ライフサイエンスコーパス: viral infection

1 y component of the innate immune response to viral infection.

2 to mitigate MuPyV-encephalopathy and control viral infection.

3 the development of novel therapies to combat viral infection.

4 c cell immunization, Listeria infection, and viral infection.

5 protein response (UPR), a common response to viral infection.

6 mory CD8 T cell formation during respiratory viral infection.

7 eins and has a putative role in facilitating viral infection.

8 ide contributes to the beta-cell response to viral infection.

9 stem-like subset late during the persistent viral infection.

10 and inform therapeutic strategies to inhibit viral infection.

11 ay in the individual immune response to this viral infection.

12 and augmented responses to acute and chronic viral infection.

13 alized innate immunity component to restrict viral infection.

14 eath pathway in cells that successfully cure viral infection.

15 context of the treatment of this respiratory viral infection.

16 aceted role in the innate immune response to viral infection.

17 erefore unlikely to contribute to or enhance viral infection.

18 e TBK1/IRF3 signaling pathway in response to viral infection.

19 es is related to diseases such as cancer and viral infection.

20 tor that recognizes double-stranded RNA from viral infection.

21 ed to handle acute illness after respiratory viral infection.

22 elopmental disorders and hypersensitivity to viral infection.

23 tion, wound healing, cancerous invasion, and viral infection.

24 rive can be used as a strategy to suppress a viral infection.

25 rmitting asthma development after early-life viral infection.

26 verexpressed Prevotella proteins can promote viral infection.

27 xamine complex neurological phenotypes after viral infection.

28 fferences between controls and bacterial and viral infection.

29 such as clonal expansion and memory, during viral infection.

30 endosomes-for initiation of autophagy during viral infection.

31 FI44L can serve as a diagnostic biomarker of viral infection.

32 ng of the processes by which m(6)A regulates viral infection.

33 es that show considerable variability during viral infection.

34 ting one potential mechanism for more severe viral infection.

35 nction with antiviral therapy during chronic viral infection.

36 gulating circulating lymphocyte responses to viral infection.

37 st cofactor that facilitates early stages of viral infection.

38 acts to suppress the interferon response to viral infection.

39 ical regulatory gene, and permit modeling of viral infection.

40 generates cyclic nucleotides in response to viral infection.

41 ole in the regulation of the IFN response to viral infection.

42 es that bind the capsid protein VP1 to block viral infection.

43 increases the risk of severe disease due to viral infection.

44 IAV-induced splicing pattern also attenuates viral infection.

45 ch with differential response options during viral infection.

46 protein and failed to protect macaques from viral infection.

47 a vaccine vector for the treatment of other viral infections.

48 IPF, which may be caused by bacterial and/or viral infections.

49 commonly used in the treatment of cancer and viral infections.

50 mune response is crucial for defense against viral infections.

51 s to mount an effective host response during viral infections.

52 ing to the clonality observed during chronic viral infections.

53 nd preparing for possible recurrent waves of viral infections.

54 s the individual's ability to control latent viral infections.

55 y also offer therapeutic potential for other viral infections.

56 rocesses that impact human health, including viral infections.

57 ost is critical for the restriction of acute viral infections.

58 the treatment of JUNV and potentially other viral infections.

59 can increase susceptibility to bacterial and viral infections.

60 neating guidelines on MAb usages in treating viral infections.

61 ion-based classifier for acute bacterial and viral infections.

62 nce of refractory fungal, mycobacterial, and viral infections.

63 cells are key for immune protection against viral infections.

64 Chronic viral infections.

65 to promote diseases, especially respiratory viral infections.

66 s seen with nucleoside/tide analogs in other viral infections.

67 e diseases or promote IFN-I secretion during viral infections.

68 to prevent, limit, and treat these dangerous viral infections.

69 an important role in this and other emerging viral infections.

70 resents an ancient defense mechanism against viral infections.

71 r specific to shared background mutations or viral infections.

72 sphingosine can be also employed to prevent viral infections.

73 on and can be linked to specific outcomes of viral infections.

74 sence of glycolipid Ags, for example, during viral infections.

75 ial cells and extend our findings to in vivo viral infections.

76 ative PCR cutoffs for diagnosing respiratory viral infections.

77 ghest for respiratory, gastrointestinal, and viral infections.

78 deleterious to the host during bacterial and viral infections.

79 l genome influences host immune responses to viral infections.

80 1 and 2 IFN signatures, normally induced by viral infections.

