ライフサイエンスコーパス: vicious

1 Since 1900, such adjectives as ignorant, vicious, and recalcitrant have been used to describe pat

2 icrogliosis and COX-2 activity may stop this vicious circle and be valuable strategies in PD therapy.

3 flammation and excitotoxicity in a potential vicious circle and indicate that an activation of the mi

4 a-large letter spacing may help to break the vicious circle by rendering the reading material more ea

5 ces but may result in severe hypoxemia and a vicious circle due to hypoxemia induced pulmonary vasoco

6 deficits must be treated by reading more--a vicious circle for a dyslexic child).

7 atients with T2DM and hypomagnesemia enter a vicious circle in which hypomagnesemia causes insulin re

8 envisioned as involving a self-perpetuating vicious circle in which mediators produced by a differen

9 peritoneal glucose exposure to prevent this vicious circle is essential for high-quality, long-term

10 -volume hemofiltration (HVHF) might halt the vicious circle leading to death by improving myocardial

11 Eventually, a vicious circle of coagulation and inflammation is set in

12 of evidence into account to avoid entering a vicious circle of concept-evidence mutual substantiation

13 and nighttime sleep such that an escalating vicious circle of disturbance in affect regulation durin

14 he sensation of unsteadiness, and so on in a vicious circle of escalating activity.

15 is one where male-killing bacteria trigger a vicious circle of increasing male fatigue and female pro

16 essure (PEEP) is necessary to interrupt this vicious circle of injury but needs to be balanced agains

17 ythms of behavior and physiology, creating a vicious circle of metabolic dysfunction.

18 w generation of the data needed to break the vicious circle of underrecognition.

19 ic alterations, this interplay may trigger a vicious circle that leads to obesity and diabetes.

20 ion thus appears to be able to interrupt the vicious circle that maintains the long-lasting deleterio

21 2 expression and activation can be seen as a vicious circle that ultimately leads to cartilage destru

22 nuclear factor-kappaB, thereby instigating a vicious circle to persistently promote atherogenesis.

23 h in return, thereby forming a hard-breaking vicious circle to promote tumor development.

24 the high-incidence equilibrium, there is a "vicious circle" in which inadequate treatment capacity l

25 nflammation is a core driver: the so-called "vicious circle" of inflammation.

26 ponses, may initiate and/or contribute to a "vicious circle" of the disease process, resulting in pro

27 asmic reticulum stress-S1P-CAMP axis forms a vicious circle, creating a favorable environment for cSC

28 ulation and alpha-syn oligomerization form a vicious circle, thereby influencing and/or potentiating

29 l to fight microbial attack, thus inducing a vicious circle.

30 sed proteotoxic stress (IPTS) and creating a vicious circle.

31 els to CSCs to disrupt the CSCs-angiogenesis vicious circle.

32 Here, we report on breaking this vicious circle.

33 s LA remodeling, closing a self-perpetuating vicious circle.

34 A tangled web of vicious circles, driven by cultural issues, has prevente

35 many infectious diseases, the emergence of a vicious climate-livestock-disease cycle is a looming thr

36 P(Sc) induces ER stress, our data point to a vicious cycle accelerating prion replication, which may

37 ment, thereby setting up a self-perpetuating vicious cycle among low local endothelial shear stress,

38 d be implemented simultaneously to break the vicious cycle and gain more health benefits.

39 Malnutrition and cryptosporidiosis form a vicious cycle and lead to acute and long-term growth imp

40 in accumulation/aggregation, thus creating a vicious cycle and leading to Parkinson disease pathogene

41 lts are consistent with the development of a vicious cycle between AD and diabetes, potentiating both

42 A vicious cycle between AGE formation, lipoxidation, and m

43 an cause an immune imbalance that may fuel a vicious cycle between complement, inflammatory cells, an

44 Our study reveals the vicious cycle between early infiltrating macrophages and

45 E STATEMENT Here we provide the proof that a vicious cycle between extracellular and intracellular po

46 aling may be a therapeutic candidate for the vicious cycle between heart and kidney failure with incr

47 aling may be a therapeutic candidate for the vicious cycle between heart and kidney failure with incr

48 s that have been identified, and discuss the vicious cycle between inflammation and neurodegeneration

49 tumour persistence, and the initiation of a vicious cycle between tumour and bone-resident cells tha

50 Interrupting this vicious cycle by triggering surface beta1-integrin inter

51 litating conditions placing the patient in a vicious cycle characterized by non healing wounds and ma

52 ired T cell-intrinsic NF-kappaB may create a vicious cycle conducive to tumor progression and further

53 Our study thus uncovers a self-propagating vicious cycle contributing to chronic inflammation in ps

54 ynthase at Thr-495, leading to a detrimental vicious cycle despite restoration of normoglycemia.

