ライフサイエンスコーパス: virus particle

1 rimer set for bacteriophage MS2 (a model RNA virus particle).

2 tion structure of capsid proteins within the virus particle.

3 epitope located at the surface of the dengue virus particle.

4 budding, which then constitutes part of the virus particle.

5 ages or to explain why Vpr is carried in the virus particle.

6 nformations in the context of the infectious virus particle.

7 ral protease into the proteins that form the virus particle.

8 in expressed in the cell and packaged in the virus particle.

9 m the known hexagonal protein lattice in the virus particle.

10 xes that are packaged together into a single virus particle.

11 host factors to optimally produce infectious virus particles.

12 een the nucleocapsid and the envelope within virus particles.

13 bilization and the intracellular motility of virus particles.

14 tential for exposure to VEEV via aerosolized virus particles.

15 ull-length Gag protein was incorporated into virus particles.

16 erful tool to visualize and track individual virus particles.

17 g to observe conformational dynamics of S on virus particles.

18 assemble trimer-clustered T = 3 icosahedral virus particles.

19 down to attomole levels and as few as 10(6) virus particles.

20 r reminiscent of the cell-surface docking of virus particles.

21 ressive assembly, and packaging into progeny virus particles.

22 PD that result in intercellular movement of virus particles.

23 strates for RNA synthesis and packaging into virus particles.

24 g to HA on the surface of infected cells and virus particles.

25 mental force-deformation spectra for several virus particles.

26 ered to be packaged efficiently into vaccine virus particles.

27 otein crucial for the optimal infectivity of virus particles.

28 s of viral replication and sources of viable virus particles.

29 ein lattices that drive assembly of immature virus particles.

30 e cells to recognize genomes within incoming virus particles.

31 mediated by exosomes rather than infectious virus particles.

32 , but there was very little C3 deposition on virus particles.

33 produced and are packaged into "infectious" virus particles.

34 ermine the position of protein layers within virus particles.

35 s cells to recognize genomes within incoming virus particles.

36 significantly higher IFN responses than free virus particles.

37 and the A17 membrane protein for assembly of virus particles.

38 s to budding and release of progeny immature virus particles.

39 erely attenuated upon depletion of GSLs from virus particles.

40 stponed and reduced production of infectious virus particles.

41 tes the properties of ApoE on the surface of virus particles.

42 FN-gamma resulted in a reduced production of virus particles.

43 by imaging individual, fluorescently labeled virus particles.

44 f the NA could render it more immunogenic on virus particles.

45 (Env) protein trimers are incorporated into virus particles.

46 as the subcellular localization of incoming virus particles.

47 ral protein responsible for the formation of virus particles.

48 , a step required for its incorporation into virus particles.

49 e to efficiently colocalize target cells and virus particles.

50 rporation of a complete set of segments into virus particles.

51 s the infectious cellular internalization of virus particles.

52 eneity in size and integrity among influenza virus particles.

53 s in virus assembly and in the morphology of virus particles.

54 pating in budding or being incorporated into virus particles.

55 oduction, thereby increasing the chances for virus particle acquisition by aphid vectors and CaMV tra

56 is required for complete budding of Sindbis virus particles although several different amino acids c

57 s, termed HK2, still is capable of producing virus particles, although these particles have been rega

58 n of RT and, in some cases, integrase in the virus particle and this abolishes infectivity.

59 CHK-124 aggregates virus particles and blocks attachment.

60 n between the glycosphingolipid (GSL) GM3 on virus particles and CD169/Siglec-1 on MDCs.

61 rafficking pathways to effect the release of virus particles and disrupts the structure of the Golgi

62 We identified virus particles and intranuclear dense tubules, which ar

63 To investigate the distribution of virus particles and morphological changes in host cells,

64 ucture, dynamics, and biological function in virus particles and other large protein cages.

65 NA protein can enhance its immunogenicity on virus particles and overcome the immunodominance of the

66 uch as heat and disinfectants can inactivate virus particles and prevent viral transmission.

