ライフサイエンスコーパス: virus genome

1 tides to a linearized version of the m13mp18 virus genome.

2 nitiate transcription and replication of the virus genome.

3 virus proteins onto specific regions of the virus genome.

4 r trafficking and packaging of the influenza virus genome.

5 talyzes transcription and replication of the virus genome.

6 ng viral host range, and organization of the virus genome.

7 not be the only source of mutations in a RNA virus genome.

8 iniscent of its cognate binding sites in the virus genome.

9 ding the distance between these sites in the virus genome.

10 catalyzes the replication of the hepatitis C virus genome.

11 ylation events in the integrated hepatitis B virus genome.

12 varying residue positions in the hepatitis C virus genome.

13 ithin the E7 open reading frame (ORF) of the virus genome.

14 at nearly normal rates while replicating the virus genome.

15 st in the translation and replication of the virus genome.

16 mutations were introduced into the influenza virus genome.

17 ncephalomyelitis due to rapid replication of virus genome.

18 6 (Delta36) were recombined into the K37eGFP virus genome.

19 hat cannot form conjugates, from the Sindbis virus genome.

20 AAVS1 and may also require an RBS within the virus genome.

21 ify previously unidentified functions in the virus genome.

22 ithin the untranslated regions of the dengue virus genome.

23 hanism inhibits translation of the infecting virus genome.

24 ify regions of conservation in the influenza virus genome.

25 f approximately 30,000 bases of the smallpox virus genome.

26 -1 and specifically decreases H3K4me3 on the virus genome.

27 stribution of the siRNA population along the virus genome.

28 riggers the expression of the herpes simplex virus genome.

29 the efficient replication of the hepatitis C virus genome.

30 that stem-loop IV functions similarly in the virus genome.

31 ructure, based on a modified hepatitis delta virus genome.

32 these two elements function similarly in the virus genome.

33 he introduction of targeted mutations in the virus genome.

34 solates and all publicly available influenza virus genomes.

35 ngly, RNA virus genes recombining with ssDNA virus genomes.

36 a group that includes the largest known RNA virus genomes.

37 aea and encompasses more than 1,000 distinct virus genomes.

38 us replication and correspond to full-length virus genomes.

39 recombination within Tomato yellow leaf curl virus genomes.

40 ned based on analysis of the zika and dengue virus genomes.

41 dard for reporting sequences of uncultivated virus genomes.

42 omplete or near-complete double-stranded DNA virus genomes.

43 on after being horizontally transferred into virus genomes.

44 get sites when aligned to the Liberian Lassa virus genomes.

45 diversity exists between the Liberian Lassa virus genomes.

46 argeted processing of persistently infecting virus genomes.

47 ords of the human genome were found in Ebola virus genomes.

48 ts the biological information present in the virus genomes.

49 uencing to produce two coding-complete Ebola virus genomes 5 days after declaration of the EVD outbre

50 s hypothesis, we inserted into the wild-type virus genome a wild-type REST [recombinant (R) 111], a d

51 Virus genome accumulation was inhibited 6- to 10-fold in

52 by the lack of methods for the enrichment of virus genomes across the phylogenetic breadth of HIV-1 a

53 The segmented nature of the influenza virus genome allows reassortment between coinfecting vir

54 s, genetic modifications introduced into the virus genomes along passages, and the extent of attenuat

55 g genes from the PHO4 superfamily in several virus genomes, along with other transporter-encoding gen

56 me and across anatomic compartments by using virus genomes amplified directly from oropharyngeal wash

57 ing the 3'-terminal nucleotides of the DEN-2 virus genome and a random-sequence P4-PMO showed relativ

58 d evidence for the first time that the foamy virus genome and Gag translocation into the nucleus are

59 n the viral life cycle, as it replicates the virus genome and generates viral mRNA via a cap-snatchin

60 The virus genome and infectious virus were observed soon aft

61 escribed in detail for only a portion of the virus genome and never for a virus from a detailed urban

62 identified which chromosome arm harbors the virus genome and obtained a high-resolution map of the i

