ライフサイエンスコーパス: virus-derived

1 (LS strain) fused to the cauliflower mosaic virus-derived 35S promoter.

2 hosphatase 11 (DUSP11) acts on both host and virus-derived 5'-triphosphate RNAs rendering them less a

3 tified 32 independent incursions of an avian virus-derived A allele into mammals, whereas 6 introduct

4 be detected from tissues 14 d postinfection, virus-derived Ag continues to drive a CD4(+) T cell resp

5 tion to determine the duration and impact of virus-derived Ag presentation.

6 cted DC maintain the ability to present both virus-derived and exogenous Ags, but that they actively

7 Assays measuring both Epstein-Barr virus-derived and human IL-10 yielded higher values than

8 When a similar test using virus-derived antigen was performed, a loss of both spec

9 gle day of antigenic stimulation even though virus-derived antigens (Ags) are still presented by DCs

10 The kinetics of presentation of influenza virus-derived antigens (Ags), resulting in CD4 T cell ef

11 nd proliferation in response to bacteria and virus-derived antigens.

12 biological niche will benefit prevention of virus-derived cancers such as MCC.

13 ncapsulins, HK97-like capsids, or indeed any virus-derived capsids reported in the Protein Data Bank,

14 Mutation within virus-derived CD8 T-cell epitopes can effectively abroga

15 smic hepatitis C virus is processed to yield virus-derived circRNAs (vcircRNAs).

16 Virus-derived circRNAs have recently been described in g

17 vances in our understanding of both host and virus-derived circRNAs, with a focus on their biological

18 uantum dots, carrying a controlled number of virus-derived (cognate) and other (noncognate) pMHC-I co

19 s transposon reverse transcriptases, produce virus-derived complementary DNAs (vDNA).

20 ll nuclei, usually through the deployment of virus-derived components.

21 ve previously shown that vaccines expressing virus-derived cytotoxic-T-lymphocyte (CTL) epitopes as s

22 n, many prokaryotes incorporate fragments of virus-derived DNA into loci called clustered regularly i

23 the ancestral parvovirus genome into a large virus-derived DNA transposon of the Polinton (polintovir

24 The Sindbis virus-derived DNA vectors described here increase the ut

25 RNAi is programmed by siRNAs processed from virus-derived double-stranded RNA by Dicer endonuclease.

26 thway that responds through the detection of virus-derived double-stranded RNA to suppress virus repl

27 viruses, host nonself RNA sensors recognize virus-derived dsRNA as danger signals and initiate innat

28 P19 homodimers sequester 21-nt virus-derived duplex siRNAs, and it is thought that this

29 nstituted of viruses that infect host cells, virus-derived elements in our chromosomes, and viruses t

30 mpared with other mammals, yet the role that virus-derived endogenous elements may have played in the

31 characteristic properties of murine leukemia virus-derived engineered VLPs and HIV-derived engineered

32 These virus-derived entities are passed on through wasp genera

33 Rel is a chimeric protein that has 11 helper virus-derived Envelope (Env) amino acids (aa) at its N t

34 t three mutant residues in the eleven helper virus-derived Envelope (Env) amino acids (aa) at the N-t

35 plication, orchestrated by integrase (IN), a virus-derived enzyme.

36 e HLA-A2-restricted, immunogenic hepatitis B virus-derived epitope HBcAg18-27 by replacing each amino

37 Using a panel of 38 defined influenza A virus-derived epitopes recognized by C57BL/6 mouse CD8(+

38 as yet inadequate for identifying influenza virus-derived epitopes.

39 f persistent exposure to structurally stable virus-derived epitopes.

40 of HIV-, hepatitis B virus-, and hepatitis C virus-derived epitopes.

41 mulation with a lymphocytic choriomeningitis virus-derived escape mutant as demonstrated by the susta

42 d humans were infected by an HIV-1 precursor virus derived from a contaminated poliovaccine.

