ライフサイエンスコーパス: vestibular

1 Of 109 cranial schwannomas, 106 (97.2%) were vestibular.

2 The feedback model of podokinetic and vestibular adaptive processes had a good fit with the da

3 Contention surrounds whether the evoked vestibular afferent activity encodes a signal of net rot

4 gely explain the main features of GVS-evoked vestibular afferent dynamics.

5 etylcholine receptors (nAChRs) in regulating vestibular afferent gain and activation timing.

6 gical recordings reveal tuning of individual vestibular afferent inputs and their postsynaptic target

7 A group of vestibular afferent nerve fibers with irregular-firing r

8 Here we directly investigate single vestibular afferent responses to GVS applied to the mast

9 f vestibulocollic reflexes, we then recorded vestibular afferent responses to the same electrical sti

10 r previous hypotheses about how I (H) shapes vestibular afferent responses.SIGNIFICANCE STATEMENT Ves

11 Vestibular afferents also responded to electrical stimul

12 e effect of electrical vestibular stimuli on vestibular afferents and a current model of central vest

13 lated signal of head rotation encoded by the vestibular afferents can cause perceptions of both linea

14 gs and found aberrant central projections of vestibular afferents in both cases.

15 her electrical vestibular stimuli encoded by vestibular afferents induce a net signal of linear accel

16 me that efferent-mediated slow excitation of vestibular afferents is mediated by muscarinic acetylcho

17 Efferent-mediated slow excitation of vestibular afferents is of considerable interest given i

18 by a model combining the influence of EVS on vestibular afferents with known mechanisms of vestibular

19 ing from neurons receiving direct input from vestibular afferents within minutes, as well as a decrea

20 by high-frequency signals encoded by primary vestibular afferents, but undergo low-pass filtering at

21 keys during temporally precise activation of vestibular afferents.

22 aps between the inner ear hair cells and the vestibular and auditory nuclei to allow vestibular and s

23 sensory neurons, to the later appearance of vestibular and cerebellar dysfunction.

24 rizing the vestibulo-ocular reflex (VOR) and vestibular and headache symptom severity.

25 it in which SOM cells are key integrators of vestibular and luminance signals.

26 We propose a dynamic feedback model of vestibular and podokinetic adaptation that can fit rotat

27 t role in determining a cell's PFD, and that vestibular and proprioceptive cues drive these computati

28 Path integration is thought to rely on vestibular and proprioceptive cues yet most studies in h

29 n of multiple sensory inputs such as vision, vestibular and somatosensory systems.

30 the vestibular and auditory nuclei to allow vestibular and sound information processing.

31 aine develop abnormal responsiveness to both vestibular and visual stimuli characterized by heightene

32 However, the potential of the vestibular apparatus for phylogenetic reconstruction amo

33 odel for nonsyndromic deafness with enlarged vestibular aqueduct (EVA; OMIM #600791).

34 ularly if sensory neuronopathy and bilateral vestibular areflexia coexist.

35 the cause of cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) and a major cause

36 Cerebellar ataxia, neuropathy and vestibular areflexia syndrome (CANVAS) is a progressive

37 ebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome (CANVAS) is a recently rec

38 ebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome (CANVAS).

39 s also termed cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS).

40 mic bilateral sensorineural hearing loss and vestibular areflexia.

41 nized tissue (KT) width (i.e., <2 mm) at the vestibular aspect of 19 implants who underwent soft tiss

42 oved vestibular function; however, no direct vestibular assessment was made.

43 The CAVA (Continuous Ambulatory Vestibular Assessment) device has been developed to prov

44 Vestibular balance control is dynamically weighted durin

45 cdh15a transgene-mediated rescue of auditory/vestibular behavior and hair cell morphology and activit

46 tant pan-otic CREs recombine in auditory and vestibular brain nuclei, making it difficult to ascribe

47 iating from its binding site and support our vestibular Ca(2+) sensor-model further.

48 In vestibular cerebellum, primary afferents carry signals f

49 ated in responses to fast head movements and vestibular compensation.

50 that combines an inner ring barrier with two vestibular condensates.

51 prove clinical care and our knowledge of the vestibular contributions to balance.

