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2 the ORF1 polyprotein was generated, and the virus-encoded 3C-like (3CL) proteinase (Pro) mediated cl
4 ORFs of equine H3N8 and avian H3N2 influenza viruses encoded 61 amino acids but were truncated after
11 ion between corresponding family clusters of virus-encoded ANK and Skp1 proteins from three chlorovir
13 e triggered at mitochondria and modulated by virus-encoded anti-apoptotic B cell leukemia (BCL)2-like
15 pase-8, cytokine response modifier A (cowpox virus-encoded antiapoptotic protein), or DN Fas-associat
17 e efficiency difference between cellular and virus-encoded antigens is based on whether the antigen i
18 red thirty-six of the proteins were vaccinia virus-encoded ( approximately 64% of the known vaccinia
19 view the discovery of viral master circuits: virus-encoded autoregulatory gene networks that autonomo
21 wed that CBP interacts with the Epstein-Barr virus-encoded basic region zipper (b-zip) protein, Zta,
23 Virulence in animal models depends on the virus-encoded bifunctional Z-DNA/double-stranded RNA (ds
24 (GILGFVFTL) and the dissimilar Epstein-Barr virus-encoded BMLF1(280-288) epitope (GLCTLVAML), that,
25 ression of immune subversion proteins of the virus encoded by genes belonging to the US gene family.
30 ecruits new macrophages to the tumor via the virus-encoded chemokine MCK2, and viruses lacking this c
33 with diversity-generating retroelements and virus-encoded Clustered Regularly Interspaced Short Pali
38 relevant to understanding the potential of a virus-encoded cytokine-like molecule, HHV8 vIL6, to indu
39 intramolecular disulfide bond formed by the virus-encoded cytoplasmic redox pathway, and is incorpor
40 the formation of which required the vaccinia virus-encoded cytoplasmic redox pathway, and was localiz
41 iated proteins localized to the periphery of virus-encoded cytoplasmic structures, termed virus facto
44 progress is leading to the identification of virus-encoded determinants responsible for altering fung
47 ous amounts of methylated nucleotides due to virus-encoded DNA methyltransferases (MTases); about 25%
48 inding protein (OBP), one of seven essential virus-encoded DNA replication proteins, to specific sequ
49 evaded by transcription of highly structured virus-encoded dsRNA inhibitors that bind to and inactiva
50 circumvent PKR function by transcription of virus-encoded dsRNA inhibitors that bind to and inactiva
51 tethering, mediated by Brd4 interaction with virus-encoded E2 protein, facilitates viral genome segre
52 understanding of the mechanisms by which the virus-encoded E6 oncoproteins contribute to cell transfo
53 hile their direct autoregulatory activity on virus-encoded early gene products is completely preserve
60 somal DNA of a host cell and is one of three virus-encoded enzymes that are required for replication.
62 es, episome maintenance requires a dedicated virus-encoded episome maintenance protein (EMP), namely
64 analysis indicated that the mutation in the virus-encoded external scaffolding protein was primarily
67 ssociated proteins around the peripheries of virus-encoded factories, interrupting the normal formati
70 both plant and invertebrate hosts requires a virus-encoded function to block the RNA silencing antivi
71 eptibility to cucumber mosaic virus when the virus-encoded function to suppress RNAi was disrupted.
73 es is transcribed, including one of the four virus-encoded G protein-coupled receptors (GPCRs), US28.