43 Two were infected with a wild-type virus derived from a full-length infectious clone (A12-I

44 d for efficacy against a multidrug-resistant virus derived from a highly experienced patient expressi

45 f influenza A/WSN/33 (H1N1), a mouse-adapted virus derived from a human influenza strain first isolat

46 f HIV-associated immunopathogenesis, using a virus derived from a human pathogen, we identified a sig

47 Virus derived from a second clone, p19/wenv16, caused so

48 ccines are based on a live-attenuated YF-17D virus derived from a virulent African isolate.

49 cular evolution of a feline immunodeficiency virus derived from a wild cougar, Puma concolor, during

50 no long-term viral evolution, implying that virus derived from activated latent cells must dominate.

51 Virus derived from both clones caused persistent infecti

52 Virus derived from clone p19/wenv17 caused severe debili

53 Thus, HPAI H5N1 virus derived from dairy cattle transmits by respiratory

54 The building blocks of a virus derived from de novo biosynthesis during infection

55 tions with different subtypes of influenza A virus derived from different hosts, we found that evolut

56 ith BALB/c-adapted A/New Caledonia influenza virus derived from four consecutive lung pool passages.

57 Here, we describe a chimeric virus derived from GB virus B (GBV-B), an unclassified h

58 A virus derived from HSV-1(U(L)17-stop) but containing a r

59 isrupt the U5-PBS-tRNAMet interaction of the virus derived from HXB2(Met-AC).

60 Virus derived from IN-minus provirus is noninfectious.

61 defects in particle morphology compared with virus derived from mosquito cells.

62 in pig cell lines productively infected with virus derived from NIH miniature pig and Yucatan pig PBM

63 Virus derived from pHXB2(His-AC-GAC) with M184V RT had s

64 d provirus from a cell culture infected with virus derived from pHXB2(His-AC-TGT) revealed a G-to-A c

65 tRNA(His) to initiate reverse transcription [virus derived from pHXB2(His-AC-TGT)] revealed five addi

66 Virus derived from pMRE16ic replicated with the same eff

67 SHIV-KB9, a molecularly cloned virus derived from SHIV-89.6P, also caused CD4+ T-cell d

68 otypic analyses showed no difference between virus derived from subjects after TCN-032 treatment and

69 virus isolates and rechallenged them with a virus derived from the 2009 H1N1 A/CA/04/09 virus, named

70 Virus derived from the BAC clone had a wild-type phenoty

71 While virus derived from the clone containing the M47 mutation

72 Using the Wyeth strain of vaccinia virus derived from the Dryvax vaccine, we generated a re

73 y circulating strains of African swine fever virus derived from the Georgia 2007 isolate.

74 Plaque-purified virus derived from the infectious construct replicated e

75 Plaque-purified virus derived from the infectious construct replicated e

76 An infectious molecular clone of virus derived from the isolate from macaque PGm (PGm5.3)

77 Using a recombinant virus derived from the JFH1 strain, we confirmed that pl

78 inated target cells infected with autologous virus derived from the latent reservoir, both in vitro a

79 A at 1,000 times the lethal dose of vaccinia virus derived from the licensed Dryvax vaccine seed.

80 Several studies have used virus derived from the molecular clone SFV4.

81 Nevertheless, comparison of the virus derived from the mutant (ps51) and wild-type (ps55

82 Following long-term infection with virus derived from the pathogenic GL8 molecular clone of

83 Virus derived from this clone differs from nonneuroinvas

84 CP22-encoding alpha22 (US1/US1.5) gene and a virus derived from this mutant bearing a restored alpha2

85 A virus derived from this mutant but bearing a restored U(

86 ld-type S.A.AR86 infectious clone, ps55, and virus derived from this mutant clone, ps51, was signific

87 The virus derived from this yeast-assembled genome, KOS(YA),

88 Virus derived from transcripts containing mutations in t

89 iants that arose after drug selection, using virus derived from two different HIV proviral clones, NL

90 Animals were inoculated with a plaque-cloned virus derived from VR-2332, the North American PRRS viru

91 rain of the 2009 new pandemic H1N1 influenza virus, derived from the A/California/07/2009 isolate and

92 components, prompting hypotheses that these viruses derived from a fourth domain of cellular life.

