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1 hing mechanism during RNA replication by the viral replicase.
2  mature nonstructural proteins that form the viral replicase.
3 d p92 that is needed for the assembly of the viral replicase.
4 t N interacts with nsp3a, a component of the viral replicase.
5 ch then inhibits the normal functions of the viral replicase.
6  by stimulating plus-strand synthesis by the viral replicase.
7 tion proteins as well as the assembly of the viral replicase.
8  Cdc34p is a novel component of the purified viral replicase.
9                          (i) It binds to the viral replicase.
10 us is believed to be an integral part of the viral replicase.
11 itis C virus (HCV) is a key component of the viral replicase.
12 proteins (nsPs) representing subunits of the viral replicase.
13 ructure is required for RNA synthesis by the viral replicase.
14 or the retromer for the full activity of the viral replicase.
15 osed of multiple domains and is known as the viral replicase.
16 c virus (BMV), are modulated by the host and viral replicase.
17  the site of replication and assembly of the viral replicase, activities that are mediated by cis-act
18 uctural proteins (nsPs) function to form the viral replicase and replicate virus RNA.
19 plays a crucial role for the activity of the viral replicase and, thus, the amplification of the vira
20 ose mature products include cofactors of the viral replicase, and identified the order of cleavages.
21 ponents of VRCs or VRCs in toto, we isolated viral replicase- and VRC-enriched fractions from TMV-inf
22  replication-competent RNA and expression of viral replicase are uncoupled.
23                              Positive strand viral replicases are membrane-bound complexes of viral a
24                         Purified recombinant viral replicases are useful for studying the mechanism o
25 , the HEV ORF1 protein, corresponding to the viral replicase, as well as HEV positive- and negative-s
26 consists of essential proteins that form the viral replicase, as well as structural proteins for viru
27              To understand this mechanism, a viral replicase assay that utilizes extracts from dengue
28  corresponding genome counterpart to provide viral replicase (B1+B2+B3/FCP and F1+F2/BCP) resulted in
29 lication, indicating that Xrn1 decay and the viral replicase compete to set RNA abundance within infe
30 irst, the minus strand is synthesized by the viral replicase complex (VRC), which then serves as a te
31 viruses are replicated by the membrane-bound viral replicase complex (VRC).
32 tion of several co-opted host factors in the viral replicase complex (VRC).
33 replication proteins and is recruited to the viral replicase complex (VRC).
34  in membrane-bound structures containing the viral replicase complex (VRC).
35 n proteins and inhibited the assembly of the viral replicase complex and viral RNA synthesis in vitro
36 facilitate the recruitment of GAPDH into the viral replicase complex in the yeast model host.
37 ating pyruvate kinase (PK) directly into the viral replicase complex to boost progeny RNA synthesis.
38 f viral RNA recruitment, the assembly of the viral replicase complex, and viral RNA synthesis.
39 f replication and assembly of the functional viral replicase complex.
40  is also necessary for assembly of an active viral replicase complex.
41 seems to be critical for the assembly of the viral replicase complex.
42 cation by interacting with components of the viral replicase complex.
43 nfected cells is believed to be catalyzed by viral replicase complexes (RCs), which may consist of va
44        To gain insights into the assembly of viral replicase complexes (VRCs) and dissect the roles o
45   We demonstrate that the in vitro assembled viral replicase complexes (VRCs) in artificial PE vesicl
46 NA] viruses assemble numerous membrane-bound viral replicase complexes (VRCs) with the help of viral
47 ase (RdRp) and regulation of the assembly of viral replicase complexes (VRCs).
48 slation, some are recruited to improvise the viral replicase complexes for genome multiplication, and
49 ) replicase, we affinity purified functional viral replicase complexes from yeast.
50 and RNA viruses, replicate in membrane-bound viral replicase complexes in the cytoplasm of infected c
51 virus replication occurs via the assembly of viral replicase complexes involving multiple viral and h
52 rus replication requires the assembly of the viral replicase complexes on intracellular membranes in
53 eplication to facilitate the assembly of the viral replicase complexes, which perform viral RNA repli
54  selectively recruit viral RNAs into cognate viral replicase complexes.
55 bilizing activities, is a major component of viral replicase complexes.
