explain the differential regulati

91 l ventral pallidum (RVP), but not the caudal ventral pallidum (CVP), were robustly Fos activated duri

92 ay to the dorsolateral subcompartment of the ventral pallidum (dlVP) and through the direct pathway t

93 ons in subregions of medial accumbens shell, ventral pallidum, elements of extended amygdala, and lat

94 s from these, including the globus pallidus, ventral pallidum, entopeduncular nucleus and substantia

95 ry bulbs, frontal cortex, or nucleus basalis/ventral pallidum following hormone treatment; however, a

96 nsory cortex, and in contralateral amygdala, ventral pallidum, globus pallidus, and hippocampus, as w

97 tral condition for most regions of interest (ventral pallidum, globus pallidus, limbic striatum, asso

98 al and lateral septum, diagnoal band nuclei, ventral pallidum, globus pallidus, substantia innominata

99 circuitry in both the nucleus accumbens and ventral pallidum has been reported to mediate taste-reac

100 sion of opto-MOR in GABAergic neurons of the ventral pallidum hedonic cold spot led to real-time plac

101 umbens and the GABA(A) agonist muscimol into ventral pallidum (i.e., "disconnection" methods) also im

102 tside the nucleus accumbens (such as rostral ventral pallidum), immediately medial and adjacent to th

103 posing a role for mu-opioid receptors in the ventral pallidum in mediating the reinstatement of cocai

104 mbic circuit regions (putamen, thalamus, and ventral pallidum) in fibromyalgia.

105 0 nl) into the tubercle but not the shell or ventral pallidum induced conditioned place preference.

106 l circuits connecting the nucleus accumbens, ventral pallidum, insula and orbitofrontal cortex as cri

107 However, the ventral pallidum is a heterogeneous structure, and how t

108 The ventral pallidum is centrally positioned within mesocort

109 Because the ventral pallidum is involved in reinforcement and addict

110 esencephalon, only D1-MSN innervation of the ventral pallidum is necessary for cue-induced cocaine se

111 rebrain and brainstem targets, including the ventral pallidum, lateral and magnocellular preoptic nuc

112 own VTA targets including nucleus accumbens, ventral pallidum, lateral habenula, and prefrontal corte

113 connections with the hippocampus, amygdala, ventral pallidum, lateral hypothalamus, and ventral tegm

114 r cingulate, left orbitofrontal cortex, left ventral pallidum, left amygdala, and left inferior tempo

115 acity of morphine (0.01-10 microm) to reduce ventral pallidum levels of extracellular GABA was augmen

116 The ventral pallidum, located in the ventral basal ganglia,

117 g LTDGABA in D2-MSN, but not D1-MSN input to ventral pallidum may promote cue-induced reinstatement o

118 uronal activity in the nucleus accumbens and ventral pallidum may underlie the augmented behavioral r

119 es in areas including the nucleus accumbens, ventral pallidum, medial preoptic area, medial amygdala,

120 both structures, only D1 innervation of the ventral pallidum mediates cue-induced cocaine seeking.

121 The ability of intra-ventral pallidum morphine to reinstate lever pressing wa

122 Ventral pallidum neurons do not ordinarily fire vigorous

123 of sucrose in behavior and firing signals of ventral pallidum neurons, and likewise, they increased i

124 ons (caudate putamen, nucleus accumbens, and ventral pallidum) of mice that were given either water (

125 eral, or ventromedial neostriatum, or in the ventral pallidum or globus pallidus of rats.

126 lockade of kappa-opioid receptors within the ventral pallidum or mu-opioid receptors with the specifi

127 Naloxone infused into either the ventral pallidum or nucleus accumbens shell blocked the

128 n the caudate putamen, nucleus accumbens and ventral pallidum (p<0.001).

129 ager outputs to the forebrain, mainly to the ventral pallidum, preoptic-lateral hypothalamic continuu

130 projection from the nucleus accumbens to the ventral pallidum regulates the reinstatement of cocaine

131 receptors with morphine (1-30 microg) in the ventral pallidum reinstated cocaine seeking.

132 restricted within the nucleus accumbens and ventral pallidum, respectively.

133 the ventromedial part of the subcommissural ventral pallidum resulted in robust anterograde labeling

134 ounted in series of sections cut through the ventral pallidum, rostral globus pallidus, nucleus of th

135 und that projections to VTA from the rostral ventral pallidum (RVP), but not the caudal ventral palli

136 same reward within the nucleus accumbens to ventral pallidum segment of mesocorticolimbic circuitry.