63 Moreover, the structure of the virus genome and phylogenetic analysis of multiple genes

64 throughout the non-structural region of the virus genome and provide a defined biochemical assay to

65 a blasticidin (Bsd) resistance gene into the virus genome and selected variants that grew at high con

66 ned to enhance encapsidation of the chimeric virus genome and to express an attenuated simian immunod

67 individual viral genes in the context of the virus genome and to understand their contributions to vi

68 re with the replication of nondefective (ND) virus genomes and activate the IFN-induction cascade bef

69 platform to concentrate replicase proteins, virus genomes and host proteins required for replication

70 AN) likely participates in the maturation of virus genomes and in DNA recombination.

71 Sequences were compared with existing Lassa virus genomes and published Lassa virus assays.

72 They associate with DNA virus genomes and repress the very early stages of the D

73 these proteins are dispersed throughout the virus genome, and most are transcribed late or early-lat

74 Multipartite virus genomes are composed of several segments, each pac

75 s its antiviral activity.IMPORTANCE Some RNA virus genomes are suppressed in the nucleotide combinati

76 Persisting latent herpes simplex virus genomes are to some degree found in a heterochroma

77 Positive-strand RNA virus genomes are translated into polyproteins that are

78 as method of choice to detect herpes simplex virus genomes as early as possible rather than relying o

79 the other seven segments during influenza A virus genome assembly, we continued to use this HEF viru

80 Ramos and KE37 cells maintained the virus genome at over 100 copies per cell over a comparab

81 tifies cis-acting sequences in the influenza virus genome at the nucleotide level.

82 on of virus-derived siRNAs on the respective virus genome at three temperatures (25 degrees C, 25 deg

83 on, we constructed an ORF45-null recombinant virus genome (BAC-stop45) by using a bacterial artificia

84 Some RNA virus genomes bear 5'-triphosphates, which can be recogn

85 tricted latency (where an EBNA2 gene-deleted virus genome broadens antigen expression to include the

86 o restrict the expression of murine leukemia virus genomes but not retroviral genomes of the lentivir

87 the entire 3'-end of the mouse mammary tumor virus genome, but further deletions at the 5'- or 3'-end

88 tions were identified throughout the vaccine virus genome, but their contributions to attenuation wer

89 t cells and to facilitate the release of the virus genome by catalyzing the transition from the matur

90 e the selective packaging of the influenza A virus genome by forming a sequence-dependent supramolecu

91 in on virus production in the context of the virus genome by using a MHV A59 infectious clone.

92 The herpes simplex virus genome can enter a repressed transcriptional state

93 enetic information of the non-retroviral RNA virus genome can flow into the DNA of mammalian cells ex

94 Using two synthetic maize streak virus genome chimeras containing alternating genome segm

95 stantial majority of the currently available virus genomes come from metagenomics, and some of these

96 rom the role of E4 ORF3 in the regulation of virus genome concatenation via inhibition of cellular do

97 g this change back into the wild-type cowpox virus genome conferred resistance to ST-246, suggesting

98 The influenza A virus genome consists of eight negative-sense RNA segmen

99 The influenza A virus genome consists of eight negative-sense RNA segmen

100 RNA virus genomes contain cis-acting sequence and structural

101 anslated region (UTR) of the mouse hepatitis virus genome contains two essential and overlapping RNA

102 ue culture cytopathic effect, an increase in virus genome copy equivalents (GCE), and positive result

103 equences, the detection of core antigen, the virus genome copy number, and the virus titer in IHH cul

104 most one-third of all ORFs in 1,456 complete virus genomes correspond to ORFans, a figure significant

105 gh the large-scale generation of full-length virus genome data.

106 A search of the influenza virus genome database reveals anomalies associated with

107 The levels of the virus genome declined over an extended period up to 60 d

108 Indeed, mutant virus genomes deficient for IE1 expression exhibit globa

109 with an essential contribution to influenza virus genome delivery and reveal a potential role for RA

110 otic viruses, little is known about archaeal virus genome delivery and the associated particle change

111 ied in this region of the avian encephalitis virus genome, despite little nucleotide sequence related

112 Human immunodeficiency virus genome dimerization is initiated through an RNA-RN

113 in order to accumulate defective interfering virus genomes (DIs).