67 Like Nef, S2 excludes SERINC5 from virus particles and requires an ExxxLL motif predicted t

68 led that the vaccine contained visible split-virus particles and retained the native conformation of

69 ow HSV gE/gI and US9 promote the assembly of virus particles and sorting of these virions into neuron

70 ncorporated into the encapsidated genomes of virus particles and subsequently UV-crosslinked to adjac

71 y blocked post-entry long-range transport of virus particles and suppressed infection approximately 5

72 vesicular compartments or surface-localized virus particles and that large fluorescent signals corre

73 h a thin layer of a composite containing M13 virus particles and the electronically conductive polyme

74 onstrated to be by both the direct action on virus particles and the interference on the host cells.

75 otein (Env) spike, located on the outside of virus particles and the only relevant protein for the in

76 motifs implicated in Env incorporation into virus particles and viral transmission.

77 lamentous and branched respiratory syncytial virus particles, and assembly with genomic ribonucleopro

78 d incorporates more VP26 fusion protein into virus particles, and individual virus particles exhibit

79 observed to impair Env protein assembly into virus particles, and several of these are suppressed by

80 the incorporation of IAV gene segments into virus particles, and this process is thought to be media

81 f these eight ribonucleoproteins into single virus particles, and yet the underlying interaction netw

82 mechanisms involved in morphogenesis of the virus particle are still poorly understood.

83 e mechanisms by which infectious hepatitis C virus particles are assembled and released from the cell

84 Efficient replication and assembly of virus particles are integral to the establishment of inf

85 th the viraemia, but the generated defective virus particles are not adequate to reduce high fever an

86 e studies demonstrate that noncapped Sindbis virus particles are produced as a result of viral RNA sy

87 to changes in environmental conditions after virus particles are released from the host cells.

88 e input virus, suggesting that a fraction of virus particles are resistant to antibody neutralization

89 We establish that virus particles are secreted in two distinct populations

90 anterograde axonal transport, ensuring that virus particles are transported from the cytoplasm into

91 uctures of flavivirus (dengue virus and Zika virus) particles are known to near-atomic resolution and

92 e contrast using ice-embedded tobacco mosaic virus particles as test samples at 20-80 keV electron en

93 luorescence microscopy can detect individual virus particles as they enter cells, allowing us to map

94 proteins have important roles in assembling virus particles as well as modifying host cells to promo

95 In all cases, the mutant virus particles, as well as the antibody-bound wild-type

96 lete structure of assembled M1 within intact virus particles, as well as the structure of M1 oligomer

97 ranules suggest that they may be sites where virus particles assemble.

98 However, the mechanisms involved in virus particle assembly and egress are still elusive.

99 ributions of MA-mediated membrane binding to virus particle assembly are not well understood.

100 teins in virus assembly.IMPORTANCE Influenza virus particle assembly involves the careful coordinatio

101 hermore, defects in NS4A oligomerization and virus particle assembly of two mutants were rescued by N

102 ORTANCE A key aspect in virus replication is virus particle assembly, which is a poorly understood pr

103 nd provides new insights into the process of virus particle assembly.

104 main in coordinating HCV RNA replication and virus particle assembly.

105 n implicated in both HCV RNA replication and virus particle assembly.

106 each other in some, but not all, aspects of virus particle assembly.

107 A) to a subsequent delay in uncoating of the virus particle at 33 degrees C during the next cycle of

108 of the A17 protein were packaged into mature virus particles at a reduced level, demonstrating that t

109 human immunodeficiency virus type 1 (HIV-1) virus particles at the plasma membrane (PM).

110 airing late steps in the assembly/budding of virus particles at the plasma membrane.