137 d that accumbens neurons that project to the ventral pallidum showed adenosine A(2A) receptors immuno

138 Thus, only the ventral pallidum showed changes in molecular processes t

139 phin, an opioid neuropeptide abundant in the ventral pallidum, shows differential modulation of GABA

140 ion from the IL to the substantia innominata-ventral pallidum (SI/VP), an area that processes aversiv

141 We further show that, in hippocampus and ventral pallidum, spinophilin is occasionally present in

142 This double dissociation in ventral pallidum subregional roles in drug seeking is li

143 tional significant changes were noted in the ventral pallidum, superior colliculus, dentate gyrus (in

144 the density was 346+/-27 fmol/g, and in the ventral pallidum the density was 317+/-27 fmol/g.

145 dial septum, the diagonal band of Broca, the ventral pallidum, the globus pallidus, the bed nucleus o

146 ata in the ventromedial globus pallidus, the ventral pallidum, the internal capsule, and the substant

147 ibution pattern, with high expression in the ventral pallidum, the islands of Calleja and pars compac

148 nveyed through the subiculum, accumbens, and ventral pallidum to the VTA where it contributes (along

149 ent dedicated neuronal subpopulations in the ventral pallidum tracked signal enhancements for hedonic

150 These data show that astrocytes in the ventral pallidum undergo plasticity after extinction of

151 a1 siRNA vector (pHSVsiLA1) infused into the ventral pallidum, unrelated to TLR4.

152 bited a pattern of nucleus accumbens OTR and ventral pallidum V1aR binding different from that associ

153 ut specificity, e.g., being different at NAc-ventral pallidum versus NAc-ventral tegmental area synap

154 nteromedial olfactory tubercle (OT), and the ventral pallidum (VP) - 2 connected nuclei of the basal

155 In parallel with nucleus accumbens (NAS), ventral pallidum (VP) also receives a dopaminergic proje

156 her the nucleus accumbens shell (NAc) or the ventral pallidum (VP) amplifies hedonic "liking" reactio

157 The ventral pallidum (VP) and basolateral amygdala (BLA) are

158 t, Area X and surrounding MSt project to the ventral pallidum (VP) and dorsal thalamus via pallidal-l

159 The nucleus accumbens shell (NAcSh) and the ventral pallidum (VP) are critical for reward processing

160 The central extended amygdala (CEA) and ventral pallidum (VP) are involved in diverse motivated

161 ens shell (NAc-S) and its projections to the ventral pallidum (VP) are thought to be critical for sti

162 evious work implicated OxR1 signaling within ventral pallidum (VP) as a potential target.

163 Here, we identify the ventral pallidum (VP) as a site of convergence of medium

164 The ventral pallidum (VP) contains GABA and glutamate neuron

165 ic neurons exerts powerful modulation over a ventral pallidum (VP) disinhibitory circuit, thereby con

166 ceptor D3 (DRD3)-dependent plasticity in the ventral pallidum (VP) drives potentiation of dopamine re

167 Neural activity in the ventral pallidum (VP) has been shown to encode changes i

168 The role of the nucleus accumbens (NAC) and ventral pallidum (VP) in food reward modulation was inve

169 of orexin-1 receptor signaling (OxR1) within ventral pallidum (VP) in remifentanil demand and cue-ind

170 of ionotropic glutamate receptors within the ventral pallidum (VP) in the expression of conditioned p

171 e amygdala (AMG), nucleus accumbens (NA) and ventral pallidum (VP) influence goal-oriented behaviors.

172 The ventral pallidum (VP) is a central hub in the reward cir

173 The ventral pallidum (VP) is a central node in the reward sy

174 The ventral pallidum (VP) is a key hub in the reward system

175 The ventral pallidum (VP) is a key node in the neural circui

176 The ventral pallidum (VP) is a key structure in the reward s

177 The ventral pallidum (VP) is a major component of the BG lim

178 The ventral pallidum (VP) is a major intermediary in the pre

179 n stress response.SIGNIFICANCE STATEMENT The ventral pallidum (VP) is a structure connected to both r

180 The ventral pallidum (VP) is a target of dense nucleus accum

181 Ventral pallidum (VP) is a well-established locus for th

182 Ventral pallidum (VP) is an important source of limbic i

183 The ventral pallidum (VP) is critical for invigorating rewar

184 The ventral pallidum (VP) is critical for motivated behavior

185 The ventral pallidum (VP) is necessary for drug-seeking beha

186 The ventral pallidum (VP) is often viewed as an output struc

187 The ventral pallidum (VP) is posited to contribute to reward

188 Here, we show that the songbird ventral pallidum (VP) is required for song learning and

189 ere, we present evidence suggesting that the ventral pallidum (VP) may participate in this process.