55 The vicious cycle established between bone-associated tumour

56 ominant inflammation, in turn resulting in a vicious cycle further impairing the SC structure.

57 However, under pathologic conditions, a vicious cycle generated by profibrotic growth factors/cy

58 Mechanistic insights into this vicious cycle have suggested new therapeutic opportuniti

59 This vicious cycle highlights the pressing need for an S. aur

60 ur aim in this study was to demonstrate this vicious cycle in gram-negative bacteria and show the uti

61 refore, sensory aberrations help construct a vicious cycle in post-traumatic stress disorder that is

62 RyR2 and mitochondrial ROS generation form a vicious cycle in the development of AF.

63 hronic inflammation-and creates a pathogenic vicious cycle in which dying CD4 T cells release inflamm

64 A vicious cycle in which ER stress promotes inflammation,

65 to MTB at sites of infection may initiate a vicious cycle in which immune activation and loss of ant

66 These effects may create a vicious cycle in which low-level inflammation promotes f

67 contributing to an inflammatory feed-forward vicious cycle including NLRP3-inflammasome activation an

68 necrosis represents the starting point for a vicious cycle including the uptake of infected necrotic

69 This transmission creates a vicious cycle increasing the presence of diabetes from o

70 This vicious cycle is thought to play a pivotal role in the d

71 pair mucosal healing, thereby establishing a vicious cycle leading to chronic inflammatory bowel dise

72 tribution may change in diverticulosis and a vicious cycle may occur where pouch size increases due t

73 vated microglia and damaged neurons formed a vicious cycle mediating chronic, progressive neurodegene

74 is inflammatory reaction by interrupting the vicious cycle might become a disease-modifying therapeut

75 data on these issues strongly suggest that a vicious cycle might exist in which HIV persistence cause

76 of the evidence supporting the mitochondrial vicious cycle model comes from pharmacological experimen

77 ut a patient at risk and then effectuate the vicious cycle now recognized as CRS type 1.

78 critical mass of misfolded proteins starts a vicious cycle of a prion-like expansion.

79 Opioid use often progresses into a vicious cycle of abuse and withdrawal, resulting in very

80 exposure to large amounts of drug produces a vicious cycle of additional maladaptive changes in brain

81 Stopping the vicious cycle of AGE-RAGE and RAGE axis signaling in the

82 In the mitochondria-mediated vicious cycle of Alzheimer's disease (AD), intracellular

83 n of autoreactive T cells, thus breaking the vicious cycle of autoimmunity and inflammation.

84 The vicious cycle of biophobia risks accelerating the extinc

85 We propose the 'vicious cycle of biophobia', a concept that encapsulates

86 The vicious cycle of bone degradation and formation driven b

87 c stress reprograms myeloid cells, fueling a vicious cycle of cell death and immune activation.

88 These episodes also play a key role in the vicious cycle of childhood diarrhea and malnutrition in

89 lipid accumulation in neurons, we uncover a vicious cycle of cholesterol synthesis and accretion, wh

90 eraction is a critical molecular link in the vicious cycle of chronic inflammation and metabolic dysf

91 We hypothesize a vicious cycle of chronic morphine tolerance: morphine-in

92 nresolved paradigm that stems from the known vicious cycle of clot formation and tumor growth.

93 Common for the pathogenesis seems to be the vicious cycle of complement activation, endothelial cell

94 Such a vicious cycle of continuous virus replication and immuno

95 mented and full-length alphaSyns, creating a vicious cycle of cytotoxicity.

