ライフサイエンスコーパス: via binding to

1 al level of regulation for the CrkII protein via binding to 14-3-3 proteins, which was independent fr

2 repressed luciferase reporter gene activity via binding to 3' untranslated regions of TMEFF2, NTRK2,

3 -phosphotransferase I resistance gene (mphA) via binding to a 35-bp DNA operator upstream of the star

4 licing of a defined subset of cassette exons via binding to a C-rich subset of polypyrimidine tracts

5 ily, is a multifunctional cytokine that acts via binding to a cell surface receptor named Fn14 (fibro

6 TWEAK acts on responsive cells via binding to a cell surface receptor named Fn14.

7 ensing ion channels (ASICs) from vertebrates via binding to a central cavity enclosed by beta-sheets

8 TR2 can regulate several target genes via binding to a consensus response element (AGGTCA) in

9 on, as able to down-regulate CD69 expression via binding to a conserved site in the 3'UTR of CD69 mRN

10 FAK recruitment was via binding to a domain within the virulence factor TarP

11 ntrolling insulin receptor exon 11 inclusion via binding to a downstream intronic enhancer element.

12 human papilloma virus type 16 (HPV-16) genes via binding to a DR4 response element in the long contro

13 They function via binding to a family of structurally related cell sur

14 tor of the fungal virulence factor, laccase, via binding to a GC-rich element within the 5'-UAS in re

15 w that CUGBP1 induces the translation of p21 via binding to a GC-rich sequence located within the 5'

16 s of hypoxia on induction of HEF1 expression via binding to a hypoxia-responsive element of the HEF1

17 specific for activated glycoprotein IIb/IIIa via binding to a Ligand-Induced Binding Site (LIBS-MBs)

18 ing HMGA1 to repression of XPA transcription via binding to a negative regulatory element in the endo

19 are phosphorylation-independent and mediated via binding to a non-catalytic domain, we highlight how

20 expression of the CD44 cell-surface molecule via binding to a noncanonical p53-binding sequence in th

21 ne subunit regulates the activity of another via binding to a noncatalytic site(s) rather than throug

22 ted Na(+) channels (FaNaCs) of invertebrates via binding to a pocket at the external face of their la

23 EM16A channel activation and desensitization via binding to a putative binding site at the cytosolic

24 liferation, whereas proNGF induces apoptosis via binding to a receptor complex of the common neurotro

25 h transcriptionally activates the CXCR4 gene via binding to a responsive element located in positions

26 catalytic domain to the peptidoglycan layer via binding to a secondary cell wall polymer component.

27 from the freshwater polyp Hydra (the HyNaCs) via binding to a similar pocket, although there is not y

28 the mu-opioid receptor (MOR) gene regulation via binding to a single-stranded (ss) DNA element.

29 open state block of this channel occurs not via binding to a site directly in the pore but rather by

30 TWEAK acts on responsive cells via binding to a small cell surface receptor named Fn14.

31 TWEAK acts on responsive cells via binding to a small cell-surface receptor named fibro

32 Gammaretroviruses that enter cells via binding to a surface receptor use one of two fundame

33 that conferred an elevated promoter activity via binding to a transcription factor SOX5.

34 CSK is brought in contiguity to LCK via binding to a transmembrane adaptor known as phosphop

35 varying degrees of deuterium incorporation, via binding to a tungsten complex.

36 adhesion of alpha4beta7+ mucosal lymphocytes via binding to aberrantly expressed MAdCAM-1 on liver en

37 n epigenetic regulator that localizes to DNA via binding to acetylated histones and controls the expr

38 nd purified Muc5ac reduced infection, likely via binding to alpha2,3-linked sialic acids, consistent

39 ich the anchoring of the motor to the cortex via binding to an adhesion molecule mediates the tetheri

40 assembly through feedback inhibition of RmlA via binding to an allosteric site.

41 AR activity was mediated via binding to an estrogen receptor half-site 3' to the

42 sensing pathway mediated by calmodulin (CaM) via binding to an IQ motif immediately adjacent to the E

43 y of c-Myc (a driver of metastasis), largely via binding to and activating mitogen-activated protein

44 ay dysfunction by modulating IL-5 expression via binding to and inhibiting the repressive function of

45 n of actin cytoskeleton and gene expression, via binding to and modulating the activity of diverse ef

46 nhanced TLR3/4-triggered IFN-beta production via binding to and phosphorylating IL-1 receptor-associa

47 regulated by the ubiquitin proteasome system via binding to and ubiquitination by the E3 ubiquitin li

48 ular, we show that NOTCH1 transactivates MYC via binding to B-cell-specific regulatory elements, thus

49 APRIL functions via binding to BCMA (B cell maturation antigen) and TACI

50 comycin-like drugs target peptidoglycan (PG) via binding to C-terminal d-Ala-d-Ala dipeptide.

