ライフサイエンスコーパス: ventricular septal defect

1 ortly after birth with lung hypoplasia and a ventricular septal defect.

2 nt mice have other cardiac defects including ventricular septal defect.

3 eltaI)/B(-) mice were born with a membranous ventricular septal defect.

4 viduals, as well as atrial septal defect and ventricular septal defect.

5 septum, and 6.4% for pulmonary atresia with ventricular septal defect.

6 ciation holds in patients with and without a ventricular septal defect.

7 of the IVS, hypertrophic cardiomyopathy, and ventricular septal defect.

8 etralogy of Fallot or pulmonary atresia with ventricular septal defect.

9 ocardial hypoplasia, hypertrabeculation, and ventricular septal defect.

10 poplasia, double-outlet right ventricle, and ventricular septal defect.

11 mal cardiac function, and had no evidence of ventricular septal defect.

12 entricular septum and 298 (38%) for TGA with ventricular septal defect.

13 ble outlet right ventricle with a concurrent ventricular septal defect.

14 ning defects, pulmonary artery stenosis, and ventricular septal defects.

15 ing common arterial trunk and perimembranous ventricular septal defects.

16 eptal defects and between ozone and isolated ventricular septal defects.

17 p-helix factor (CHF)1Hey2 gene show isolated ventricular septal defects.

18 developed a cardiomyopathy but did not have ventricular septal defects.

19 ions and coarctations of the aortic arch and ventricular septal defects.

20 S) including hypertrophic cardiomyopathy and ventricular septal defects.

21 al heart disease (CHD), including atrial and ventricular septal defects.

22 rdiac outflow tract alignment and membranous ventricular septal defects.

23 lar mass compared with naive pigs, developed ventricular septal defects.

24 Some mutant individuals also had heart ventricular septal defects.

25 low tract obstruction and decreased risk for ventricular septal defects.

26 t obstruction and between sertraline use and ventricular septal defects.

27 uspid valve, and perimembranous and muscular ventricular septal defects.

28 ity alleles at different loci for atrial and ventricular septal defects.

29 ackground C57Bl/6 frequently have atrial and ventricular septal defects.

30 cular septal defects and C57Bl/6 to muscular ventricular septal defects.

31 mpaction, double outlet right ventricles and ventricular septal defects.

32 interventricular septum and display profound ventricular septal defects.

33 bryonic stage with thin ventricular wall and ventricular septal defects.

34 k, -0.41 (95% CI, -0.74 to -0.09); and major ventricular septal defects, -0.25 (95% CI, -0.35 to -0.1

35 confidence interval, -0.87 to -0.10); major ventricular septal defects, -0.41 (95% confidence interv

36 re pulmonary insufficiency (4), and residual ventricular septal defect (1).

37 vascular malformations (1.09, 1.00 to 1.18), ventricular septal defect (1.07, 0.95 to 1.21), atrial s

38 This association was significant for ventricular septal defects (1.1% vs 0.6%; P = .001) and

39 s, 2 warfarin embryopathies, 1 stillbirth, 1 ventricular septal defect, 1 growth retardation) were re

40 68-1.57) or premature CAD (OR for CoA versus ventricular septal defect, 1.44; 95% CI, 0.79-2.64) afte

41 imester infection were 1.59 (1.16, 2.20) for ventricular septal defects, 1.55 (1.21, 1.99) for atriov

42 lformation [25 (56.82%) vs. 31 (34.83%)] and ventricular septal defect [10 (22.73%) vs. 6 (6.74%)] to

43 HDs were tetralogy of Fallot (20%), isolated ventricular septal defect (14%), and transposition of th

44 ssociated cardiovascular anomalies, of which ventricular septal defects (22/47, 47%), atrial septal d

45 Overall, 400 patients, 154 (38.3%) with a ventricular septal defect, 238 (59.5%) with an intact se

46 7) hair dye in multiple/multiplex membranous ventricular septal defect, 3.3%; and 8) urinary tract in

47 % for tetralogy of Fallot, 2.7% for isolated ventricular septal defect, 3.5% for coarctation of the a

