ライフサイエンスコーパス: vitamin K-dependent

1 The carboxylation process is vitamin K dependent, and current evidence suggests that

2 support by genetically engineered 3T3 is not vitamin K dependent, and soluble recombinant GAS6 does n

3 The Drosophila carboxylase is vitamin K-dependent, and it has a K(m) toward a model pe

4 Protein C, a secretory vitamin K-dependent anticoagulant serine protease, inact

5 nome-wide CRISPR-Cas9 knockout screen with a vitamin K-dependent apoptotic reporter cell line.

6 The vitamin K-dependent biosynthesis of gamma-carboxyglutami

7 VKOR) drives the vitamin K cycle, activating vitamin K-dependent blood clotting factors.

8 domain, a membrane-anchoring domain found on vitamin K-dependent blood coagulation and regulatory pro

9 Some recombinant vitamin K-dependent blood coagulation factors (factors V

10 the bloodstream, Ad vectors can bind several vitamin K-dependent blood coagulation factors, which con

11 d mechanism, which involves virus binding to vitamin K-dependent blood coagulation factors.

12 arboxylase gene, and hence the regulation of vitamin K-dependent blood coagulation protein synthesis.

13 Prothrombin is a vitamin K-dependent blood coagulation protein that under

14 ntial post-translational modification of the vitamin K-dependent blood coagulation proteins, the regu

15 n amino acid critical to the function of the vitamin K-dependent blood coagulation proteins.

16 Human factor X is a two-chain, 58-kDa, vitamin K-dependent blood coagulation zymogen.

17 This domain is strongly conserved among vitamin K-dependent blood proteins and, in addition to a

18 rboxyglutamic acid-containing regions of the vitamin K-dependent blood-clotting proteins.

19 properties of matrix Gla protein (MGP) as a vitamin K-dependent calcification inhibitor.

20 mma-carboxylases argue for conservation of a vitamin K-dependent carboxylase across animal species an

21 is cDNA in COS cells or insect cells yielded vitamin K-dependent carboxylase activity and vitamin K-d

22 Assay of hagfish liver demonstrated vitamin K-dependent carboxylase activity in this hemicho

23 The vitamin K-dependent carboxylase also catalyzes the epoxi

24 us is the sole invertebrate wherein both the vitamin K-dependent carboxylase and its product, gamma-c

25 Vitamin K-dependent carboxylase catalyzes the post-trans

26 The vitamin K-dependent carboxylase catalyzes the posttransl

27 g [(3)H]-N-ethylmaleimide indicated that the vitamin K-dependent carboxylase contains two or three fr

28 ian vitamin K-dependent carboxylases and the vitamin K-dependent carboxylase from Conus textile, a ma

29 ts demonstrate the broad distribution of the vitamin K-dependent carboxylase gene, including a highly

30 The vitamin K-dependent carboxylase is an integral membrane

31 The vitamin K-dependent carboxylase modifies and renders act

32 odendrocytes nor neurons possess significant vitamin K-dependent carboxylase or epoxidase activity.

33 The vitamin K-dependent carboxylase was located in the endop

34 Incubation of the vitamin K-dependent carboxylase with the sulfhydryl-reac

35 The vitamin K-dependent carboxylase, a constituent of the en

36 Using recombinant vitamin K-dependent carboxylase, purified in the absence

37 only known invertebrate with a demonstrated vitamin K-dependent carboxylase.

38 Given the functional similarity of mammalian vitamin K-dependent carboxylases and the vitamin K-depen

39 KORC1L1 reduces vitamin K epoxide to support vitamin K-dependent carboxylation as efficiently as does

40 he diversity of animal species that maintain vitamin K-dependent carboxylation to generate gamma-carb

41 ements beyond the Gla domain of factor IX in vitamin K-dependent carboxylation, we have examined the

42 reductase (VKOR) is an essential enzyme for vitamin K-dependent carboxylation, while the physiologic

43 l ferroptosis, displays strong inhibition of vitamin K-dependent carboxylation.

44 el to the function of FSP1, does not support vitamin K-dependent carboxylation.