111 iruses must surmount to achieve entry; among virus particles attaching to the cell surface, around on

112 Using a ZIKV reporter virus particle-based infection assay, our data demonstra

113 hypothesize that this antibody binds to the virus particle before internalization and endosomal proc

114 ism of action by the lipids is disruption of virus particle binding to host cell plasma membrane rece

115 structural protein is the primary driver of virus particle biogenesis, and the CA CTD is the primary

116 tion by increasing the efficiency with which virus particles bud from infected cells and restoring fi

117 this mutant is grown at a lower temperature, virus particles bud from the host cell, but budding arre

118 mation while having limited effects on total virus particle budding.

119 step for immature Gag lattice formation and virus particle budding.

120 iral genome is not recapitulated in a single virus particle but in the viral population.

121 ntral role in the intracellular transport of virus particles but also regulate a wider range of proce

122 and the repetitive structure of the original virus particle, but lack infectious genomic material.

123 opment of envelope immunogens that mimic the virus particle, but less is known about how different va

124 ence and spontaneous generation of defective virus particles, but have not examined both the antibody

125 compensatory mutant strains showed complete virus particles, but these now formed paracrystalline ar

126 RNA synthesis by even a single virus particle can initiate a productive infection.

127 The interiors of virus particles can encapsulate and protect sensitive co

128 ns resulted in up to 92 and 80% reduction of virus particle capture and trans-infection, respectively

129 ed nanolenses are rapidly formed around each virus particle captured on the substrate using a portabl

130 nfectious endocytic entry platforms carrying virus particles consist of two-fold larger CD151 domains

131 Icosahedral virus particles constitute paradigms to study self-assem

132 Here we show that inactivated rabies virus particles containing the MERS-CoV S1 protein induc

133 Virus particles containing those fusions maintained the

134 is evidently highly specific such that every virus particle contains a set of 10 RNA segments, the or

135 The resulting fluorescent virus particles could be visualized in virus entry studi

136 We detected changes in virus particle density, suggesting that cholesterol depl

137 provides highly sensitive detection of whole virus particles despite their low diffusion coefficient.

138 Purified PA-X mutant virus particles displayed an increased ratio of hemagglu

139 With the BRAVE approach, each virus particle displays a peptide, derived from a protei

140 h beta-propiolactone-inactivated recombinant virus particles elicited protective RABV antibody titers

141 These virus particles, engineered to selectively bind HSA, ser

142 sponse to low-level stimuli and suggest that virus particle entry is sensed as a stress signal.

143 However, the mechanism by which enveloped virus particle entry mediates a stress response, leading

144 uring fusion, a necessary step for enveloped virus particle entry, appears sufficient to induce trans

145 pHrodo-labeled virus particles' entry and residence time in the endocyt

146 protein into virus particles, and individual virus particles exhibit brighter red fluorescence.

147 FEZ1 depletion blocks early infection, with virus particles exhibiting bi-directional motility but n

148 irected to slide during the formation of the virus particle, exposing transcription factor binding si

149 mammalian cells due to severely compromised virus particle formation and secretion.

150 ntiviral effect, since it may interfere with virus particle formation and virus production.

151 three-dimensional reconstruction to analyze virus particles formed by mutants that do not express pa

152 BOR OF BRCA1 (NBR1) targets nonassembled and virus particle-forming capsid proteins to mediate their

153 complex proteins to promote scission of the virus particle from the plasma membrane.

154 Therefore, purified influenza A virus particles from adherent and suspension MDCK host c

155 ans, that blocks the release of newly formed virus particles from infected cells.

156 hestrate the assembly and release of nascent virus particles from the plasma membranes of infected ce

157 The standard approach for purification of virus particles has been to use a multiple-step, complex

158 While virus particles have been observed in M cells, it is not

159 to complete infection, it must produce a new virus particle in which the genome is able to support a

160 c hippocampal injections of adeno-associated virus particles in APP/PS1 mice, localized primarily to

161 E1 is detrimental to the assembly of Sindbis virus particles in baby hamster kidney cells.

162 The dynamic properties of virus particles in cells can be imaged by fluorescent pr

163 acellular HCV RNA and accumulates infectious virus particles in cells.

