ライフサイエンスコーパス: viral receptor

1 into mammalian cells that lacked the cognate viral receptor.

2 ion of Na/Pi uptake by the Na/Pi transporter/viral receptor.

3 nto virus particles normally and bind to the viral receptor.

4 ight be controlled by factors other than the viral receptor.

5 ecificity and convert LDL-A4 to an efficient viral receptor.

6 noglobulin, indicating that it is a specific viral receptor.

7 s but compromises the spike affinity for the viral receptor.

8 an expected control encoding the SARS-CoV-2 viral receptor.

9 cell attachment by increasing binding to the viral receptor.

10 ay have been influenced by its function as a viral receptor.

11 irulence thresholds may be competition for a viral receptor.

12 ry events rather than by availability of the viral receptor.

13 incubation time, as would be expected for a viral receptor.

14 velope glycoprotein E2 to CD81, the putative viral receptor.

15 entry into cells is a function solely of the viral receptor.

16 s to the expression of beta(3) integrin, the viral receptor.

17 th a tetraspanin molecule CD81, the putative viral receptor.

18 castaneus and from hamsters were inactive as viral receptors.

19 hat the family of LDL receptors may serve as viral receptors.

20 adaptations linked to immunity, including in viral receptors.

21 nction as important drug transporters and as viral receptors.

22 proteoglycans (CSPGs) as alternative initial viral receptors.

23 bial proteins and peptides and bacterial and viral receptors.

24 developing treatment strategies targeted to viral receptors.

25 id transporters (CATs) act pathologically as viral receptors.

26 ransporter SIT1 in complex with the COVID-19 viral receptor ACE2 by cryo-electron microscopy.

27 tion, exosomes containing high levels of the viral receptor ACE2 in bronchoalveolar lavage fluid (BAL

28 lap between expression of ENaC-alpha and the viral receptor ACE2 in cell types linked to the cardiova

29 oV-2 proteins partially colocalized with the viral receptor ACE2 in kidney biopsy specimens in tubule

30 We find expression of viral receptor ACE2 in mature choroid plexus cells expre

31 f four clinically relevant target genes: the viral receptors ACE2 and CCR5 and the immune checkpoint

32 Such inhibitors could be derivatives of the viral receptor, ACE2, or peptides engineered to interact

33 RNA caused enhanced amino acid transport and viral receptor activities, the AUG codon nearest to its

34 d substitutions S78N-S79Y-K80E restored full viral receptor activity to the CDR2 of human CD134 in th

35 membrane protein containing this domain has viral receptor activity.

36 ) and the CD46 (Ad35) and desmoglein-2 (Ad7) viral receptors all induce the cGAS/STING/TBK1/IRF3 casc

37 red interactions between the viruses and the viral receptor and co-receptor.

38 t CD4(+) T-cells induces polarization of the viral receptor and coreceptor, CD4/CXCR4, and cellular s

39 In addition to the lack of expression of the viral receptor and coreceptors and the rate-limiting vir

40 Recent identification of the viral receptor and coreceptors for AAV type 2 (AAV-2) ha

41 irus and adenovirus receptor (CAR) is both a viral receptor and homophilic adhesion protein.

42 SU binds to the viral receptor and is thought to trigger conformational

43 coxsackievirus-adenovirus receptor (CAR), a viral receptor and putative cell-cell adhesion molecule,

44 infection results in down-regulation of its viral receptor and thus superinfection exclusion, whethe

45 The restriction of viral receptors and coreceptors to the basolateral surfa

46 ecognize viral nucleic acids, which activate viral receptors and signaling, leading to immunity.

47 Interestingly, these viral receptors and signals are also present in nocicept

48 al HN expression results in depletion of the viral receptors and thus prevents entry and cell fusion,

49 ization by decreasing cell surface levels of viral receptors and viral trafficking likely by modulati

50 glycoprotein, gp120, mediates binding to the viral receptors and, along with the transmembrane glycop

51 n was found to be responsible for binding to viral receptors, and the recombinant P protein forms P d

52 (RBD) of SARS-CoV-2 spike protein, blocking viral receptor angiotensin-converting enzyme 2 (ACE2).

53 Many host cell surface proteins, including viral receptors, are incorporated into enveloped viruses

54 The viral receptor behaves as a classic transition state the

55 s in the VP2 protein, a major determinant of viral receptor binding and host specificity.