48 CAD compared with 224 of 6481 patients with ventricular septal defect (4.9% versus 3.5%; P=0.04).

49 nd associated CHD (9 atrial septal defect, 7 ventricular septal defect, 4 transposition of the great

50 6) pesticide exposure in isolated membranous ventricular septal defect, 5.5%; 7) hair dye in multiple

51 eptal defects [12.4 months sooner, P=0.037], ventricular septal defects [6.0 months sooner, P<0.003],

52 12 had Taussig-Bing anomaly, 12 had multiple ventricular septal defects, 8 had right ventricular hypo

53 If AVVI is < 0.67 in the presence of a large ventricular septal defect, a single-ventricle approach t

54 nt of the neural crest such as cleft palate, ventricular septal defect, abnormal development of hypog

55 es, including pulmonic arterial stenosis and ventricular septal defects accompanied by high peak outf

56 eeks' gestation, with d-TGA, with or without ventricular septal defects, admitted to our institution

57 ere not significantly related to presence of ventricular septal defect, age at surgery, perfusion var

58 ouble outlet right ventricle, and atrial and ventricular septal defects, all occurring with variable

59 owed structural cardiac defects, including a ventricular septal defect, an aortic root that either st

60 s of 58 patients, 3 to 57 years of age, with ventricular septal defect and a marked increase in pulmo

61 n of Ets1(-/-) embryos revealed a membranous ventricular septal defect and an abnormal nodule of cart

62 , likely resulting from a profound subaortic ventricular septal defect and associated malalignment of

63 on of the entire miR-200 family results in a ventricular septal defect and embryonic lethality by emb

64 tissue defects, including liver hypotrophy, ventricular septal defect and haemorrhage.

65 We report an infant with a ventricular septal defect and infective endocarditis cau

66 cts in cardiovascular development, including ventricular septal defect and non-compaction, as well as

67 ing to left-to-right shunting in the form of ventricular septal defect and paradoxical thromboembolis

68 This pattern was also true for patients with ventricular septal defect and subaortic stenosis compare

69 stenosis and 12 patients with perimembranous ventricular septal defect and subaortic stenosis-and wer

70 uses, with high penetrance, large membranous ventricular septal defects and a bifid cardiac apex, and

71 fects or embryonic death, but does result in ventricular septal defects and a low incidence of semilu

72 study of the ontogeny and natural history of ventricular septal defects and cardiomyopathy.

73 lethality due to omphalocele accompanied by ventricular septal defects and conduction anomalies.

74 nt article describes the clinical aspects of ventricular septal defects and current management strate

75 HDAC5 and HDAC9 show a propensity for lethal ventricular septal defects and thin-walled myocardium.

76 We report severe cardiac defects such as ventricular septal defects and thinned myocardium, place

77 e tetralogy of Fallot, overriding aorta with ventricular septal defect, and bicuspid aortic valves.

78 elopment including hypoplasia of myocardium, ventricular septal defect, and disorganized morphology.

79 including hypoplastic myocardium, membranous ventricular septal defect, and double outlet right ventr

80 uch as abnormalities of the tricuspid valve, ventricular septal defect, and pulmonary stenosis, occur

81 Of surviving embryos, 23% showed ventricular septal defects, and 11% showed neural tube d

82 ht ventricle, with obligatory perimembranous ventricular septal defects, and double-sided aortic arch

83 ar valve development, bicuspid aortic valve, ventricular septal defects, and embryonic lethality.

84 e Gsk3b(-/-) embryos had a double outlet RV, ventricular septal defects, and hypertrophic myopathy, w

85 efects overall, pulmonary-artery hypoplasia, ventricular septal defects, and hypoplastic left heart.

86 sgenesis of the aortic and pulmonary valves, ventricular septal defects, and other cardiac anomalies.

87 ovascular abnormalities including atrial and ventricular septal defects, and tetralogy of Fallot, res

88 rch arteries, double-outlet right ventricle, ventricular septal defects, and thin-walled myocardium.

89 ls severe cardiac defects such as atrial and ventricular septal defects, and valvular defects includi

90 ns, including double outlet right ventricle, ventricular-septal defects, and pericardial edema.

