ライフサイエンスコーパス: virulence factor

1 ient to sustain the function of an important virulence factor.

2 -glutamyltransferase enzyme (GGT) as a novel virulence factor.

3 of the A. fumigatus biofilm matrix and a key virulence factor.

4 oxins (MARTX) toxin is an important secreted virulence factor.

5 has conferred functional versatility to this virulence factor.

6 se mechanisms of this important Lyme disease virulence factor.

7 ntibody response against a key streptococcal virulence factor.

8 annii pathogenesis, supporting its role as a virulence factor.

9 Tarp effector as a bona fide C. trachomatis virulence factor.

10 ession of more than a dozen immunomodulatory virulence factors.

11 responsive aphid gene family that operate as virulence factors.

12 to encode mobile genetic elements as well as virulence factors.

13 UAMS-1, potentially due to isolate-specific virulence factors.

14 tion, cell envelope lipids are mycobacterial virulence factors.

15 is critical for the production of S. aureus virulence factors.

16 ad of antibiotic-resistance determinants and virulence factors.

17 erial capsular polysaccharides are important virulence factors.

18 the acquisition of antibiotic resistance and virulence factors.

19 deubiquitinating activity, are two important virulence factors.

20 ative cell-surface and membrane-anchored MIP virulence factors.

21 subvert host cell functions by using various virulence factors.

22 nction of these critical periodontal disease virulence factors.

23 putative member of the OmpW family of porins/virulence factors.

24 integrity highlights the importance of these virulence factors.

25 associated with strains expressing acquired virulence factors.

26 cell envelope or beyond, including bacterial virulence factors.

27 ion systems that export a range of bacterial virulence factors.

28 imultaneous inactivation of several types of virulence factors.

29 ciated diseases is determined by a number of virulence factors.

30 rectly regulates the two primary V. cholerae virulence factors.

31 rns, such as the ones found for pneumococcal virulence factors.

32 ion pathway involving SigB regulation of key virulence factors.

33 one approach is the targeting of established virulence factors.

34 nated expression of genes encoding different virulence factors.

35 S virulence phenotype as defined by secreted virulence factor activity in vitro and tissue destructio

36 rbacterial inhibition system and a bacterial virulence factor against a mammalian host.

37 Escherichia coli secreting the pore-forming virulence factor alpha-hemolysin (HlyA).

38 n by the host and S. aureus secretion of the virulence factor, alpha-hemolysin (Hla).

39 mily, that we recently showed functions as a virulence factor alternating the host's immune response

40 bacterial infections by the dissemination of virulence factors amongst bacterial hosts.

41 the FSA from Foc TR4 functions as a positive virulence factor and acts at the early stage of the dise

42 of S-layer protein A (SlpA), which is a key virulence factor and an absolute requirement for disease

43 WGSA revealed heterogeneity in virulence factor and antimicrobial resistance genes carr

44 d on investigating the role of MHO_0730 as a virulence factor and demonstrated that MHO_0730 is a sur

45 ate the understanding of LtxA as a bacterial virulence factor and development of it as a potential th

46 protein, encoded by the emm gene, is a major virulence factor and vaccine candidate and forms the bas

47 It is a major virulence factor and was used in previous studies in the

48 ntified include a combination of established virulence factors and a larger set of seemingly more mun

49 positive bacteria leads to a rapid spread of virulence factors and antibiotic resistance.

50 cterial strains from these babies identified virulence factors and clinically relevant antimicrobial

51 they are also involved in the production of virulence factors and conferring resistance to various a

52 l hydrocarbon receptor (AhR), which binds TB virulence factors and controls antibacterial responses.

53 A, dupA, and vacA); the relationship between virulence factors and gastroduodenal diseases among pati

54 h kinase, including phosphosites on parasite virulence factors and host erythrocyte proteins.

55 he accumulation and distribution of secreted virulence factors and in the impact of extracellular pro

56 phage regions, a CRISPR-Cas system, numerous virulence factors and no relevant antibiotic resistance

57 dly altered, leading to release of microbial virulence factors and proinflammatory mediators to surro

58 tween clinical and environmental isolates in virulence factors and stress response genes.