52 Our results demonstrate that vestibular control of the upper limb maintains reaching

53 n subjects reported that the parieto-insular vestibular cortex (PIVC), a core area of the vestibular

54 ortex modulate activity in core areas of the vestibular cortex during attentive visual processing.SIG

55 vestibular cortex (PIVC), a core area of the vestibular cortex, is inhibited when visual processing i

56 modulate the magnitude of inhibition of the vestibular cortex.

57 vide support for the notion of altered visuo-vestibular cortical interactions in vestibular migraine,

58 symptoms are attributable to impaired visuo-vestibular cortical interactions, which in turn disrupts

59 macaque area MSTd that integrate visual and vestibular cues regarding self-motion.

60 comotor efference copies selectively replace vestibular cues, similar to what was previously observed

61 Hearing or vestibular deficits were reported in 18/121 (15%) childr

62 and depending on the species, mild to strong vestibular deficits.

63 are the key RA-synthesis enzymes involved in vestibular development.

64 rrent approaches for diagnosis of hearing or vestibular disorders are mostly based on physical examin

65 s for efficient gene therapy of cochlear and vestibular disorders by showing that even severe dysmorp

66 drug delivery systems to treat auditory and vestibular disorders.

67 low dose of DT caused profound SNHL without vestibular dysfunction and had no effect on wild-type (W

68 the severity rather than the age of onset of vestibular dysfunction differentiates whether hyperactiv

69 ids have been used to treat hearing loss and vestibular dysfunction for many years.

70 reflex (VOR) responses demonstrated that the vestibular dysfunction of the Zpld1 mutant mice is cause

71 tial for using antisense technology to treat vestibular dysfunction.

72 igh rates of post-operative hearing loss and vestibular dysfunction.

73 sociated with profound retinal, auditory and vestibular dysfunction.

74 mproves hearing sensitivity, and ameliorates vestibular dysfunction.

75 ir death leads to permanent hearing loss and vestibular dysfunction.

76 Stimulation of vestibular efferent neurons excites calyx and dimorphic

77 our genetic evidence indicates that auditory/vestibular end organs and subsets of hair cells therein

78 findings support the notion that peripheral vestibular end organs are not passive transducers of hea

79 naling and plasticity.SIGNIFICANCE STATEMENT Vestibular end organs in the inner ear receive efferent

80 primary afferents carry signals from single vestibular end organs, whereas secondary afferents from

81 barrier (BLB) was investigated in the human vestibular endorgan, the utricular macula, using postmor

82 he deletion of sst1.1 did not impact acousto-vestibular escape responses but led to abnormal explorat

83 test and examinations of ocular and cervical vestibular evoked myogenic potentials and dynamic visual

84 Mutants have deficient vestibular evoked potential (VsEP) responses to jerk sti

85 ence frame confirms the functional nature of vestibular-evoked arm movement.

86 efore the upper limb plays an active role in vestibular-evoked balance responses.

87 Furthermore, modulation of vestibular-evoked muscle responses occurred rapidly ( ap

88 These high-frequency contributions to vestibular-evoked neck muscle responses could stabilize

89 ected head transients.SIGNIFICANCE STATEMENT Vestibular-evoked neck muscle responses rely on accurate

90 Vestibular excitatory inputs in Group I motoneurons are

91 g different surgical techniques-suturing the vestibular flap margin apically to the base of the recip

92 timulation as a potential therapy to restore vestibular function after bilateral vestibulopathy.

93 ividuals with documented normal auditory and vestibular function and surgical specimens from patients

94 dicated an apparent persistent importance of vestibular function at increasing speeds.

95 ence of an effective treatment of peripheral vestibular function in a mouse model of USH1C and reveal

96 These findings suggest a need to evaluate vestibular function in hearing impaired individuals, esp

97 he deafness progressed with aging, while the vestibular function of Elmod3-/- mice was normal.

98 ear areas; moreover, it rescued hearing and vestibular function of mice in vivo.

99 Improvements in auditory and vestibular function were sustained well into adulthood.

100 r cell survival, restoration of cochlear and vestibular function, restoration of neural responses in

101 interactions, which in turn disrupts normal vestibular function.