76 d cells that express a broad spectrum of the virus-encoded genes (type III latency; EBV+/III), EBV-po
77 c analysis reveals that 65% of the predicted virus-encoded genes are expressed during lytic infection
78 ce, host-cell-derived tissue factor (TF) and virus-encoded glycoprotein C (gC) can stimulate protease
79 s initiated by the interaction of the Friend virus-encoded glycoprotein gp55 with the erythropoietin
83 s expressing only US28 but not the remaining virus-encoded GPCRs is phenotypically similar to that of
85 acterization of the aptamers showed that the virus-encoded hemagglutinin, a protein expressed on the
88 s and vaccinia virus specifically, utilize a virus-encoded host range factor(s), such as a member of
89 ropism at the cellular level is regulated by virus-encoded host range proteins acting downstream of v
91 hermore, the absence of analogous degrons in virus-encoded IAPs explains their relative stability and
94 t has resulted in a delicate balance between virus-encoded immune evasion mechanisms and host antivir
95 rus, extending the known diversity of insect virus-encoded immune inhibitors.IMPORTANCE Coevolution o
97 However, the relative contribution of each virus-encoded innate immune antagonist has not been full
99 This enzymatic process is catalyzed by the virus-encoded integrase protein, which is conserved amon
100 ces correlate with the sequence/structure of virus-encoded integrases, supporting the idea that integ
105 e class of agent has been licensed targeting virus-encoded ion channels, or 'viroporins', contrasting
108 rs (vTAs) coordinate to direct expression of virus-encoded late genes, which are critical for viral a
109 he latter, (iii) neither viral DNA nor other virus-encoded late proteins are required for the interac
111 virus (EBV) nuclear antigen 3C (EBNA3C) is a virus-encoded latent antigen essential for primary B-cel
113 al tumor nasopharyngeal carcinoma (NPC), the virus-encoded latent membrane protein LMP2A is consisten
114 nd transmembrane domains of the Epstein-Barr virus-encoded latent membrane protein-1 (LMP1) fused to
115 ng infected cells to differentiate using the virus-encoded LMP1 and LMP2a proteins, which act as func
116 ed that several nonenveloped viruses utilize virus-encoded lytic peptides for host membrane disruptio
117 ty between the HLA-A2-restricted influenza A virus-encoded M1(58-66) epitope (GILGFVFTL) and the diss
118 We propose that the NEC functions as minimal virus-encoded membrane-budding machinery during nuclear
119 transforms host metabolism, in part through virus-encoded metabolic genes; the functions performed b
120 e identification and characterization of two virus-encoded methyltransferases (MTases) involved in RN
123 genes in the animal kingdom, although animal virus-encoded microRNAs (miRNAs) are known to guide effi
128 ese findings imply that some host targets of virus-encoded miRNAs are likely to be of little selectiv
131 s are continuing but the recent discovery of virus-encoded miRNAs indicates that viruses also use thi
133 miRNAs and there is evidence to suggest that virus-encoded miRNAs target specific host genes and path
139 itiation factor eIF4E and VP39 (the vaccinia virus-encoded mRNA cap-specific 2'-O-methyltransferase),
142 pect to virus production and accumulation of virus-encoded mRNAs measured by real-time PCR when K-Rta
144 mbinant fusion protein comprised of a cowpox virus encoded NKG2D binding protein (OMCP) and a mutated
145 ied, little is known about the structures of virus-encoded non-structural proteins that are essential
148 rsistent insect reovirus took advantage of a virus-encoded nonstructural protein, P10, for efficient
151 s observed as discrete foci, associated with virus-encoded NS5A and core proteins and identical in mo
153 oliferation and the EBV latency Epstein-Barr virus-encoded nuclear antigen (EBNA)2 transcriptional tr
154 -alanine repeat domain (GAr) of Epstein-Barr virus-encoded nuclear antigen 1 (EBNA1) prevents major h
156 ive sense RNA that are encapsidated with the virus-encoded nucleocapsid (N) protein to form a ribonuc
157 t C6 in the 2'-deoxynucleoside series showed virus-encoded nucleoside kinase-sensitive anti-VZV activ
158 RB) family of tumor suppressor proteins, and virus-encoded oncogenes disrupt the RB-E2F repressor com
159 nd the carcinogenic mechanism of hepatitis B virus-encoded oncoprotein HBx, we explored the function
160 factor receptor family, and the Epstein-Barr virus-encoded oncoprotein latent membrane protein 1 (LMP
162 nducing kinase and the human T-cell leukemia virus-encoded oncoprotein Tax or be constitutively turne
168 MERS-CoV replication depends in part on a virus-encoded papain-like protease (PL(pro)) that cleave
170 onformation of gamma, a membrane-disrupting, virus-encoded peptide usually sequestered inside the cap
176 ermediate transcription factor, comprised of virus-encoded polypeptides A8 and A23, was previously id
177 provide direct evidence that AC4 is a unique virus-encoded posttranscriptional gene-silencing suppres
178 s from cellular transcription in requiring a virus-encoded preinitiation complex that binds to TATT m
179 ved after CVB3 infection at G175 and G436 by virus-encoded protease 2A(pro), independent of caspase a
183 terminal alpha-l-Rha is achieved by another virus-encoded protein A061L, which requires an O-2 methy
184 e mechanism of STAT signaling evasion, but a virus-encoded protein called V plays a central role in t
186 mplexes (RNPs) formed by these RNAs with the virus-encoded protein hepatitis delta antigen (HDAg) per
189 assemble in the host cell membrane from the virus-encoded protein PVAP and open at the end of the in
190 nsactivator of transcription (Tat), an early virus-encoded protein required for the efficient transcr
191 to the ability to phosphorylate H5, the only virus-encoded protein shown to be a B1 substrate in vivo
195 hondria-localized inhibitor of apoptosis), a virus-encoded protein with a unique, albeit poorly under
196 otic function of NSP4 is balanced by another virus-encoded protein, NSP1, which is implicated in PI3K
198 icornaviral RNA replication utilizes a small virus-encoded protein, termed 3B or VPg, as a primer to
200 oteins that are proteolytically processed by virus-encoded proteinases to produce mature replicase pr
203 f the human nervous system that uses its own virus-encoded proteins and the normal cellular ESCRT mac
207 Combined, these analyses revealed 148 unique virus-encoded proteins associated with the virion (about
213 udies have uncovered new mechanisms by which virus-encoded proteins inhibit Ub and Ub-like (Ubl) modi
215 duce a restrictive defense response but that virus-encoded proteins may be involved in differential i
216 e focusing on agents that block Epstein-Barr virus-encoded proteins or induce lytic cycle agents.