56 hat computationally account for variation in viral receptor binding avidities.

57 ill be important to account for variation in viral receptor binding avidity when performing antigenic

58 strated that the N145K HA mutation increases viral receptor binding avidity.

59 ensin converting enzyme-2 for binding to the viral receptor binding domain (RBD).

60 Additionally, we generated over 100 viral receptor binding domain and whole-genome sequences

61 ralizing antibodies and generally target the viral receptor binding protein, such as the VP2 of bluet

62 S 220-loop and can be buffered by avidity in viral receptor binding.

63 tes with HCV by competitively inhibiting HCV viral receptor binding.

64 Abs deactivate the virus by attaching to the viral receptor-binding domain (RBD), which interacts wit

65 e we use deep mutational scanning to predict viral receptor-binding domain evolution and to select fo

66 -free expressed human ACE2 receptor with the viral receptor-binding domain in a specific manner.

67 nto their spike protein, and evolved it into viral receptor-binding domains with altered sugar specif

68 Thus, unlike previously described viral receptor-binding domains, the PRV gC receptor-bind

69 ory epithelial cells via interaction between viral receptor-binding molecules and sialic acid-contain

70 mAb, designated VIR-7229, which targets the viral receptor-binding motif (RBM) with unprecedented cr

71 The viral receptor-binding protein (RBP or G) attaches to ho

72 n with less dependence on interaction by the viral receptor-binding protein with known MeV receptors.

73 by local contacts between F- and neighboring viral receptor-binding proteins (HN) only when HN binds

74 We propose that viral receptor-binding site accessibility explains the s

75 ity by disrupting energy sensing and fueling viral receptor biosynthesis, highlighting the importance

76 s determined by the presence of not only the viral receptor but also post-entry factors.

77 , does not involve downregulation of surface viral receptors but instead occurs inside the cell at th

78 Blocking of the ecotropic viral receptor by secreted gp70 SU may contribute to res

79 onent of the T cell antigen receptor and the viral receptor, by accelerating its endocytosis.

80 he data indicate that while up-regulation of viral receptors can greatly enhance retrovirally mediate

81 ia and revealed that beta-arrestin 2 and the viral receptor CAR are candidate cargoes of the BBSome.

82 gests that, in addition to its function as a viral receptor, CAR may have a pathophysiological role i

83 with distinct modes of interaction with the viral receptors CD134 and CXCR4, and sensitivities to ne

84 HIV-1 entry inhibitor temsavir prevents the viral receptor CD4 (cluster of differentiation 4) from i

85 pus laevis oocytes that also coexpressed the viral receptor CD4 and a G protein-coupled inward-rectif

86 The fusion proteins (SIV gp140-ATC) bind viral receptor CD4 and a number of monoclonal antibodies

87 ism is the expression pattern of the primary viral receptor CD4 and co-receptor(s), such as CXCR4 and

88 IV-1) Vpu protein are the degradation of the viral receptor CD4 and the enhancement of virion release

89 HIV-1) infection is the rapid removal of the viral receptor CD4 from the cell surface.

90 ed particles, Env already interacts with the viral receptor CD4 on target cells, thus enabling the fo

91 ophages (MDMs) through downregulation of the viral receptor CD4.

92 ior envelope glycoprotein interacts with the viral receptor (CD4) and with the gp41 transmembrane env

93 The binding sites for the viral receptor, CD4, and neutralizing MAbs appear to clu

94 ability to trigger fusion through the native viral receptors CD46 and SLAM.

95 B cells express the viral receptors CD81, SR-BI, and the C-type lectins DC-S

96 While ACE2 has been identified as the viral receptor, cellular polysaccharides have also been

97 iew of influenza virus infection is that the viral receptor consists of cell surface carbohydrate sia

98 a strategy to engineer functional customized viral receptors (CVRs).

99 ed binding to both the ephrinB2 and ephrinB3 viral receptors: D257A, D260A, G439A, K443A, G449A, K465

100 receptor-expressing cells through canonical viral-receptor-dependent pathways.

101 eptor, guiding viral entry through canonical viral-receptor-dependent pathways.