114 Viral latency, in which a virus genome does not replicate independently of the hos

115 lly eliminated from classical H1N1 influenza virus genomes during virus evolution in humans.

116 influenza virus 5 (PIV5), copyback defective virus genomes (DVGs) are erroneously produced and are pa

117 amplification.IMPORTANCE Copyback defective virus genomes (DVGs) are powerful inducers of innate imm

118 Segments 7 (M) and 8 (NS) of the influenza virus genome encode mRNA transcripts that are alternativ

119 Giant virus genomes encode proteins considered as signatures o

120 ombinant cytomegaloviruses (CMVs) from which virus genome-encoded immune modulation genes have been d

121 a virus with a targeted deletion in gp145, a virus genome-encoded inhibitor of protein kinase R, usin

122 the addition of two uridine residues to the virus genome-encoded RNA replication primer VPg prior to

123 ular translation initiation factors with the virus genome-encoded viral protein genome (VPg) protein,

124 The hepatitis B virus genome encodes an oncoprotein, HBx, which binds va

125 tudies have identified a gene cluster in the virus genome, encoding enzymes involved in nucleotide-su

126 The virus genome encompasses most key chordopoxvirus genes t

127 man DC, flagellin expressed from the rM51R-M virus genome enhanced the production of cytokines.

128 ilencing, especially for newly infecting DNA virus genomes entering the nucleus.

129 s strains shows that CRISPR targeting drives virus genome evolution.

130 Moreover, we show that the virus genomes exhibit considerable degree of polymorphis

131 ram of transcription from the superinfecting-virus genomes, failing to transition to latency I.

132 d by evaluating their distribution along the virus genome for isolates of five species of cassava gem

133 Age, and reconstructed near-complete variola virus genomes for four of them.

134 analysis indicated that the canine influenza virus genomes form a monophyletic group, consistent with

135 ting virus replication and to protecting the virus genome from deleterious mutation.

136 lso act as molecular sieves that isolate the virus genome from host defense mechanisms and allow the

137 We sequenced 99 Ebola virus genomes from 78 patients in Sierra Leone to ~2000x

138 re found among the three currently available virus genomes from microcephaly cases.

139 chnical difficulties for recovering complete virus genomes from natural assemblages.

140 to quickly and accurately assemble all known virus genomes from next-generation sequencing datasets.

141 arget-enrichment sequencing to produce Ebola virus genomes from samples obtained in the 2018 Equateur

142 1 and methods for the robust assembly of the virus genomes from short-read data.

143 we sequenced 153 pandemic influenza H1N1/09 virus genomes from United Kingdom isolates from the firs

144 was taken to assemble segments of these RNA virus genomes from viral populations isolated directly f

145 The 23 new Liberian Lassa virus genomes grouped within two clades (IV.A and IV.B)

146 As the number of sequenced virus genomes grows into the thousands, and the number o

147 Akhmeta virus genomes harbor evidence suggestive of recombinatio

148 1 (Mahoney) [PV1(M)] sequence, the synthetic virus genome harbored 27 nucleotide (nt) changes deliber

149 s demonstrate that rearranging the influenza virus genome has great potential for the development of

150 dividually or in combination within a single virus genome has not been defined, nor do we fully under

151 ion of slightly mutated and highly divergent virus genomes has been shown to be most challenging.

152 Evolution of minimal DNA tumor virus' genomes has selected for small viral oncoproteins

153 distinct mutations in the 2009 pandemic H1N1 virus genome have occurred with increased frequency afte

154 Most nonsegmented negative strand (NNS) RNA virus genomes have complementary 3' and 5' terminal nucl

155 , that even when recombinationally disrupted virus genomes have extremely low fitness and there are n

156 2019;116:8535-8543) reported that Ebola virus genomes have variable 3' terminal nucleotides.