102 l in Usher mice, indicating profound loss of vestibular function.

103 inally rescues hearing and partially rescues vestibular function.

104 The findings were suggestive of improved vestibular function; however, no direct vestibular asses

105 ASO-29 treatment at P15 despite the profound vestibular functional deficits that persist with treatme

106 gous S324Tfs*3 mice have normal auditory and vestibular functions but show an abrupt onset of spontan

107 ized coding via temporal whitening for other vestibular functions.

108 Nrp2- and PlxnA1-expressing neurites of the vestibular ganglion away from nonsensory epithelia, thus

109 Previous studies from immature vestibular ganglion neurons (VGNs) identified hyperpolar

110 Vestibular ganglion neurons (VGNs) transmit information

111 ally redundant FGF ligands may contribute to vestibular hair cell differentiation and supports a deve

112 ion is a specific and early marker of Type-I vestibular hair cell identity.

113 Little is known about how vestibular hair cells adopt a Type I or Type II identity

114 used dual patch-clamp recordings from turtle vestibular hair cells and their afferent neurons to show

115 Both type I and type ll vestibular hair cells express the alpha9 and alpha10 sub

116 and ultrastructure of efferent terminals on vestibular hair cells in alpha9, alpha10, and alpha9/10

117 Vestibular hair cells in the inner ear encode head movem

118 fferentially expressed genes in auditory and vestibular hair cells suggests that GFI1 serves differen

119 ou4f3 expression in cochlear hair cells than vestibular hair cells, administration of a low dose of D

120 -rich stereocilia elongation in auditory and vestibular hair cells, causing deafness and balance defe

121 s, a robust model for mammalian auditory and vestibular hair cells, we identified a urea-thiophene ca

122 oad punctate cytoplasmic distribution in the vestibular hair cells, whereas it was detected in the en

123 heading in neurons with congruent visual and vestibular heading preferences, whereas they stabilize t

124 n result from cerebellar, proprioceptive, or vestibular impairment; when in combination, it is also t

125 ouse and human databases of genetic auditory/vestibular impairments confirms the critical role of the

126 y lack acoustic-evoked behavioral responses, vestibular-induced eye movements, and hair-cell activity

127 These results suggest that vestibular influence on ankle muscle control is adjusted

128 These results demonstrate that the vestibular influence on ankle muscles during locomotion

129 KEY POINTS: The vestibular influence on human walking is phase-dependent

130 Using a split-belt treadmill, we show that vestibular influence on locomotor activity is modulated

131 circuits that in flies control auditory and vestibular information processing and motor coordination

132 brains, hippocampal cells combine visual and vestibular information to encode head direction.

133 beam tests that are consistent with abnormal vestibular input, but normal vestibulo-ocular reflexes a

134 during rotation to isolate the influence of vestibular input, uncontaminated by inertial factors.

135 part, due to altered temporal processing of vestibular input.

136 might result from a selective suppression of vestibular inputs in favor of a feed-forward balance reg

137 b amputees (LLAs) heavily rely on visual and vestibular inputs, and somatosensory cues from their int

138 eeds has potential as an assessment tool for vestibular interventions.

139 ly, but not only, if cerebellar dysfunction, vestibular involvement and cough coexist.

140 howed cerebellar involvement, and six showed vestibular involvement.

141 oupling between the C-loop and the Cys-loop, vestibular loop, and beta1-beta2 loops.

142 Vestibular loss triggers transient increases in postsyna

143 apillaries constituting the BLB in the human vestibular macula utricle from normal and Meniere's dise

144 two eye-head coupling types, associated with vestibular mechanisms.

145 Vestibular migraine (VM) is the most common cause of spo

146 Chronically, patients with vestibular migraine develop abnormal responsiveness to b

147 Vestibular migraine is among the commonest causes of epi

148 Our findings reveal that vestibular migraine patients exhibited abnormally elevat

149 olds were significantly further increased in vestibular migraine patients relative to healthy control

150 ed visuo-vestibular cortical interactions in vestibular migraine, as evidenced by vestibular threshol

151 The independent vestibular modulation of muscle activity from each limb

152 clades, our results confirm the relevance of vestibular morphology for addressing the controversial p

153 tify the phylogenetic signal embedded in the vestibular morphology of extant anthropoids (monkeys, ap

154 This fin-body synergy was absent in vestibular mutants, suggesting sensed imbalance promotes

155 Behaviorally relevant patterns of vestibular nerve activation generated a rapid and substa

156 his study, the effects of iDC stimulation on vestibular nerve fiber firing rate was investigated usin

157 To directly manipulate OKAN vestibular-neurectomy was performed in goldfish that sev

158 we measure sensory computations in zebrafish vestibular neurons across multiple axes in vivo.