190 Ventral pallidum (VP) neurons are known to contribute to

191 of parvalbumin-positive (PV) neurons in the ventral pallidum (VP) projecting to either the lateral h

192 GABAergic neurons in the ventral pallidum (VP) provide a major input to VTA neuro

193 The ventral pallidum (VP) receives orexin projections from l

194 e found that cue-evoked neural firing in the ventral pallidum (VP) reflected the strength of incentiv

195 MENT The central extended amygdala (CEA) and ventral pallidum (VP) regulate multiple motivated behavi

196 Ventral pallidum (VP) serves important roles in reward a

197 Altered activity of the ventral pallidum (VP) underlies disrupted motivation in

198 The ventral pallidum (VP) was defined as a basal ganglia nuc

199 We recorded neural activity in the ventral pallidum (VP) while rats learned a pavlovian rew

200 ied outcome history-based RPE signals in the ventral pallidum (VP), a basal ganglia region functional

201 Ventral pallidum (VP), a key limbic node involved in dru

202 mino acid (EAA)-containing projection to the ventral pallidum (VP), a major limbic system output regi

203 o block alcohol-maintained responding in the ventral pallidum (VP), a novel alcohol reward substrate,

204 e to show that optogenetic inhibition of the ventral pallidum (VP), a region known for processing rew

205 We asked how optogenetic modulation of the ventral pallidum (VP), a subcortical DMN node, impacts t

206 e nucleus accumbens (NAc), lateral habenula, ventral pallidum (VP), and amygdala.

207 The NAc-S projects prominently to the ventral pallidum (VP), and in the current experiments, w

208 The medial preoptic area (MPOA), ventral pallidum (VP), and nucleus accumbens (NA) receiv

209 lized in the nucleus accumbens (NAC) and the ventral pallidum (VP), areas known to be important compo

210 rophic factor (BDNF) immunoreactivity in the ventral pallidum (VP), as determined by optical density

211 The dorsal-lateral BF, including the ventral pallidum (VP), contains reward-sensitive neurons

212 n locally administered into the NAc, VTA, or ventral pallidum (VP), dose-dependently reinstated cocai

213 ons involves a projection from area X to the ventral pallidum (VP), which in turn projects to dopamin

214 amic nucleus (MD) via its projections to the ventral pallidum (VP), with the core and shell regions o

215 l segment (GPe), internal segment (GPi), and ventral pallidum (VP)-in 8 HD cases compared with 7 matc

216 dopaminergic neurons via a connection in the ventral pallidum (VP).

217 in neurons projecting from the NAcSh to the ventral pallidum (VP).

218 in an emerging mesolimbic circuit nexus: the ventral pallidum (VP).

219 o the NAc, ventral tegmental area (VTA), and ventral pallidum (VP).

220 target of VTA GABA projection neurons is the ventral pallidum (VP).

221 tput structure of the mesolimbic system, the ventral pallidum (VP).

222 lateral nucleus of the amygdala (BLA) or the ventral pallidum (VP).

223 ctivation of a downstream target of BLA, the ventral pallidum (VP).

224 d the motivation to eat generated within the ventral pallidum (VP)?

225 (PFCd), nucleus accumbens core (NAcore), and ventral pallidum (VP)] blocked the ability of footshock

226 core of the nucleus accumbens (NAcore), and ventral pallidum (VP)] prevented cocaine-induced reinsta

227 rly through its output to the rostral medial ventral pallidum (VP-m).

228 y was associated with V1aR expression in the ventral pallidum (VPall) or lateral septum, areas causal

229 umbens shell (AcbSh) terminate in the medial ventral pallidum (VPm) and neurons in the VPm project to

230 he membrane insertion of mu receptors in the ventral pallidum was altered by withdrawal from cocaine,

231 olfactory bulbs, septum, and nucleus basalis/ventral pallidum were dissected.

232 bic structures such as nucleus accumbens and ventral pallidum (where opioid/endocannabinoid/orexin si

233 and vasopressin-immunoreactive fibers in the ventral pallidum, with males showing a greater density o