ライフサイエンスコーパス: viral assembly

1 sed to stimulate the efficient nucleation of viral assembly.

2 le roles of pV and protein X/Mu precursor in viral assembly.

3 repulsion present a strong energy barrier in viral assembly.

4 tegument proteins remains a key question in viral assembly.

5 fold provides new constraints for models of viral assembly.

6 ane vesicular transport pathway important in viral assembly.

7 a model in which NS2 provides the matrix for viral assembly.

8 two homologous strands of genomic RNA during viral assembly.

9 on of the large HDV antigen is essential for viral assembly.

10 ch character have potential use as probes of viral assembly.

11 responsible for initiation of this aspect of viral assembly.

12 ional roles in the replication cycle such as viral assembly.

13 (ds) RNA, a process that occurs at sites of viral assembly.

14 lyprotein, from which it is cleaved prior to viral assembly.

15 capsid proteins principally interfered with viral assembly.

16 and molecular interactions that occur during viral assembly.

17 ons in the virus-producing cells and affects viral assembly.

18 ions related to viral replication, including viral assembly.

19 unter dimerized GagPol in the cytosol during viral assembly.

20 rs at the level of replication instead of at viral assembly.

21 These interaction domains may play roles in viral assembly.

22 e of unusual hydrophobic environments in the viral assembly.

23 31)] is required for capsid dimerization and viral assembly.

24 brane lipids, and with which one, to promote viral assembly.

25 ntry but allows for late gene expression and viral assembly.

26 into ribonucleoprotein particles (RNPs) for viral assembly.

27 ntact amino acid residues is deleterious for viral assembly.

28 pport a role for M homodimers in scaffolding viral assembly.

29 l replication with critical implications for viral assembly.

30 the directed trafficking of Env to sites of viral assembly.

31 hoflavivirus infection through modulation of viral assembly.

32 s the first to demonstrate a role for Akt in viral assembly.

33 from the nucleus to the cytoplasm to aid in viral assembly.

34 s with potential impact on the late steps of viral assembly.

35 reveal interactions that result in efficient viral assembly.

36 th specific lipid environments formed during viral assembly.

37 heir synthesis was found to be essential for viral assembly.

38 large HDAg (HDAg-L), which is essential for viral assembly.

39 which includes the late domain required for viral assembly.

40 protein-lipid interactions are critical for viral assembly.

41 g to facilitate lipid droplet biogenesis and viral assembly.

42 alpha and cellular lipogenesis to facilitate viral assembly.

43 d the protein-binding site to prepare it for viral assembly.

44 rms state-of-the-art methods for genome-wide viral assembly.

45 es its interaction with core protein and the viral assembly.

46 geted toward fatty acid synthesis to support viral assembly.

47 ciated lipid droplet formation to facilitate viral assembly.

48 fic capture of the genomic RNA genome during viral assembly.

49 hway to transport viral proteins to sites of viral assembly.

50 G-catalyzed fusion as well as study steps of viral assembly.

51 f the virion that plays an essential role in viral assembly.

52 implicated in host-pathogen interaction and viral assembly.

53 The retroviral Gag polyprotein mediates viral assembly.

54 s in all retroviruses and is a key player in viral assembly.

55 to the plasma membrane of host cells during viral assembly.

56 eraction between Gag and TRIM5alpharh during viral assembly.

57 ld be useful for studying other nonviral and viral assemblies.

58 scopy for structural analysis of viruses and viral assemblies.

59 orters for studying anaerobic biosystems and viral assemblies.

60 the virological synapse and by extracellular viral assemblies.

61 uses is well conserved and has a key role in viral assembly(1,2).

62 he important roles of ORF33 and ORF38 during viral assembly, a process critical for virus propagation

63 We show it significantly improves viral assemblies and demonstrate that long-reads result

64 ns that modify surface electrostatics affect viral assembly and budding by altering VP40 membrane-bin

65 Although HIV-1 Gag is known to drive viral assembly and budding, the precise mechanisms by wh

66 However, it differs as to viral assembly and budding, which take place on plasma m

67 urg viral proteins within lipid rafts during viral assembly and budding.

68 l membrane curvature, could ultimately drive viral assembly and budding.

69 viral protease is initially activated during viral assembly and confirm that prematurely activating H

70 um-concentration state, which is relevant to viral assembly and disassembly inside host cells.

71 esidues in mediating the contacts needed for viral assembly and disassembly.

72 ping functions within this sequence for both viral assembly and effective T cell transduction.

73 es of cell-cell contact to support polarized viral assembly and egress for efficient cell-cell spread

74 ins interact with membrane lipids to mediate viral assembly and egress that is needed to guide antivi

75 During viral assembly and egress, the late domain within the p1

76 llowing viral entry as well as for efficient viral assembly and egress.

