ライフサイエンスコーパス: virus shedding

1 aboratory-confirmed influenza (symptoms plus virus shedding).

2 o transmission, despite high levels of fecal virus shedding.

3 sult in clinical relapses or in asymptomatic virus shedding.

4 te immunity in controlling the rapid peak in virus shedding.

5 necessarily lead to late gene expression and virus shedding.

6 not exhibit any clinical signs or detectable virus shedding.

7 ed groups showed a modest reduction of nasal virus shedding.

8 lly or via feeding tube (gavage) and assayed virus shedding.

9 d generalization of infection, and decreased virus shedding.

10 ion from rotavirus challenge, as measured by virus shedding.

11 us serum antibody responses and detection of virus shedding.

12 a single dose of AZD2816 or AZD1222 reduced virus shedding.

13 -limiting disease with transient viremia and virus shedding.

14 on in mucosal epithelial cells and therefore virus shedding.

15 phenotype and a high prevalence of prolonged virus shedding.

16 ding symptom progression and the dynamics of virus shedding.

17 for decreased LAIV A/H1N1 immunogenicity and virus shedding.

18 ion in the respiratory system, and prolonged virus shedding.

19 ess of different vaccine strategies to block virus shedding.

20 and that knockdown of HPSE in vivo inhibits virus shedding.

21 ble to reduce influenza symptom duration and virus shedding.

22 on the odds of seroconversion and/or vaccine virus shedding.

23 the presence of factors reported to increase virus shedding.

24 itored for symptoms of influenza disease and virus shedding.

25 s regimen induced partial protection against virus shedding (58%) and diarrhea (44%) upon challenge o

26 and was superior to gD2 vaccines in reducing virus shedding after challenge in both groups of animals

27 inoculation but higher rates of diarrhea and virus shedding after challenge than did groups 3 and 5.

28 1 and 2 had significantly less diarrhea and virus shedding after inoculation but higher rates of dia

29 rotection against both influenza disease and virus shedding against all influenza A viruses.

30 denced by seroconversion, viremia, and fecal virus shedding, although mutant aHVRd3, with complete HV

31 -0.89]), was observed in the odds of vaccine virus shedding among NPEV-infected individuals.

32 s ratio, and a short duration of illness and virus shedding among those with influenza indicated pres

33 vaccine elicited a significant reduction in virus shedding and a decrease in both the severity and f

34 as associated with a significant decrease in virus shedding and a reduction in both the severity and

35 An inverse correlation was noted between virus shedding and both serum type 2 neutralisation at c

36 ution of hepatic inflammation restores fecal virus shedding and circulating viral RNA.

37 d by significantly prolonged fecal score and virus shedding and decreasing VH:CD ratio in the jejunum

38 gous H5N1 virus challenge and a reduction in virus shedding and disease severity after heterologous c

39 ended version of the model that incorporates virus shedding and dispersal of individuals.

40 sed individuals is associated with prolonged virus shedding and evolution of viral variants.

41 d a higher total viral burden with prolonged virus shedding and had an increased risk of acquiring re

42 d a higher total viral burden with prolonged virus shedding and had an increased risk of acquiring re

43 layed appearance of seroconversion and fecal virus shedding and had undetectable viremia.

44 ection prevalence in exposed populations and virus shedding and infection intensity from infected hos

45 and no diminution in the level of persistent virus shedding and latency.

46 internal proteins were associated with lower virus shedding and less severe illness.

47 precise, mechanistic readout of respiratory virus shedding and local immune responses.

48 sponses and were partially protected against virus shedding and lung pathology on subsequent rechalle

49 ell cultures and was associated with reduced virus shedding and mortality in piglets.

50 Overall, the vaccination reduced virus shedding and nasal discharge (p = 0.0059 and p = 0

51 virus resulted in a significant increase in virus shedding and pathogenicity.

52 ts of the HEV life cycle require ORF3: fecal virus shedding and persistent infection.

53 story require consideration when correlating virus shedding and protection.

54 ociated with a significant reduction in both virus shedding and recurrent corneal herpetic disease.

55 PRV G9P[13] induced longer rectal virus shedding and RV RNAemia in pigs than HRV Wa G1P[8]

56 h of exposure as demonstrated by respiratory virus shedding and seroconversion.