81 adaptive immune defense against a variety of viral infections.

82 entified as an endosomal protein that blocks viral infection(1-3).

83 nder various conditions (for example, during viral infection)(1-11).

84 both coinfections (1, 2.2%) and alternative viral infections (4, 13.3%) that were not detected by ro

85 98 (49%) of them had a single viral infection (41 [20%] had Zika, 55 [27%] had chikung

86 s that breast milk can be protective against viral infections(8-10).

87 st translation, and tested it in the case of viral infection, a common form of naturally occurring ex

88 rons, one of the first mediators produced by viral infection, act directly on nociceptors to produce

89 irus (SINV) in Drosophila, here we show that viral infections affect TE transcript amounts via modula

90 Viral infections affected 45.1% of OTRs, and were more c

91 Although HCC is associated with chronic viral infections, alcoholic cirrhosis, and nonalcoholic

92 lic reprogramming of host cells during lytic viral infection alters the flow of energy and nutrients

93 testing algorithms identify most respiratory viral infections among SARS-CoV-2 PUIs, when available a

94 recognition and binding is the first step of viral infection and a key determinant of host specificit

95 The interplay between viral infection and Alzheimer's disease (AD) has long be

96 orm of the hepatitis B virus (HBV) genome in viral infection and an undisputed antiviral target for a

97 endogenous cyclic GMP-AMP signalling during viral infection and anti-tumour immunity(1-5).

98 SGs form during viral infection and are thought to promote the antiviral

99 nterferon (IFN) is a key cytokine that curbs viral infection and cell malignancy.

100 ribing how m(6)A modulates host responses to viral infection and discuss future directions that will

101 ver, the MG-hBORG model supported productive viral infection and exhibited increased inflammatory res

102 rbation in response to a different secondary viral infection and highlight the usefulness of these vi

103 detailed overview of the role of glycans in viral infection and highlights experimental approaches t

104 esults indicated that S411A Kunjin decreased viral infection and increased cytopathogenicity in cell

105 n post-operative inflammation, bacterial and viral infection and infection with or without organ dysf

106 VSV-eGFP-SARS-CoV-2 show profoundly reduced viral infection and inflammation in the lung, indicating

107 SAMHD1 suppresses innate immune responses to viral infection and inflammatory stimuli by inhibiting t

108 ely reflecting their dual role as targets of viral infection and key components of the host response.

109 Viral infection and malignancy must be ruled out.

110 ent signaling pathways in the attenuation of viral infection and may lead to the development of new a

111 ogical events including signal transduction, viral infection and membrane curvature induction.

112 lope protein glycosylation and its impact on viral infection and pathogenesis.

113 ad T cell activation characteristic of acute viral infection and plasmablast responses reaching >30%

114 organ culture to study the initial steps of viral infection and the consequent innate immune respons

115 ential therapeutic interventions that target viral infection and/or immunoregulation.

116 by increased susceptibility to bacterial and viral infections and (to a lesser extent) autoimmune man

117 ll receptors (TCRs) are potent therapies for viral infections and cancer.

118 y, limiting our understanding of alternative viral infections and coinfections in these patients.

119 re key innate immunity effectors that combat viral infections and control several cancer types.

120 s of the immune system are involved in three viral infections and Crohn's disease.

121 ty, stimulated by cellular stresses, such as viral infections and ER stress, leads to the regulation

122 biome differences after chronic versus acute viral infections and identify CD8 T cell responses and d

123 III, in a child with recurrent and systemic viral infections and Langerhans cell histiocytosis.

124 ld enhance our understanding of hepatotropic viral infections and lead to improved vaccines and thera

125 nctions between symptomatic and asymptomatic viral infections and may partly explain the propensity f

126 lantation monitoring of common opportunistic viral infections and of graft rejection, and should faci

127 YAP slows T cell responses in systemic viral infections and retards effector T cells in autoimm

128 response can increase individuals' risk for viral infections and several inflammation-related diseas

129 learned from birth cohort studies examining viral infections and subsequent asthma and from understa

130 hich is important for activating CTL against viral infections and tumors.