102 Moreover, we characterized MAb dosages in viral-receptor-dependent, Fc-receptor-dependent, and bot

103 significantly increased by inhibition of the viral receptor-destroying enzyme neuraminidase (NA).

104 ction of enzymes, transcription factors, and viral receptors directly influences the niches viruses c

105 s, which may be required for both immune and viral receptor downregulation as well as viral replicati

106 target cells expressing large amounts of the viral receptor DPP4.

107 target cells expressing high amounts of the viral receptor, DPP4, and did not modulate MERS-CoV infe

108 These antibodies prevented viral receptor engagement by locking the receptor-bindin

109 These viral receptors exhibit homology to human chemokine rece

110 e glycoprotein, responsible for engaging the viral receptor, exhibits the highest density of mutation

111 To understand the relative contribution of viral receptor expression and cell proliferation in retr

112 uding its role in both the regulation of key viral receptor expression and the mediation of inflammat

113 In a previous study we used viral receptor expression in D2 receptor knockout mice t

114 Viral receptor expression levels increased upon polariza

115 ological restoration of Ldlr deficiency, and viral receptor expression.

116 s, when present on cell surface, also act as viral receptors, facilitating cell fusion and virus infe

117 s impacted viral entry into cells expressing viral receptor, Fc receptor, or both receptors.

118 lications of our findings for the process of viral receptor-finding in higher systems.

119 d heparan sulfate proteoglycan serves as the viral receptor for AAV type 2, and provide an explanatio

120 The viral receptor for ecotropic MLV (eMLV), a classical mod

121 se the ability of CCR5 to serve as a primary viral receptor for the SIV isolates examined.

122 tory tract of guinea pigs possesses specific viral receptors for ICV.

123 v, and Vpu participate in the removal of the viral receptor from the cell surface.

124 The viral receptor function of Tva is determined by a 40-res

125 The viral receptor function of Tva is determined by a 40-res

126 A module decreased both envelope binding and viral receptor function, confirming the importance of th

127 vides mechanistic insights into how a simple viral receptor functions in retrovirus entry.

128 used to planar lipid bilayers containing the viral receptor GD1a at pH 5.0.

129 tant murine cells expressing the E36-derived viral receptor, HaPit2.

130 o cells, and the cloning of several of these viral receptors has allowed refinement of models to expl

131 dentification of host proteins that serve as viral receptors has enabled insights into virus particle

132 Selective expression of viral receptors has the potential to attenuate infection

133 oximate sequences that could bind a putative viral receptor, heparan sulfate.

134 hat infects human hepatocytes expressing the viral receptor hNTCP.

135 Viral receptors, however, are present in rat lens epithe

136 determined by analyzing their affinity for a viral receptor, human angiotensin-converting enzyme 2 (h

137 replicate in mouse L cells that express the viral receptor, human intercellular adhesion molecule 1

138 nd replicate in cells expressing the natural viral receptors HveA or nectin-1.

139 fficient growth in mouse cells producing the viral receptor ICAM-1 (ICAM-L cells).

140 Near this locus is CXADR, a gene encoding a viral receptor implicated in myocarditis and dilated car

141 l vectors replicate only in avian cells, the viral receptor in infected transgenic mouse cells remain

142 body/Fc-receptor complex functionally mimics viral receptor in mediating viral entry.

143 gy, cell tropism, and ability to compete for viral receptors in vitro.

144 (HSV-1) glycoprotein gC-1, participating in viral receptor interactions and immunity interference, h

145 for experimental probing and manipulation of viral-receptor interactions.

146 navirus disease 2019 (Covid-19), because the viral receptor is angiotensin-converting enzyme 2 (ACE2)

147 The absence of viral receptors is a major barrier to efficient gene tra

148 In addition to activity as a viral receptor, it may play a role in cellular adhesion.

149 Human NPC1 fulfills a cardinal property of viral receptors: it confers susceptibility to filovirus

150 y hamster kidney cell line lacking the known viral receptors (J1-1) and Vero cells with a plasmid enc

151 Binding of gp120 to viral receptors leads to large structural rearrangements

152 The differences in viral receptor levels in these cells correlated with the

153 have documented a significant difference in viral receptor levels that may be due to transcriptional

154 dentical to human KS, with expression of the viral receptor limited to a few cells, suggestive of a p

155 e a mutation of the IFIH1 gene, encoding the viral receptor MDA5 that causes constitutive IFN product

156 -mediated viral entry, rather than canonical viral receptor-mediated entry.

