ライフサイエンスコーパス: viral titer

1 d illness and later-time-point (day 6 to 10) viral titer.

2 (P < .05) that correlated with a decrease in viral titer.

3 s, infiltration of leukocytes, or changes in viral titer.

4 a sensitivity, it also resulted in decreased viral titer.

5 controls in the TG based on measurements of viral titer.

6 mph node responses and a lesser reduction in viral titer.

7 nated animals also showed reduced nasal wash viral titers.

8 e of the virus or a significant reduction of viral titers.

9 CD8(+) T cells into foci, modestly reducing viral titers.

10 d viral translation and, ultimately, overall viral titers.

11 les by 48 h postinfection, despite identical viral titers.

12 ed in delayed reovirus infection and reduced viral titers.

13 treatment that ultimately leads to increased viral titers.

14 NP396-specific T cell responses and reduced viral titers.

15 gain weight, and 10- to 100-fold higher lung viral titers.

16 neutralizing antibody responses, and reduced viral titers.

17 gen in cigarette smoke, resulted in enhanced viral titers.

18 n of ISG15 resulted in the reduction of FMDV viral titers.

19 e of CXCL10(-/-) mice, despite increased CNS viral titers.

20 t loss and clinical signs in the presence of viral titers.

21 istence enhances T-cell function and reduces viral titers.

22 BaP exposure also increased HPV16 and HPV18 viral titers.

23 ors, these mutants had drastically decreased viral titers.

24 ed apoptosis resulting in a dramatic drop in viral titers.

25 affected ZIKV protein and RNA levels but not viral titers.

26 bsence of TLR2 or TLR13 did not affect lytic viral titers.

27 cretion, which was associated with increased viral titers.

28 VZV glycoprotein biosynthesis and diminished viral titers.

29 ng failed to enhance TCD8 function or reduce viral titers.

30 ortality and showed drastically reduced lung viral titers.

31 l vectors and have no detrimental effects on viral titers.

32 ction led to a 2.5- to 5.5-log10 decrease in viral titers.

33 iral gene expression and increased pulmonary viral titers.

34 enged animals, coinciding with reductions in viral titers.

35 ginal HPV prime/boost reduced cervicovaginal viral titers 1,000-fold after intravaginal challenge wit

36 ic MCMV challenge, as evidenced by decreased viral titers (10(5) plaque-forming units to undetectable

37 rus using real-time RT-PCR across a range of viral titers (100-1,000,000 viral copies/mL) and enablin

38 igher anti-HIV activity than free darunavir (viral titer 2 to 2.6-fold higher in latter group).

39 effect was associated with a reduction in 1) viral titer, 2) viral gene expression, 3) IFN-gamma leve

40 o compared well to an additional data set on viral titer after experimental infection and treatment w

41 hose of other groups and had the lowest lung viral titers after challenge.

42 AS1411 results in a significant reduction of viral titers after DENV infection.

43 nization significantly reduced morbidity and viral titers after influenza challenge.

44 was accompanied by a millionfold increase in viral titer and a massive reduction in DWV diversity, le

45 Viral titer and bacterial load were compared following i

46 pulmonary function occurs 4 days after peak viral titer and correlates with infiltration of monocyte

47 h increases as each prior mutation increases viral titer and effective population size.

48 PD also had more severe infection (increased viral titer and pulmonary inflammation, and compromised

49 W) and basic (K and H) residues critical for viral titer and suggest that AII, BV2, and CP internal c

50 amivir to be efficient in reducing influenza viral titer and symptom intensity.

51 strate that these differences correlate with viral titer and that both the titer and expression diffe

52 observing a strong relationship between the viral titer and the proportion of influenza virus reads

53 ress gM, produced a 3- to 4-fold decrease in viral titers and a 50% reduction in average plaque sizes

54 ovir were both equally effective in reducing viral titers and decreasing the duration of viral sheddi

55 agglutinin stalk-immunized ferrets had lower viral titers and delayed or no virus replication at all

56 and CCR2-deficient mice exhibited increased viral titers and elevated expression of the liver enzyme

57 luenza virus infection led to decreased lung viral titers and enhanced survival.