51 Ca(2+) inhibits TRPV6 via binding to calmodulin (CaM), which mediates Ca(2+) -

52 peptidase N (APN) and p19ARF gene expression via binding to canonical DNA recognition sites in the re

53 factor (SRF) controls SMC gene transcription via binding to CArG box DNA sequences found within genes

54 AFM13 recruits natural killer (NK) cells via binding to CD16A as immune effector cells.

55 ells (pDCs) produced FasL in response to HIV via binding to CD4 and chemokine coreceptors.

56 d promote trans infection by dendritic cells via binding to cell surface lectins.

57 PRRs) expressed on glial cells are activated via binding to cellular damage-associated molecular patt

58 hosphorylation and its activity is regulated via binding to cellular regulatory proteins via conserve

59 y activate intracellular signaling cascades, via binding to cognate cytoplasmic or membrane-associate

60 ys, including posttranscriptional modulation via binding to complementary and semicomplementary sites

61 ression of the collagen alpha(2)(I) promoter via binding to CREB-binding protein (CBP).

62 ells and translocates to the plasma membrane via binding to cytohesin 2 in epidermal growth factor-st

63 G dampens the activation of human DCs by LPS via binding to DC-SIGN and MMR-1, leading to attenuated

64 experiments indicate that the inhibitor acts via binding to DC-SIGN.

65 ressively, the FtsN septal density increases via binding to denuded sPG (dnG) and serves as the templ

66 toskeleton suggests that Nck/Dock regulates, via binding to distinct effectors, various cell type-spe

67 icate that MeCP2 interacts with genomic loci via binding to DNA as well as histones, and that interac

68 ), which serve as a reservoir for chemokines via binding to Duffy antigen receptor for chemokines (DA

69 rugs as a potent EBOV viral entry inhibitor, via binding to EBOV glycoprotein (GP).

70 IL-6 signals via binding to either the membrane bound IL-6Ralpha (cla

71 lastic tissues of the gastrointestinal tract via binding to elements in the 5'-flanking region of the

72 assembly and interaction with hemicelluloses via binding to emerging cellulose microfibrils.

73 r endothelin 1, which increases PKC activity via binding to endogenous endothelin(A) receptors.

74 2.1%) regulated their target genes primarily via binding to enhancers.

75 role in the release of proteins from the ER via binding to Ero1-Lalpha.

76 und that ERalpha activates p53 transcription via binding to estrogen response element half-sites with

77 d into the cellular component of whole blood via binding to FKBP.

78 ones and cytokines regulate L channel gating via binding to G-protein-coupled receptors.

79 he ability of macrophages to clear pathogens via binding to galectin 9.

80 state cancer (PCa), drive oncogenic programs via binding to GGAA repeats.

81 igate whether CLEC18 modulates host immunity via binding to glycolipids, and are also involved in gly

82 ochondrial outer membrane either directly or via binding to GM130.

83 t-PA induces SK-N-SH cell proliferation via binding to GRP78 on the cell surface.

84 e conferred the ability to invade host cells via binding to GRP78.

85 is also controlled at the cell surface level via binding to heparan sulfate proteoglycans, such as sy

86 n the tubulointerstitium and peri-glomerulus via binding to heparan sulphate (HS) chains of proteogly

87 picomolar concentrations, directly virucidal via binding to HIV envelope glycoproteins, and capable o

88 3G is its incorporation into progeny virions via binding to HIV RNA.

89 the 233^416 splicing of HPV18 E6E7 pre-mRNAs via binding to hnRNP A1, a well-characterized, abundantl

90 antigen transfer of DBY is tightly regulated via binding to HSC70 and that this mechanism influences

91 20 is associated with the virions presumably via binding to Hsp70h.

92 pike glycoprotein to mediate host cell entry via binding to human angiotensin-converting enzyme 2 (hA

93 rs to mediate parasite-host cell interaction via binding to human galectin-1.