159 dition to projecting to motoneurons, central vestibular neurons also receive direct sensory input fro

160 a genetically defined population of central vestibular neurons in rhombomeres 5-7 of larval zebrafis

161 ing preferred directions converge on central vestibular neurons, conferring more simple or complex tu

162 ischarge rate and sensitivity of first-order vestibular neurons.

163 in mice the deep cerebellar nuclei (DCN) and vestibular nuclei (VN) are two major sources of inhibiti

164 Importantly however, the vestibular nuclei also comprise other neuronal classes t

165 ularly dense in the dorsal tegmentum, medial vestibular nuclei and lateral parabrachial nucleus, and

166 rs to compare how the brainstem auditory and vestibular nuclei develop in embryonic chicks and mice.

167 exposure results in activation of the caudal vestibular nuclei in pigeons that is independent of ligh

168 ticular formation (RF), pontine and midbrain vestibular nuclei, and medullary raphe.

169 l where vestibular symptoms emanate from the vestibular nuclei, which are sensitized by migraine-rela

170 end organs, whereas secondary afferents from vestibular nucleus carry integrated signals.

171 diverse fast-firing capacities among medial vestibular nucleus neurons of mice, we identify a group

172 tentiation, and reductions in BK currents in vestibular nucleus neurons.

173 ity of fast-spiking cell types in the medial vestibular nucleus of mice of both sexes, we examined th

174 t of the periaqueductal gray, and the medial vestibular nucleus that were also neurotensinergic.

175 of the thalamus, 0.24 ug . g(-1) +/- 0.04 in vestibular nucleus) and significantly greater than that

176 fasciculus (MLF), and neurons in the lateral vestibular nucleus, whose axons project through the asce

177 uals and avestibular patients, could disrupt vestibular ocular reflex and vestibular-perceptual thres

178 benign intracranial tumours, which included vestibular or other benign schwannomas, WHO grade 1 meni

179 and regenerated hair cells in the utricle, a vestibular organ detecting linear acceleration, acquired

180 UBC to specific ganglion cell, hair cell and vestibular organ subtypes in mice.

181 In both the organ of Corti and the vestibular organ, impaired terminal differentiation mani

182 tanding of sensorineural plasticity in adult vestibular organs and further elucidate the roles that s

183 The vestibular organs of reptiles, birds, and mammals posses

184 sensory hair cells of both the auditory and vestibular organs on E8-E10 may implicate Sema signaling

185 ermine the reliance of zebrafish hearing and vestibular organs on Tmc proteins.

186 3D expression flanking the sensory tissue in vestibular organs suggests that it may repel Nrp2- and P

187 In sensory hair cells of auditory and vestibular organs, the ribbon synapse is required for th

188 Herein, we investigated PCP of the mouse vestibular organs.

189 ctionally coupled Purkinje cell types in the vestibular part of the caudal vermis (lobules IX and X)

190 weeks old), normal activity in the efferent vestibular pathway is required for function of these irr

191 whereas abducens activation by the pretectum-vestibular pathway was not affected.

192 We investigated the hypothesis that central vestibular pathways are sensitized in VM by measuring se

193 to 300-400 Hz, raising the question whether vestibular pathways contribute to head stabilization at

194 ontext of parallel work focused on how early vestibular pathways encode self-motion.

195 , could disrupt vestibular ocular reflex and vestibular-perceptual thresholds of self-motion during r

196 role in responses to fast head movements and vestibular plasticity.

197 e occipital cortex and found that the visual-vestibular posterior insular cortex area was less activa

198 Here, we demonstrate that vestibular primary afferents encode high-frequency stimu

199 nformation at the earliest stages of central vestibular processing in a manner that depends on the cu

200 lar afferents and a current model of central vestibular processing.