77 nfection, where BiP performs unique roles in viral assembly and egress.

78 For many paramyxoviruses, M proteins drive viral assembly and egress; however, some paramyxoviral g

79 ing the roles of essential viral proteins in viral assembly and exit.

80 All stages in viral assembly and export therefore coexist, making it i

81 ablate the function of the ligand or disrupt viral assembly and function.

82 f influenza virus plays an essential role in viral assembly and has a variety of functions, including

83 ratifying and differentiating host tissue in viral assembly and has allowed for the rapid analysis of

84 t time, indicate a role for Akt signaling in viral assembly and highlight additional phenotypic diffe

85 of HCV-infected cells to daclatasvir reduced viral assembly and induced clustering of structural prot

86 a mild innate immune antagonist and aids in viral assembly and infectious virus production, and sugg

87 racterized the effects of these mutations on viral assembly and infectivity by using a single-step in

88 complex is required early in replication for viral assembly and initiation of DNA synthesis through a

89 ocalization of nanoATV at endosomal sites of viral assembly and its slow release sped antiretroviral

90 as a prototypic retrovirus in order to study viral assembly and later to produce large amounts of rev

91 ene, tat, rev, and nef, eventually affecting viral assembly and leading to the overall inhibition of

92 HIV-1 Gag and Gag-Pol are responsible for viral assembly and maturation and represent a major para

93 from the cytoplasm to the Golgi, the site of viral assembly and maturation.

94 e conformational flexibility observed during viral assembly and maturation.

95 p28, and pp65) known to be indispensable for viral assembly and maturation.

96 eractions, which are important in regulating viral assembly and maturation.

97 dant virion protein and the key component in viral assembly and morphogenesis.

98 ntains all of the determinants important for viral assembly and must move around in the cell in order

99 nfirmed that there was a correlation between viral assembly and NS2B-NS2A interaction.

100 the one hand segregate molecules needed for viral assembly and on the other hand furnish peptides th

101 iomolecular condensates and visualization of viral assembly and packaging in situ.

102 endra virus F protein is required for proper viral assembly and particle release.

103 actions of three Nipah virus proteins during viral assembly and particularly on the role of one of th

104 ced, thus the molecular interactions driving viral assembly and production are still unclear.

105 In general, the requirements on Gag for viral assembly and propagation are more stringent than o

106 ractions and also examined the efficiency of viral assembly and release in vivo.

107 CD81, are actively recruited by HIV-1 Gag to viral assembly and release sites.

108 us type 1 (HIV-1) Gag protein, which directs viral assembly and release, accumulates at surface TEMs

109 dentified 3 that were severely defective for viral assembly and release.

110 oxes are likely to be required for efficient viral assembly and release.

111 y in mouse cells, with a resulting defect in viral assembly and release.

112 the role of the RNP-binding domain of M1 in viral assembly and replication, mutations in the coding

113 he zinc finger motif and the RKLKR domain in viral assembly and replication, we introduced multiple m

114 y virus type 1 (HIV-1) is a critical step in viral assembly and replication.

115 onal protein critical for several aspects of viral assembly and replication.

116 cell cycle regulation, gene regulation, and viral assembly and replication.

117 packaging provides significant insights into viral assembly and replication.

118 coronavirus 2 (SARS-CoV-2) has a key role in viral assembly and scaffolding of the viral RNA.

119 ngeable, contribute to crucial functions for viral assembly and spread, and have evolved in a virus-s

120 To further define its role in viral assembly and to identify host cell proteins that i

121 s a useful tool for dissecting mechanisms of viral assembly and transmission.

122 s may possess antiviral effects against both viral assembly and uncoating.

123 We also showed that FQ has no effect on viral assembly and virion secretion.

124 s-encoded late genes, which are critical for viral assembly and whose transcription initiates only af

125 late time points of infection, is linked to viral assembly, and depends on the expression of viral s

126 etecting Human Immunodeficiency Virus type-1 viral assembly, and evaluating microtubule dynamics modu

127 -enriched domains of the plasma membrane for viral assembly, and that Gag multimerization can further

128 teins relocalize to lipid droplets, sites of viral assembly, and their depletion increases infectious

129 Viral assembly appears directed toward a relatively smal

130 examining nucleocapsid protein variants in a viral assembly assay.

131 is paralleled, at the subcellular level, by viral assembly at different microsegments of the plasma

132 (Gag) structural protein, a critical step in viral assembly at the plasma membrane, is mediated by th

133 toichiometry of functional units involved in viral assembly, be they single molecules or oligomers.

134 Viral assembly begins with the packaging of the pgRNA in

135 Many viral assemblies belonged to the Naomiviridae, lacked me

136 s at these positions cause severe defects in viral assembly, budding and Gag processing.