57 pigs developed diarrhea and fecal and nasal virus shedding and seroconverted with serum and intestin

58 ection in ferrets, leading to high levels of virus shedding and spread to naive contacts.

59 antially reduce A(H3N2)v (A/Indiana/08/2011) virus shedding and subsequent transmission to naive host

60 Virus shedding and symptoms are prolonged and debilitati

61 the mouse model and correlate inversely with virus shedding and symptoms in humans.

62 The amount and duration of virus shedding and the frequency of transmission followi

63 SIM showed the most complete suppression of virus shedding and the greatest improvement in pathology

64 The association between the duration of virus shedding and the persistence of detectable viral-s

65 esulted in a striking recrudescence of fecal virus shedding and the reappearance of viral RNA in seru

66 Virus shedding and tissue replication were route depende

67 ent with endemic swine IAV gene segments for virus shedding and transmission in pigs.

68 om latency occurs sporadically, resulting in virus shedding and transmission to uninfected cattle.

69 atently infected with BoHV-1, culminating in virus shedding and transmission.

70 6 to evaluate the evidence on modes of Ebola virus shedding and transmission.

71 A statistical association was seen between virus shedding and unexplained cases of gastroenteritis

72 Protection from virus shedding and viremia during challenge infection in

73 yed appearance and shorter duration of fecal virus shedding and viremia, and lower viral loads in liv

74 Virus shedding and virus functions did not change signif

75 antibodies on protection (from diarrhea and virus shedding), and on active antibody responses (measu

76 ed animals had low viremia titers, showed no virus shedding, and developed a strong virus-specific an

77 luding a human intestinal cell line, reduced virus shedding, and downregulated inflammatory response

78 from H1N1 infection as indicated by vaccine-virus shedding, and high efficacy against H1N1 challenge

79 d description of viral kinetics, duration of virus shedding, and intraviral evolution in different bo

80 lovirus (CMV) shedding, seminal Epstein-Barr virus shedding, and levels of anti CMV immunoglobulin in

81 s old) show higher viral loads, longer nasal virus shedding, and more severe lung inflammatory cell i

82 pletely abrogated epithelial cell infection, virus shedding, and the associated induction of proinfla

83 inidase (NA) of IAV reduce clinical disease, virus shedding, and transmission, particularly in the ab

84 lent HRV-inoculated pigs developed diarrhea, virus shedding, and viremia, similar to the orally inocu

85 he absence of fever, clinical disease, nasal virus shedding, and viremia.

86 cal signs associated with transmission, peak virus shedding, and virulence.

87 fected with HIV experience prolonged vaccine virus shedding, and, therefore, they probably represent

88 g pathology was identified post-clearance of virus shedding (antigen/RNA), with an association of vir

89 Using the duration of virus shedding as an outcome, the sample size to detect

90 7 children, 29 (61.7%) had prolonged measles virus shedding, as defined by detection of measles virus

91 sident CD4(+) and CD8(+) T cells in reducing virus shedding at the vaginal site of infection and the

92 ship between influenza virus infectivity and virus shedding, based on different diagnostic methods, h

93 Virus shedding began at postinoculation days (PID) 1 to

94 ug-treated HEV-infected pigs continued fecal virus shedding beyond the acute phase of infection, wher

95 A in stool were associated with cessation of virus shedding by day 7.

96 g-term variation and short-term stability of virus shedding can be generated by three possible factor

97 Virus shedding can occur in either the presence or absen

98 ions, low or rare pathogenicity, and chronic virus shedding, can all complicate disease association s

99 Ferrets re-challenged, after virus shedding ceased, are fully protected from acute lu

100 fever response, gross lesions, viremia, and virus shedding compared to parental and revertant viruse

101 ficant reductions in fever, weight loss, and virus shedding compared to these parameters in nonimmune

102 ith Ab4DeltaORF2 had reduced fever and nasal virus shedding compared to those infected with Ab4 but m

103 HIV)-infected children had prolonged measles virus shedding, compared with 19 (52.8%) of 36 HIV-uninf

104 nasal wash IgA and reduction of heterologous virus shedding, compared with IIV.

105 Under this protocol, detectable infectious-virus shedding continued until passage 5 and viral gene

106 of infected cells to propagate as long-term virus-shedding cultures; electron microscopy studies sho

107 by a model of human influenza based only on virus-shedding data.

