ライフサイエンスコーパス: viral factory

1 cipitated with A32, and (v) localized to the viral factory.

2 res known as viral inclusion bodies (VIB) or viral factories.

3 oNS and that viral RNA is synthesized within viral factories.

4 cerned transiting away from and back towards viral factories.

5 cytoplasmic inclusion bodies, which we call viral factories.

6 cytoplasmic, nonmembranous structures called viral factories.

7 and p17 proteins colocalized with sigmaNS in viral factories.

8 C, and p17 from colocalizing with sigmaNS in viral factories.

9 P5 in the formation of replication-competent viral factories.

10 al for the in vitro reconstitution of pseudo-viral factories.

11 and nonstructural protein sigmaNS of ARV in viral factories.

12 zed with the viral E3 protein in cytoplasmic viral factories.

13 r viral infectivity, localize to cytoplasmic viral factories after virus infection, and ultimately ar

14 , type 1 Lang (T1L), which forms filamentous viral factories, altered the distributions of both prote

15 (RV) replicates in round-shaped cytoplasmic viral factories, although how they assemble remains unkn

16 AM-signaling intermediate Syk to cytoplasmic viral factories and this recruitment requires the mu2 IT

17 d localizes to ER-associated inclusions, the viral factories, and along microtubules before it is fin

18 Reovirus replicates in cytoplasmic viral factories, and there is no evidence that reovirus

19 show that intracellularly reconstituted EBOV viral factories are biomolecular condensates, with compo

20 These cytoplasmic viral factories are not membrane bound, and they serve t

21 structure, and specific functions of these "viral factories" are poorly understood.

22 Virus-induced cellular condensates, or viral factories, are poorly understood high-density phas

23 In addition, MVs were shown to move from viral factories at speeds consistent with microtubular t

24 ins A13, A14, D8, and H3 did not localize to viral factories but instead accumulated in the secretory

25 soforms, which are subsequently recruited to viral factories by an interaction of their C-terminal do

26 synthesis to assemble morphologically normal viral factories containing functional replicase complexe

27 ies, we report the formation of network-like viral factories during EBOV infection.

28 Although sigma NS colocalized with mu NS in viral factories during infection, it was distributed dif

29 form the core of viruses and assemble within viral factories, dynamic compartments formed within the

30 tein sigmaC and inner core protein sigmaA in viral factories for virus assembly.

31 oteins and accumulation of viral proteins in viral factories for virus assembly.

32 Virally induced structures called viral factories form throughout the cytoplasm of cells i

33 mut2 was normal at viral gene expression and viral factory formation, but it was defective for proteo

34 forms inclusions that resemble the globular viral factories formed in cells infected with reovirus s

35 Key to viral factory function is the recruitment of EBOV polyme

36 dsRNA and E3 colocalized within cytoplasmic viral factories in cells infected with a decapping enzym

37 and cellular components are recruited to the viral factories in infected cells and provide further ev

38 lso involved in the formation of cytoplasmic viral factories in infected cells, called inclusion bodi

39 may mediate the localization of sigma NS to viral factories in infected cells.

40 as a paradigm for the assembly of functional viral factories in other RNA viruses.IMPORTANCE The rota

41 s suggests a key role for microNS in forming viral factories in reovirus-infected cells.

42 viral RNAs and proteins taking place within viral factories in viruses containing segmented RNA geno

43 mbrane-less, cytoplasmic compartments termed viral factories, in which multiple viral proteins gather

44 ruses contain phase-dense inclusions, called viral factories, in which viral replication and assembly

45 zes with VFs in infected cells and also with viral factory-like structures (VFLs) formed by ectopical

46 the RRM and RGG domains of G3BP1 for maximal viral-factory-like structure (VFL) localization and sigm

47 he symbiont, virions are still taken up, but viral factory maturation is inhibited, leading to surviv

48 Unlike droplet-like viral factories, network-like factories are inactive for

49 of actin rocket tails, concentrating in the viral factories of the perinuclear cytoplasm.

50 forms of F10 were stable and concentrated in viral factories, only the wild-type protein complemented

51 ytoplasmic inclusion bodies, commonly called viral factories or viroplasms.

52 in infection, accumulated in the cytoplasmic viral factory regions, and associated primarily with amo

53 tify a conserved molecular grammar governing viral factory scaffold protein: charge-patterned intrins

54 ike structures very similar in appearance to viral factories, suggesting that it is involved in formi

55 NA-binding protein essential for forming the viral factories that support replication of the double-s

56 that several PB components are co-opted into viral factories that support virus multiplication.

57 specific chaperone function for Hsc70 within viral factories, the sites of reovirus replication and a

58 d, ER-derived structures that may represent "viral factories." The ER-derived structures required an

59 he core surface proteins may be recruited to viral factories through specific associations with mu NS

60 (IMV) utilizes microtubules to move from the viral factory to the site of intracellular envelopment a

61 id proteins (MCPs) before the formation of a viral factory (VF).

62 forms large inclusion-like structures called viral factories (VFs) in which assembling viral particle

63 uses to giant viruses) universally assembles viral factories (VFs) resembling biomolecular condensate

64 Although these viral factories (VFs) were described half a century ago,

65 ovirus) nonstructural protein muNS nucleates viral factories (VFs), which are sites of viral genome r

66 t cells, mammalian orthoreovirus (MRV) forms viral factories (VFs), which are sites of viral transcri

67 ses (reoviruses) build neo-organelles called viral factories (VFs).

68 ragments to build the membranous scaffold of viral factories (VFs).

69 In addition to the typical droplet-like viral factories, we report the formation of network-like

70 Within the viral factory, we found the EBOV polymerase clusters int

71 ure virions (MVs) predominantly localized in viral factories where virions were assembled.

72 gomerization and RNA in the morphogenesis of viral factories, where viral transcription and replicati