96 haracterized by respiratory failure due to a vicious cycle of defective Cystic Fibrosis Transmembrane

97 IL-7 produced by FRCs may thus perpetuate a vicious cycle of depletion of T cells and the FRC networ

98 ymphatics and consider a novel paradigm of a vicious cycle of detrimental organ cross talk.

99 rbidity and identifies children at risk of a vicious cycle of diarrhea and malnutrition.

100 ally and bidirectionally related, creating a vicious cycle of disadvantage.

101 eonatal and weaned mice provide models for a vicious cycle of enteroaggregative E. coli infection tha

102 This perpetuates a vicious cycle of epidermal inflammation and regeneration

103 n data collection and dissemination causes a vicious cycle of exclusion.

104 Retinal mitochondria remain damaged and vicious cycle of free radicals continues to self-propaga

105 ansport chain is compromised, fueling into a vicious cycle of free radicals.

106 The lethal triad comprises the vicious cycle of hypothermia, acidosis, and coagulopathy

107 ty and incomes, trapping subpopulations in a vicious cycle of ill health and poverty.

108 Such complications often fuel a vicious cycle of immobility and functional decline, cent

109 malization of plasma glucose might break the vicious cycle of impaired glucose effectiveness in type

110 e concept of a photooxidative stress-induced vicious cycle of increased iron uptake leading to furthe

111 hat misdiagnosis of malaria contributes to a vicious cycle of increasing ill-health and deepening pov

112 By interrupting the vicious cycle of inflammation and marrow dysregulation,

113 m immune cells during early sepsis, drives a vicious cycle of inflammation through excessive NETosis

114 Taken together, we identify the vicious cycle of inflammation, COUP-TFII, VEGF-C, and ly

115 inding to its receptors, thus mitigating the vicious cycle of inflammation.

116 cells, monocytes, and T cells, leading to a vicious cycle of inflammation.

117 n of its tight regulatory control can fuel a vicious cycle of inflammatory damage that exacerbates pa

118 The result is a vicious cycle of isoflurane-induced apoptosis, Abeta gen

119 y coexists with anxiety symptoms, creating a vicious cycle of itch-anxiety comorbidities that are dif

120 ation of thymocytes by TSAbs could lead to a vicious cycle of iterative improvement of the affinity a

121 n and support the use of zinc to prevent the vicious cycle of malnutrition and diarrhea.

122 n may preclude or mitigate the later adverse vicious cycle of malnutrition and infection.

123 rovide critical insights toward breaking the vicious cycle of maternal-child obesity and T2D.

124 e a novel role of Runx2 in up-regulating the vicious cycle of metastatic bone disease, in addition to

125 stions on advancing our understanding of the vicious cycle of microbes and malnutrition and finding w

126 ter cessation of hyperglycemic insult, and a vicious cycle of mitochondria damage continues.

127 opathy by preventing the continuation of the vicious cycle of mitochondrial damage.

128 In this opinion article, we propose that the vicious cycle of NADPH oxidase (NOX)-mediated oxidative

129 o takes much longer than hypothesized, and a vicious cycle of NET formation/disassembly affects subse

130 nd proinflammatory cytokines, resulting in a vicious cycle of neurodegeneration.

131 This may in turn propagate a vicious cycle of oxidative stress and iron accumulation,

132 ment activation induces TGFbeta, promoting a vicious cycle of perimetastatic NPY secretion and liver

133 e load is believed to be responsible for the vicious cycle of progressive myocardial dysfunction in c

134 etween tumours and neurons that propagates a vicious cycle of proliferation, synaptic integration and

135 ediated regulatory pathways, contribute to a vicious cycle of proteotoxic stress and neuronal vulnera

136 in (ETC) function has been implicated in the vicious cycle of reactive oxygen species (ROS) productio

137 onomic] symptom responses) and thus causes a vicious cycle of recurrent hypoglycemia.

138 sociated autonomic failure and the resultant vicious cycle of recurrent iatrogenic hypoglycemia.

139 hyperactivity with dantrolene mitigates the vicious cycle of sarcoplasmic Ca(2+) leak-induced increa

140 This process leads to a vicious cycle of sleeplessness, persistent unwanted thou

141 tnatal life of the 1-HC female rat sets up a vicious cycle of spontaneous transfer of the HC phenotyp

142 ns can foster negative thinking and create a vicious cycle of stress and disability.