58 +) T cells had significantly lower pulmonary viral titers and greatly improved pulmonary function as

59 eassortant virus also significantly improved viral titers and HA protein yield in eggs.

60 S and 2009 H1N1 viruses exhibited comparable viral titers and histopathologies following virus infect

61 , B6-lpr mice had decreased liver and spleen viral titers and increased numbers of and increased gamm

62 Ifnlr1(-/-) mice of higher intestinal tissue viral titers and increased viral shedding in the stool.

63 veral aspects of the HCMV replication cycle, viral titers and infected-cell processes.

64 ture infectious dose [TCID50]) in nasal wash viral titers and inflammation response.

65 Despite similar initial viral titers and inflammatory responses between wild-typ

66 fected Bax(-/-) mice had significantly lower viral titers and levels of activated caspase 3 in the br

67 species that belong to the same virus clade, viral titers and particle morphologies and compositions

68 imulation of autophagy resulted in increased viral titers and pathogenicity in the mouse.

69 their lungs were collected for evaluation of viral titers and pathological findings.

70 hich included prolonged viremia and elevated viral titers and persistence in the muscle, resulting in

71 on of the DNA damage response (DDR) enhances viral titers and prevents host DNA damage.

72 Viral titers and RNA analyses revealed that mutant viral

73 both types of infections showed increases in viral titers and severity of acute illness in Foxj1-Scgb

74 ceiving a single dose (25 mg/kg) had reduced viral titers and showed less lung tissue injury, despite

75 However, deleting ORF10 reduced viral titers and the extent of cutaneous lesions signifi

76 The depletion of iNKT cells increased both viral titers and the frequency of EBV-infected B cells.

77 Ocular viral titers and vaccinia-specific antibody titers were

78 Ocular viral titers and vaccinia-specific antibody titers were

79 In mice, nalmefene treatment increased viral titers and was associated with more pronounced wei

80 in the lung associated with markedly reduced viral titers and weight loss after challenge with H1 and

81 istic regression (P = 0.04) along with race, viral titer, and genotype.

82 FN-lambda reduced the disease severity, lung viral titer, and inflammatory response in the lung.

83 lpr) mice had decreased morbidity, decreased viral titers, and an increased percentage and number of

84 uced type I interferon production, increased viral titers, and enhanced cell sensitivity to viral inf

85 subsets increases mortality, sustains higher viral titers, and impairs pulmonary CD8 T cell responses

86 yed reduced viral gene expression, decreased viral titers, and improved survival compared to the untr

87 ng antibodies, morbidity postchallenge, lung viral titers, and inflammatory cytokines.

88 served only one nucleotide change, low heart viral titers, and no heart and liver pathology in adult

89 ed with rIL-33 developed significantly lower viral titers, and pancreatitis was attenuated.

90 infection, they do reduce weight loss, lower viral titers, and promote recovery of mice challenged wi

91 a virus infection enhanced survival, lowered viral titers, and reduced clinical disease.

92 Myocardial inflammation, viral titers, and viral RNA levels were also reduced sig

93 Viral structural gene expression, viral titers, and viral spread are also enhanced in endo

94 RNA viral titers are often suppressed in insects co-infected

95 rus-shedding rates than IHNV or where higher viral titers are required to initiate infection of naive

96 t secondary viral challenge by reducing lung viral titers as efficiently as immunization with RSV rec

97 3-methyladenine (3-MA) markedly reduced the viral titer, as determined by assays measuring both cell

98 At present, monitoring viral titer at sites of replication requires biopsy.

99 cell culture-derived particles (HEVcc) with viral titers between 10(5) and 10(6) FFU/mL.

100 spite there being no difference in mean lung viral titers between the groups.

101 dies, however, eliminated the differences in viral titers between the two groups, suggesting that the

102 6-lpr mice and eliminated the differences in viral titers between them.

103 after RSV infection) effectively reduced the viral titer but had a minimal effect on pulmonary inflam

104 n of unlicensed NK cells impaired control of viral titers, but depletion of licensed NK cells did not

105 SCP-null mutation decreased viral titer by 1,000 times and impaired but did not full

106 ty (CC(5)(0) = 30.9 +/- 1.1 muM) and reduced viral titer by 100-fold.

107 0 with 2.5 mM NVC-422 for 1 hour reduced the viral titer by 4 logs and 4.5 logs, respectively.