94 ionally regulate the LncRNA-SARCC expression via binding to hypoxia-responsive elements on the promot

95 induced by shPHD2 to induce IGF-1 secretion via binding to IGF-1 gene promoter.

96 ctive synaptic choice from alphaRGC to NPWFs via binding to Integrin alpha8beta1.

97 otein Nef abrogates incorporation of SERINCs via binding to intracellular loop 4 (ICL4).

98 ptidase 33 (USP33) protein expression levels via binding to its 3' untranslated region.

99 R-185-5p, which suppresses VEGF-C expression via binding to its 3' UTR.

100 nt in RNA binding, stabilizes HuR transcript via binding to its 3'-untranslated region.

101 ion, TDP-43 regulates Ran expression, likely via binding to its 3'-UTR.

102 n as a death ligand that initiates apoptosis via binding to its cell surface death receptors such as

103 activation, migration, and tissue retention via binding to its extracellular matrix ligand hyalurona

104 Mxtx2 directly activates expression of ndr2 via binding to its first intron and is required for ndr2

105 FoxG as a wnt1 up-stream regulator, probably via binding to its first intron enhancer region.

106 hat FIP200 functions as an inhibitor of Pyk2 via binding to its kinase domain.

107 th EVs through surface localized fibronectin via binding to its leucine-aspartic acid-valine motif, a

108 leged sites, such as the brain and placenta, via binding to its ligand, GAS6.

109 promotes skin wound healing and angiogenesis via binding to its receptor integrin alpha5beta1, and en

110 on of MM cells in an in vivo scaffold system via binding to its receptor, CD147, on MM cells.

111 n angiogenesis, exerts its angiogenic effect via binding to its receptor, VEGF receptor-2 tyrosine ki

112 sm to recruit STIM1 into the ER-PM junctions via binding to junctate.

113 duced MKP-1 in the spastic cerebral arteries via binding to L-arginyl-glycyl-L-aspartate-dependent in

114 RMS is controlled in part by beta1 integrins via binding to laminin.

115 ng the cell wall, suggesting that PYO12 acts via binding to lipid II or other lipid intermediates inv

116 metabolites, CRMs) that can lead to toxicity via binding to macromolecular targets (e.g., proteins or

117 nction as a master transcriptional regulator via binding to many cis-acting sites genome-wide.

118 lating cholangiocyte Cl- and fluid secretion via binding to membrane P2 receptors, though the physiol

119 g of polycations and plasmid DNA enter cells via binding to membrane-associated proteoglycans.

120 e compounds likely confer antiviral activity via binding to methyltransferase (MTase).

121 al cyclin-dependent kinase inhibitors (CKIs) via binding to Miz1; whether this interaction is importa

122 oxidation regulates water molecule insertion via binding to Mn4.

123 1 is able to destabilize the MDM2 transcript via binding to multiple AU-/U-rich elements in MDM2 3'un

124 e recruited to centrosomes in dividing cells via binding to N-terminal CM1 domains within y-TuRC-teth

125 hat toxins that modify inactivation kinetics via binding to Na(V)1.x site 3 lack the ability to bind

126 w that WRN associates with the Mre11 complex via binding to Nbs1 in vitro and in vivo.

127 s in cell adhesion and synaptic organization via binding to neurexins.

128 ite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).

129 In addition, plasminogen, via binding to one of its dozen cell surface receptors,

130 HRI is inhibited by heme via binding to one or two heme-binding domains within th

131 CD36 modulates platelet function via binding to oxidized LDL (oxLDL), cell-derived microp

132 teins that can identify viral RNA as nonself via binding to pathogen associated molecular patter (PAM

133 des resulting in a prolonged serum half-life via binding to patients' serum albumin in vivo.

134 ear and in photoreceptor cells of the retina via binding to PDZ domains in the scaffold protein harmo

135 drolysis and translocates to ER-PM junctions via binding to phosphatidic acid.

136 PCI can penetrate through cellular membranes via binding to phosphatidylethanolamine.

137 hway and is recruited to endosomal membranes via binding to phosphatidylinositol 3-phosphate (PtdIns[

138 RKIN recruitment and enzymatic amplification via binding to phosphorylated UB chains.

139 choline acquisition from host phospholipids (via binding to plcH and pchP promoters), is required for

140 that mediates protein membrane translocation via binding to pleckstrin homolog (PH) domains within ta

141 cell types, which inhibit T cell activation via binding to programmed death-1 (PD-1) on T cells.