59 her T. pallidum genes encoding putative OMPs/virulence factors and that is often employed as a strate

60 tanding of the relationship between S aureus virulence factors and the immune system is continuously

61 tly binds to the promoters of genes encoding virulence factors and to master regulators of virulence.

62 age nucleotide identity, 2) determination of virulence factors and undesirable genes, 3) determinatio

63 n the murine host identifies novel and known virulence factors and we confirm results using cloned kn

64 PrgB is a strong virulence factor, and PrgA is involved in post-translati

65 d readily available information on serotype, virulence factors, and antimicrobial resistance genes.

66 ulator to directly control the expression of virulence factors, and by doing so, tempers its pathogen

67 sicles (OMVs) that package genetic elements, virulence factors, and cell-to-cell communication signal

68 re consistent with RD2 directly, via encoded virulence factors, and indirectly, via encoded regulator

69 We investigated how two A. haemolyticum virulence factors, arcanolysin (ALN) and phospholipase D

70 ith proteomics, we revealed that a number of virulence factors are differentially regulated in the ab

71 and mechanism of action of its repertoire of virulence factors are lacking.

72 it autophagy, but the precise mechanisms and virulence factors are mostly unknown.

73 This method of regulation suggests that virulence factors are only utilized in early infection t

74 ential it is largely unclear which bacterial virulence factors are responsible for increased clinical

75 ion of innate immune receptors and bacterial virulence factors as well as the analysis of human humor

76 tification and characterization of important virulence factors, as well as serve as a surrogate model

77 anscript analysis (RNA sequencing), in vitro virulence factor assays, and mouse and nonhuman primate

78 t encode 80 genes, including novel and known virulence factors associated with adherence and autoaggr

79 In this sense, the identification of virulence factors associated with changes in ZIKV virule

80 e mouse models of lung infection to identify virulence factors associated with severe bacteraemic pne

81 expression of multiple chromosomally-encoded virulence factors besides T6SS.

82 ly reduced production of secreted toxins and virulence factors but increased surface protein A abunda

83 ses a polysaccharide capsule that is a major virulence factor, but is challenging to study.

84 of Streptococcus pneumoniae is an important virulence factor, but the mechanisms that regulate capsu

85 r abscesses in humans worldwide and contains virulence factor capsular polysaccharides and lipopolysa

86 scription factor csvR, and the putative ETEC virulence factor cexE.

87 in four diverse amoebae, defining universal virulence factors commonly required in all host cell typ

88 terium tuberculosis (Mtb) SapM is a secreted virulence factor critical for intracellular survival of

89 main drivers of protective mucosal immunity; virulence factor-deficient, like killed, bacteria show r

90 Schu S4 infection, consistent with a role in virulence factor delivery to host cells.

91 d thus indirectly stabilizes mRNA of a known virulence factor, delta-amastin surface antigen.

92 ella enterica serovar Enteritidis requires a virulence-factor-dependent increase in epithelial oxygen

93 lenged commensal Escherichia coli MG1655 and virulence factor-depleted E. coli C600 strains with ente

94 n germ-free mice to show that live bacterial virulence factor-driven immunogenicity can be uncoupled

95 as a pleiotropic regulator of flotation and virulence factor elaboration in this strain.

96 e compounds were able to reduce QS-regulated virulence factors (elastase, rhamnolipid, and pyocyanin)

97 Protective IgG largely recognizes virulence factors encoded within the locus of enterocyte

98 g assembly that translocates a wide range of virulence factors, enzymes and effectors through the out

99 The Mycobacterium tuberculosis virulence factor EsxA and its chaperone EsxB are secrete

100 Mtb Type VII secretion machine and its major virulence factor EsxA.

101 This study reveals NTHI1441 as a novel NTHi virulence factor expressed during infection of the COPD

102 sufficient to impact the growth kinetics of virulence factor-expressing cells.

103 tional alterations in bacteria, which enable virulence factor expression and biofilm formation.