108 Variation in duration of virus shedding (days to weeks) between animals, evolutio

109 ted for replication, with only low levels of virus shedding detected in respiratory secretions.

110 Prolonged measles virus shedding did not correlate with levels of measles

111 tant did not reactivate from latency because virus shedding did not occur in ocular or nasal cavities

112 ng viral regulatory proteins, which enhanced virus shedding during explant-induced reactivation from

113 etic corticosteroid dexamethasone influenced virus shedding during reactivation from latency using tr

114 We determined that infectious virus shedding early in infection correlates with transm

115 mice (Ifnar1(DeltaHep)), resulting in fecal virus shedding, elevated serum alanine aminotransferase

116 We found that the frequency of virus-shedding episodes, but not the incidence of clinic

117 cause clinical signs of disease, viremia, or virus shedding even when inoculated at doses 100-fold hi

118 This limited virus shedding explained the absence of secondary transm

119 cell subset frequencies coincided with peak virus shedding, followed by marked activation of T and N

120 red vaccines reduces pH1N1 swine influenza A virus shedding following challenge and can prevent trans

121 2 virus infection displayed reduced A(H3N2)v virus shedding following challenge, which blunted transm

122 antagonist impairs productive infection and virus shedding following explant of trigeminal ganglia f

123 2006b variant and monitored for diarrhea and virus shedding for 7 days.

124 tterns of seroconversion, viremia, and fecal virus shedding for pigs inoculated with RNA transcripts

125 rain EDIM [epizootic diarrhea of infant mice virus]) shedding for at least 1 year.

126 o the challenge strain significantly reduced virus shedding from directly infected pigs, but vaccinat

127 Increased virus shedding from individuals who are especially susce

128 Conversely, virus shedding from TG explants was significantly impair

129 aerosols, determining the duration of viable virus shedding from the respiratory tract is critical fo

130 ntly lower microscopic lung lesions and less virus shedding from the respiratory tract than did unvac

131 Virus shedding from the upper respiratory tract was not

132 ever, Ban/AF significantly reduced challenge virus shedding from the vaccinated birds compared to B1

133 e studies indicate that the LR gene promotes virus shedding from tonsil tissue during acute infection

134 BoHV-1 viral gene expression and virus shedding from tonsils also occur during reactivati

135 pulated did antibody production increase and virus shedding fully resolve.

136 Infectivity of ca virus (virus shedding, > or = 4-fold rise in serum hemagglutina

137 s has been cleared from the blood, and fecal virus shedding has terminated.

138 ics can account for the observed spectrum of virus shedding, immune response, and influenza pathology

139 in groups of vaccinated animals with reduced virus shedding.IMPORTANCE This study was designed to det

140 results in our laboratory were from vaccine virus shedding in 71/152 (46.7%) infants with a request

141 Furthermore, we quantified vaccine virus shedding in a subset of children's saliva using RT

142 provide a quantitative view of heterogeneous virus shedding in birds that may be used to better param

143 r 2 were also linearly, inversely related to virus shedding in breast milk.

144 itory antibody titers, significantly reduced virus shedding in challenged animals.

145 Vaccine virus shedding in children was time-limited and only obs

146 s are needed to understand the high rates of virus shedding in children without AGE symptoms.

147 of liver inflammation and cessation of fecal virus shedding in chimpanzees and murine models of hepat

148 Data from a recent study have shown that the virus shedding in EBV positive individuals is relatively

149 n risk from a meta-analysis, and respiratory virus shedding in exhaled breath to shed light on the do

150 tivate frequently, resulting in symptoms and virus shedding in healthy individuals.

151 l drug concentrations correlate with genital virus shedding in human immunodeficiency virus (HIV)-inf

152 e induced diarrhea without (or with limited) virus shedding in inoculated calves (n = 3).

153 uced the incidence of UV-B-induced recurrent virus shedding in latently infected mice.

154 stration of CDCA significantly reduced fecal virus shedding in mice (P < 0.05).

155 e Delta variants resulted in high infectious virus shedding in nasal secretions (up to 6.3 log(10) TC

156 with rWA1-D614G presented higher infectious virus shedding in nasal secretions, when compared to rWA

157 fluenza viruses, resulting in high titers of virus shedding in nasal washes for up to 5 days postinoc

158 ith resolution of viremia and termination of virus shedding in oropharynges and feces.