143 besogenic processes, ultimately describing a vicious cycle of stress to obesity to stigma to stress.

144 These findings suggest a vicious cycle of stroke injury in which initial ischemic

145 y challenges are truly daunting because of a vicious cycle of three synergistic factors: the social d

146 strategies may hold the key to overcome the vicious cycle of TKI resistance.

147 tumor-bone marrow microenvironment drives a vicious cycle of tumor progression and bone resorption.

148 n attractive therapeutic target to block the vicious cycle of tumor-stromal interactions that plagues

149 By diminishing the vicious cycle of unemployment, the present studies show

150 lationship between staffing and safety as a 'vicious cycle of unsafestaffing' which comprised: (1) un

151 sts that, during AD onset and progression, a vicious cycle revolves around amyloid beta (Abeta) produ

152 ous alphaS compromise this ability, likely a vicious cycle scenario faced by microglia in Parkinson's

153 on of a single prostate cancer cell yields a vicious cycle similar in cellular composition and pathop

154 s highlight the possibility of a feedforward vicious cycle such that the Hh pathway might be turned o

155 repetitive TLR7/8 activation, perpetuating a vicious cycle sustaining autoimmunity.

156 itivity (elevated lipogenesis) establishes a vicious cycle that aggravates hyperinsulinemia and insul

157 s, and it has been argued that they create a vicious cycle that amplifies the dominance of establishe

158 s are complex and bidirectional, producing a vicious cycle that compounds the deleterious consequence

159 actions to unemployment can trap people in a vicious cycle that derails their reemployment efforts.

160 cancer cells and their microenvironment is a vicious cycle that enhances the survival and progression

161 gger cellular senescence, thereby enabling a vicious cycle that exacerbates metabolic dysfunction.

162 scence to nearby healthy cells, generating a vicious cycle that extends the affected area over time.

163 cell clonal expansion, thereby generating a vicious cycle that favors a prothrombotic state in these

164 lease initiated and sustained by c-Met fed a vicious cycle that generated a favorable microenvironmen

165 It is perhaps the nature of such a vicious cycle that is the key pathophysiologic concept.

166 Together these pathways can create a vicious cycle that leads to fibrosis or keloid formation

167 This ultimately precipitated a vicious cycle that licensed chronic inflammation to driv

168 r decline of insulin sensitivity, creating a vicious cycle that may contribute to the development of

169 d to use of broader-spectrum alternatives; a vicious cycle that may gradually limit therapeutic optio

170 ic function, extracellular Abetaos promote a vicious cycle that propagates synaptic pathology from di

171 ow that this autoinflammation is driven by a vicious cycle through neutrophil-derived IL-26.

172 ustains their own activation, facilitating a vicious cycle to exacerbate tumorigenesis and drug resis

173 ncreases tau phosphorylation, this creates a vicious cycle where varied precipitating factors all lea

174 d excessive expansive remodeling establish a vicious cycle which leads to the formation of severe pla

175 Insights into mechanisms underlying the vicious cycle will help to design rational therapies to

176 el of cryptosporidial disease, including its vicious cycle with body weight loss and heavier infectio

177 vascular function, creating and sustaining a vicious cycle with deranging effects on coronary blood f

178 The proposed "vicious cycle" model integrates hyperandrogenism and hyp

179 east cancer cells and the initiation of the "vicious cycle" of bone destruction induced by these cell

180 ngs underscore osteocyte involvement in the "vicious cycle" of bone metastasis, and targeting senesce

181 ignorance cycle which we conceptualise as a "vicious cycle" of environment, health, and safety knowle

182 results provide compelling evidence for the "vicious cycle" of mitochondrial ROS production and lead

183 he effect of Runx2 on key components of the "vicious cycle" of transforming growth factor beta (TGFbe

184 lobulin production create a self-sustaining "vicious cycle" that exacerbates PCOS manifestations, whi

185 void extreme pathophysiology and the "bloody vicious cycle".