157 Incorporation of IFN-gamma into the rabies virus genome highly attenuated the virus.

158 Replication of the B19 virus genome, however, introduced either by viral infect

159 al Latency I expressing EBNA1 only from a WT virus genome, (ii) Wp-restricted latency expressing EBNA

160 ucleotides (nt) (5'-GGAUCU(OH)-3') of the WN virus genome in viral replication.

161 , we assembled the fragments into a complete virus genome in yeast, transferred it into an Escherichi

162 ntial for the replication and maintenance of virus genomes in latently KSHV-infected cells.

163 , will improve the reporting of uncultivated virus genomes in public databases.

164 thin the positive-strand genomic copy of the virus genome, in predominantly structure-dependent mecha

165 able annotations are cross-referenced on the virus genome, including those from major databases (PDB,

166 However, a lack of virus genome information hinders our ability to answer f

167 cluding HIV-1, and introducing CpGs into RNA virus genomes inhibits their replication.

168 ke previously reported HSV-2 BAC clones, the virus genome inserted into this BAC clone has no known g

169 the virus and cell membranes to release the virus genome into the cell.

170 and the subsequent release of the influenza virus genome into the cytoplasm.

171 developments including transcription of DNA virus genomes into RNA ligands, and the recognition of v

172 The 3'-untranslated region of the Sindbis virus genome is 0.3 kb in length with a 19-nucleotide co

173 The influenza virus genome is an 8-segment single-stranded RNA with hi

174 rst open reading frame (ORF1) of the Norwalk virus genome is analogous in gene order to proteins 2A a

175 a indicate that packaging of the influenza A virus genome is controlled by a redundant and plastic ne

176 The foamy virus genome is detected by confocal microscopy in the n

177 hat targets the capsid, but less so when the virus genome is directly targeted.

178 Following a HSV-1 virus infection, the virus genome is localized to promyelocytic leukemia prot

179 hus, we conclude that replication of the B19 virus genome is the primary limiting step governing B19

180 The virus genome is translated to produce a single polypepti

181 The virus genome is tripartite, including large (L) (6766 bp

182 Insertion of reporter genes into plant virus genomes is a common experimental strategy to resea

183 Recombination between RNA virus genomes is also well known.

184 Replication fidelity of RNA virus genomes is constrained by the opposing necessities

185 Sequence information from influenza virus genomes is instrumental in determining mechanisms

186 volutionary processes that shape influenza A virus genomes is key to elucidating the mechanisms under

187 show that TLR7 recognition of enveloped RNA virus genomes is linked to virus fusion or uncoating fro

188 al artificial chromosome recombinants of the virus genome, it was reported that the enhancer region o

189 on during the DNA repair process of the ASFV virus genome; it is highly error prone and plays an impo

190 translated regions (UTRs) of plus-strand RNA virus genomes jointly control translation and replicatio

191 PCR amplification and Illumina sequencing of virus-genome junctions; the resulting sequences define a

192 dates one of the largest single-stranded RNA virus genomes known.

193 llenges with the sampling and cultivation of viruses, genome-level viral diversity remains poorly des

194 eered to constitutively produce an influenza virus genome-like luciferase reporter RNA driven by the

195 e interactions between PAP and turnip mosaic virus genome-linked protein (VPg) were investigated.

196 Replication and transcription of influenza virus genome mainly depend on its RNA-dependent RNA poly

197 conserved mechanism, which ensures faithful virus genome maintenance in host cells during cell divis

198 Minimum Information about an Uncultivated Virus Genome (MIUViG) standards were developed within th

199 Verdinexor blocks progeny influenza virus genome nuclear export, thus effectively inhibiting

200 I) particle and did not bind the full-length virus genome or any other viral RNAs.

201 containing either the full-length, complete virus genome or precise deletions of the NSs gene alone

202 rotocol did not introduce bias in either the virus genome or transcriptome, the findings indicate the

203 SVG in infected cells confirmed the expected virus genome organization.

204 uggesting a similar mechanism of influenza B virus genome packaging.