93 Viruses derived from a Merlin-BAC derivative in which RL

94 ), and infection of a single pony (678) with viruses derived from a mixture of five of these molecula

95 reen of primary viral isolates revealed that viruses derived from asymptomatic, infected people had l

96 parent virus at 32 degrees C. ts+ revertant viruses derived from both mutants have also reverted in

97 These results show that viruses derived from C499 are more pathogenic for chimpa

98 s with HCV pseudoparticles and cell-cultured viruses derived from different heterologous 1a, 1b, 2a,

99 uate the infectivity and cellular tropism of viruses derived from different hosts.

100 ross-species virulence evolution in zoonotic viruses derived from diverse mammalian hosts.

101 for the HBV infection assay in cell culture, viruses derived from HBV genome-integrated cell lines of

102 sting each primer-probe pair against various viruses derived from laboratory virus stocks, as well as

103 arboviruses more efficiently infect DCs than viruses derived from mammalian cells.

104 To assess the cellular source of infectious viruses derived from MDM, virus-containing media from in

105 Viruses derived from Merlin-BAC in fibroblasts had mutat

106 ral strains, including neutralization escape viruses derived from other nAbs; however, no single nAb

107 p6 domain of Gag are frequently observed in viruses derived from patients on protease inhibitor (PI)

108 vealed that by day 15 of culture, the PBS of viruses derived from pHXB2(His) and pHXB2(His-T psi C) r

109 In contrast, viruses derived from pHXB2(His-AC) maintained a PBS comp

110 erably more nucleotide substitutions than in viruses derived from pHXB2(His-AC-GAC) containing the M1

111 s obtained after transfection, we found that viruses derived from pHXB2(His-AC-GAC) with the wildtype

112 ) with wild-type RT and M184V RT compared to viruses derived from pHXB2(His-AC-GAC).

113 tion of reverse transcription was delayed in viruses derived from pHXB2(His-AC-TGT) with wild-type RT

114 proviral genomes revealed that the PBSs from viruses derived from pHXB2(Met) and pHXB2(AC-Met) revert

115 In contrast, the viruses derived from pHXB2(Met-AC-Met) stably maintained

116 , novel mutant viruses were identified among viruses derived from pHXB2(Met-C-Met) at day 35 postcocu

117 Viruses derived from plasmids were propagated in MDCK ce

118 Viruses derived from pMRE16icDeltaE200-Y229 and pMRE16ic

119 We characterized the replication fitness of viruses derived from pNL4-3 containing P236L or K103N in

120 f the growth phenotypes of additional mutant viruses derived from RNAs containing DEN2-WN chimeric 3'

121 Recombinant viruses derived from S648 and HSV-1(delta U(L)15ExII) an

122 Here we use wild-type and Vif-deficient viruses derived from the CD4(+) T cells of multiple dono

123 Sequencing of the viruses derived from the D17 cell lines revealed second-

124 We used NS1 truncated mutant influenza viruses derived from the human isolate influenza A/TX/91

125 e with a randomized DIS, infected cells with viruses derived from the library, and monitored the emer

126 Furthermore, viruses derived from the MLV chimera with SNV CA could s

127 ase-driven replication capacity than that of viruses derived from the mothers (P < 0.0001 by a paired

128 were inoculated with two recombinant hybrid viruses derived from the parent viruses SIVmac239, a lym

129 hich nef genes were sequenced from outgrowth viruses derived from the quantitative viral outgrowth as

130 oliomyelitis have been shown to be caused by viruses derived from the Sabin vaccine strains.

131 Viruses derived from the transfection of these proviral

132 Using a set of viruses derived from these chimeras by exchanging portio

133 re detected in the growth characteristics of viruses derived from these clones as compared to the ori

134 In assays using a panel of reassortant viruses derived from these strains, the difference in AT

135 Viruses derived from these transfected cells were infect

136 Propagation of viruses derived from TR-BAC, TB40-BAC4, and FIX-BAC in e

137 ptation, we selected mutant receptor-adapted viruses derived from two P1/Mahoney variants, one which

138 ted subjects or seronegative plasma to which viruses derived from wild-type and mutant infectious mol

139 include highly pathogenic emerging zoonotic viruses, derived from bat, rodent, and shrew reservoirs.