217 man cytomegalovirus (HCMV), contains over 70 virus-encoded proteins that are incorporated during a nu
218 of herpesvirus late genes depends on several virus-encoded proteins whose function is not completely
220 HCMV gB is also one of the most immunogenic virus-encoded proteins, and a significant fraction of vi
222 ng live-cell imaging of viral RNA (vRNA) and virus-encoded proteins, we show that the TGB proteins ha
231 eparations, >88% of the theoretical vaccinia virus-encoded proteome was detected with high confidence
235 lving interactions between the viral genome, virus-encoded replication factors, and host factors.
236 luding a requirement of two PCV Oris and the virus-encoded replication initiator Rep protein, suggest
237 auses G(1) cell cycle arrest mediated by the virus-encoded replication-associated protein (RAP) (or K
238 A(1) was found to block the expression of a virus-encoded reporter gene in both infection and transf
239 Holliday junctions, which are cleaved by the virus-encoded resolvase enzyme to form unit-length genom
243 se is a multiprotein complex, containing the virus-encoded RNA polymerase L and P proteins, and two c
245 provide evidence for a mechanism by which a virus-encoded RNA silencing suppressor represses the tra
247 (HCV) nonstructural protein 5B (NS5B) is the virus-encoded RNA-dependent RNA polymerase (RdRp) essent
251 n the nucleocapsid must be accessible by the virus-encoded RNA-dependent RNA polymerase in order to s
254 onal assays confirm that the two most common virus-encoded RPs, bS21 and bL12, are incorporated into
255 equence similarity with RuvC, the absence of virus-encoded RuvA and RuvB to interact with, and the di
257 ted by differential substrate specificity of virus-encoded serine palmitoyltransferase, a key enzyme
258 ted herpesvirus (KSHV) lytic infection, many virus-encoded signaling molecules (e.g., viral G protein
262 plication, we recently demonstrated that the virus-encoded single-stranded (ss) DNA-binding protein (
263 d with a multisubunit complex containing the virus-encoded single-stranded DNA-binding protein ICP8.
266 ASFV growth, indicating that ASFV utilizes a virus-encoded small RNA to disrupt its own replication.I
267 ovirus-associated (VA) RNAs and Epstein-Barr virus-encoded small RNAs (EBERs) with respect to RNA seq
268 gest a potential role for either cellular or virus-encoded SSB protein in improving the processivity
269 ing to a better understanding of the role of virus-encoded structural proteins not only in KSHV-relat
270 en1 mutant plants and in plants expressing a virus-encoded suppressor of RNA silencing (P1/HC-Pro), w
273 of how early protein interactions involving virus-encoded tegument proteins are critical for virus a
278 tes by Epstein-Barr virus (EBV) requires the virus-encoded transactivator EBNA2 and the products of b
279 V gene 62, is the major immediate-early (IE) virus-encoded transactivator of viral gene transcription
280 (HTLV-1) gene expression is mediated by the virus-encoded transactivator protein Tax and three imper
282 coding changes in the core components of the virus-encoded transcription and replication apparatus.
285 irus-transposon vector that stably maintains virus-encoded transgenes in vivo through integration int
287 sform vertebrate cells through the action of virus-encoded tumor antigens that interfere with normal
289 SV40) large tumor antigen (Tag) represents a virus-encoded tumor-specific antigen expressed in many t
291 ntrol of PABP1, Paip2, and EDD1 required the virus-encoded UL38 mTORC1 activator and resulted in augm
292 observations together with the presence of a virus-encoded uracil DNA glycosylase indicates that HSV-
295 ne responses likely drove the evolution of a virus-encoded virulence factor that regulates complement
296 acking MISTRAV or expressing the squirrelpox virus-encoded vMISTRAV exhibit resistance to the same in
298 n of translation initiation factors with the virus-encoded VPg protein covalently linked to the 5' en
299 ate transcription factor (VITF)-1 and -3 are virus-encoded, whereas VITF-2 was partially purified fro