164 is to show that identification of individual virus particles in clinical sample materials quickly and

165 ia virus DNA, it can be recovered from these virus particles in enzymatically active form; it is stil

166 eplicons as well as production of infectious virus particles in mammalian cell culture models were cl

167 c hippocampal injections of adeno-associated virus particles in mutant hAPP Tg mouse brains decreases

168 ffects, promote the anterograde transport of virus particles in neuronal axons.

169 Intracellular transport of virus particles in neurons is important, as this process

170 rmed single-particle tracking of fluorescent virus particles in primary neurons to measure anterograd

171 of computer simulations and experiments with virus particles in tailor-made disk- and annulus-shaped

172 (MMTV) orchestrates the assembly of immature virus particles in the cytoplasm which are subsequently

173 and US9 fail to properly assemble enveloped virus particles in the cytoplasm, which blocks anterogra

174 The tc-VLPs resembled authentic virus particles in their protein composition and neutral

175 a serial section array (SSA)-SEM identified virus particles in vesicles within the cytoplasm and/or

176 osphate (IP6) synergize to generate immature virus particles in vitro The results identify an importa

177 we chose a mechanism typical of influenza A virus particles in which ectoenzymatic hemagglutinin act

178 ectious virus and RNA-containing hepatitis C virus particles, indicating a block in virus assembly.

179 Gag, the protein that assembles into the virus particle, interacts specifically with psi, but thi

180 with JUNV attachment to the cell surface or virus particle internalization into host cells, it preve

181 as viral receptors has enabled insights into virus particle internalization, host and tissue tropism,

182 US9 promotes axonal dissemination by sorting virus particles into axons, but whether it is also an ef

183 ing both gE and US9 that failed to transport virus particles into axons.

184 c domains play important roles in sorting of virus particles into axons.

185 on is dependent on the release of infectious virus particles into the virological synapse.

186 acilitate fluorescence microscopy studies of virus particle intracellular transport, as a brighter pa

187 the assembled lattice of Gag within immature virus particles is necessary to understand the interacti

188 envelope (Env) protein trimers assemble into virus particles is poorly understood but involves an int

189 -encoded glycoprotein on the surfaces of the virus particles, is critical for infection of B cells.

190 of fusion proteins-and their distribution on virus particles-is crucial for fusion activity(2,3).

191 is mainly transmitted via mature infectious virus particles, it has also been suggested that HCV-inf

192 on, linking viral metagenomic sequences to a virus particle, its sequenced genome, and its host direc

193 spumaviruses; (ii) within the extracellular virus particle itself, transitioning from an RNA-contain

194 siological conditions of one of the simplest virus particles known, the minute virus of mice (MVM) ca

195 ion (V165I) restored polyprotein processing, virus particle maturation, and significant levels of rep

196 Although multiple virus particles may enter a cell at the same time, mecha

197 lycosphingolipid (GSL) incorporated into the virus particle membrane, as the receptor and ligand for

198 displayed a very good detection limit of 30 virus particles/ml and a wide linear dynamic range of 10

199 , when the viremia level had reached 4 log10 virus particles/mL, rescued 100% of Lassa virus-infected

200 mportant in vitro function, which is to make virus particles more infectious, but the mechanism has b

201 A comparison of virus particle morphologies and gene content demonstrate

202 persist and transmit to a new host, enteric virus particles must remain stable once they are in the

203 rom the test samples, the projected titer of virus particles necessary for the detection of SARS-CoV-

204 e report the first successful observation of virus particles, not only in AEC-IIs, but also in Ms/M s

205 o the standard-dose cohort (3.5-6.5 x 10(10) virus particles of ChAdOx1 nCoV-19) and the same randomi

206 Detection limits of 1 x 10(3) virus particles of Human adenovirus C (HAdV), Human astr

207 etection of individual fluorescently labeled virus particles of three influenza A subtypes in two imp