108 to a greater than 300-fold reduction in the viral titer by 48 h but had little effect on the number

109 , were highly efficacious, each reducing the viral titer by greater than 5.7 log10 compared to contro

110 cid changes (N133D/G198E) in the HA improved viral titer by more than 10-fold (reached a titer of 10(

111 CRISPR antivirals resulted in a reduction of viral titer by up to 92.97% for an individual target.

112 ith defects in 3' RNA processing and reduces viral titers by >10-fold.

113 Wortmannin (WM) and LY294002 (LY) increased viral titers by 3-16 folds in primary mouse macrophages,

114 (T) ] values, <30) and 6/13 samples with low viral titers (C(T) values, 30 to 40).

115 ced death in infected flies and increases in viral titers compared to those in WT flies.

116 in; however, it showed significantly reduced viral titers compared to those of the parental RABV stra

117 d by no loss in body weight and reduced lung viral titers compared to WT mice.

118 CVB3/0, had significantly higher mean heart viral titers compared with CVB3/0-infected adult mice.

119 .5% cidofovir significantly (P<0.05) reduced viral titers compared with tobramycin/dexamethasone or b

120 G(+) and CD8(+) cells dramatically increased viral titers, consistent with their synergistic but spat

121 ect viral replication, and respiratory tract viral titers correlate with both symptoms and measures o

122 Viral titers could be further enhanced by an HEV variant

123 onpermissive high temperatures, whereas high viral titers could be obtained at permissive low tempera

124 rus reads for 27/27 samples with mid-to-high viral titers (cycle threshold [C(T) ] values, <30) and 6

125 ng NAI drug efficacy using only the observed viral titer decay rates seen in patients.

126 viral replication than wild-type MEFs, with viral titers decreased at least 10-fold.

127 In contrast, the viral titers detected in the central nervous systems of

128 The reduction in viral titer downstream of PLD2 inhibition was dependent

129 g, (P = 0.008), and the mean combined ocular viral titer during the early (days 1-5; P = 0.0001) and

130 -/- mice had worsened survival and increased viral titers during infection, normal innate immune cell

131 blockade prevented TCD8 impairment, reduced viral titers during primary infection, and enhanced prot

132 ibody production are associated with lowered viral titers during the infection challenge.

133 Viral titer estimation, nucleocapsid gene amplification,

134 etrovirus-infected CD8-deficient I/LnJ mice, viral titers exceed the neutralizing capability of antiv

135 All mutant genomes tested showed reduced viral titers following growth in organotypic raft cultur

136 as well as increased and sustained pulmonary viral titers following influenza virus infection.

137 , decreased splenic pathology, and decreased viral titers from 10(6) pfu to undetectable levels.

138 Further, obese mice had elevated viral titers, greater lung inflammation and lung damage,

139 muM, SI > 100), which significantly reduced viral titer (>400,000-fold), and several analogs were sh

140 l E1A 10S and E1B 19k mRNA but not IIIa, and viral titers had fallen two logs by day 4 after injectio

141 of cellular responses by rapid reduction of viral titer, have been proposed.

142 d the cellular targets of infection, maximal viral titers, immune response to the viral infection, an

143 distinct viral types that differ 100-fold in viral titer in infected individuals, with similar differ

144 stically significant reduction (P < 0.05) in viral titer in liver and spleen at day 5 postinfection (

145 BAL response correlated with a reduction in viral titer in nasal swabs and lungs, following challeng

146 has similar sensitivity as the corresponding viral titer in phosphate buffer despite the presence of

147 In contrast, the mortality rate and viral titer in the brains of mice inoculated intracrania

148 The mortality rate and viral titer in the brains of mice inoculated intraperito

149 that succumbed to infection, including high viral titers in all organs, increased levels of liver fu

150 uced NS3 and E proteins and generated higher viral titers in amniotic epithelial cells from mid-gesta

151 ultimately resulted in significantly reduced viral titers in both A549 and differentiated normal huma

152 ral clearance in the periphery and increased viral titers in brain.