104 on our current understanding of heterogenous virulence factor expression and discuss the evidence tha

105 relies on its ability to precisely fine-tune virulence factor expression in response to rapidly chang

106 that supports or refutes the hypothesis that virulence factor expression is linked to slowed growth a

107 It still remains unclear whether virulence factor expression is truly energetically costl

108 DSFs regulate diverse phenotypes, including virulence factor expression, antibiotic resistance, and

109 challenging to study how pneumococci control virulence factor expression, because cues of natural env

110 es have shown host cell interactions promote virulence factor expression, forcing subsets of bacteria

111 microaerobic environments, which influences virulence factor expression.

112 LtxA acts as a virulence factor for A. actinomycetemcomitans by binding

113 cytosolic O(2) (*-)-catabolizing enzyme as a virulence factor for CD.

114 We report a bacterial virulence factor for evasion of platelet-mediated innate

115 xpansin proteins may be an under-appreciated virulence factor for many pathogen species.

116 Typhoid toxin is a virulence factor for the bacterial pathogen Salmonella T

117 se infection, identifying this receptor as a virulence factor for transmission.

118 eria and evidence indicates that they act as virulence factors for host infection.

119 III protein secretion systems are essential virulence factors for many important pathogenic bacteria

120 several debilitating diseases, and NSTs are virulence factors for many pathogens.

121 re pore-forming proteins that serve as major virulence factors for pathogenic bacteria.

122 e range of plant pathogens that use numerous virulence factors for pathogenicity and fitness in plant

123 aureus mutants can regain expression of key virulence factors for survival in the bloodstream was in

124 o induce inflammation and show that multiple virulence factors from the same pathogen with conserved

125 The Agr system controls virulence factor gene expression in S. aureus by sensing

126 Overall, virulence factor gene expression is also higher in vivo

127 mplification through AgrC/A and induction of virulence factor gene expression.

128 ed detection of antimicrobial resistance and virulence factor genes.

129 locations included expression of Salmonella virulence factors, genes involved in pertussis, and anti

130 ow that DKP formation en route to the fungal virulence factor gliotoxin requires a seemingly extraneo

131 we show that NleDs form a growing family of virulence factors harbored by human and plant pathogens

132 tion biology of A. baumannii, and only a few virulence factors have been characterized, including lip

133 ion system 5 (T6SS-5), which is an essential virulence factor in both species.

134 human colonoids, suggesting a role for this virulence factor in EAEC colonization of the gastrointes

135 and we identify a new role for T6SS as a key virulence factor in gastrointestinal infection.

136 e findings confirm that galactofuranose is a virulence factor in M. mycoides.

137 ualifies ClpG as a potential persistence and virulence factor in P. aeruginosa.

138 The exotoxin TcsL is a major virulence factor in Paeniclostridium (Clostridium) sorde

139 study reveals a role for EndoU activity as a virulence factor in PEDV infection and provides an appro

140 used by the related enzyme LicC, which is a virulence factor in Streptococcus pneumoniae.

141 s study, OSP24 is identified as an important virulence factor in systematic characterization of the 5

142 SS), widely considered to be the most potent virulence factor in the P. aeruginosa arsenal, and also

143 NA thermometer as a bona fide S. dysenteriae virulence factor in this bacterial pathogen.

144 Putative virulence factors in K. aerogenes may account for these

145 s are believed to be suppressed by Y. pestis virulence factors in order to prevent clearance, while l

146 Capsular polysaccharides are important virulence factors in pathogenic bacteria.

147 1 expression, indicating active secretion of virulence factors in pathogenic M. tuberculosis contribu

148 Phospholipase C (PLC) enzymes are key virulence factors in several pathogenic bacteria.

149 l regulation to coordinate the expression of virulence factors in tandem with the core genome is a ha

150 efined; 3) the regulatory organization of 65 virulence factors in the form of three i-modulons associ

151 grown cells and their enhanced production of virulence factors in the intestine underpin the biofilm

152 was not associated with single C. neoformans virulence factors in vitro or in vivo; rather, a trend i

153 We emphasize the virulence factors in xanthomonads, such as type III secr

154 ression of hundreds of genes, including most virulence factors, in response to the availability of ke

155 Quorum sensing controlled virulence factors include secreted toxins responsible fo

156 nslocation of eleven expression-optimized Bb virulence factors, including the signal sequence, to the