208 imiting HIV-1 endocytosis and in maintaining virus particles on dendrites, which is required for effi

209 nv) is sparsely incorporated onto assembling virus particles on the host cell plasma membrane in orde

210 interferon-inducible factor tetherin retains virus particles on the surfaces of cells infected with v

211 semen is present in different forms: as free virus particles or as cell-associated virus (ie, within

212 nd virus replication utilize either purified virus particles or deficient genomes that do not complet

213 al (neutralizing) antibodies that target the virus particles (or capsids) of the most common HPV canc

214 intramuscular ChAdOx1 nCoV-19 (2.2 x 10(10) virus particles) or a control vaccine, MenACWY, using bl

215 dministration of Ad5.hAC6 (3.2 x 109 to 1012 virus particles) or placebo.

216 Some poxviruses embed infectious virus particles outside of factories in membraneless pro

217 rus-like particles, it is not known if these virus particles package and transmit HK2-related sequenc

218 ablish a detection limit of approximately 67 virus particles per milliliter (vp/ml) of EV71 in a Dulb

219 h HTLV-1 particle populations containing few virus particles possessing a complete capsid core struct

220 receptors recognize genomes within incoming virus particles prior to virus replication.

221 id sensors recognize genomes within incoming virus particles prior to virus replication.

222 cells, 2-fold less Env is incorporated into virus particles produced from MT-4 than SupT1 cells.

223 level of GP1,2 expression profoundly affects virus particle production and release and uncovers a new

224 mRNAs bearing tandem RREs (GP-2xRRE), rescue virus particle production in murine cells even in the ab

225 the actin cytoskeleton severely reduced net virus particle production.

226 relocates sites of assembly, and reduces net virus particle production.

227 ectors to modulate HCV genome replication or virus particle production.

228 thesis within a replication compartment, and virus particle production.

229 y as a powerful and versatile tool to define virus particle profiles.

230 the persistently infected cells by detecting virus particles, protein and transcripts.

231 cellulose particles reduced the influenza A virus particle purification time from 3.5 h to 30 min be

232 We employed virus particle purification, genome amplification, pyros

233 A virus was assembled from RNA sequencing of virus particles purified from threespine stickleback int

234 duce high titers of VZV, the number of total virus particles relative to the number of viral particle

235 t gaps in the architecture of the infectious virus particle remain.

236 mers, and incorporation of the proteins into virus particles requires an interaction of Env CT domain

237 Retroviruses first assemble into immature virus particles, requiring interactions between Gag prot

238 sence results in an accumulation of deformed virus particles retaining the scaffold protein and defic

239 electron microscopy analyses of the purified virus particles revealed three classes of particles base

240 neutralizing antibody titer against reporter virus particles (RVPs) representing AA, A1-160K, A1-160Q

241 struct of ZIKV was used to generate reporter virus particles (RVPs) that package a green fluorescent

242 We then generated the virus particle, self-complementary adeno-associated viru

243 plasma membrane of live cells, and on single virus particles, show the high potential of these dyes f

244 ase, yielding a DNA-containing extracellular virus particle similar to the spumaviruses; (ii) within

245 VP2 is shed from virions in early endosomes, virus particles still consisting of VP5 were trafficked

246 nsitivity of cellular responses to low-level virus particle stimulation, but provide important insigh

247 therapies, and more molecular information on virus particle structure and function is needed.