153 mportantly, WNV grew to significantly higher viral titers in chop(-)(/)(-) mouse embryonic fibroblast

154 ith ANDV hantavirus pulmonary syndrome, high viral titers in combination with attendance at massive s

155 for IFN-beta in control of WNV replication, viral titers in ex vivo cultures of macrophages, dendrit

156 result of failure in viral clearance because viral titers in granzyme B-deficient mice were similar t

157 itinib in WT mice resulted in 10-fold higher viral titers in heart tissues while suppressing by about

158 and reduced expression of viral proteins and viral titers in influenza virus-infected human lung aden

159 ring the primary infection did not influence viral titers in lung tissue.

160 Moreover, BST2(-/-) mice had lower viral titers in lungs following intranasal infection wit

161 the HBV enhancer I that contribute to higher viral titers in men.

162 In contrast, sunitinib had no effect on viral titers in mice deficient in both RNase L and PKR.

163 onstructs, were able to significantly reduce viral titers in nasal turbinates, lungs, and olfactory b

164 The observed increases in viral titers in NLRC5-deficient mice correlated with imp

165 msters with both viruses resulted in similar viral titers in respiratory tissues and pulmonary diseas

166 ntrast, HSV-2-infected GT KO mice had higher viral titers in spleen and liver and exhibited significa

167 ponse correlated with an improved control of viral titers in target organs after the development of t

168 5TERM P-PMO treatment reduced viral titers in target organs and protected mice against

169 Later, others reported decreased AD169 viral titers in the absence of ATM.

170 Concordantly, viral titers in the blood were higher following infectio

171 control the virus, exhibited persisting high viral titers in the brain after day 6, and died of viral

172 nstrate that death correlates with increased viral titers in the brain and that this loss of virus co

173 Importantly, the decreased viral titers in the brains of mice infected with the mut

174 matory response, leading to the reduction of viral titers in the CNS and survival of animals.

175 XCL10-/- mice possessed significantly higher viral titers in the CNS in comparison to WT mice consist

176 ted WT and CXCL1(-/-) mice possessed similar viral titers in the cornea during late acute infection.

177 This was associated with increased viral titers in the heart, increased left ventricular ma

178 RV-Ravn caused uncontrolled viremia and high viral titers in the liver, spleen, lymph node, and other

179 d with SARS-CoV-2, and this resulted in high viral titers in the lung, lung pathology, and weight los

180 Furthermore, viral titers in the mosquito saliva were lower for ZIKVD

181 novel H1N1 influenza virus and assessed for viral titers in the nasal wash, morbidity, and mortality

182 ce at the time of infection modestly reduced viral titers in the nervous system suggesting in additio

183 Viral titers in the spleens, livers, lungs, and salivary

184 Viral titers in the tear film were determined by plaque

185 challenged with wild-type RSV A, DB1 reduced viral titers in the upper and lower airways by 3.8 log10

186 Correspondingly, viral titers in the upper-and lower-respiratory tract we

187 ptible to SeV than Ifit2(-/-) mice, although viral titers in their lungs were even higher.

188 In addition, appreciable viral titers in this first human may enable infection of

189 UL24-betagluc replicated to wild-type viral titers in three different cell lines.

190 tment with favipiravir significantly reduced viral titers in tissue samples and reduced mortality rat

191 ) infection and regulates fecal shedding and viral titers in tissue.

192 indicated by maintained weight and low lung viral titers in treated animals, the passive transfer of

193 and IFN-lambda, which resulted in decreased viral titers in vitro and in vivo.

194 rence of PLD delayed viral entry and reduced viral titers in vitro.

195 om mice that had been exposed to the highest viral titers in vivo induced the lowest levels of T cell

196 cells cultured with DC exposed to increasing viral titers in vivo resulted in a gradually decreased T

197 mice caused a significant reduction in lung viral titers, in contrast to those from control CII(-/-)

198 8+ cells from brain slices, and intratumoral viral titers increased 10-fold.

199 Intratumoral viral titers increased 5-fold.

200 By day 3 p.i., viral protein expression and viral titers increased dramatically in NPSCs with result

201 he percentage of DV-infected K562 cells, and viral titer (infected K562 cell supernatants) was measur

202 IFN-alpha showed significantly reduced lung viral titers, inflammation, and clinical disease than un

203 ding evidence that the observed reduction in viral titers is ISG15 dependent.