131 in Nfkbia(NES/NES) mice poorly expand during viral infection, and this can be overcome by exogenous I

132 of environmental exposure on the severity of viral infections, and how the viral genome influences ho

133 IFI44L are upregulated after a wide range of viral infections, and IFI44L can serve as a diagnostic b

134 he context of the CNS development, acute CNS viral infections, and post-infectious and noninfectious

135 ns of the two pathways to the attenuation of viral infection are different in mouse versus human cell

136 of intestinal homeostasis.IMPORTANCE Enteric viral infections are a major cause of gastroenteritis wo

137 Acute respiratory viral infections are a major cause of respiratory morbid

138 Viral infections are common and are potentially life-thr

139 Chronic hepatitis B and C viral infections are major risk factors for hepatocellul

140 Abortive viral infections are usually studied in populations of s

141 Environmental factors, such as viral infection, are proposed to play a role in the init

142 , additional environmental triggers, such as viral infections, are usually required to initiate the o

143 or health laboratories that seek to identify viral infections as early as possible, optimally at the

144 ndidate inhibitors were validated in several viral infection assays.

145 e regulated by T1D genetic risk variants and viral infections associated with T1D.

146 ar distinctions drawn between enhancement of viral infection at the plasma membrane and amphipathicit

147 The initial events of viral infection at the primary mucosal entry site follow

148 f new antiviral strategies aimed at blocking viral infection at very early stages.

149 provide a possible mechanistic link between viral infection, bloom termination, and mass carbon expo

150 cardiomyopathy is predominantly mediated by viral infection, but can also be induced by bacterial, p

151 Both ARVs and NAbs prevent new rounds of viral infection, but NAbs may have the additional capaci

152 ctive in the intestinal epithelium following viral infection, but our understanding of the benefits o

153 to provide quantitative descriptions of many viral infections, but for the Ebola virus, which require

154 ease is strongly associated with respiratory viral infections, but the impact of viruses on Streptoco

155 erge in the development of human cancers and viral infections, but their relevance to bacterial disea

156 region (MPER) results in robust blocking of viral infection by a class of broadly neutralizing antib

157 late innate and adaptive immune responses to viral infection by engaging with receptors on immune cel

158 o amplify innate immune responses to control viral infections by activating AKT3.

159 sting T-cells, SAMHD1 blocks HIV-1 and other viral infections by depletion of the dNTP pool to a leve

160 st innate immunity against hepatitis B and C viral infections by inducing m(6)A modification of viral

161 step and suggest promising routes to hinder viral infections by inducing mis-assembly.

162 tal roles in immune defenses against enteric viral infections by integrating diverse signals, includi

163 cate that sphingosine prevents at least some viral infections by interfering with the interaction of

164 lls that facilitate clearance of the initial viral infection can affect host susceptibility to coinfe

165 Viral infection can cause organ dysfunction, but its rol

166 Viral infection can change the expression patterns of di

167 Viral infection can trigger immunogenic cell death, acti

168 It is well established that chronic viral infections can cause immune suppression, resulting

169 Immunopathogenesis in systemic viral infections can induce a septic state with leaky ca

170 nfavorable conditions (e.g. tumor hypoxia or viral infection), canonical, cap-dependent mRNA translat

171 Our work reveals a mechanism through which viral infections cause heightened pain sensitivity.

172 Respiratory viral infection causes chronic obstructive pulmonary dis

173 as blood coagulation, skeletal development, viral infection, cell-cell fusion, and ataxia.

174 in humans and is prototypic of a persistent viral infection characterized by periods of latency.

175 to bumble bees, but evidence of a sustained viral infection characterized by virus replication and a

176 luenza-like illness and laboratory-confirmed viral infection; clinical respiratory illness had incons

177 s integral for mechanistic insights into the viral infection cycle, very little is known about the lo

178 Second, viral infection depends on the physiological state of th

179 rpesviral protein kinase homologs.IMPORTANCE Viral infection dramatically changes the levels of many

180 Viral infections during pregnancy can have devastating c

181 n, or uncontrolled inflammation triggered by viral infections during pregnancy, and its potential dow

182 Review highlights the need for understanding viral infection dynamics in realistic physiological and

183 A mathematical model describing the viral infection dynamics reveals two transmissibility pa

184 t of granule-mediated cytotoxicity, specific viral infections, excess IL-18, and chimeric antigen rec

185 We propose a role during viral infection for RNase L-cleaved RNAs in inducing avS

186 biomarkers that can differentiate any severe viral infection from immune-enhanced disease, whether by

187 immunotherapeutic approaches for persistent viral infections.FUNDINGDeutsche Forschungsgemeinschaft

188 However, no involvement of MAL in viral infections has been reported so far.

189 bution to the outcome of acute or persistent viral infections has remained elusive.