157 ar pathogen harboring the surface-associated virulence factor InlB, which enables entry into certain

158 The secreted Listeria virulence factor InlC associated with the exocyst compon

159 The virulence factor intimin is essential for the attachment

160 n, rhoptries inject an array of invasion and virulence factors into the cytoplasm of the host cell, b

161 recent First Pandemic strains affecting two virulence factors, intriguingly overlapping with a delet

162 cus aureus protein A, an important S. aureus virulence factor involved in immune evasion and biofilm

163 The most potent H. pylori virulence factor is cytotoxin-associated gene A (CagA),

164 ystone pathogen, and its Lys-gingipain (Kgp) virulence factor is involved in the pathogen-host intera

165 One important virulence factor is its urease enzyme, which requires ni

166 an opportunistic bacterium of which the main virulence factor is the Type III Secretion System.

167 ation reaction that inhibits the activity of virulence factors is activated by host-factor-dependent

168 on sensing and metal-dependent expression of virulence factors is also discussed.

169 One of its key antifungal virulence factors is the type IV pili that are required

170 The plasmid-encoded pGP3, a genital tract virulence factor, is essential for Chlamydia muridarum t

171 Viruses evade antiviral RNAi by expressing virulence factors known as viral suppressors of RNAi (VS

172 omplex, is required for the transport of the virulence factor laccase to the cell wall in Cryptococcu

173 inhibitory factor (MIF) cytokine homolog, a virulence factor linked to severe disease.

174 y detect and map the Gram-negative bacterial virulence factor lipid A derived from lipopolysaccharide

175 es (adhE, pflA, nrdDG) and a large number of virulence factors (lukSF, lukAB, nuc, gehB, norB, chs, s

176 n, subcompartmentalization and the export of virulence factors, making its functional molecules attra

177 ies by 18- to 210-fold, including the silent virulence factor malleilactone.

178 egative pathogens where they function as key virulence factors, many aspects of their biology remain

179 ydial chromosomal-gene-encoded genital tract virulence factors may be essential for Chlamydia to main

180 y as our previous work has shown C. albicans virulence factor modulation by oral bacteria.

181 red to homogenous knock-out lines of the key virulence factor MYR1.

182 To identify novel K. pneumoniae virulence factors needed to cause pneumonia, a high-thro

183 The HIV-1 virulence factor Nef promotes high-titer viral replicati

184 gonize key immune defence mechanisms via the virulence factor non-structural protein 1 (NS1).

185 to be defined, due to the large variation of virulence factors observed in UPEC strains.

186 ional response of human small intestine to a virulence factor of a pathogenic intestinal bacterium, h

187 of the pore-forming toxin tolaasin, the main virulence factor of brown blotch disease.

188 rgets, controls fungal morphogenesis - a key virulence factor of C. albicans.

189 he M protein is the major surface-associated virulence factor of group A Streptococcus (GAS) and an a

190 The principal virulence factor of human pathogenic enterohemorrhagic E

191 CpaA is also a virulence factor of medically relevant Acinetobacter str

192 synthesis of diterpene isotuberculosinol, a virulence factor of Mycobacterium tuberculosis as a repr

193 immuno globulin gamma (IgG) interaction with virulence factor of S. aureus, staphylococcal protein A

194 Typhoid toxin is a virulence factor of Salmonella enterica serovar Typhi, t

195 Pneumolysin (PLY), a major virulence factor of Streptococcus pneumoniae, perforates

196 galactosaminogalactan (GAG) is an important virulence factor of the fungal pathogen Aspergillus fumi

197 Phthiocerol dimycocerosate (DIM) is a major virulence factor of the pathogen Mycobacterium tuberculo

198 Among the virulence factors of B. anthracis is the S-layer-associa

199 Lethal and edema toxins are critical virulence factors of Bacillus anthracis.

200 e of the gut vascular barrier in response to virulence factors of enteric pathogens.