91 formations (aOR = 1.28; 95% CI: 1.03, 1.61), ventricular septal defect (aOR = 1.19; 95% CI: 1.00, 1.4

92 ght ventricle, transposition, and membranous ventricular septal defects), aortic sac (persistent trun

93 Ventricular septal defects are a rare complication after

94 Ventricular septal defects are common in human infants,

95 Ventricular septal defects are either isolated small def

96 Because congenital ventricular septal defects are of different sizes and lo

97 Ventricular septal defects are the most common congenita

98 Atrial and ventricular septal defects are the most common forms of

99 le device closure and closure of postinfarct ventricular septal defects, are also discussed.

100 of the aorta (aRR, 0.77; 95% CI, 0.61-0.96), ventricular septal defects (aRR, 0.85; 95% CI, 0.75-0.96

101 x37 and found a high incidence of atrial and ventricular septal defects at birth.

102 ube defects, transposition of great vessels, ventricular septal defect, atrial septal defect, tetralo

103 Severe nonchromosomal CHD (ie, excluding ventricular septal defects, atrial septal defects, and p

104 Mortality rates for coarctation, ventricular septal defect, atrioventricular septal defec

105 k; (b) the transcatheter closure of muscular ventricular septal defects; (c) the transcatheter closur

106 A type of ventricular septal defect called the Gerbode defect, whi

107 Postinfarction ventricular septal defect carries a grim prognosis.

108 mentation (n=5), mitral valvuloplasty (n=5), ventricular septal defect closure (n=4), apicoaortic con

109 c stenosis resection/Konno procedure (n=10), ventricular septal defect closure (n=8), apical aortic c

110 s associated with death after postinfarction ventricular septal defect closure included the following

111 of Fallot by the traditional technique with ventricular septal defect closure through a ventriculoto

112 Postinfarction ventricular septal defect closure was attempted in 53 pa

113 with the modified technique with transatrial ventricular septal defect closure, a short infundibular

114 , aortoplasty, subaortic stenosis resection, ventricular septal defect closure, and ascending aorta r

115 ioventricular block and operations involving ventricular septal defect closure.

116 lthough transcatheter valve replacements and ventricular septal defect closures have already been per

117 The associations with major ventricular septal defects, common arterial trunk, and a

118 nce of congenital cardiac malformations like ventricular septal defects, common atrioventricular cana

119 This review discusses the different types of ventricular septal defects commonly seen in adults in th

120 mic consequences and treatment strategies of ventricular septal defects complicating acute myocardial

121 ar ventricular septal defect, perimembranous ventricular septal defect, conotruncal defects, left ven

122 for trabecular and papillary muscle defects, ventricular septal defects, conotruncal ridge defects, a

123 lar chamber (chamber hypoplasia and muscular ventricular septal defects), conotruncus (double-outlet

124 t ventricular hypertrophy, overriding aorta, ventricular septal defects, coronary vessel abnormalitie

125 ntal abnormalities include overriding aorta, ventricular septal defects, cranial nerve, and craniofac

126 tro-transposition of the great arteries with ventricular septal defect (d-TGA-VSD), and double-outlet

127 the transcatheter closure of perimembranous ventricular septal defects; (d) the placement of biopros

128 The Amplatz ventricular septal defect device appears highly efficaci

129 eptal defects using the Amplatzer membranous ventricular septal defect device have been encouraging.

130 on of the delivery system for the membranous ventricular septal defect device that is aimed to overco

131 is study was to close MVSDs with the Amplatz ventricular septal defect device.

132 verall, we observed an accuracy of 89.8% for ventricular septal defect diagnosis.

133 decreasing NMII-B by 80% results in cardiac (ventricular septal defect, double outlet of the right ve

134 eart defects (CHD) which included atrial and ventricular septal defects, double outlet right ventricl

135 g Jun in Isl1-expressing progenitors display ventricular septal defects, double outlet right ventricl

136 Two naive pigs developed ventricular septal defects due to excessively deep lacer

137 e flow measurements of mitral regurgitation, ventricular septal defect flow and aortic regurgitation.

