ライフサイエンスコーパス: very late antigen

1 The alpha1beta1 integrin, very late antigen-1 (VLA-1), is a collagen receptor expr

2 thelial growth factor receptor-3) and VLA-1 (very late antigen-1) promotes high-risk transplant survi

3 AQC2 to the alpha1 chain of human and sheep very late antigen-1, given 30 minutes before challenge,

4 on, but an increase in p150,95 (CD11c/CD18), very late antigen-1, or ICAM-1 expression was not observ

5 The integrin alpha1beta1 (very late antigen-1; CD49a/CD29) is a major adhesion rec

6 These findings establish human very late antigen 2 transgenic mice as a model for echov

7 Production of human integrin very late antigen 2, a receptor for echovirus type 1, in

8 eater glycoprotein (GP) IIb/IIIa (p = 0.04), very late antigen-2 (p = 0.04) and platelet/endothelial

9 ated antigen 1 (LFA-1) (alpha(L)beta(2)) and very late antigen 4 (VLA-4) (alpha(4)beta(1)).

10 Very late antigen 4 (VLA-4) and CD11/CD18 integrins medi

11 tes matrix metalloproteinase-9 secretion and very late antigen 4 (VLA-4)-mediated adhesion to vascula

12 e function-associated antigen 1 (LFA-1), and very late antigen 4 (VLA-4).

13 f chemokine receptor (CCR2) and the integrin Very Late Antigen 4 (VLA-4).

14 s mediated by a single integrin heterodimer, very late antigen 4 (VLA-4).

15 Anti-very late antigen 4 (VLA-4; on neutrophils) inhibited ad

16 ting of the chemokine receptor CXCR2 and the very late antigen 4 (VLA4) integrin.

17 The integrin very late antigen 4 (VLA4), is differentially expressed

18 from the expression of its molecular target, very late antigen 4 (VLA4), on most immune cells and con

19 To provide further insights into the anti-very late antigen 4 (VLA4)/anti-vascular cell adhesion m

20 Very Late Antigen 4 (VLA4, integrin alpha(4)beta(1)) is

21 e detected the active conformational form of very late antigen 4 after stimulation with a peptide mim

22 s of beta1 phosphorylation and a decrease in very late antigen 4 binding to its ligand vascular cell

23 ular signature, which includes expression of very late antigen 4 in peripheral blood, was also enrich

24 , also known as the adhesion molecule VLA-4 (very late antigen 4), dependent on the presence of the L

25 r by chemokines leads to the inactivation of very late antigen 4.

26 The leukocyte integrin very late antigen-4 (alpha(4)beta(1), CD49d/CD29) is an

27 The leukocyte integrin very late antigen-4 (VLA-4) (alpha 4 beta 1, CD49d/CD29)

28 hocytes that expressed low or high levels of very late antigen-4 (VLA-4) and non-antigen-specific act

29 rs to stromal cells is primarily mediated by very late antigen-4 (VLA-4) and vascular cell adhesion m

30 Extremely potent very late antigen-4 (VLA-4) antagonists with picomolar,

31 nction-associated antigen (LFA-1) and VCAM-1/very late antigen-4 (VLA-4) at select time points compar

32 rsor cells were transiently transfected with very late antigen-4 (VLA-4) binding to vascular cell adh

33 As very late antigen-4 (VLA-4) can exist in different funct

34 Further, B cell-restricted very late antigen-4 (VLA-4) deficiency abrogated EAE dep

35 later, GVHD-associated increase in CD25 and very late antigen-4 (VLA-4) expression on donor T cells

36 lar endothelial growth factor receptor-1 and very late antigen-4 (VLA-4) have been shown to arrive at

37 ell adhesion molecule-1 (VCAM-1), LFA-1, and very late antigen-4 (VLA-4) have relatively little effec

38 esent study was to determine the role of the very late antigen-4 (VLA-4) integrin/ligand interaction

39 te function-associated antigen-1 (LFA-1) and very late antigen-4 (VLA-4) on adhesion of influenza hem

40 The expression of very late antigen-4 (VLA-4) on the surface of MBP-primed

41 scular cell adhesion molecule 1 (VCAM-1) and very late antigen-4 (VLA-4) played an integral role in t

42 Interaction of very late antigen-4 (VLA-4) with its ligand vascular cel

43 ion, we show that MBP-primed T cells express very late antigen-4 (VLA-4), and functional blocking ant

44 the adhesion molecules CD11a, CD11b, CD11c, very late antigen-4 (VLA-4), and L-selectin, as assessed

45 we evaluated the role of targeted imaging of very late antigen-4 (VLA-4), as a key integrin mediating

46 The alpha(4)beta(1)-integrin (very late antigen-4 (VLA-4), CD49d/CD29) is an adhesion

47 portance of VCAM-1, and its leukocyte ligand very late antigen-4 (VLA-4), in such leukocyte migration

48 Natalizumab, which binds very late antigen-4 (VLA-4), is a potent therapy for mul

49 he affinity of the alpha(4)beta(1) integrin, very late antigen-4 (VLA-4), measured with an LDV-contai

50 lasts within the bone marrow is adhesion via very late antigen-4 (VLA-4), the alpha(4)beta(1) integri

51 D49d), in complex with integrin beta1, forms very late antigen-4 (VLA-4), which interacts with vascul

52 cular cell adhesion molecule-1 (VCAM-1)- and very late antigen-4 (VLA-4)-mediated localization of CXC

53 and human monoblastoid U937 cells expressing Very Late Antigen-4 (VLA-4).