201 lytic uremic syndrome (HUS) and are the main virulence factors of enterohemorrhagic Escherichia coli

202 Tc toxin complexes are virulence factors of many bacteria, including insect and

203 As important virulence factors of Mycobacterium tuberculosis, EsxA an

204 Toxin complex (Tc) toxins are virulence factors of pathogenic bacteria.

205 The virulence factors of this bacterium and their interactio

206 Noncapsular virulence factors on the pneumococcus are thought to fac

207 Bacterial virulence factors or effectors are proteins targeted int

208 Many pathogens deliver virulence factors or effectors into host cells in order

209 ough factors encoded in their genomes (often virulence factors) or by disrupting host genes as a resu

210 are limited examples of direct regulation of virulence factors, PASTA kinases are critical for virule

211 leton and trafficking of the adhesin and key virulence factor PfEMP1 to the host cell surface.

212 The HIV-1 Nef virulence factor prevents viral incorporation of SERINC5

213 Pyocyanin is a virulence factor produced as a secondary metabolite by t

214 Anthrax lethal toxin (LT) is a protease virulence factor produced by Bacillus anthracis that is

215 emagglutinin (FHA) is a critically important virulence factor produced by Bordetella species that cau

216 Among the multiple virulence factors produced by EAEC, the Pic serine prote

217 ABC toxins are pore-forming virulence factors produced by pathogenic bacteria.

218 The effects of indole on virulence factor production and biofilm were linked to T

219 mutant, and ompR deletion partially restored virulence factor production in the RND-negative backgrou

220 repress genes involved in acid tolerance and virulence factor production.

221 olved in metabolism, biofilm production, and virulence factor production.

222 atory genes for contributions to V. cholerae virulence factor production.

223 ses genes required for biofilm formation and virulence factor production.

224 Quorum sensing (QS) controls biofilm and virulence factors production.

225 phenotypes, such as growth, differentiation, virulence-factor production, and stress responses.

226 The Pseudomonas virulence factor (pvf) operon is essential for the biosy

227 O-C(12)-homoserine lactone, and QS-regulated virulence factors pyocyanin and protease.

228 eas TcdA and TcdB are considered the primary virulence factors, recent studies suggest that CDT incre

229 In an effort to disentangle hypha-associated virulence factor regulation from morphological transitio

230 a no longer causes inflammation, its mucosal virulence factors remain the main drivers of protective

231 Targeting virulence factors represents a promising alternative app

232 type three secretion system, which is a key virulence factor required for host colonization, through

233 protein tyrosine phosphatase B (mPTPB) is a virulence factor required for Mtb survival in host macro

234 tem (T6SS) and type 1 fimbriae are important virulence factors required for gastrointestinal infectio

235 IV secretion system (T4SS) is one of the key virulence factors required for intracellular bacterial r

236 tor (agr) operon to coordinate expression of virulence factors required for invasive infection.

237 Biofilm formation is a key virulence factor responsible for a wide range of infecti

238 s pneumoniae secrete a giant metalloprotease virulence factor responsible for cleaving host IgA1, yet

239 The virulence factor S. suis adhesin P (SadP) recognizes the

240 Part of the virulence factors secreted by P. gingivalis are the esse

241 oluminescence production, biofilm formation, virulence factor secretion systems, and competence.

242 targeting virulence via toxin production and virulence factor secretion, impeding bacterial adhesion

243 Some virulence factors serve to maintain the integrity of the

244 Pde2 were critical to the production of the virulence factor SpeB and to the overall virulence of S.

245 reptococcus pyogenes, production of secreted virulence factor SpeB is controlled by a quorum-sensing

246 directly regulated genes encode the key GAS virulence factors Streptolysin S, PrtS (IL-8 degrading p

247 tilize dedicated secretion systems to export virulence factors such as exotoxins and effectors(1-4).

248 In addition, production of several virulence factors, such as BosR, RpoS, and OspC, was ele

249 In particular, bacteria use virulence factors, such as secreted toxins and effector

250 Bacterial virulence factors, such as the oncoprotein CagA, augment

251 nfection are centered on core metabolism and virulence factor synthesis.

252 ile infection (CDI) is largely caused by two virulence factors, TcdA and TcdB.

