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1 ls for investigating the biological roles of vitamin B12 .
2 processing and intracellular trafficking of vitamin B12.
3 insic fluorescence of betaLG was quenched by vitamin B12.
4 tructure of the betaLG remains unaffected by vitamin B12.
5 riority to the MBA in determining the active vitamin B12.
6 materials, potential new dietary sources of vitamin B12.
7 ssociated with reduced levels of circulating vitamin B12.
8 SAM cycle, genetically or due to low dietary vitamin B12.
9 c acid and thus may lead to malabsorption of vitamin B12.
10 bdate, is approximately 10-fold smaller than vitamin B12.
11 ansporters for diverse iron siderophores and vitamin B12.
12 activated CORM) to the 5'-OH ribose group of vitamin B12.
13 N2O can be rescued by addition of exogenous vitamin B12.
14 B6 while FUT2 interferes with absorption of vitamin B12.
15 e intakes of dietary folate, vitamin B6, and vitamin B12.
16 folic acid, 50 mg of vitamin B6, and 1 mg of vitamin B12.
17 e of Gram-negative bacteria which transports vitamin B12.
18 croenvironment of betaLG was affected by the vitamin B12.
19 ral density, serum creatinine, magnesium, or vitamin B12.
20 atment (folic acid 0.8 mg, vitamin B6 20 mg, vitamin B12 0.5 mg) slowed shrinkage of the whole brain
21 iron (1.17 [1.00-1.36]; p=0.049), and serum vitamin B12 (1.21 [1.04-1.42]; p=0.016), although potent
22 y for choline, 10.5 (SD, 5.1) microg/day for vitamin B12, 240 (SD, 104) mg/day for betaine, and 1,268
23 nts with TCM and Vitamin B(12) (epsilon(13)C(Vitamin B12) = -26.0 +/- 0.9 per mille, epsilon(37)Cl(Vi
24 12) = -26.0 +/- 0.9 per mille, epsilon(37)Cl(Vitamin B12) = -4.0 +/- 0.2 per mille, lambda(Vitamin B1
26 n the ABC transporter BtuCD-F, which imports vitamin B12 across the inner membrane of Escherichia col
27 binding and transport of cobalamin (CBL), or vitamin B12, across the asymmetric outer membrane (OM) o
28 the quantitation of four bioactive forms of vitamin B12 (adenosylcobalamin, cyanocobalamin, hydroxoc
29 de novo biosynthesis of the coenzyme form of vitamin B12, adenosylcobalamin, representing aerobic and
31 the endocytic receptor for intrinsic factor-vitamin B12, albumin and apolipoproteinA-I/HDL allows ma
32 utant on an Escherichia coli strain with low vitamin B12 also strongly suppressed the mitochondrial f
37 ir clinical utility, it has been unclear how vitamin B12 and folic acid (FA) function at the molecula
39 [SD] age, 70.9 [9.1] years), higher baseline vitamin B12 and holotranscobalamin levels were associate
43 epsilonC/epsilonCl values of 4.6 and 5.0 for vitamin B12 and norvitamin B12 were significantly differ
44 antifying physiologically relevant levels of vitamin B12 and performing human trials where it was use
46 These results expand the biological role of vitamin B12 and provide fundamental insight into a new m
48 ed that EutR expression is induced by EA and vitamin B12 and that EutR promotes expression of the eut
49 the determination of cobalt in egg yolk and Vitamin B12 and the recovery results were found in the r
54 er (4 g betaine, 800 mug folic acid, 5.2 mug vitamin B12, and 2.8 mg vitamin B2), (b) a widely used m
56 erfere with the absorption of iron, calcium, vitamin B12, and certain drugs as well as predispose to
57 as well as the absorption of iron, calcium, vitamin B12, and certain medications as well as prevents
60 boflavin, pyridoxal phosphate (PLP), folate, vitamin B12, and flavin mononucleotide (FMN) were measur
61 ating form is pyridoxal-5'-phosphate (PLP)], vitamin B12, and homocysteine in relationship to pancrea
62 ein (RBP), 25-hydroxy vitamin D, folate, and vitamin B12; and a panel of immune response markers.