140 susceptible to infection with avian leukosis virus-derived gene vectors.

141 ronger cellular immunity in rodents than did virus-derived gene.

142 ell death in response to the accumulation of virus-derived glycosphingolipids upon infection of natur

143 uced a predominant Th1 response, and the PR8 virus-derived HA110-120 peptides induced a mixed Th1/Th2

144 complexed with a H-2Kk-restricted influenza virus-derived hemagglutinin peptide (Ha255-262) but does

145 nce an alternatively added HA (for influenza virus-derived hemagglutinin) epitope tag caused similar

146 Hepatic overexpression of the virus-derived human ET-1 mRNA was accompanied by a 13-fo

147 ructural motifs within Op-IAP, an efficient, virus-derived IAP.

148 and with VSV-mediated virotherapy, and that virus-derived IFN-beta would add further safety to the V

149 ough which LASV NP has been shown to degrade virus-derived immunostimulatory dsRNA in biochemical ass

150 h ExoN motif, through which LASV NP degrades virus-derived, immunostimulatory dsRNA in biochemical as

151 In contrast, expression of CrmA, a cowpox virus-derived inhibitor of the Ced-2-like proteases ICE

152 iated herpesvirus are autocrine dependent on virus-derived interleukin-6 (IL-6), but not on cellular

153 ant genes and there are no reports of animal virus derived IRES activity in plant cells.

154 oto-oncogene from which the Abelson leukemia virus derived its Gag-v-Abl oncogene, recent results hav

155 so recognized an epitope of the Epstein-Barr virus-derived latent membrane protein 1 (LMP1) presented

156 sites, located between two Moloney leukemia virus-derived LTR, into which genes of interest may be i

157 Thus far, detection of virus-derived miRNAs has been largely limited to DNA vir

158 o express both GFP and a sgRNA from a single virus-derived mRNA in Nicotiana benthamiana This vector

159 well known that these pathogens make use of virus-derived multitasking proteins, as well as dedicate

160 SHIV(MD14) carrying simian immunodeficiency virus-derived nef established significantly higher virus

161 Correspondingly, virus-derived noncoding and antisense transcripts may sh

162 Subgenomic flaviviral RNAs (sfRNAs) are virus-derived noncoding RNAs produced by pathogenic mosq

163 hus, neither the A nor the B allele of avian virus-derived NS segments necessarily attenuates virus r

164 responses to infection showed that the avian virus-derived NS segments provoked lower levels of expre

165 o test this, a number of clade A and B avian virus-derived NS segments were introduced into human H1N

166 ty of infected cells or cells triggered with virus-derived nucleic acids to produce type I interferon

167 Mammalian cells recognize virus-derived nucleic acids using a defined set of intra

168 n (IFN-I) and other cytokines in response to virus-derived nucleic acids.

169 HSAECs were exposed to stimulants mimicking virus-derived PAMPs, either in the absence or presence o

170 cognition receptors (PRRs), which respond to virus-derived pathogen-associated molecular patterns (PA

171 ly related to the avidity of the TCR for the virus-derived peptide (p) + major histocompatibility com

172 vestigated whether intratumoral injection of virus-derived peptide epitopes could activate preexistin

173 l cytokine production after stimulation with virus-derived peptide pools and absence of torque teno v

174 te algorithms identified 101 influenza A PR8 virus-derived peptides as potential epitopes for CD8+ T

175 Six virus-derived peptides from five different viral protein

176 se by inhibiting the cell surface display of virus-derived peptides on MHC class I molecules.