159 st reduction in the duration of symptoms and virus shedding in people with uncomplicated influenza in

160 these viruses were shown to infect and cause virus shedding in pigs.

161 By using infectious virus shedding in respiratory secretions and seroconvers

162 inoculations with PC-intact RhCMV, although virus shedding in saliva and urine was limited.

163 Frequency of virus shedding in serial urine samples by patients posit

164 stroenteritis, but the onset and duration of virus shedding in stool and serum antibody responses wer

165 ng HSV-1 reactivation from TG and subsequent virus shedding in tears that trigger recurrent corneal h

166 ion from latently infected TG and subsequent virus shedding in tears that trigger the recurrent corne

167 5N1) viruses was due to a lack of infectious virus shedding in the air, rather than the absence of ne

168 ociated with increased viral replication and virus shedding in the air.

169 the Hong Kong markets in 1997 but permitted virus shedding in the feces.

170 occurs in both epithelial cells (explaining virus shedding in the gastrointestinal tract) and lympho

171 occurs in both epithelial cells (explaining virus shedding in the gastrointestinal tract) and lympho

172 e virus frequently reactivates, resulting in virus shedding in the genital area, which serves as a so

173 ion from latently infected DRG and recurrent virus shedding in the genital mucosal epithelium causing

174 ses and exhibited partial protection against virus shedding in the lungs compared to controls.

175 strategy elicited a significant reduction in virus shedding in the vaginal mucosa and decreased the s

176 gnificant reduction in the number of days of virus shedding in those vaccinees who developed influenz

177 replication titers and the time of onset of virus shedding in triple-reassortant viruses.

178 ies, increase in anti-MV antibody titers, or virus shedding in urine or saliva.

179 h as nutritional stress, that correlate with virus shedding in wild-caught bats.

180 rotavirus challenge (> or = 50% reduction in virus shedding) in 50% of the mice.

181 ctors to explain the short-term stability of virus shedding into saliva.

182 ferential equations to study the dynamics of virus shedding into the saliva of infected hosts.

183 with infectious spread dependent on progeny viruses shedding into mucus secretions overlaying the ap

184 rease control of HSV-2 recurrent disease and virus shedding is an important goal of therapeutic immun

185 We show that influenza virus shedding is highly heterogeneous between subjects.

186 Whereas the overall magnitude of respiratory virus shedding is not linked to disease severity, the on

187 The basis for host control of virus shedding is not well understood, although adaptive

188 Our analysis also shows that clearance of virus shedding is possible only when there is no virus r

189 The role of under-nutrition on influenza virus shedding is unclear.

190 The resulting quantitative virus shedding kinetics data resembled ferret-to-ferret

191 Long-term virus shedding, lasting from one to 12 months, was obser

192 Based on virus shedding, limited replication was observed with th

193 ).Ml(-1)), whereas strikingly lower level of viruses shedding (<3.1 log(10) TCID(50).Ml(-1)) was obse

194 1.22; 95% CI, 1.09-1.36; P<.001) and lesion virus shedding (median, 3 days vs 3 days; HR, 1.35; 95%

195 crease in corneal IL-la mRNA in reactivated (virus shedding) mice.

196 The resolution of fecal virus shedding occurred concurrently with induction of i

197 Fecal virus shedding of FECV occurred in both groups starting

198 , duration of viral RNA shedding, and viable virus shedding of severe acute respiratory syndrome coro

199 Nevertheless, there was restricted virus shedding on challenge with a second vaccine dose a

200 clinical signs and did not develop viremia, virus shedding or antibodies against FMDV nonstructural

201 The virus shedding pattern of RSV was not different between

202 Additionally, virus shedding patterns indicate a different pathogenesi

203 Fecal virus shedding persisting for at least 7 days was detect

204 RVA immunity could be explored, using fecal virus shedding post-dose 2 as a marker of mucosal immuni

205 obiotic) pigs had lower diarrhea and reduced virus shedding postchallenge compared with noncolonized

206 ded with lower diarrhea severity and reduced virus shedding postchallenge in Vac+Pro compared with Va

207 s as young as 4 weeks old, with undetectable virus shedding postchallenge.