142 ng target genes in early Xenopus development via binding to promoter-proximal CTGCNA sequences as par

143 he arcuate nucleus of the hypothalamus (ARH) via binding to protein tyrosine phosphatase receptor del

144 protein PU.1, and can activate transcription via binding to PU.1/IRF composite sequences.

145 n oxygen delivery and demand (e.g. exercise) via binding to purinergic receptors (P2Y) on the endothe

146 e and hormone action involves direct effects via binding to receptors on the intestinal epithelium as

147 prevented by high density lipoprotein (HDL) via binding to scavenger receptor BI (SR-BI), which is c

148 hough cGAS localized to ruptured micronuclei via binding to self-DNA, we failed to observe cGAS activ

149 the expression of functionally related genes via binding to shared regulatory sequences, such as the

150 olded domains mediating protein interactions via binding to short linear peptides in proteins.

151 as been proposed to activate gene expression via binding to sigmaA4.

152 the binding of M-T5 to cullin 1 is indirect via binding to Skp1 in the host SCF complex.

153 tein that regulates neurotransmitter release via binding to SNARE complexes, is essential for AMPAR e

154 ight alleviate MIRI in heart transplantation via binding to SNRNP200 and regulating its ubiquitinatio

155 timulated proliferation of human aortic SMCs via binding to somatostatin receptors (sst2 and sst5) an

156 2 plays a significant role in cell migration via binding to specific cytoskeletal regulators such as

157 gulates GABRA2 and GABRA4 subunit expression via binding to specific promoter responsive elements, as

158 shown to associate with the plasma membrane via binding to specific transmembrane proteins.

159 P family, including DUSP2, DUSP4, and DUSP5, via binding to SUV39H1 in the nucleus.

160 induced loss of cell adhesion on fibronectin via binding to syndecan-4, leading to activation of PKCa

161 tenin/TCF directly regulates MSX2 expression via binding to TCF binding elements in multiple regions

162 ected from a phage-displayed peptide library via binding to tetragonal BaTiO3 powder.

163 ptide sequence associates with co-chaperones via binding to tetratricopeptide repeat domains.

164 r superfamily that modulates gene expression via binding to the AGGTCA direct repeat hormone response

165 rowth of normal prostate and prostate cancer via binding to the androgen receptor (AR).

166 cates that AR enhances miR-185-5p expression via binding to the androgen response elements located on

167 tionally regulate the miR-146a-5p expression via binding to the Androgen Response Elements on its 5'

168 xicity; (ii) activation of metabolic enzymes via binding to the arylhydrocarbon receptor (AhR) and th

169 und to and aggregated Gram-positive bacteria via binding to the bacterial cell wall peptidoglycan.

170 s been reported to promote cellular adhesion via binding to the beta2 integrin cytoplasmic domain.

171 and that removal of plasma TPO by platelets via binding to the c-Mpl receptor is involved in the cle

172 ce that platelets regulate plasma TPO levels via binding to the c-mpl receptor on circulating platele

173 -accelerating factor (DAF) promoter activity via binding to the cAMP response element, mutation of wh

174 acids apart, eIF3g binds to eIF3a indirectly via binding to the carboxyl-terminal domain of eIF3b.

175 ocks K(+) conduction by an unknown mechanism via binding to the channel turrets.

176 st protein found in milk to neutralize HIV-1 via binding to the chemokine coreceptor site, potentiall

177 een shown to act as a T-cell chemoattractant via binding to the chemokine receptor and HIV-1 corecept

178 ere was yeast Apd1 which used the CIA system via binding to the CIA targeting complex through its C-t

179 ENTR1 regulates, via binding to the coiled coil domain protein Dysbindin,

180 at FOXO3a can induce 5' AR promoter activity via binding to the consensus DNA-binding sequence in the

181 pressed the inclusion of an alternative exon via binding to the conserved UGCAUG element in the upstr

182 ore, data demonstrate that gp120 induces p53 via binding to the CXCR4 co-receptor.

183 ted in the modulation of host cell apoptosis via binding to the death domains of tumor necrosis facto

184 modulator that controls various target genes via binding to the DNA hormone response elements.

185 dor-adapted animal, it increases translation via binding to the egl-4 3' UTR.