177 ple, of a large collection of ~30,000 dengue virus-derived peptides only 0.3% were predicted to bind

178 virus-infected cells through recognition of virus-derived peptides presented at the cell surface by

179 ly lyse infected cells expressing the target virus-derived peptides presented by human leukocyte anti

180 ors in antiviral immunity, recognizing short virus-derived peptides presented by MHC class I (pMHCI)

181 inal proline residues was observed in Hendra virus-derived peptides presented by Ptal-N*01:01 on the

182 CD8(+) T cells that recognize virus-derived peptides presented on MHC class I are vita

183 mice to two naturally presented influenza A virus-derived peptides previously identified from virall

184 In summary, our findings indicate that virus-derived peptides targeted to MAST2-PDZ stimulate n

185 elicit cytotoxic CD8(+) T cells specific for virus-derived peptides.

186 :01, and elucidated the binding capacity for virus-derived peptides.

187 Piwi4 binds preferentially to virus-derived piRNAs but not to transposon-targeting piR

188 We also report detection of virus-derived PIWI-interacting RNAs (piRNAs) in Drosophi

189 Similarly, the production of virus-derived piwi-interacting RNAs (vpiRNAs) was not su

190 Using a Tobacco rattle virus-derived plasmid for in planta transient expression

191 and 8 CFU of Escherichia coli carrying Ebola virus-derived plasmids.

192 nt DLAV vaccine (TV005) with pools of dengue virus-derived predicted major histocompatibility complex

193 Peptides were fused to the hepatitis B virus-derived PreS domain as recombinant fusion proteins

194 I mainly by interfering with the function of virus-derived primary siRNAs.

195 (siRNA) tool, which precisely distinguishes virus-derived (primary) from target-generated (secondary

196 The geometric construction principle of virus-derived protein cages is by now fairly well unders

197 lerated primary B cell response to influenza virus-derived protein, evidenced by high anti-nucleoprot

198 These results provide evidence that virus-derived, protein-encoding circular RNAs are biolog

199 To study the role of the virus-derived proteins on the development of these elect

200 ent of a single recombinant adeno-associated virus-derived (rAAV-derived) vector gene therapy strateg

201 r untreated primary cultures with viruses or virus-derived replicons that lacked the structural prote

202 n of replication-incompetent murine leukemia virus-derived retroviral vectors.

203 the 3' U3 region of Moloney murine leukemia virus-derived retroviral vectors.

204 fense against viral infection by recognizing virus-derived RNAs and are localized to intracellular me

205 replication-competent, noncytopathic Sindbis virus-derived RNAs.

206 ve-strand RNA viruses requires production of virus-derived secondary small interfering RNAs (siRNAs)

207 gh mice infected with viruses with the avian virus-derived segment 8s had reduced weight loss compare

208 nal plasmid vector and from a Semliki Forest virus derived, self-replicating vector.

209 ese include endogenous viral elements (EVEs)-virus-derived sequences that can dramatically impact hos

210 A virus-derived serpin, Serp-1, has proven efficacy in tre

211 esults reveal the large extent to which Zika virus-derived sfRNAs interact with cellular RNA-binding

212 ting genetic subtypes were included, as were viruses derived shortly after transmission and during th

213 report here the generation of an X31 (H3N2) virus-derived single-cycle infectious influenza virus, X

214 s was associated with a much higher level of virus-derived siRNA accumulation compared to plants infe

215 In plants, virus-derived siRNAs (viRNAs) can target and silence cel

216 antiviral RNAi pathway and the generation of virus-derived siRNAs (viRNAs).

217 iRNAs, yet the mechanisms by which secondary virus-derived siRNAs (vsiRNAs) confer protection remain

218 efense relies on the production of secondary virus-derived siRNAs (vsiRNAs) to achieve an amplified a

219 ivirus-induced gene silencing by quantifying virus-derived siRNAs and by evaluating their distributio

220 mature human somatic cells produce abundant virus-derived siRNAs co-immunoprecipitated with AGOs in

221 paper describes the profile of mutations in virus-derived siRNAs for three members of the family Pot

222 for the production and antiviral function of virus-derived siRNAs in both undifferentiated and differ

223 Next, we evaluated the distribution of virus-derived siRNAs on the respective virus genome at t

224 NV) does not result in the production of any virus-derived siRNAs or viral miRNAs.

225 fering RNAs (siRNAs) derived from viral RNA (virus-derived siRNAs) through gene silencing.