205 In many DNA viruses, genome packaging is initiated by the small subu

206 In herpesviruses and many bacterial viruses, genome-packaging is a precisely mediated proces

207 Flagellin expressed from the rwt virus genome partially protected human DC from VSV-induc

208 stool of humans is less prevalent, although virus genomes persist in gut-associated lymphoid tissue

209 gether, these results suggest that the foamy virus genome persists in nondividing cells without integ

210 The influenza A virus genome possesses eight negative-strand RNA segment

211 Recent studies have identified ancient virus genomes preserved as fossils within diverse animal

212 We further found that while virus genome production is higher in cells infected at a

213 Integrated virus genomes (prophages) are common in such genomes.

214 diting through assembly methods in large DNA virus genomes raises dual-use concerns, we believe the i

215 de percent difference between Liberian Lassa virus genomes ranged up to 27% in the L segment and 18%

216 h the addition of the NS1/2A and NS5 vaccine virus genome regions.

217 types in vitro and that the number of total virus genomes relative to the number of viral particles

218 e biomolecular conditions that promote giant virus genome release.

219 This report shows that the foamy virus genome remains unintegrated in G(1)/S phase-arrest

220 previous reports, it only modestly inhibits virus genome replication and transcription but is import

221 s highly phosphorylated and involved in both virus genome replication and virion assembly.

222 plays key, yet poorly defined, roles in both virus genome replication and virion assembly/release.

223 ence that aberrant RNA products of influenza virus genome replication can trigger retinoic acid-induc

224 Positive-strand RNA virus genome replication is invariably associated with e

225 Positive-strand RNA virus genome replication occurs in membrane-associated R

226 We propose a model of influenza virus genome replication that relies on the trans-activa

227 our study implies that HCV coopts FAPP2 for virus genome replication via PI4P binding and glycosphin

228 es for a subset of these phosphoacceptors in virus genome replication.

229 egulated in an inverse relationship with the virus genome replication.

230 n, suggesting a similar role during vaccinia virus genome replication.

231 -interacting protein 1 (Rint1) to facilitate virus genome replication.

232 Due to high variability of the virus genome, resistance to available antiviral drugs is

233 ation within and among different loci in the virus genome restricted the genealogical analyses to hap

234 Genetic analyses of the new virus genome revealed a classic genomic organization but

235 RNA, complementary positive-strand influenza virus genome RNA (cRNA) and influenza virus gRNA were dr

236 tion and replication of vesicular stomatitis virus genome RNA.

237 s creating attenuating deletions on multiple virus genome segments.

238 d and requires no prior knowledge beyond the virus genome sequence.

239 proach, enabling direct recovery of complete virus genome sequences from environmental samples.

240 ic analysis of representative complete Ebola virus genome sequences from previous outbreaks.

241 sequencing was used to generate Angolan Zika virus genome sequences from three people positive for Zi

242 argue that the extraordinary conservation of virus genome sequences is best explained by a niche-fill

243 , we show how evolutionary analyses of Ebola virus genome sequences provided key insights into virus

244 thousands of full-length, high-quality draft virus genome sequences that were not recovered using sta

245 omplementary features, generated purely from virus genome sequences, leads to improved accuracy for a

246 ed in the generation of tens of thousands of virus genome sequences.

247 As influenza virus genome sequencing becomes cheaper, faster, and mor

248 cal innovations have ignited an explosion in virus genome sequencing that promises to fundamentally a

249 quences and develop well annotated reference virus genome sets.

250 CpG and UpA dinucleotides in most plant RNA virus genomes show degrees of suppression comparable to

251 Phylogenetic analysis of the virus genome showed that EPEV roots the Aedes-associated

252 Sequence analysis of the assembled virus genome showed the presence of five open reading fr

253 identify sites of positive selection in the virus genome, showed that primary HIV-1-specific T cells

254 otation and submission package to facilitate virus genome submissions to NCBI GenBank.