137 of MV spread between neurons at the level of viral assembly but allows an alternate, CD46-independent

138 16 is important for the efficiency/timing of viral assembly but is not essential for HSV-1 replicatio

139 e not in preformed membrane patches prior to viral assembly but rather that glycoproteins are activel

140 al capsids, and 5 mutations supported normal viral assembly but were nevertheless reduced more than 2

141 Gag proteins perform important functions in viral assembly, but are also involved in other steps in

142 and matrix (M) protein are key mediators of viral assembly, but the underlying mechanisms are poorly

143 ion complex biogenesis, daclatasvir prevents viral assembly by blocking transfer of the viral genome

144 nt spacer peptide 1 (SP1) play a key role in viral assembly by forming a lattice of CA hexamers, whic

145 They play an essential role during viral assembly by interacting with all of the other stru

146 These domains drive viral assembly by mediating multiple interactions betwee

147 M plays an essential role in viral assembly by organizing other structural proteins t

148 Substitutions for G61 may inhibit viral assembly by preventing the protein from achieving

149 gnitude, indicating that factors involved in viral assembly can be targets for efficient and specific

150 orms a visually distinct unitary cytoplasmic viral assembly center (cVAC) in both cancerous and prima

151 t in trafficking of pp150 to the cytoplasmic viral assembly compartment (AC), without altering traffi

152 Formation of the cytoplasmic viral assembly compartment (cVAC) is an important step f

153 ed ECs, Golgi stacks were disrupted, and the viral assembly compartment characteristic of HCMV infect

154 ous virions, takes places in the cytoplasmic viral assembly compartment.

155 with true-late kinetics and localizes to the viral assembly complex during infection.

156 ally similar cholesterol accumulation at the viral assembly complex.

157 a model in which entry into mitosis disrupts viral assembly due to nuclear envelope breakdown, which

158 ble deficiency in late-phase replication and viral assembly during VZV infection of neurons in cultur

159 rmation, we improve our understanding of the viral assembly/egress process and point to potential int

160 eticulum (ER)/Golgi-resident ISGs inhibiting viral assembly/egress.

161 -characterized model system for the study of viral assembly, especially for herpesviruses and adenovi

162 onent of the viral RNA polymerase complex, a viral assembly factor, and an inhibitor of host interfer

163 lication and capsid assembly, functioning as viral assembly factories.

164 In the current view of this viral assembly, Gag forms low-order oligomers that bind

165 ement of viruses, and as such, understanding viral assembly has great potential in the development of

166 ring structure dynamics and heterogeneity of viral assemblies have revealed important insights into g

167 pid rafts and point to a role for rafts as a viral assembly hub.

168 findings suggest that E protein facilitates viral assembly in a manner that does not require E prote

169 Increased efficiency of viral assembly in murine cells was observed from MHIV co

170 We localized the defect for viral assembly in the first two-thirds of the gag gene b

171 NS2B and NS2A may participate in modulating viral assembly in the flavivirus life cycle.

172 bility of Vpu to displace BST2 from sites of viral assembly in the plane of the plasma membrane.

173 To study viral assembly in vivo, we inoculated wild-type and repl

174 studies that help clarify the mechanisms of viral assembly, infection, and replication.

175 rgely unknown because it is not required for viral assembly, infection, or replication.

176 This domain has been implicated in viral assembly, infectivity, and cytopathogenicity.

177 ate, thus offering an explanation underlying viral assembly initiation by an AAG motif.

178 the intracellular localization of these two viral assembly intermediate complexes was investigated b

179 ly identified two distinct forms of putative viral assembly intermediate complexes, a detergent-resis

180 e propose that these complexes may represent viral assembly intermediates and that Vif is appropriate

181 Viral assembly is an ideal system in which to investigat

182 ration of a sufficient number of Envs during viral assembly is critical for viral infectivity.

183 cription from the major late promoter and in viral assembly is discussed.

184 Human immunodeficiency virus type 1 (HIV-1) viral assembly is mediated by multiple protein-protein a

185 A role for AP-2 complex in viral assembly is supported by immunofluorescence analys

186 terminal acetylation of Gag is essential for viral assembly, it is completely dispensable for functio

187 small viral proteins that are essential for viral assembly, L2 and A30.5, function during early morp

188 provide a unique site for the initiation of viral assembly, leading to a one-start helix, rather tha

189 This mutation enhances viral assembly, leading to an increase in viral producti

190 viruses, reverse transcription occurs during viral assembly, leading to DNA-containing virions.

191 k provides insight into elegantly programmed viral assembly machinery, where targeting of capsid asse

192 folding and to ensure proper function during viral assembly, maturation, and infection.

193 ved across retroviruses and is essential for viral assembly, maturation, and infectivity.

194 o virions in vivo, suggesting that defective viral assembly may be associated with the induction of s

195 ant degree of stability, and the kinetics of viral assembly may dominate the folding process.