45 In addition, VKOR variants can cause vitamin K-dependent clotting factor deficiency or alter

46 here for protein C have general relevance to vitamin K-dependent clotting factors containing epiderma

47 rrhage and normal functional activity of the vitamin K-dependent clotting factors IX, X, and prothrom

48 ited capacity, and cell lines overexpressing vitamin K-dependent clotting factors produce only a frac

49 The propeptide sequences of the vitamin K-dependent clotting factors serve as a recognit

50 quired for posttranslational modification of vitamin K-dependent clotting factors.

51 gs have been encountered in association with vitamin K-dependent coagulation factor deficiency, an au

52 ings with characteristic features of PXE and vitamin K-dependent coagulation factor deficiency.

53 e novel insight into mechanisms by which the vitamin K-dependent coagulation factors are regulated.

54 Vitamin K-dependent coagulation factors deficiency is a

55 including the binding of Ad to platelets and vitamin K-dependent coagulation factors, but we found th

56 In this study, we examined whether other vitamin K-dependent coagulation protease zymogens can mo

57 structural features that distinguish it from vitamin K-dependent coagulation proteases.

58 yme complex formation with gla variants of a vitamin K-dependent coagulation protein and provides evi

59 Factor VII is a vitamin K-dependent coagulation protein essential for pr

60 carboxylase (GGCX) results in production of vitamin K-dependent coagulation proteins (FII and FX) wi

61 evaluate Ca2+-specific adsorption of several vitamin K-dependent coagulation proteins to monolayers t

62 se of decreased biological activities of all vitamin K-dependent coagulation proteins.

63 nism confirmed by in vitro reconstitution of vitamin K-dependent disulphide bridge formation.

64 bit calcification requires the activity of a vitamin K-dependent enzyme, which mediates MGP carboxyla

65 vitamin K-dependent carboxylase activity and vitamin K-dependent epoxidase activity.

66 Analyses of vitamin K-dependent factors in 6 cancer patients with av

67 Vitamin K-dependent factors protect against vascular and

68 and < 1% on warfarin, at a point where other vitamin K-dependent factors were at 30-40% activity leve

69 ogical role for these two new members of the vitamin K-dependent family of proteins.

70 inhibit the overall activity of the complete vitamin K-dependent g-carboxylation system.

71 binding of the cationic PF4 to the anionic, vitamin K- dependent gamma-carboxyglutamic acid domain o

72 sidues is catalyzed by the membrane-embedded vitamin K-dependent gamma-carboxylase (VKGC), which typi

73 lanogaster cDNA clone encodes a protein with vitamin K-dependent gamma-carboxylase activity.

74 between the Conus carboxylase and vertebrate vitamin K-dependent gamma-carboxylases argue for conserv

75 anticoagulant factor protein S is a secreted vitamin K-dependent gamma-carboxylated protein that is m

76 Human osteocalcin (OC) undergoes reversible, vitamin K-dependent gamma-carboxylation at three glutami

77 ding has been shown to be dependent upon the vitamin K-dependent gamma-carboxylation modification of

78 The vitamin K-dependent gamma-carboxylation of glutamate to

79 The vitamin K-dependent gamma-carboxylation system in the en

80 The vitamin K-dependent gamma-carboxylation system is respon

81 The eukaryotic cell harbors a vitamin K-dependent gamma-carboxylation system that conv

82 ngineering of cells containing a recombinant vitamin K-dependent gamma-carboxylation system with enha

83 d vitamin K cofactor-producing enzyme of the vitamin K-dependent gamma-carboxylation system, produced

84 mental approaches aimed at understanding the vitamin K-dependent gamma-carboxylation system.