248 ddition, there are defects in the sorting of virus particles such that particles, when formed, do not

249 nd the presence of both unbound and expanded virus particles suggests receptor binding initiates a ca

250 To do this, virus particles tether themselves to dyneins and kinesin

251 hiophene)) composite containing embedded M13 virus particles that are engineered to recognize and bin

252 o hairy insects for pollination to nanoscale virus particles that are highly infectious toward host c

253 essfully genetically manipulated to generate virus particles that could be visualized in infected cel

254 ve cell imaging, we show that herpes simplex virus particles that have entered primary human cells ex

255 anisms related to the assembly of infectious virus particles that is supported by experimental data o

256 the envelope glycoprotein (Env) structure on virus particles that is targeted by neutralizing antibod

257 ry of the envelope glycoprotein structure on virus particles that is targeted by neutralizing antibod

258 ity of HIV-1 infections result from a single virus particle (the transmitted/founder) that makes it p

259 ctive packaging of one copy of each vRNP per virus particle, the required RNA-RNA and RNA-NP interact

260 antigenically indistinguishable from mature virus particles, they are less stable and readily conver

261 As symmetry exists in many virus particles, this method may also be applied to 3D s

262 r the first time in any metazoan, infectious virus particles through self-assembly from transgenes.

263 ntous actin, which hints toward transport of virus particles through the use of a myosin motor.

264 on drives the conversion of stable, immature virus particles to a mature, metastable state primed for

265 during viral infections, carrying infectious virus particles to immune privileged sites and/or to sit

266 tivity correlates with physical tethering of virus particles to prevent their release.

267 cted target T cells and then transfer HTLV-1 virus particles to the target cells.

268 ies of proteins on the surface of individual virus particles.To become infectious, HIV-1 particles un

269 Extracellular virus particles transmit infection between organisms, bu

270 have proven to be a valuable method to study virus particle transport in living cells.

271 More interestingly, the virus particle underneath the MOF shell can be chemicall

272 IKV C-prM-E cell line that produces reporter virus particles upon transfection with a GFP replicon pl

273 r and how cell-matrix interactions influence virus particle uptake is unknown, as it is usually studi

274 Here we analyse the properties of Junin virus particles using a sensitive flow virometry assay a

275 A method for the purification of influenza virus particles using novel magnetic sulfated cellulose

276 be used for the functionalisation of intact virus particles via chemical groups attached to the DNA.

277 s sensing of the genomic RNA within incoming virus particles via cytoplasmic RNA sensors to produce t

278 n substrates in vitro and in vivo in nascent virus particles via one-dimensional diffusion along the

279 retic behavior of complexes between rod-like virus particles (virions) and bivalent antibodies.

280 he multivalent consensus vaccine (1 x 10(10) virus particles (vp)/mouse) induced protective HI titers

281 s that physical contact between nanorods and virus particles was not required for viral inactivation

282 binding sites genome-wide within mature RNA virus particles, we have developed a Next-Generation Seq

283 e defects in assembly of gE(-) US9(-) mutant virus particles were novel because they were neuron spec

284 Observed cores were generally polygonal, and virus particles were on average 115 nm in diameter.

285 om mycelia and RNA from samples enriched for virus particles were sequenced.

286 of total AAV capsid proteins (4.3 femtomole virus particles) were loaded to the autosampler vial.

287 as maintained within both infected cells and virus particles, where N is assembled as RNPs.

288 yo-electron microscopy reconstruction of the virus particle, which demonstrated that most structural

289 s based on recombinant vaccine strain rabies virus particles, which concurrently display the protecti

290 with NAb activity measured using pseudotyped virus particles, which offer the most informative assess

291 Encapsidated DI-RNAs were incorporated into virus particles, which reduced the infectivity of virus

292 at its genomic RNA be packaged in assembling virus particles with high fidelity.

293 ng in the release of non-infectious immature virus particles with uncleaved pr peptide from host cell

294 L2 resulted in the production of infectious virus particles, with no differences in efficiencies of

295 nsional (3D) modeling of the distribution of virus particles within an ACE-II, a M/M , and a Neu.IMPO

296 ripheral tissue, whereas the second delivers virus particles within nerve fibers to the neural gangli

297 The finding of a M/M harboring numerous virus particles within vesicles and at the cell surface

298 ced reference genomes from individual sorted virus particles without the need for cultivation.

299 acromolecules, macromolecular complexes, and virus particles, without the need for crystallization, t

300 le additives to slow down the degradation of virus particles would address the problem.