201 es and for our understanding of disorders of vestibular processing.

202 estibular afferents with known mechanisms of vestibular processing.

203 We focused on vestibular projections to ON and OFF classes of unipolar

204 nner ear function, causes hyperactivity; (2) vestibular rather than auditory failure causes hyperacti

205 ment at P1, P5 or P15 resulted in sufficient vestibular recovery to support normal balance behaviors,

206 ing ASO-29 treatment have normal or elevated vestibular response thresholds when treated during a cri

207 Vestibular schwannoma (VS) is the most common tumor of t

208 elf-reported occupational noise exposure and vestibular schwannoma (VS), found in several studies, re

209 ent option for small-sized (Koos I up to II) vestibular schwannoma (VS).

210 Diagnostic entities included vestibular schwannomas (1011 [20.6%] of 4905 patients),

211 nherited disorder characterized by bilateral vestibular schwannomas (VS) that arise from neoplastic S

212 NF2 is characterized by bilateral vestibular schwannomas (VSs) that cause progressive and

213 urofibromatosis type 2 (NF2) and progressive vestibular schwannomas (VSs).

214 ial schwannoma had an LZTR1 mutation (3 were vestibular schwannomas and 1 was a nonvestibular schwann

215 e evaluations, particularly in patients with vestibular schwannomas and candidates for cochlear impla

216 Here, we show that vestibular schwannomas from NF2 patients and human, merl

217 w-grade tumors affecting the cranial nerves (vestibular schwannomas), meninges (meningiomas), and spi

218 ate normal anatomic structures, evaluate for vestibular schwannomas, assess for inflammatory and/or i

219 haracterized by the development of bilateral vestibular schwannomas.

220 during embryogenesis; and soon after birth, vestibular SCs in mammals transition to lasting quiescen

221 Central processing of vestibular self-motion signals occurs through an interna

222 In central regions of vestibular semicircular canal epithelia, the [K(+) ] in

223 ses present in central regions of the turtle vestibular semicircular canal epithelia.

224 , rewarding effects of physical exercise, or vestibular sensation produced via self-motion.

225 nt of coordinated locomotion is regulated by vestibular sensation.

226 es of bodily experiences, such as tactile or vestibular sensations, were not affected by tDCS, confir

227 ne therapy applications in both cochlear and vestibular sense organs.

228 Together these findings link the vestibular sense to the maturation of coordinated locomo

229 ne delivery systems that target auditory and vestibular sensory cells with high efficiency, we delive

230 Visual and vestibular sensory deficits were simulated by having eac

231 g resemblance of Tmc protein reliance in the vestibular sensory epithelia of mammals to the maculae o

232 rmation of highly specialized regions of the vestibular sensory epithelia with specific functions in

233 mation of significantly smaller auditory and vestibular sensory epithelia, while conditional overexpr

234 Each vestibular sensory epithelium in the inner ear is divide

235 Normal vestibular sensory evoked potential (VsEP) responses and

236 ar afferent responses.SIGNIFICANCE STATEMENT Vestibular sensory information is conveyed on parallel n

237 induces Cyp26b1 expression in the developing vestibular sensory organs, which generates the different

238 otoconial formation and zonal patterning of vestibular sensory organs.

239 Here, by investigating the inhibition of the vestibular sensory system when visual processing is prio

240 way that plays a critical role in peripheral vestibular signaling and plasticity.SIGNIFICANCE STATEME

241 thermore, new findings have established that vestibular signals are selectively combined with extrave

242 Findings suggest that vestibular signals do not serve to scale the internal re

243 Thus, vestibular signals enhance the separability of joint tun

244 tion decoding, we tested the hypothesis that vestibular signals help to dissociate self-motion and ob

245 th single neuron and population levels, that vestibular signals help to dissociate self-motion and ob

246 Behavioral studies suggest that vestibular signals play a role in dissociating object mo

247 We show that vestibular signals stabilize tuning for heading in neuro

248 bers determines how the cerebellum processes vestibular signals.

249 (63%) and 17 out of 41 patients showed audio vestibular signs (41%), and 11 showed skin signs (27%).