157 arker, CD9, implying that CD9 may serve as a viral receptor or coreceptor in this system.

158 ed viruses may be useful for identifying new viral receptors or for defining functional requirements

159 any CD34(+) cells express high levels of the viral receptor protein CD4 and the coreceptor CXCR4 on t

160 to cover the whole surface of EV and another viral receptor protein remains active.

161 Precedents set by viral receptor proteins would suggest that this is likel

162 that Pit-2 is the form of Na/Pi transporter/viral receptor regulated by PKC.

163 at or near the gene encoding the polytropic viral receptor, Rmc1.

164 try and suggests that oligomerization of the viral receptor serves as an attractive target for drug d

165 In addition to viral receptors, several intracellular factors can be in

166 ication of heparan sulfate proteoglycan as a viral receptor should facilitate development of new reag

167 Mechanistically, nanodiscs carrying the viral receptor sialic acid bind to influenza virions and

168 In addition, variation in the viral receptor, sialic acid, did not affect influenza vi

169 utations acquired during adaptation affected viral receptor specificity by enhancing binding to alpha

170 To evaluate the role of the viral receptor specificity in promoting innate immune re

171 s suggested a trend from a more "avian-like" viral receptor specificity with G222 in prepandemic case

172 chemokine receptor can function as a primary viral receptor strongly suggests that the HIV envelope g

173 as the T-cell receptor, B-cell receptor, and viral receptors such as CD4.

174 through Toll-like receptors or intracellular viral receptors such as retinoic acid-inducible gene I.

175 re produced in cells with high levels of the viral receptor, suggesting a functional link between CD4

176 NPC1 is the first known viral receptor that recognizes its ligand within an intr

177 translational potential for targeting other viral receptors that have PDZ binding domains, such as t

178 s murine transporter mASCT2 is inactive as a viral receptor, that a related (ca. 55% identity) murine

179 However, for ACE2 to function as the viral receptor, the RBD binding site must be positioned

180 In the presence of purified viral receptor, the trimeric ectodomain of EnvA was conv

181 Among these viral receptors, the M33 GPCR carried by MCMV is an acti

182 ), and specific binding of FeLV-A Env to its viral receptor, thiamine transporter feTHTR1, is the fir

183 hout the need for physical attachment of the viral receptor to a cellular membrane.

184 synthetic DNA-lipid conjugates as surrogate viral receptors to tether virions to target vesicles.

185 that self-noncoding dsRNA activates the anti-viral receptor toll like receptor 3 (TLR3) to induce int

186 urface spike protein of coronaviruses like a viral receptor, triggers a conformational change of the

187 rs to the liver cells of mice expressing the viral receptor TVA under the control of the albumin gene

188 igand, neuregulin (NRG1), fused to the avian viral receptor TVB (TVB-NRG1), along with EnvB pseudotyp

189 that a bridge protein composed of the avian viral receptor TVB fused to NRG, along with EnvB-pseudot

190 V, our transgenic mice expressing hCD26/DPP4 viral receptor uniformly succumbed to death within 6 day

191 To define whether viral receptor up-regulation by itself increased gene tr

192 ured cells expressing either CX(3)CR1 or the viral receptor US28.

193 bv) that partially inhibits signaling of the viral receptor US28.

194 an evolutionary first step toward expanding viral receptor usage in response to inefficient viral en

195 ble role of Vpr in the downregulation of the viral receptor Vpr alleles from HIV-1 and simian immunod

196 Accessibility to viral receptors was critically linked to depolarization

197 tter define endogenous glycans that serve as viral receptors, we have explored glycan recognition in

198 a(V) integrins from a susceptible species as viral receptors, we molecularly cloned the bovine beta(1

199 The HA binds to sialyloligosaccharide viral receptors, while the NA removes sialic acids from

200 In addition, other possible viral receptors will be considered.

201 influenza viruses since glycans are natural viral receptors with a possibility to selectively distin

202 ity of PiT1 and PiT2 to function as discrete viral receptors with unique properties presumably is ref

203 t cholesterol-mediated spatial clustering of viral receptors within the target membrane does not sign