186 These observations support a 'vicious cycle' theory which states that there is a feedb

187 fore, autoimmunity to HIP/PAP might create a vicious cycle, accelerating the immune process leading t

188 ignals that prevent IEC death and break this vicious cycle, allowing resolution of intestinal inflamm

189 XNIP induction plays a critical role in this vicious cycle, and suggest that inhibition of TXNIP may

190 r1 in CNS-myeloid triggers a Cxcl10-mediated vicious cycle, cultivating a br-met-promoting, immune-su

191 ggesting an induction of a tumour-autonomous vicious cycle, driven by cancer cell-intrinsic electrica

192 As a vicious cycle, global warming increases the occurrence,

193 hysiology are altered in ways that can, in a vicious cycle, lead to further allostatic load.

194 Viral pathologies imply a vicious cycle, oxidative stress promoting inflammatory r

195 suggest that anxiety disorders can create a vicious cycle, perpetuating ongoing mental and immunolog

196 ionship among the components of the putative vicious cycle, with particular emphasis on the role of m

197 is required to prevent continuation of this vicious cycle.

198 large artery stiffness and thus perpetuate a vicious cycle.

199 and worsens systemic insulin resistance in a vicious cycle.

200 directionally and causally linked, forming a vicious cycle.

201 sleep loss further accelerates AD through a vicious cycle.

202 eased colistin consumption, exemplifying the vicious cycle.

203 g unemployment, which presumably breaks this vicious cycle.

204 T and EZH2 in metastatic CRC, thus forming a vicious cycle.

205 ified Abeta dimers were able to sustain this vicious cycle.

206 ear film, amplify inflammation, and create a vicious cycle.

207 te each of their activations in a pernicious vicious cycle.

208 get simultaneously the three partners of the vicious cycle.

209 CBD quells an epileptogenic vicious cycle: seizures strengthen LPI-GPR55 signaling w

210 g to the question: How can we interrupt this vicious cycle?

211 cially powerful for local factors, given the vicious cycles set in motion by these factors and the ef

212 ile age-related insults initiate interacting vicious cycles that increase vulnerability to Alzheimer'

213 vil society will be necessary to break these vicious cycles.

214 f food security and the strong potential for vicious cycles: Globally hunger is back on the rise, the

215 IV-1 generates in ex vivo lymphoid tissues a vicious destructive circle of activation and infection.

216 s to identify mechanisms responsible for the vicious feed-forward loop between systemic and oral dise

217 tabolic conditions sustains and propagates a vicious feedback cycle of chronic inflammation and metab

218 tissue identified contributors that drive a vicious feedback cycle of hyperconcentrated mucus secret

219 The resulting vicious feedback cycle of karyopherin pathology and prot

220 /WHSC1/mTORC2 signaling cascade represents a vicious feedback loop that elicits unrestrained AKT sign

221 human AD and believed to serve as part of a vicious inflammatory cycle that drives AD pathology.

222 ation of mechanoreceptors, it propagates the vicious itch-scratch cycle in chronic itch by further ag

223 th a lack of kidney clearance, facilitates a vicious kidney/muscle signaling cycle, leading to exacer

224 effects in the vasculature are enhanced by a vicious loop and cross-talk with the IL-18 signaling pat

225 t toward another pathway to MPE formation: a vicious loop of interactions between pleural-based tumor

226 In this setting, Na(+) loading fuels a vicious loop whereby increased CaMKII activation perturb

227 a tiny undetectable deformation can lead to vicious misleading targeted at safety-critical applicati

228 S, exacerbate the gliosis, and result in the vicious neuroinflammatory cascade.

229 hibition may block TGF-beta propagation of a vicious osteolytic cycle in this MDA-MB-231 model of bon

230 reduced metabolic adaptability may lead to a vicious pathogenic cycle leading to the co-morbidities o

231 nce to propose a testable hypothesis that, a vicious positive feedback loop of des-Arg(9)-bradykinin-

232 ly, increased expression of LDHA served as a vicious positive feedback to reduce tumor cell stiffness

233 sregulated, overactivated microglia create a vicious self-propagating cycle causing uncontrolled, pro

234 cG and miRNA deregulations often establish a vicious signal-amplification loop in lymphoma associated

235 were altered, triggering a transition from a vicious to a virtuous cycle.

236 he computer-based health-education tool 'The Vicious Worm' was developed to create awareness and prov