208 linical signs of disease and quantitated for virus shedding postexposure.

209 t infection (PI) with RNA viruses can extend virus shedding, prolong inflammation, and be a source of

210 In the worst-case scenario (i.e., maximum virus shedding rate, highest emission rate, and longest

211 recombination dynamics, as well as to assess virus shedding rate, level of viremia, expression of sel

212 ngs that include viral infections with lower virus-shedding rates than IHNV or where higher viral tit

213 er respiratory tract virus load, duration of virus shedding, select mucosal chemokine and cytokine le

214 We conducted LAIV virus shedding studies to assess the effect of this chan

215 adulthood did not alter immune responses or virus shedding, suggesting that sex steroids may organiz

216 nd and third prolines appear to aid in fecal virus shedding, suggesting that the PSAP motif, but not

217 ant person-to-person variation in infectious virus shedding suggests that individual-level heterogene

218 ial effect of rimantadine was documented for virus shedding, symptom load, and sinus pain.

219 role for CD4(+) T lymphocytes in control of virus shedding that may be mediated in part by maintenan

220 Therapeutic ART suppresses genital virus shedding throughout the menstrual cycle, even in t

221 Mean peak virus shedding titers and mean cumulative fecal scores w

222 Although the double mutant had virus shedding titers and transmissibility comparable to

223 ad prolonged mean death times (MDT), and the virus-shedding titers were significantly lower than thos

224 ilent IAV infections with possible impact on virus shedding to the population.

225 ned the role of CD4(+) T cells in control of virus shedding using a guinea pig model of genital HSV-2

226 Clinical signs, virus shedding, virus replication in respiratory tissues

227 Although virus shedding was comparable between the N(752) and D(7

228 ificantly lower titers and that the onset of virus shedding was delayed compared to the replication t

229 Virus shedding was detected beginning at 3 days p.i. fro

230 RV1 vaccine virus shedding was detected by quantitative real-time po

231 Vaccine virus shedding was detected in 17% of participants.

232 enge with bovine coronavirus, no diarrhea or virus shedding was detected in calves inoculated with HE

233 PHEV did not produce viremia, but virus shedding was detected in nasal secretions (1 to 10

234 Little or no virus shedding was detected in nose-throat swabs or trac

235 Virus shedding was detected in the respiratory and intes

236 Fecal virus shedding was detected variably from 1 to 20 dpi fo

237 No virus shedding was detected.

238 o significant protection against diarrhea or virus shedding was evident in any of the 2/6-VLP (with o

239 Virus shedding was examined via tissue culture and rever

240 The maximal concentration of virus shedding was higher for persons with gastroenterit

241 Virus shedding was much higher and prolonged in quail an

242 Vaccine virus shedding was observed in 31.7% of children, peakin

243 Virus shedding was readily detected when viral DNA-posit

244 the infection by H3N2 virus, the duration of virus shedding was shortened, and clinical disease was m

245 on in women but seems to be more limited, as virus shedding was undetectable more than 40 days after

246 Pharyngeal virus shedding was very high during the first week of sy

247 were manipulated and antibody responses and virus shedding were assessed following inoculation with

248 d mucosal IL-6 level, and longer duration of virus shedding were associated with severe disease.

249 inical disease, but intermittent viremia and virus shedding were detected up to day 60 postinfection

250 Fecal and nasal virus shedding were first detected by reverse transcript

251 levels, immediate early RNA expression, and virus shedding were readily detected when NALT explants

252 enzyme gamma-glutamyl transferase and fecal virus shedding were significantly higher in immunocompro

253 t commercial vaccine was not able to prevent virus shedding when chickens were challenged with antige

254 ation at the onset of clinical signs reduced virus shedding, which may support outbreak control.

255 arrhea and 49% homologous protection against virus shedding, while the P particle and VLP vaccines pr

256 mmunocompromised mice demonstrated prolonged virus shedding with modest induction of immune responses

257 Sustained virus shedding with transmission to contact-exposed bird

258 c calf, GiCoV-OH3 caused severe diarrhea and virus shedding within 2 to 3 days.

259 The mechanisms underlying the regulation of virus shedding within a host are not fully understood.

260 isseminated viral replication and infectious virus shedding, without clinical disease, while the othe