138 from 1.9 per mille to 4.1 per mille, and of ventricular septal defect from 3.6 per mille to 4.5 per

139 s, such as operative urgency and postinfarct ventricular septal defect, have been relatively stable o

140 t defects (persistent truncus arteriosus and ventricular septal defect), hypoplastic lungs, hypoplast

141 ) and of a tunnel type in 7, with associated ventricular septal defect in 28 (37%).

142 syndrome was present in 31% (n = 46 of 149), ventricular septal defect in 95% (n = 142 of 149), and p

143 s associated with ventricular hypoplasia and ventricular septal defects in beta-myosin heavy chain-mi

144 Because we observed ventricular septal defects in embryos that are null for

145 0.15); however, the incidence of membranous ventricular septal defects in Nkx2-5 mutant hearts was n

146 hereas deletion of both miRNAs causes lethal ventricular-septal defects in approximately half of doub

147 Percutaneous closure of postinfarction ventricular septal defect is a reasonably effective trea

148 significantly increased by the presence of a ventricular septal defect, left ventricular outflow obst

149 Repair of muscular ventricular septal defects (MVSDs) has always been chall

150 The cardiac diagnoses included ventricular septal defect (n = 11), tetralogy of Fallot

151 fetal/newborn mice revealed an abundance of ventricular septal defects (n=307).

152 mbryos showed heart malformations, including ventricular septal defect, noncompaction of the ventricu

153 ently used devices were the Vascular Plug 3, Ventricular Septal Defect Occluder, Vascular Plug 2, and

154 test odds of offspring with a perimembranous ventricular septal defect (odds ratio = 3.23, 95% confid

155 1.43, 3.60), and sulfur dioxide and isolated ventricular septal defects (odds ratio = 2.16, 95% confi

156 all or large IVS, appears to confer risk for ventricular septal defect or hypertrophic cardiomyopathy

157 in patients with acute mitral regurgitation, ventricular septal defect or poor left ventricular funct

158 s and cross-clamp times, and the presence of ventricular septal defects or abnormal coronary anatomy.

159 redictors of failure included moderate/large ventricular septal defect (OR=22, P=0.001), unicommissur

160 t defects (OR = 0.46; 95% Cl 0.24, 0.86) and ventricular septal defects (OR = 0.61; 95% Cl: 0.38, 0.9

161 struction (OR, 1.28 [95% CI, 1.10-1.49]) and ventricular septal defects (OR, 0.92 [95% CI, 0.86-0.98]

162 abundant endocardial cushions accompanied by ventricular septal defects, outflow tract abnormalities

163 The cardiac defects include atrial and ventricular septal defects, overriding aorta, double-out

164 The presence of a ventricular septal defect ( P=0.009) and older age at su

165 rea at diastole was associated with risk for ventricular septal defect (p(IVW)=0.007).

166 persistent left superior vena cava (P=0.85), ventricular septal defect (P=0.12), and bicuspid aortic

167 ly implicated (ie, in 90.0%) was between the ventricular septal defect patch and pulmonary annulus.

168 ying pulmonary homograft in 1, and overlying ventricular septal defect patch in 1.

169 to-tricuspid annulus, (1B) ventriculotomy-to-ventricular septal defect patch, (2) ventriculotomy-to-p

170 -pulmonary annulus, (3) pulmonary annulus-to-ventricular septal defect patch, and (4) ventricular sep

171 -to-ventricular septal defect patch, and (4) ventricular septal defect patch-to-tricuspid annulus.

172 ng the outlet septum and an appropriate-size ventricular septal defect patch.

173 ed in the outflow tract (99%) or the site of ventricular septal defect patching (98%) and in the infe

174 peroxia 1.51 0.04) and frequency of muscular ventricular septal defects per heart (1.53 0.32 vs. 0.68

175 with intact ventricular septum and TGA with ventricular septal defect performed from 2010 to 2013.