66 ntake of B vitamins (folate, vitamin B6, and vitamin B12) as ascertained by repeated administration o
67 solving a long-standing problem in anaerobic vitamin B12 assembly and reveal an unanticipated interse
68 oped, reduction-free, direct alkynylation of vitamin B12 at the central cobalt ion proved to be versa
72 in a bacterial-diatom model system based on vitamin B12 auxotrophy as a sensitive assay for metaboli
73 perature (-13.3 +/- 0.9 per thousand), trace vitamin B12 availability (-12.7 +/- 1.0 per thousand), l
74 ntary experimental approaches, the impact of vitamin B12 availability and methotrexate exposure on Da
75 In the present study, we have shown that vitamin B12 (B12) deficiency in a murine genetic model r
78 the associations between intakes of choline, vitamin B12, betaine, and folate during the first and se
81 y mutations in genes encoding enzymes of the vitamin B12 biosynthesis pathway and the vitamin B12-dep
85 and follow-up levels of plasma Hcy, folate, vitamin B12, blood pressure and other pertinent covariab
87 reflects nutritional status with regards to vitamin B12, but at these low concentration current Cbl
88 pendent degradation of ethanolamine if given vitamin B12, but it can make B12 from exogenous Cbi only
90 aluate the effects of topical citicoline and vitamin B12 (Cit-B12: OMK2, Omikron Italia srl, Italy) o
93 onas rostrata requires an external supply of vitamin B12 (cobalamin) for growth, which it can obtain
99 uct of propionic acid metabolism through the vitamin B12 (cobalamin)-dependent enzyme methylmalonyl C
103 320 binds transcobalamin (TC) saturated with vitamin B12 [cobalamin (Cbl)] and mediates cellular upta
104 ibition during development, and an excess of vitamin B12 coenzyme, which is essential for class II ac
107 orted associations between total circulating vitamin B12 concentrations and a common null variant in
111 s of strict vegetarians, an investigation of vitamin B12 content in plant sources, was carried out.
113 the addition of cobalt or cobalt-containing vitamin B12 could further enhance chlorophyll a yields b
115 new diagnoses were prediabetes (28 [6.1%]), vitamin B12 deficiency (20 [4.4%]), diabetes mellitus (8
116 I pills/d were more strongly associated with vitamin B12 deficiency (OR, 1.95 [95% CI, 1.77-2.15]) th
117 tests for diabetes, thyroid dysfunction, and vitamin B12 deficiency allowed neurologists to identify
120 TIENTS: We evaluated the association between vitamin B12 deficiency and prior use of acid-suppressing
121 25,956 patients having incident diagnoses of vitamin B12 deficiency between January 1997 and June 201
125 long-term exposure to these medications and vitamin B12 deficiency in large population-based studies
130 Among patients with incident diagnoses of vitamin B12 deficiency, 3120 (12.0%) were dispensed a 2
135 shunt that is transcriptionally activated on vitamin B12 deficient diets, or under genetic conditions
136 een proposed for such different processes as Vitamin B12-dependent biodegradation and zerovalent meta
138 In the present study, we have found that vitamin B12-dependent methionine metabolism is dysregula
139 the vitamin B12 biosynthesis pathway and the vitamin B12-dependent methylmalonyl-CoA-mutase MutAB.
141 ctivity lead to the bacterium switching from vitamin B12-dependent to vitamin B12-independent biosynt
144 f DNA double-strand breaks, was increased in vitamin B12 depletion, and this effect was exacerbated b
145 te that a nuclear 5-methylTHF trap occurs in vitamin B12 depletion, which suppresses de novo dTMP bio
146 ly discovered CarH-type photoreceptors use a vitamin B12 derivative, adenosylcobalamin, as the light-
148 (ACATs) exist that are capable of converting vitamin B12 derivatives into coenzyme B12 by catalyzing
149 crucial step involved the synthesis of new, vitamin B12 derived cobryketone via palladium-catalyzed
150 bination pill of folic acid, vitamin B6, and vitamin B12 did not reduce a combined end point of total
154 factors that affect circulating vitamin B6, vitamin B12, folate and homocysteine, a genome-wide asso
156 s, we estimated the production of vitamin A, vitamin B12, folate, iron, zinc, calcium, calories, and
157 robial compounds; dietary factors, including vitamin B12, folic acid, and fish oil; obesity; and stre
158 h on propanediol plus Cbi and can use pseudo-vitamin B12 for all of their corrinoid-dependent enzymes
159 ieves chromatographic baseline resolution of vitamin B12 forms on a modern column platform without th
164 delian randomization estimated that maternal vitamin B12 had a small causal effect on DNA methylation
167 nsporters (importers of trace elements, e.g. vitamin B12, heme, and iron-siderophores) the role of AT
170 ntify additional loci associated with plasma vitamin B12, homocysteine, folate and vitamin B6 (active
177 idated for the determination of human active vitamin B12 in cell extracts of Propionibacterium freude
178 method is needed to analyse in situ produced vitamin B12 in plant-based materials, potential new diet
180 lasma total homocysteine (tHcy), folate, and vitamin B12 in plasma and liver, as well as biliary tHcy
181 an milk and serum show that past analyses of vitamin B12 in samples with high HC content might have b
185 rium switching from vitamin B12-dependent to vitamin B12-independent biosynthetic pathways, through t
186 ntification and carbon tracing, we uncover a vitamin B12-independent propionate breakdown shunt that
187 n incubations with reduced cobalamins (e.g., vitamin B12) indicating that biomolecules can transform
189 mortality, and between multivitamin use and vitamin B12 intake on CVD mortality and total mortality.