186 heir mechanisms of activation and inhibition via binding to the extracellular loops and Cap domain, a

187 incorporates affinity capture of human IgGs via binding to the Fab region, followed by on-bead IdeS

188 ntly inhibiting cellular tyrosinase activity via binding to the free fatty acid receptor 2 (FFAR2).

189 articipates in acute intestinal inflammation via binding to the G-protein-coupled neurokinin-1 recept

190 e is known to mediate certain of its effects via binding to the gamma aminobutyric acid A (GABA(A)) r

191 emesis, and anorexia following chemotherapy via binding to the GFRAL-RET receptor complex expressed

192 n of MPER-directed bNAbs at the cell surface via binding to the high-affinity Fc receptor FcgammaRI p

193 that RhoA acts to regulate Trio localization via binding to the immunoglobulin-like domain.

194 its inhibition of cell migration is mediated via binding to the low-density lipoprotein receptor rela

195 osterically activated on the mitotic spindle via binding to the microtubule-associated protein, TPX2.

196 otubules to F-actin in growth cone filopodia via binding to the microtubule-binding +TIP protein EB3

197 criptional regulator of myogenic commitment, via binding to the MyoD mRNA 3' untranslated region.

198 ors, and its orexigenic actions occur mainly via binding to the only known ghrelin receptor, the grow

199 on and differentiation of osteoblastic cells via binding to the parathyroid hormone receptor (PTH-1R)

200 ransition by inactivating Cdc25C phosphatase via binding to the phosphorylated serine residue at posi

201 potential to induce human podocyte apoptosis via binding to the PLA2R.

202 ects attenuated charge repulsion within SERF via binding to the polyanionic RNA and provides a ration

203 anistically, LncRNA-SERB may increase ERbeta via binding to the promoter area, and ERbeta functions t

204 5p also promotes HIF2alpha/VEGF-A expression via binding to the promoter region of HIF2alpha.

205 s Rgg-mediated activation of speB expression via binding to the promoter region.

206 aip-1 acts via binding to the proteosome and enhancing proteosomal

207 boundary effects on Hippo activity, probably via binding to the protocadherin Dachsous.

208 rming the mechanism of allosteric activation via binding to the rear channel.

209 nsport across the murine blood-brain barrier via binding to the receptor Ly6a.

210 rogesterone activates CatSper of human sperm via binding to the serine hydrolase ABHD2.

211 nection between the viral and cell membranes via binding to the sialic acid-containing receptors.

212 s inhibited by low concentrations of 5'-AMP, via binding to the substrate (i.e. the kinase).

213 is a potent transcription coactivator acting via binding to the TEAD transcription factor, and plays

214 ng and is known to be localized to telomeres via binding to the telomere-binding protein TRF2.

215 ays show that TR3 can induce E2F1 expression via binding to the TR3 response element (TR3RE) in the E

216 n essential for trophoblast syncytialization via binding to the trophoblast receptor for syncytin-1,

217 atively regulates VEGFR2 receptor activation via binding to the VEGFR2, as well as stabilizes cell-ce

218 of cytokines exert their biological effects via binding to their cognate ligand-binding receptor sub

219 steroids are generally known to have actions via binding to their cognate steroid receptors, it is be

220 s it to bind with and regulate many proteins via binding to their heparin-binding domains.

221 eal angiogenesis in vivo, and apparently act via binding to their receptors CXCR1 and CXCR2.

222 ted Foxp2 protein repress gene transcription via binding to this consensus site or to a naturally occ

223 log MdNAC5 also stimulates MdAAT1 expression via binding to this gene's promoter.

224 lls and that its internalization could occur via binding to transferrin or caveolin.

225 f six proteins that regulate RBPJ expression via binding to two fSNPs on the RA-associated RBPJ locus

226 BMP exert their biologic effects via binding to two types of serine/threonine kinase BMP

227 st TFs are thought to regulate transcription via binding to upstream activating sequences, which are

228 somes, which are closely aligned with the ER via binding to VAPA/B.

229 cardiovascular effects and behavioral traits via binding to various receptors (e.g., beta2-adrenergic

230 totic protein, promoting tumor cell survival via binding to VDAC1.

231 3,7,8-tetrachlorodibenzo-rho-dioxin (dioxin) via binding to xenobiotic-responsive elements (XREs) in