176 ransposition of the great arteries, muscular ventricular septal defect, perimembranous ventricular se

177 rabeculation defects in the right ventricle, ventricular septal defect, persistent truncus arteriosus

178 One family with forelimb anomalies and ventricular septal defects, phenotypes similar to Holt-O

179 Post-infarction ventricular septal defect (PIVSD) is a mechanical compli

180 patients with a posterior malalignment type ventricular septal defect (PMVSD) and only 1 of 20 patie

181 ck) after operative repair of perimembranous ventricular septal defect (PMVSD) in a large multi-insti

182 s of transcatheter closure of perimembranous ventricular septal defects (PmVSDs) using the new Amplat

183 ation secondary to papillary muscle rupture, ventricular septal defect, pseudoaneurysm, and free wall

184 ial septal defect, patent ductus arteriosus, ventricular septal defect, pulmonary artery anomalies, p

185 or anomalies, include pulmonary atresia with ventricular septal defect, pulmonary valve agenesis, aor

186 tract obstruction (ratio of RRs, 4.98), and ventricular septal defects (ratio of RRs, 2.51) but not

187 than mild tricuspid regurgitation, residual ventricular septal defect) reduces this protective assoc

188 (relative risk = 10.2), followed by multiple ventricular septal defects (relative risk = 4.7).

189 o 1.93) or between the use of sertraline and ventricular septal defects (relative risk, 1.04; 95% CI,

190 ions overall, cardiac malformations overall, ventricular septal defect, secundum atrial septal defect

191 ion of mXinbeta led to abnormal heart shape, ventricular septal defects, severe growth retardation, a

192 the neonatal period as well as for muscular ventricular septal defects should be the transcatheter a

193 lial-specific NSML SHP2 expression developed ventricular septal defects, suggesting that NSML-associa

194 veal that > or = 2 loci influence membranous ventricular septal defect susceptibility, whereas > or =

195 e (Cx40+/-) included bifid atrial appendage, ventricular septal defect, tetralogy of Fallot (TOF), an

196 eath after surgery for atrial septal defect, ventricular septal defect, tetralogy of Fallot, and tran

197 all patients with CHD (atrial septal defect, ventricular septal defect, tetralogy of Fallot, Ebstein

198 spectrum of cardiac malformations including ventricular septal defects, tetralogy of Fallot, and tri

199 ular septum (TGA/IVS, n = 79, 63%), TGA with ventricular septal defect (TGA/VSD, n = 37, 30%), and Ta

200 Five experienced 3 of 76 (3.9%) iatrogenic ventricular septal defects that did not require repair a

201 e but have severe dilated cardiomyopathy and ventricular septal defects that mimic a human congenital

202 ndromic patients with isolated atrial and/or ventricular septal defects, the predominant cardiac defe

203 Moderate/large ventricular septal defect, unicommissural aortic valve,

204 ate, cleft palate only, conotruncal defects, ventricular septal defects, urinary tract defects, limb

205 tflow tract and creation or enlargement of a ventricular septal defect using stents are potential the

206 results of device closure of perimembranous ventricular septal defects using the Amplatzer membranou

207 egrees and 0 degree), presence/location of a ventricular septal defect (VSD) (3-mm VSD; 2 and 6 mm fr

208 rmine the accuracy of expert examination for ventricular septal defect (VSD) among children with a he

209 ar to those in the human proband, as well as ventricular septal defect (VSD) and double-outlet right

210 Pulmonary atresia with ventricular septal defect (VSD) and major aortopulmonary

211 nd the presence of MAPCAs, with TOF, PA, and ventricular septal defect (VSD) being the most common, a

212 Transcatheter ventricular septal defect (VSD) closure is a safe and ef

213 Ventricular septal defect (VSD) complicating acute myoca

214 Postinfarction ventricular septal defect (VSD) is a catastrophic compli

215 Ventricular septal defect (VSD) is a lethal complication

216 urvival of patients with isolated congenital ventricular septal defect (VSD) is not well described.