190 Recent studies on chronic viral infections have defined a novel programmed cell de

191 Among 1039 viral infections, herpesviruses predominated (51%) in ki

192 We performed serological profiling of the viral infection history in 899 individuals from an NCI-U

193 To investigate viral infection history in KD patients, we performed com

194 CE CD8 TCR repertoires responding to chronic viral infections (HIV, hepatitis C virus [HCV], Epstein-

195 (ART) in relation to those of other chronic viral infections (i.e., cytomegalovirus [CMV] and Epstei

196 nds for the potential treatment of influenza viral infections.IMPORTANCE Influenza viruses are highly

197 sional (3-D) human airway tissues to examine viral infection in a physiologically relevant model syst

198 a genomic record of historical tolerance to viral infection in bats.

199 However, the effect of these mutations on viral infection in cell culture and in vivo is not well

200 mary receptor for pathogenic NWAs, enhancing viral infection in guinea pigs.IMPORTANCE JUNV is one of

201 tive agent of the most widespread tick-borne viral infection in humans.

202 ters the cellular environment, which impacts viral infection in immortalized cells.

203 in K18-hACE2 mice results in high levels of viral infection in lungs, with spread to other organs.

204 F) is the most widely distributed tick-borne viral infection in the world.

205 eletion increases cellular susceptibility to viral infection in vitro, and that Snx5 knockout in mice

206 el antivirals for the treatment of influenza viral infections in humans, a search that could be exped

207 the treatment of mammarenavirus and/or other viral infections in humans.

208 /Victoria-, and B/Yamagata-lineage influenza viral infections in mouse models.

209 NGS to assess the frequencies of alternative viral infections in SARS-CoV-2 RT-PCR-negative PUIs (n =

210 ic, innate, and adaptive immune responses to viral infections in the respiratory tract.

211 monstrate the differential effect of primary viral infections in the susceptibility to disease exacer

212 complex pathophysiological features of human viral infections in vitro.

213 o exert different functions in vivo during a viral infection, in a manner tightly orchestrated in tim

214 ents presenting with symptoms of respiratory viral infection, including influenza-like illness (ILI).

215 echanisms by which aging impacts respiratory viral infections, including SARS-CoV-2.

216 IFNs, produced during viral infections, induce the expression of hundreds of I

217 Viral infection induces the expression of numerous host

218 Besides viral infections, IRF3 is also involved in resistance to

219 Viral infection is an environmental trigger that has bee

220 One of the first signs of viral infection is body-wide aches and pain.

221 traits that peak and last long after active viral infection is cleared.

222 Viral infection is detected through the presence of vira

223 knowledge of the progression of the initial viral infection is limited, and no safe or effective vac

224 Viral infection is now recognized as a ubiquitous top-do

225 Viral infection is one environmental factor that may con

226 A key part of the response to viral infection is production of interferons (IFNs), whi

227 llnesses, leading some to hypothesize that a viral infection is the inciting event for KD.

228 at other functions pDCs exert in vivo during viral infections is controversial, and more studies are

229 chanism by which the pathogenesis of certain viral infections is enhanced in the presence of sub-neut

230 liorate lung inflammation during respiratory viral infections is possible but that the timing and dur

231 We anticipate that future studies of viral infection kinetics with this reporter system will

232 Chronic viral infection leads to inflammation and liver damage,

233 of tissue-specific effects of primary acute viral infections like COVID-19 are essential for underst

234 Here, we have shown that upon DNA and RNA viral infection, macrophages reduced 7-dehydrocholestero

235 pes of RNA sensed by RLRs in the contexts of viral infection, malignancies and autoimmune diseases.

236 and the TLR3 pathways in the attenuation of viral infection may be species specific.IMPORTANCE The m

237 Antecedent viral infection may contribute to increased susceptibili

238 Macaques had clinical signs of viral infection, mild to moderate pneumonitis and extra-

239 During viral infection, Mx proteins are known to show markedly

240 in mediating antiviral protection in various viral infections, necessitating a detailed understanding

241 ancer development and progression as well as viral infection, notably by HIV-1.

242 ylate (cOA) second messengers in response to viral infection of bacteria and archaea, potentiating an

243 als, such AuraShield L, can prevent in vitro viral infection of cell cultures.

244 S2 (transmembrane protease serine 2) mediate viral infection of host cells.

245 dentify host factors required for SARS-CoV-2 viral infection of human alveolar epithelial cells.