196 Furthermore, our method is the first viral assembly method that scales to millions of sequenc

197 ure block, DNA packaging and later events in viral assembly nevertheless occurred at near-normal leve

198 Viral assembly occurs at the plasma membrane, where nasc

199 Since viral assembly occurs in the nucleus, our findings are c

200 to the plasma membrane where, subsequently, viral assembly occurs.

201 Since replication and viral assembly of Ad5-dV/TSB could still occur in the ab

202 e transcription [RT]-PCR product) as well as viral assembly on the cell membrane.

203 rtant role in recruiting Envs to the site of viral assembly on the plasma membrane, but direct bioche

204 termine whether the A9L protein functions in viral assembly or infectivity, we made a conditional-let

205 e exclusively in VP2 had a minimal effect on viral assembly or infectivity.

206 could promote biomedical efforts to prevent viral assembly or nanomaterials applications that exploi

207 the wild type, suggesting a defect in early viral assembly or trafficking.

208 chanism by which LysRS is recruited into the viral assembly pathway can be exploited for the developm

209 a few seconds, thus demonstrating a distinct viral assembly pathway.

210 of replication-defective mutants with normal viral assembly phenotypes indicates that CA also perform

211 embrane (IBPM), which probably represent the viral assembly platforms, were not found.

212 and (ii) that one or more components of the viral assembly pool decay in the absence of drug.

213 The conclusion suggests that some viral assembly principles are limited paradigms for prot

214 able to bind to nucleic acids; however, the viral assembly process and packaging of viral genomic RN

215 the IVa2 protein plays multiple roles in the viral assembly process.

216 NMR spectroscopy, provides insight into the viral assembly process.

217 e fusions, into the virion during the normal viral assembly process.

218 o as to aid its encapsidation and assist the viral assembly process.

219 ng near the carboxy terminus (M-site) of the viral assembly protein precursor.

220 incorporation and had a minor effect on the viral assembly rate.

221 d on IE62/CDK1/cyclin B1 colocalization near viral assembly regions, we hypothesized that these cellu

222 Gag structural protein is a critical step in viral assembly, relying in part on interaction between t

223 rgely unknown because it is not required for viral assembly, replication, or infection.

224 establishment of the infecting provirus and viral assembly, respectively.

225 show that disruption of domains controlling viral assembly site [matrix (MA)] or virus particle rele

226 h specific lipid-protein interactions at the viral assembly site.

227 cleus to the cytoplasm prior to transport to viral assembly sites on the cellular plasma membrane.

228 mical reconstitution of ESCRT recruitment to viral assembly sites, using purified proteins and giant

229 he recruitment of MxA protein to perinuclear viral assembly sites, where the protein surrounded the v

230 ing the movement of Vpu-bound BST2 away from viral assembly sites.

231 coproteins are actively recruited to certain viral assembly sites.

232 ed to describe at nanoscale resolution other viral assembly steps involving RNA or protein-protein in

233 This organization regulates viral assembly such that capsid assembly is coordinated

234 trates host membranes that are important for viral assembly, such as Golgi- and recycling endosome-de

235 Unlike most viral assembly systems, two scaffolding proteins, B and

236 rions and the determination of parameters of viral assembly that are inaccessible with conventional t

237 otein interactions during the final stage of viral assembly that result in the incorporation of the v

238 the most abundant viral protein, and during viral assembly, the N protein forms trimers and packages

239 During viral assembly, the p17MA domain of Pr55gag promotes mem

240 tios of mutant to wild-type pRNA in in vitro viral assembly, the percent mutant pRNA versus the yield

241 Besides being a key step in viral assembly, this process is of interest as a model f

242 for ATP binding caused both ATP binding and viral assembly to cease, suggesting that the ATP binding

243 en viral envelope (Env) and receptor directs viral assembly to cell-cell contact sites to promote eff

244 e-specific host factors may aid in directing viral assembly to distinct destinations.

245 ct was assayed for dependence on Ubc9 during viral assembly, trafficking, and Env incorporation.

246 aphy with electron microscopy to investigate viral assembly, viral infection of cells, and neutraliza

247 ecific role of the envelope glycoproteins in viral assembly, we created chimeric SeVs whose HN (rSeVh

248 egions in the fusion glycoprotein that drive viral assembly, we further our understanding of how thes

249 Because this matrix function is integral to viral assembly, we reasoned that this would be reflected

250 ell proteins that interact with pp150 during viral assembly, we utilized yeast two-hybrid analyses to

251 eiotropic effects: Mutation of Gln287 blocks viral assembly while mutation of Arg299 permits assembly

252 he Sulfolobus ESCRT machinery is involved in viral assembly within the cytoplasm and in escape from t

253 the relocation of SNAP-23 to the cytoplasmic viral assembly zone, and knockdown of SNAP-23 inhibited