226 olymerases to the generation of mutations in virus-derived siRNAs.

227 consistent with two sources of mutations in virus-derived siRNAs: viral RNA-dependent RNA polymerase

228 S is likely initiated by a process guided by virus-derived small (s) RNAs that are 21/22-nt in length

229 Virus-derived small interfering RNA (siRNA) is a primary

230 of polymorphisms and recombination, and the virus-derived small interfering RNA (vsiRNA) sequences i

231 In addition, AGO1 recruits virus-derived small interfering RNAs (siRNAs) in vivo, s

232 ntiviral RNA interference (RNAi) directed by virus-derived small interfering RNAs (siRNAs) represents

233 eins to suppress RNAi as their hosts produce virus-derived small interfering RNAs (siRNAs) that direc

234 Diverse eukaryotic hosts produce virus-derived small interfering RNAs (siRNAs) to direct

235 ies and mosquitoes induces the production of virus-derived small interfering RNAs (siRNAs) to specifi

236 is antiviral immunity involves production of virus-derived small interfering RNAs (viRNAs) and result

237 llenberg virus resulted in the production of virus-derived small interfering RNAs (viRNAs) of 21 nucl

238 We identified virus-derived small interfering RNAs (viRNAs), 21 nt in

239 s in infected cells showed the production of virus-derived small interfering RNAs (viRNAs), which are

240 iate double-stranded RNAs are processed into virus-derived small interfering RNAs (vsiRNAs) by the ho

241 (RNAi), which relies on the accumulation of virus-derived small interfering RNAs (vsiRNAs) to guide

242 nd RNA viruses can trigger the biogenesis of virus-derived small interfering RNAs (vsiRNAs), we show

243 resistance by promoting amplification of the virus-derived small interfering RNAs (vsiRNAs).

244 verse eukaryotic organisms, Dicer-processed, virus-derived small interfering RNAs direct antiviral im

245 omparative view of the antiviral activity of virus-derived small interfering RNAs in fungi, plants, i

246 ible for antiviral defense and generation of virus-derived small interfering RNAs, in DI RNA producti

247 The roles of virus-derived small RNAs (vsRNAs) have been studied in p

248 We now report the accumulation of virus-derived small RNAs (vsRNAs) in hypovirus CHV1-EP71

249 obtain insights into the connection between virus-derived small RNAs (vsRNAs), viral genome methylat

250 he generation by Dicer-like (DCL) enzymes of virus-derived small RNAs of 21 to 24 nucleotides (nt) th

251 ped a sequence-independent strategy based on virus-derived small RNAs produced by the host response,

252 By sequencing virus-derived small RNAs, we show that the viruses repre

253 Here we describe examples of influenza A virus-derived small viral RNAs (svRNAs).

254 we show that upon antiviral RNAi activation, virus-derived small-interfering RNAs (vsiRNAs) from Noda

255 results in the RNAi-dependent production of virus-derived, small-interfering RNAs (viRNAs), which in

256 to miRNAs, we also identified novel forms of virus-derived smRNAs, revealing greater complexity withi

257 ne/chemokine production after challenge with virus-derived stimulants.

258 their versatility and their ability to move, virus-derived systems have emerged as an interesting alt

259 Mice were immunized with a pool of virus-derived T-cell epitopes.

260 f HIV-1 RT and on wild-type HIV-1 and mutant viruses derived thereof, Ile100 and Cys181, in cell cult

261 tly delivering sgRNAs using a Tobacco mosaic virus-derived vector (TRBO) designed with 5' and 3' sgRN

262 the lentivirus vector and a murine leukemia virus-derived vector in thymocytes.

263 Using the Rous sarcoma virus-derived vector RCAS, we previously showed that mut

264 lla luciferase) expression from an influenza-virus-derived vector.

265 Gag was expressed by using a Semliki Forest virus-derived vector: under these conditions, the Semlik