217 enmenger syndrome when two ventricles with a ventricular septal defect (VSD) joined two great arterie

218 = 251), coarctation or interrupted arch with ventricular septal defect (VSD) repair (n = 150), and No

219 Prior ventricular septal defect (VSD) repair predicted neo-AI

220 tive data for atrial septal defect (ASD) and ventricular septal defect (VSD) surgeries in children 2

221 etrical and a moderate-sized apical muscular ventricular septal defect (VSD) was diagnosed after birt

222 efects in cardiac morphogenesis, including a ventricular septal defect (VSD), abnormal formation of t

223 odel, we observed an increased risk of CHDs, ventricular septal defect (VSD), and tetralogy of fallot

224 cts including double-outlet right ventricle, ventricular septal defect (VSD), atrioventricular (AV) c

225 which 6 were thought to have a subpulmonary ventricular septal defect (VSD), had incorrect prenatal

226 O for dTGA with intact ventricular septum or ventricular septal defect (VSD), including double-outlet

227 e types of congenital heart disease, such as ventricular septal defect (VSD), myocardium noncompactio

228 as double outlet right ventricle (DORV) and ventricular septal defect (VSD), similar to defects obse

229 ted heart abnormalities, including PTA and a ventricular septal defect (VSD).

230 and both an atrial septal defect (ASD) and a ventricular septal defect (VSD).

231 e aneurysm was identified with no associated ventricular septal defect (VSD).

232 sted of 9400 exposed children diagnosed with ventricular septal defect (VSD).

233 ng-term outcomes after surgical closure of a ventricular septal defect (VSD).

234 rection and magnitude of shunting across the ventricular septal defect (VSD).

235 of double outlet right ventricle (DORV) and ventricular septal defects (VSD).

236 e birth defects (atrial septal defect [ASD], ventricular septal defect [VSD], tetralogy of Fallot [TO

237 Intramural ventricular septal defects (VSDs) are interventricular c

238 The positions, sizes, and shapes of ventricular septal defects (VSDs) can be difficult to as

239 nd environmental factors on the incidence of ventricular septal defects (VSDs) caused by a heterozygo

240 heter or surgical closure of apical muscular ventricular septal defects (VSDs) requires accurate deli

241 try of device closure of congenital muscular ventricular septal defects (VSDs) using the new Amplatze

242 Ventricular septal defects (VSDs) were associated with t

243 ncation and kinking with 100% penetrance and ventricular septal defects (VSDs) with ~15% penetrance;

244 Defects within it, termed muscular ventricular septal defects (VSDs), are common, yet less

245 CHD was related to the relative frequency of ventricular septal defects (VSDs), the most common type

246 epaired congenital or postoperative residual ventricular septal defects (VSDs).

247 nt for many atrial septal defects (ASDs) and ventricular septal defects (VSDs).

248 t is recurrently deleted in individuals with ventricular septal defects (VSDs).

249 Ventricular septal defect was associated with tetralogy

250 n patients with CoA compared with those with ventricular septal defect was determined.

251 A large ventricular septal defect was present in all six nonsurv

252 Closure of a residual ventricular septal defect was required in 13 patients, a

253 Ventricular septal defect was the most common CHD observ

254 By multivariate analysis, noncommitted ventricular septal defect was the strongest independent

255 isk of specific birth defects, only that for ventricular septal defects was significantly elevated, w

256 Major ventricular septal defects were associated with larger H

257 exception of a single baby with an isolated ventricular septal defect, which closed spontaneously, n

258 t defect including cardiac noncompaction and ventricular septal defect, which phenocopies 1p36 deleti

259 cell cycling, ventricular noncompaction, and ventricular septal defects, while, in the postnatal card

260 compared patients with CoA and those with a ventricular septal defect, who are not known to be at in

261 sted cardiac disease, including classic ToF, ventricular septal defect with aortic dextroposition and

262 tation and on the left-ventricular side of a ventricular septal defect with left-to-right shunting.

263 MRI demonstrated a ventricular septal defect with over-riding aorta.

264 =3), functionally single ventricle (n=3) and ventricular septal defect with pulmonary outflow obstruc

265 36), or transposition of the great arteries, ventricular septal defect with pulmonary stenosis (n=8).

266 xhibit cardiac ventricular wall thinning and ventricular septal defects with double outlet right vent

267 ew strains model a specific subtype of atrio-ventricular septal defects with exclusive ventricular sh