ライフサイエンスコーパス: viral membrane fusion

1 antagonize HIV-1 Env at gp120 V1V2 to block viral membrane fusion.

2 disordered (ld) phase boundary to facilitate viral membrane fusion.

3 mbrane ordering is a common prerequisite for viral membrane fusion.

4 ntagonists blocked infection at the level of viral membrane fusion.

5 on at a postendocytic entry step, presumably viral membrane fusion.

6 , thereby lowering the activation energy for viral membrane fusion.

7 iochemical understanding of low-pH-triggered viral membrane fusion.

8 ral role for the N-terminal glycine ridge in viral membrane fusion.

9 the plasma membrane being less permissive to viral membrane fusion.

10 -2 spike (S) protein and thus interfere with viral membrane fusion.

11 cular basis for an improved understanding of viral membrane fusion.

12 e activation of the F protein and inhibiting viral membrane fusion.

13 ing cells, where LY6E predominantly promotes viral membrane fusion.

14 st-attachment stage, with several inhibiting viral membrane fusion.

15 To understand the steps in viral membrane fusion, a library of synthetic antibodies

16 ngs provide new fundamental understanding of viral membrane fusion and are relevant to structure-guid

17 p41 envelope glycoprotein, potently inhibits viral membrane fusion and entry.

18 irus envelope, supports the current model of viral membrane fusion and gives insight into the design

19 l glycoprotein 2 (GP2) which facilitate host-viral membrane fusion and subsequent release of the vira

20 Since the viral membrane fusion apparatus may open the passages th

21 idual mutations in the three proteins of the viral membrane fusion apparatus, M, fusion (F), and hema

22 Mechanistically, 25HC inhibits viral membrane fusion by activating the ER-localized acy

23 is required to facilitate the triggering of viral membrane fusion by destabilizing the prefusion con

24 onance analysis suggested that 10E8 inhibits viral membrane fusion by lifting the MPER N-terminal reg

25 vides an overview of the basic principles of viral membrane fusion common to all enveloped viruses an

26 We observed an inhibition of viral membrane fusion during the entry process by 25HC,

27 lical coiled-coil core relates gB to class I viral membrane fusion glycoproteins; two extended beta h

28 fusion potential of influenza HA, like many viral membrane-fusion glycoproteins, is generated by pro

29 osomal compartment are probably required for viral membrane fusion; however, despite considerable eff

30 ors and altered endosomal trafficking affect viral membrane fusion.IMPORTANCE Many enveloped viruses

31 e, which is transiently exposed during HIV-1 viral membrane fusion, is a validated clinical target in

32 ) and L (gL) comprise a basal element of the viral membrane fusion machinery conserved across herpesv

33 oop, a critical and conserved element of the viral membrane fusion machinery, and neutralize viral en

34 that New World arenaviruses exhibit class I viral membrane fusion machinery.

35 M structure of Atlas G(C) reveals a class II viral membrane fusion protein fold not previously seen i

36 nucleopolyhedrovirus (AcMNPV) is a class III viral membrane fusion protein that is triggered by low p

37 FAST proteins are the smallest viral membrane fusion proteins and, unlike their envelop

38 (FAST) proteins comprise a unique family of viral membrane fusion proteins dedicated to inducing cel

39 Here we review current concepts about viral membrane fusion proteins focusing on how they are

40 Viral membrane fusion proteins of class I are trimers in

41 The fusion peptides of viral membrane fusion proteins play a key role in the me

42 Structural studies of viral membrane fusion proteins suggest that a "trimer-of

43 ity after PRV infection due to the action of viral membrane fusion proteins, yet it is unclear if suc

44 ardtii HAP2 that reveal homology to class II viral membrane fusion proteins.

45 ved prehairpin intermediate (PHI) of class I viral membrane-fusion proteins are generally weakly neut

46 ved prehairpin intermediate (PHI) of class I viral membrane-fusion proteins typically show limited ne

47 that the coiled-coil motif occurs in several viral membrane-fusion proteins, including HIV-1 gp41 and

48 overall architecture resembles several other viral membrane-fusion proteins, including those from HIV

49 coil is a common motif found in many diverse viral membrane-fusion proteins.

50 for identifying coiled-coil-like regions in viral membrane-fusion proteins.

51 ace loop at the cleavage site that activates viral membrane fusion reveal structural features primari

52 Despite their diversity, basic principles of viral membrane fusion, simultaneous engagement of both d

53 However, mechanistic viral membrane fusion studies have predominantly focused

54 to a CoRA-dependent decrease in the rate of viral membrane fusion that extends the lifetime of the i

55 an inhibit HIV-1 replication at the level of viral membrane fusion through interaction with Env.

56 HIV-1 glycoprotein Env, which promotes viral membrane fusion through receptor-mediated conforma

57 blocked productive infection at the level of viral membrane fusion, with a range of inhibitory activi