56 ring the production of new plus strands, the viral replicase displaces the old plus strand in the dsR
57 ons may impair recognition of the RNA by the viral replicase during an early step in negative-strand
58 may interact with each other and/or with the viral replicase during genome replication.
59 ead-through domain affects the regulation of viral replicase expression by altering the likelihood th
60 rding to canonical and noncanonical modes of viral replicase expression by ribosomes and genomic orga
61 e/invertebrate host division, the control of viral replicase expression, and translation fidelity are
62 hat suppress translational initiation of the viral replicase gene in the wild-type genome, have been
63 an alternative reading frame overlapping the viral replicase gene.
64 o 20:1 ratio between p33 and p92(pol) in the viral replicase, (iii) the activity of the tombusvirus r
65 as low and that the in vitro assembly of the viral replicase in a cell extract was inhibited by the c
66                                  The role of viral replicase in modulating the capsid dynamics was ev
67 th nsp3 on the cytoplasmic side and with the viral replicase inside the DMV.
68 NA as a template for (+)RNA synthesis by the viral replicase is facilitated by recruited host DEAD bo
69 odulation of capsid dynamics by the host and viral replicase is obligatory for successful infection.
70 on of native capsid dynamics by the host and viral replicase modulate the general biology of the viru
71 e found that neither RNA1 (which encodes the viral replicase) nor RNA2 (which encodes the capsid prot
72                                              Viral replicases of many positive-strand RNA viruses are
73  Cu(2+) ions on the in vitro assembly of the viral replicase, on the activity of the viral RNA-depend
74 oteins is fully nested within the ORF of the viral replicase P.
75                     Thus, a component of the viral replicase plays an important role in the neuropath
76     PLP2 acts as a protease that cleaves the viral replicase polyprotein and as a deubiquitinating (D
77 is suggests a link between G3BP proteins and viral replicase polyprotein processing, we propose that
78 ctivity designed to block translation of the viral replicase polyprotein was first confirmed by reduc
79 ssesses protease activity, which cleaves the viral replicase polyprotein, and also DUB activity (deco
80 ain-like protease (PLP), which processes the viral replicase polyprotein, has deubiquitinating (DUB)
81 icant delay in proteolytic processing of the viral replicase polyprotein.
82 ses (PLPs), PLP1 and PLP2, which process the viral replicase polyprotein.
83 us replication by cleaving a site within the viral replicase polyproteins and also removes ubiquitin
84 ain-like protease (PL(pro)) that cleaves the viral replicase polyproteins at three sites releasing no
85  the Hop-like Sti1, and the RH30 helicase in viral replicase preparations.
86            This result was noteworthy, since viral replicase proteins have seldom been described in d
87 istant membrane fractions, which contain the viral replicase proteins, in cells with replicating HCV.
88 A also resulted in aberrant agglomeration of viral replicase proteins, including NS5A, NS5B, and NS3.
89 anscript was amplified to high levels by the viral replicase, resulting in decreased viral production
90  fraction of the yeast extract, in which the viral replicase-RNA complex became RNase- and proteinase
91 lace in a membraneous fraction, in which the viral replicase-RNA complex was RNase and protease resis
92 ement for a trans-acting protein factor, the viral replicase subunit nsp1beta.
93  mechanisms that dictate the activity of the viral replicase, thereby paving the way for future studi
94 in to define the interactions needed for the viral replicase to complete synthesis of viral RNA.
95 e that there are major differences among the viral replicases to generate and maintain interviral rec
96 ion between N and the largest subunit of the viral replicase-transcriptase complex, nonstructural pro
97  the nonstructural protein 15 subunit of the viral replicase-transcriptase complex.
98                                          The viral replicase/transcriptase generated in SVCPC-infecte
99 ribonucleotides by abortive synthesis by the viral replicase using the 3' end of the viral genomic RN
100 e nature of the (-)RNA in the membrane-bound viral replicase, we performed complete RNA replication o
101 the putative RNA polymerase component of the viral replicase, were tested for their ability to suppor
102 ersion of several cellular proteins into the viral replicase, which otherwise play proviral roles in
103 RNA viruses [(+)RNA viruses] is performed by viral replicases, whose function is affected by many cel

 
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