255 trachromosomal reporters and the hepatitis B virus genome, suggesting a direct mechanism of transcrip

256 tein structures that regulate (+)-strand RNA virus genome synthesis are potential sites for blocking

257 The recent discovery of four ssDNA virus genomes that appear to have been formed by recombi

258 ept for the feasibility of creating chimeric virus genomes that express lentivirus structural protein

259 Therefore, as that of other RNA virus genomes, the replication of the HCV genome may inv

260 RNA rapidly conformed to that in the helper virus genome through a previously described template swi

261 t protein (MP)-mediated trafficking of plant virus genomes through plasmodesmata.

262 serted neutral barcodes into the influenza A virus genome to generate a population of viruses that ca

263 Mutating RNA virus genomes to alter codon pair (CP) frequencies and r

264 mitotic chromosomes and TR DNA to segregate virus genomes to daughter cell nuclei.

265 new tool to determine the sensitivity of RNA virus genomes to mutagenesis as well as interrogation of

266 ', n = 5-20) in more than 1500 microbial and virus genomes, together with five genomes of multicellul

267 omal factor with a crucial role in influenza virus genome trafficking, suggest cooperation between un

268 tiple domains that work in concert to enable virus genome transcription and replication.

269 the cellular receptor, internalization, and virus genome transfer into the nucleus, occurred with si

270 hose we hypothesized had potential to affect virus genome translation and included murine ISG20, ISG1

271 Virus genomes typically consist of distinct structural a

272 d identified three additional regions of the virus genome under selection that were not previously re

273 RNA synthesis, as well as replication of the virus genome (viral RNA) through a complementary RNA int

274 ave variously been proposed to correspond to virus genomes, virus replication intermediates, viral tr

275 nants of MEC infection of MRE16, the TE/5'2J virus genome was altered to contain either domain chimer

276 Virus genome was identified and quantified by polymerase

277 Each virus genome was predicted to carry six open reading fra

278 the first 19 nucleotides (nt) of the rabies virus genome, we demonstrate that L alone initiates synt

279 Using sequences encoding 78% of the rabies virus genome, we explored the extent, repeatability and

280 By analyzing over 12,000 influenza B virus genomes, we describe the processes enabling the lo

281 er of publicly available, complete influenza virus genomes, we have discovered several anomalies in t

282 (RNAi) imposes diversifying selection on RNA virus genomes, we quantified West Nile virus (WNV) quasi

283 gths of chromosomes harboring the integrated virus genome were comparable to the other chromosomes.

284 d open reading frames (ORFs) in the vaccinia virus genome were expressed and tested using responder c

285 Fourteen different chimeric virus genomes were constructed from two infectious cDNA

286 gola outbreak itself, a total of 16 complete virus genomes were determined, including those of the vi

287 the 5'- and 3'-termini of the West Nile (WN) virus genome, were designed to anneal to important cis-a

288 des (residues 146 to 163 of the yellow fever virus genome, which encode amino acids 9 to 14 of the ca

289 roughout the region by analysing 1,610 Ebola virus genomes, which represent over 5% of the known case

290 Complete sequence of the B virus genome will certainly facilitate identification of

291 All 24 mutants were introduced into the virus genome with a genetic marker rescue/marker transfe

292 scue the replication defect of a hepatitis B virus genome with an ablated core gene.

293 stigate functional compatibility of the 1918 virus genome with gene segments from an LPAI virus and t

294 A copy of the cell culture-adapted HM175/18f virus genome with sequence encoding firefly luciferase.

295 (BAC36wt-KSHV), we constructed a recombinant virus genome with the gB open reading frame (ORF) delete

296 taE200-Y229 and pMRE16ic, representing MRE16 virus genomes with and without the deletion, respectivel

297 s and the CSF of cases for detection of Zika virus genomes with quantitative RT-PCR and for detection

298 ication in cells and can be deleted from the virus genome without reducing virus replication.

299 ontaminated with low levels of human enteric virus genomes, yet evidence for waterborne disease trans

300 ns in the 3' untranslated region of the Zika virus genome (ZIKV-3'UTR-LAV) prevent viral transmission