253 FHbp) is an important Neisseria meningitidis virulence factor that binds a negative regulator of the

254 xin TcdB is a major Clostridioides difficile virulence factor that contributes to inflammation and ti

255 d, our results reveal a novel ExsA-regulated virulence factor that cooperatively inhibits the functio

256 lysin (CDC) family, is a major S. pneumoniae virulence factor that generates ~25-nm diameter pores in

257 vator protease (Pla) is a critical Y. pestis virulence factor that is important for early bacterial g

258 of phospholipase C (plcC), which is a major virulence factor that makes M. abscessus highly cytotoxi

259 ata indicate that LprE (Mtb) is an important virulence factor that plays a crucial role in mycobacter

260 e conclude that PEDV EndoU activity is a key virulence factor that suppresses both type I and type II

261 Its genome encodes an arsenal of virulence factors that allow it, when required, to switc

262 ally important pathogen with an abundance of virulence factors that are necessary for survival within

263 a few yeast-specific transcripts, including virulence factors that are normally expressed only at 37

264 rally-encoded glycosphingolipids (vGSLs) are virulence factors that are produced by the activity of v

265 ycobacterium tuberculosis, is facilitated by virulence factors that are secreted by type VII secretio

266 e results identify nsp1, nsp15, and nsp16 as virulence factors that contribute to the development of

267 ive bacterium Staphylococcus aureus produces virulence factors that impede macrophages and other immu

268 s interaction with human lungs and to define virulence factors that incapacitate pulmonary cells.

269 Cell envelope lipids are also mycobacterial virulence factors that influence the host immune respons

270 ssesses an arsenal of secreted host-damaging virulence factors that mediate pathogenicity and blunt i

271 Plasmodium parasites contain various virulence factors that modulate the host immune response

272 usative agent of tuberculosis, are important virulence factors that modulate the host immune response

273 streptococci, and borrelia, likewise produce virulence factors that promote fibrin degradation.

274 S. aureus expresses a variety of virulence factors that promote infection with this patho

275 Among predicted virulence factors, the presence of phospholipase C (plcC

276 furthering our knowledge of this Pseudomonas virulence factor, this study provides an intriguing exam

277 ase through an arsenal of pathogen-specific "virulence factors." This narrow definition has been repe

278 ected bone may recover the expression of key virulence factors through a rapid microevolution pathway

279 human colonic epithelium by the injection of virulence factors through a type 3 secretion system (T3S

280 ian or swine influenza viruses that acquired virulence factors through adaptive mutation or reassortm

281 e acquisitions of the SCCmec element and key virulence factors throughout the evolution of the ST45 l

282 necessity of evaluating the contribution of virulence factors to pathogenesis in the presence of mul

283 itecture that boasts an arsenal of candidate virulence factors to rival that of its better-characteri

284 ctive antivirulence drug targets that attach virulence factors to the surface of Staphylococcus aureu

285 of the capsule operon, the main pneumococcal virulence factor, to be externally inducible (YES gate)

286 ype II secretion systems (T2SSs) translocate virulence factors, toxins and enzymes across the cell ou

287 B. pertussis virulence factor tracheal cytotoxin (TCT), a secreted pe

288 ined vectors to encode Plasmodium falciparum virulence factors: two cysteine-rich interdomain regions

289 ion characteristics, and may be specific for virulence factor VacA.

290 responses to 13 H pylori proteins, including virulence factors VacA and CagA.

291 Its virulence factor vacuolating cytotoxin A (VacA) promotes

292 Virulence factors (VFs) are molecules that allow microbi

293 nhibition prevents translation of Shigella's virulence factor VirF, hence reducing pathogenicity.

294 urface-expressed M1 protein, a classical GAS virulence factor, was required for high-level histone re

295 ic screen for Staphylococcus aureus secreted virulence factors, we identified an S. aureus mutant con

296 e the production of the tested P. aeruginosa virulence factors, we observed a trend towards more muta

297 To identify aphid virulence factors, we took advantage of the ability of t

298 ced by pathogenic bacteria function as major virulence factors, whereas when they are produced by non

299 for positively selected genes and potential virulence factors, which indicates adaptive introgressio

300 n interacts less avidly with Yersinia pestis virulence factor YopM than with wild-type human pyrin, t