204 l challenge, as demonstrated by undetectable viral titers, lack of body weight loss, and a significan

205 d not alter resistance to viral infection or viral titer levels, suggesting that the main antiviral r

206 se of disease, as determined by weight loss, viral titers, levels of neutralizing Ab, and lung pathol

207 atment for at least 3 weeks during declining viral titers mitigated the programmed contraction of CD8

208 enhanced virion production nearly 5-fold and viral titers more than 10-fold.

209 A two-log reduction in viral titers occurred despite blocking the cytotoxicity

210 ected in single living cells infected with a viral titer of 2 x 10(3.6) 50% tissue culture infective

211 orylated motif of MLV p12 and can rescue the viral titer of a strain with the lethal p12-PM14 mutatio

212 NVC-422 reduced the viral titer of HAdV-5, HAdV-8, HAdV-19, HAdV-37, and HSV

213 ne silencing and knockout events can enhance viral titers of both attenuated (Sabin strain) and wild-

214 dependent and sequence-specific reduction in viral titers of greater than 5 log(10), with a concomita

215 in vivo prolonged survival and reduced lung viral titers of mice challenged with influenza virus, as

216 K cells, macrophages, or microglia increased viral titers of oHSV in cocultures with glioblastoma cel

217 Following virus infection, the survival and viral titers of Piwi, Aubergine, Argonaute-3, and Zucchi

218 ifs into the AAV capsid without compromising viral titer or infectivity.

219 ment to the infected brain have no effect on viral titer or survival following infection with a virul

220 educed c-Jun activation without altering the viral titer or viral antigen distribution.

221 deletions in HIV-based vectors do not alter viral titers or the in vitro and in vivo properties of t

222 in ferrets, delayed 81.39a treatment reduced viral titers, particularly in the lower respiratory trac

223 0(Old)) exhibited significantly higher heart viral titers, pathology, and weight loss than adult mice

224 (-/-)7(-/-) mice 24 hpi, at which time point viral titers peaked and started to be cleared.

225 Viral titers peaked at approximately 1 x 10(6) PFU on da

226 In addition, lung H1N1 viral titers post-challenge correlated to serum antibody

227 affected neural cell syncytia formation and viral titers postinfection in vitro Transcranial inocula

228 h and that inhibiting p53 leads to increased viral titers, potentially through modulation of the inte

229 ted in reductions in lethality, weight loss, viral titers, proinflammatory cytokine and chemokine exp

230 ies, which were found to correlate well with viral titer (r2=0.96, P<0.001 for D2R80A; r2=0.98, P<0.0

231 can explain differential phenotypes such as viral titer, receptor binding, and tissue tropism exhibi

232 to additional evaluation using an authentic viral titer reduction assay employing an epidemic strain

233 of the DENV2proHeLa system were confirmed by viral titer reduction assays.

234 y was confirmed through a plaque assay where viral titer reduction was observed in the presence of se

235 th influenza A exhibited 2.75-log-fold lower viral titer relative to control mice.

236 malian cell types, although at the same time viral titers remain relatively low.

237 because even infections associated with high viral titers responded to reduction in immunosuppression

238 supernatant but had nearly 1,000-fold-higher viral titers, resulting in an increased specific infecti

239 Administration of PF-04178903 did not alter viral titers, severity of secondary bacteria infections

240 lian isolate demonstrated tissue tropism and viral titers similar to those of historical Lassa virus

241 vealed that all recombinant viruses produced viral titers similar to those produced by the wild-type

242 ed in a DENV-infected mouse model by reduced viral titers, soluble NS1 levels, mouse tail bleeding ti

243 r PP2 demonstrated a 2- to 4-log decrease in viral titers, suggesting that SFK activity is required f

244 cific CD8(+) T cells, in the absence of high viral titers, sustained proinflammatory cytokine product

245 rovement in cycle threshold value across all viral titers tested was 3.1.

246 -7.5 cells to produce nearly 100-fold-higher viral titers than the parental strain.