54 ascular cell adhesion molecule-1 (VCAM-1) or very late antigen-4 (VLA-4).

55 une cells from patients under long-term anti-very late antigen-4 (VLA-4)/natalizumab therapy (LTNT) a

56 skin fibroblasts, making it unlikely that a very late antigen-4 (VLA-4)/VCAM-1 interaction is requir

57 ion of one of the major leukocyte integrins, very late antigen-4 (VLA-4, CD49d/CD29).

58 Melanocortin-1 receptor (MC1R) and very late antigen-4 (VLA-4, integrin a(4)B(1)) are 2 att

59 Melanocortin-1 receptor (MC1R) and very late antigen-4 (VLA-4, integrin alpha(4)beta(1)) ar

60 duced by IL-3 in a dose-dependent manner via very late antigen-4 (VLA-4; alpha4beta1 integrins) and V

61 Very late antigen-4 (VLA-4; also called integrin alpha4b

62 ascular cell adhesion molecule-1 (VCAM1) and very late antigen-4 (VLA4) using monoclonal antibodies.

63 cule antagonist, compound A, to nonactivated very late antigen-4 (VLA4) was examined in lung inflamma

64 BL1(+) progenitors had similar expression of very late antigen-4 (VLA4), VLA5, leukocyte functional a

65 elated protein ligand, resulting in enhanced very late antigen-4 [VLA-4] directed adhesion and motili

66 lymphocyte adhesion but partially conserved very late antigen-4 adhesiveness.

67 irway inflammation and was prevented by anti-very late antigen-4 and anti-interleukin-5 treatments, w

68 Very late antigen-4 and CD11/CD18 integrins mediated pas

69 apse with cells collected during therapeutic very late antigen-4 blockade, we could identify immune s

70 and natalizumab (Tysabri/Antegren) targeting very late antigen-4 for the treatment of relapsing-remit

71 ncrease expression of VCAM-1, a receptor for very late antigen-4 found on many hematopoietic progenit

72 dent mechanism to increase CD11c expression, very late antigen-4 function, and integrin coclustering

73 for the integrin alpha4beta1 (also known as very late antigen-4 or VLA-4).

74 ction by 50%, whereas blocking L-selectin or very late antigen-4 showed significant but smaller effec

75 te function-associated antigen-1) and VLA-4 (very late antigen-4) is essential for T-cell trafficking

76 lymphocyte function-associated antigen-1 and very late antigen-4) on splenocytes.

77 (NPCs) expresses VLA4 (integrin alpha4beta1, very late antigen-4) that facilitates NPC entry into the

78 tide affinity ligand, VHPKQHR, homologous to very late antigen-4, a known ligand for VCAM-1.

79 The antigen alpha4beta1 (very late antigen-4, VLA-4) plays an important role in t

80 al cells, and mild expression of its ligand, very late antigen-4, was apparent in perivascular lympho

81 imilar to, but more restricted than, current very late antigen-4-directed approaches that have signif

82 Activated T cells use very late antigen-4/alpha4beta1 integrin for capture, ro

83 The optimization and validation of the very late antigen-4/vascular cell adhesion molecule-1 as

84 tion of the interaction between the integrin very-late antigen-4 (VLA-4; alpha 4 beta 1) and vascular

85 nocyte chemoattractant protein-1) and VLA-4 (very-late antigen-4).

86 , a ligand for the alpha(4)beta(1) integrin, very-late-antigen-4 (VLA-4 or CD49d).

87 Very-late-antigen-4 (VLA-4, alpha4beta1 integrin, CD49d/

88 otif that has homology to the alpha-chain of very late antigen (a known ligand for VCAM-1), was shown

89 The human integrin very late antigen (VLA)-2 (CD49b/CD29) mediates interact

90 Despite the higher level of very late antigen (VLA)-2, VLA-4, and VLA-5 on Sca-1(+)c

91 eceptors on Tc1 and Tc2 cells, we found that very late antigen (VLA)-4 (a heterodimer of CD49d and CD

92 tinct kinetic patterns for the regulation of very late antigen (VLA)-4 (alpha 4 beta 1) and VLA-5 (al

93 sp (RGD) sensitive and partially mediated by very late antigen (VLA)-4 and VLA-5 but not alpha(v) or

94 The transient regulation of very late antigen (VLA)-4 avidity by CC chemokines may p

95 This study tested the hypothesis that very late antigen (VLA)-4 mediates CD18-independent neut

96 s subset depends on the alpha4beta1 integrin very late antigen (VLA)-4.

97 lar endothelial growth factor (VEGF)-induced very late antigen (VLA)-4.

98 n to be important in hematopoiesis, CD44 and very late antigen (VLA)-4.

99 Cross-linking of adherent PMN very late antigen (VLA)-5 and VLA-6 receptors resulted i

100 adhesion/transmigration, upregulates preDC2 very late antigen (VLA)-5, and protects preDC2s from tum

101 ing that stem cells may express the integrin very late antigen (VLA)-5.

102 vious study showed that the cross-linking of very late antigen (VLA)/beta1 with anti-CD29 monoclonal

103 In this study, we investigated whether very late antigen (VLA)4 and VLA-6 integrins, which play

104 investigated the role of adhesion molecules (very late antigen [VLA]-4 [ alpha 4 beta 1 integrin] and

105 odies (MoAbs) enhanced integrin alpha4beta1 (very late antigen [VLA]-4) and alpha5 beta1 (VLA-5)-depe