191 dies (GWAS) in which we resolved total serum vitamin B12 into the fractions bound to transcobalamin a
192 clinical penetrance of <60%, elevated serum vitamin B12 is a reliable and accurate biomarker of ALPS
205 chromosome 19q13 were associated with plasma vitamin B12 levels among women in a genome-wide associat
206 hionine concurrent with decreased folate and vitamin B12 levels and Hcy transsulfuration to cysteine.
208 d rs1047781:A > T as proxies for circulating vitamin B12 levels in the Avon Longitudinal Study of Par
211 , we estimated the causal effect of maternal vitamin B12 levels on cord blood DNA methylation using t
212 findings support a causal effect of maternal vitamin B12 levels on cord blood DNA methylation, and a
213 Neonatal cord blood folate, homocysteine and vitamin B12 levels were measured, and MTHFR C677T and A1
214 ictive of HFS, including baseline folate and vitamin B12 levels, as well as genetic polymorphisms wit
222 d cell count, comprehensive metabolic panel, vitamin B12 measurement, serum protein electrophoresis w
224 order characterized by defects in cobalamin (vitamin B12) metabolism and other developmental defects.
228 l problems encountered is the development of vitamin B12 neuropathy when pernicious anemia was treate
229 onal genome-wide significant loci for plasma vitamin B12 on chromosomes 6p21 (P = 4.05 x 10(-08)), 10
232 pill containing folic acid, vitamin B6, and vitamin B12 or a matching placebo, and were treated for
239 observed no association between folate, PLP, vitamin B12, or homocysteine and pancreatic cancer risk.
240 not routinely raise their intake of calcium, vitamin B12, or magnesium beyond the Recommended Dietary
241 ection of sub-nmol/L physiological levels of vitamin B12, our assay incorporates an innovative "space
242 ase of 1 SD, beta (SE) was 0.048 (0.013) for vitamin B12 (P < .001) and 0.040 (0.013) for holotransco
243 alysis indicated that serum folate (P=0.01), vitamin B12 (P=0.05), creatinine (P=0.03), and BUN (P=0.
245 or the preparation of cobinamide (CN)2Cbi, a vitamin B12 precursor, that should allow its broader uti
247 coli outer membrane proteins-the cobalamin (vitamin B12) receptor (BtuB) and the OmpF porin, which a
248 es the drp-1 fission defect, suggesting that vitamin B12 regulates mitochondrial biogenesis and then
253 lood DNA methylation, and a causal effect of vitamin B12-responsive DNA methylation changes on childr
256 and preconcentrate cobalt from sage tea and vitamin B12 samples after complexing with a Schiff base
259 eurologic complications among those with low vitamin B12 status and lends support for reconsidering t
261 ere it was used to accurately evaluate blood vitamin B12 status of 12 participants from just a drop (
263 herichia coli TonB-dependent transporter for vitamin B12, substrate binding to the extracellular surf
266 ls are needed to determine the importance of vitamin B12 supplementation on slowing brain aging in ol
269 bF genome region - involved in the cobalamin/vitamin B12 synthesis - and gene interruptions in a subs
270 t using 5'-deoxyadenosylcobalamin, a form of vitamin B12 that is best known as an enzyme cofactor, ha
271 f DMB provides clarification of an aspect of vitamin B12 that was otherwise incomplete, and may contr
272 evolution of higher eukaryotes that utilize vitamin B12, the high reactivity of the cofactor coupled
274 dose (n=2054) of folic acid, vitamin B6, and vitamin B12 to determine whether decreasing total homocy
279 activate Met/SAM cycle gene expression, the vitamin B12 transporter, pmp-5, and adjust influx and ef
280 (2014) establish the importance of different vitamin B12 transporters that help a Bacteroides species
284 gen-doped carbon (C-N-Fe), was prepared from vitamin B12 (VB12) and the polyaniline-Fe (PANI-Fe) comp
287 de scavenger, we tested whether cobalamin, a vitamin B12 vitamer, would be neuroprotective in vitro a
294 A nutritionally relevant amount of active vitamin B12 was produced by P. freudenreichii in cereal
295 s treated with high-dosage folic acid before vitamin B12 was widely available in the early 1950s.
296 hey protein, beta-Lactoglobulin (betaLG) and vitamin B12, was studied using different spectroscopic t
297 ains of life require the cofactor cobalamin (vitamin B12), which is produced only by a subset of bact
298 d-state complex formation between betaLG and vitamin B12, which was also supported by the excitation
300 19q13, we confirm the association of plasma vitamin B12 with rs602662 and rs492602 (P-value = 1.83 x