247 ated by conventional methods for determining viral titer that high concentrations of BaP increase HPV

248 en after multiple passages to achieve higher viral titers that result in clinical disease such as wei

249 cytokine expression concomitant with reduced viral titers, thereby protecting mice from lethal infect

250 Males transmit lower viral titers through sperm than females transmit through

251 There was little difference in viral titer throughout the infection between the line 19

252 oth a delay in growth and a decrease in peak viral titer to approximately 10(4) PFU/ml.

253 ghly active antiretroviral therapy can lower viral titers to an undetectable level.

254 B plus PD-L1 blockade resulted in rebound of viral titers to original levels, the low dose of anti-4-

255 aches the brain stem) reduced nervous system viral titers to undetectable levels but did not alter br

256 nduced weight loss and mortality by reducing viral titers to undetectable levels throughout the cours

257 d an increased virulence compared to the low viral titer type.

258 d that depending on the viral entity and the viral titer used for stimulation, induction of IFN-alpha

259 For about 50% of patients, the curve of viral titer versus time has two peaks.

260 y activation to the BaP-mediated increase in viral titer was determined by Erk pathway inhibition wit

261 ve mechanism for explaining this increase in viral titer was lacking.

262 he supernatant, but the observed increase in viral titer was not mirrored by an increase in infectivi

263 findings reveal that the early (day 0 to 5) viral titer was not the determining factor in the outcom

264 The reduction in viral titer was observed even when Roscovitine was first

265 Mean viral titer was similar in older and younger children.

266 A small reduction of viral titers was detected on day 5 in ferrets infected w

267 ed mice exhibited significantly reduced lung viral titers, weight loss, and pulmonary dysfunction com

268 a IFNR-deficient (CD118(-/-)) mice, although viral titers were 2- to 3-fold higher in cornea and TG c

269 Peak viral titers were 46-fold higher in Hep3B transfected wi

270 To measure effectiveness, viral titers were analyzed in cornea and trigeminal gang

271 Survival, weight loss, and viral titers were assessed over a 14-day study period.

272 various doses of GCV and ACV, and infectious viral titers were determined by a green Raji cell assay.

273 ction were determined immunohistochemically, viral titers were determined by plaque assay, and pathol

274 Following corneal infection, HSV-1 viral titers were elevated in the nervous system of CXCL

275 When viral titers were examined, high levels were initially o

276 sion and protein production were reduced and viral titers were increased in IRF-7(-/-) primary macrop

277 By day 7 posttreatment, viral titers were lower in both of the combined regimens

278 However, lung viral titers were markedly elevated in COX-2-/- mice rel

279 ed ferret nasal turbinate cells, and similar viral titers were measured in the nasal turbinates of in

280 Pulmonary viral titers were not different between strains and path

281 High viral titers were obtained from nasal turbinates and lun

282 h disease was also significantly reduced and viral titers were reduced by 1 log at 24 hours postinfec

283 cation proceeded through the late phase, but viral titers were reduced.

284 DWV viral titers were significantly negatively correlated wi

285 Viral titers were significantly reduced on some days aft

286 Since viral titers were too low, complete serotyping was not p

287 ted reduced weight loss, mortality, and lung viral titers when treated with their susceptible NAIs, c

288 ses; influenza cross-reactive T cells reduce viral titers, whereas Abs to nucleoprotein suppress indu

289 f JMJD2A, an H3K9me3 demethylase, attenuates viral titers, whereas its overexpression increases KSHV

290 in a 10-fold increase in HPV type 31 (HPV31) viral titers, whereas treatment with low concentrations

291 g adaptive immunity as manifest by increased viral titers, with an associated loss of its protective

292 tors, namely, CXCR3 and CCR2, does not alter viral titers within the brain but markedly reduces infla

293 by reduced T cell infiltration and increased viral titers within the brain suggesting that CXCL10 fun

294 and associated with a dramatic reduction in viral titers within the CNS, followed by viral persisten

295 sed mortality that correlated with increased viral titers within the CNS.

296 However, NKG2D neutralization increased viral titers within the liver, suggesting a protective r

297 fficiency (at least a 4-log reduction in the viral titer) within minutes, as well as the airborne hum

298 m(6)A in one viral genomic region increases viral titer without affecting RNA replication.

299 unrestricted in HUHEP mice resulting in high viral titers without pathologic effects.

300 le dramatically enhancing Ad replication and viral titer yields, characteristics indistinguishable fr