250 the extent to which body-based cues, such as vestibular, somatosensory, and motoric cues, are necessa

251 Electrical vestibular stimulation (EVS) is an increasingly popular

252 Galvanic vestibular stimulation (GVS) uses the external applicati

253 ects the differential impact of a stochastic vestibular stimulation (SVS) on body sway (center-of-pre

254 peripheral spike rate relationships for iDC vestibular stimulation and validate an ex-vivo model for

255 Here, we applied galvanic vestibular stimulation concurrently with real body movem

256 Caloric vestibular stimulation did not alter perceived size of o

257 ties of first person biometric avatars under vestibular stimulation did not support this assumption.

258 Here, we first established that electrical vestibular stimulation modulates human neck motor unit (

259 During the earth-fixed task, galvanic vestibular stimulation produced large polarity-dependent

260 Galvanic vestibular stimulation was applied concurrently during r

261 ir velocity was altered without any galvanic vestibular stimulation, indicating a compensatory arm re

262 very of behavioral responses to auditory and vestibular stimulation.

263 the neural mechanisms underlying electrical vestibular stimulation.

264 based on its ability to associate light with vestibular stimulation.

265 We show that, even if electrical vestibular stimuli are encoded as a net signal of head r

266 e debate exists regarding whether electrical vestibular stimuli encoded by vestibular afferents induc

267 ponses by modelling the effect of electrical vestibular stimuli on vestibular afferents and a current

268 t 0.8 m s(-1) while exposed to an electrical vestibular stimulus.

269 encies afferents tended to phase-lock to the vestibular stimulus.

270 ilt thresholds were considered together with vestibular symptom severity or VOR dynamics, VM patients

271 ive to healthy controls, migraineurs without vestibular symptoms and patients with episodic vertigo d

272 ese results support a pathogenic model where vestibular symptoms emanate from the vestibular nuclei,

273 kinje cells to deep cerebellar nuclei and at vestibular synapses in mice.

274 Cs are thought to align with the axes of the vestibular system and provide sensitivity at rotational

275 The vestibular system broadcasts head-movement-related signa

276 In contrast, the adult vestibular system can produce new hair cells in response

277 ced could guide a more reliable screening of vestibular system deterioration.

278 Recent experiments have revealed that the vestibular system encodes this information during everyd

279 suggest that asymmetric connectivity in the vestibular system facilitates representation of ethologi

280 electrical current to selectively target the vestibular system in humans.

281 ionic direct current (iDC) can modulate the vestibular system in-vivo, with potential benefits over

282 It has been suggested that the vestibular system not only plays a role for our sense of

283 The vestibular system of the inner ear detects head position

284 tly how this non-invasive tool activates the vestibular system remains an open question.

285 This head stabilization enables the vestibular system to sense the direction of gravity.

286 involved in the sensation of gravity in the vestibular system, is essential for sour sensing in the

287 Hair cells of the auditory and vestibular systems are capable of detecting sounds that

288 Hair cells in both the auditory and vestibular systems receive efferent innervation.

289 ls, the mechanoreceptors of the auditory and vestibular systems, harbor two specialized elaborations

290 epithelia, such as those of the auditory and vestibular systems, results in the precise orientation o

291 Six-month M2 PPD improved at disto-vestibular (T0-5.2/T1-3.0 mm) and disto-lingual (T0-5.4/

292 ability was not associated with the clinical vestibular tests.

293 expression did not parallel the established vestibular-then-auditory sequence.

294 ions in vestibular migraine, as evidenced by vestibular threshold elevation following visual motion e

295 abnormally elevated reflexive and perceptual vestibular thresholds at baseline.

296 eas of the subordinate sensory system (e.g., vestibular), thus reducing potential conflict with ongoi

297 KEY POINTS: Vestibular type I and type II hair cells and their affer

298 iophysical properties of IK,L in adult mouse vestibular type I hair cells.

299 orientation and its expression in the mouse vestibular utricle is restricted, resulting in two regio

300 es (HR, 10.0; 95% CI, 7.0 to 15.3); auditory-vestibular-visual sensory deficits (HR, 2.3; 95% CI, 1.3