246 st prevalent and significant arthropod-borne viral infection of humans.

247 or human LDLRAD3 results in markedly reduced viral infection of neuronal cells, which is restored upo

248 Tick-borne encephalitis (TBE) is a viral infection of the CNS caused by TBE virus.

249 Our findings provide evidence against direct viral infection of the kidneys as the major pathomechani

250 However, the effects of chronic viral infection on T-cell responses and vaccination agai

251 al changes were observed and no evidence for viral infection or integration could be provided after l

252 austed CD8(+) T cell responses in persistent viral infections or tumors.

253 .51; 95% CI = 4.37-12.91), respiratory tract viral infection (OR = 7.75; 95% CI = 1.60-37.57), cytome

254 ions, either directly, through modulation of viral infection, or indirectly, through alteration of in

255 nsmissions in human population and detecting viral infection outbreaks.

256 lar origin, such as bacterial peptidoglycan, viral infections, parasitic infections, activated Rho GT

257 genetic regulation in immune cells following viral infection plays a role in the inflammatory respons

258 Epidemic viral infections predominated as causes of childhood enc

259 tion with implications for understanding how viral infections promote pain and can lead to neuropathi

260 roles of individual miRNAs in the context of viral infection remain largely uncharacterized.

261 roles of these induced genes in controlling viral infections remain largely unknown, limiting our ab

262 vasion mechanisms, possible drugs to prevent viral infection/replication, and health cares to minimiz

263 regulation of many ISGs, which confers broad viral infection resistance.

264 Nipah viral infections result in acute respiratory syndrome an

265 universal face masking policy on respiratory viral infections (RVIs) among admitted very-low-birthwei

266 ORTANCE Double-stranded RNAs produced during viral infections serve as pathogen-associated molecular

267 fibrils, known as semen-derived enhancer of viral infection (SEVI), that enhance the viral infectivi

268 pulations provide averaged information about viral infections, single-cell analyses offer individual

269 ighting the cells' potential role in initial viral infection, spread and clearance.

270 tem of different species under conditions of viral infection, stress, or disease.

271 fully for IFN therapeutic strategies against viral infections such as influenza and coronavirus disea

272 ultures with interferon beta-1 abrogated the viral infection, suggesting one potential mechanism for

273 g prolonged exposure to Ags, such as chronic viral infections, sustained TCR signaling can result in

274 functional insights into the role of ACE2 in viral infection that can potentially be exploited for th

275 attempts to reverse and eliminate the latent viral infection that prevents eradication of the virus.

276 ecent discoveries have revealed that, during viral infection, the presence of the RNA modification N(

277 the relationships between host genetics and viral infections, the contributions of respiratory viral

278 In chronic viral infections, the deranged B cell subset signifies u

279 In combating viral infections, the Fab portion of an antibody could m

280 ecificity in distinguishing abnormalities in viral infections, the high sensitivity of CT makes this

281 ugh recombinant EC1 is a potent inhibitor of viral infection, there is no molecular description of th

282 prior or concurrent upper respiratory tract viral infection, this bacterium commonly causes multiple

283 Natural killer (NK) cells control viral infection through the interaction between inhibito

284 ination was improved by preventing secondary viral infections through a mechanism involving significa

285 infections, the contributions of respiratory viral infections to patterns of immune development, the

286 Viral infections trigger host innate immune responses, c

287 in response to type I interferons.IMPORTANCE Viral infection triggers the secretion of type I interfe

288 SARS-CoV-2 viral infection triggers various inflammatory, biochemic

289 degradation and interferon suppression, and viral infection under interferon-competent conditions.

290 Viral infection underlies a significant share of the glo

291 The viral infection was further confirmed by molecular metho

292 are not enriched for canonical regulators of viral infection, we find that many of these genes do imp

293 d immunity after coronavirus and other acute viral infections, we posit that, with few exceptions, th

294 n of certain biomarkers associated with this viral infection which can be done by simply re-purposing

295 ntial pathogen recognition receptors sensing viral infections while LGP2 has been described as both R

296 Here, we show that viral infection with LCMV results in type I IFN-dependen

297 gene expression relevant for the control of viral infection, with both proteins potentially facilita

298 ing antibody response is typical of an acute viral infection, with declining neutralizing antibody ti

299 y the localization and spread of respiratory viral infections within the HRT.

300 entral nervous system (CNS) is vulnerable to viral infection, yet few host factors in the CNS are kno