85 in place of Gla is a poor substrate for the vitamin K-dependent gamma-glutamyl carboxylase (apparent

86 s to gamma-carboxyglutamic acid (Gla) by the vitamin K-dependent gamma-glutamyl carboxylase (gamma-ca

87 The vitamin K-dependent gamma-glutamyl carboxylase binds an

88 The vitamin K-dependent gamma-glutamyl carboxylase catalyzes

89 The vitamin K-dependent gamma-glutamyl carboxylase catalyzes

90 The vitamin K-dependent gamma-glutamyl carboxylase catalyzes

91 The vitamin K-dependent gamma-glutamyl carboxylase catalyzes

92 The vitamin K-dependent gamma-glutamyl carboxylase catalyzes

93 Vitamin K-dependent gamma-glutamyl carboxylase catalyzes

94 xin epsilon-TxIX and used in assays with the vitamin K-dependent gamma-glutamyl carboxylase from C. t

95 The expression of the vitamin K-dependent gamma-glutamyl carboxylase gene in l

96 Vitamin K-dependent gamma-glutamyl carboxylase is a 758

97 (residues 1-345 and residues 346-758) of the vitamin K-dependent gamma-glutamyl carboxylase, a glycop

98 n K antagonists such as warfarin inhibit the vitamin K-dependent gamma-glutamyl carboxylation during

99 cate impairment of the functional, secreted, vitamin K-dependent, gamma-carboxylated form of periosti

100 emonstrate the evolutionary emergence of the vitamin K-dependent Gla domain before the divergence of

101 Protein C is a vitamin K-dependent glycoprotein synthesized in the live

102 Protein S is a vitamin K-dependent glycoprotein, which, besides its ant

103 CDP is also related to disruption of vitamin K-dependent metabolism, causing secondary effect

104 Inactive vitamin K-dependent MGP (desphospho-uncarboxylated [dp-u

105 Inactive vitamin K-dependent MGP (dp-ucMGP) and prothrombin (PIVK

106 inalis as a model organism for investigating vitamin K-dependent physiological phenomena, which may b

107 Protein Z (PZ) is a multidomain vitamin K-dependent plasma protein that functions as a c

108 Protein Z (PZ) is a vitamin K-dependent plasma protein whose function has be

109 Human protein Z (PZ) is a 62,000-Mr, vitamin K-dependent plasma protein whose structure is si

110 Activated protein C (APC) is a vitamin K-dependent plasma serine protease which down-re

111 and defines a novel precursor structure for vitamin K-dependent polypeptides.

112 Because of their vitamin K-dependent post-translational modification, the

113 Matrix Gla protein (MGP) is a vitamin K-dependent post-translationally modified protei

114 in the endoplasmic reticulum (ER), catalyzes vitamin K-dependent posttranslational modification of gl

115 rowth, seen in osteoarthritis (OA), may be a vitamin K-dependent process.

116 ormation, expression, and propagation of the vitamin K-dependent procoagulant complexes and extends o

117 The affinities of the vitamin K-dependent propeptides for the gamma-carboxylas

118 rfarin resistance to rat chromosome 1 and of vitamin K-dependent protein deficiencies to the syntenic

119 utamic acid protein (MGP) is a member of the vitamin K-dependent protein family with unique structura

120 oduce functional forms of all members of the vitamin K-dependent protein family.

121 in K antagonists on the functionality of the vitamin K-dependent protein produced by extrahepatic tis

122 anin-A[rs9658644], Cystatin-C[rs2424577] and Vitamin K-Dependent Protein S[rs6123] in the schizophren

123 equired for carboxylase activity, called the vitamin K-dependent protein site of interaction (VKS).

124 Protein Z (PZ) is a plasma vitamin K-dependent protein that functions as a cofactor

125 Activation of Axl by its ligand Gas6, a vitamin K-dependent protein, is inhibited at doses of wa

126 his contrasts with bone Gla protein, another vitamin K-dependent protein, which appears not to requir

127 However, two anticoagulant proteins, vitamin K-dependent protein-S (p < 0.0001) and heparin c

128 r for the membrane-binding conformation of a vitamin K-dependent protein.

129 at factor-X-encoding cDNA revealed that this vitamin-K-dependent protein has a dibasic Arg-Arg sequen

130 ilic ligand, Gas6, a member of the family of vitamin K dependent proteins that is preferentially expr

131 frozen plasma (mFFP), PCC, mixtures of human vitamin K-dependent proteins (VKDP) (prothrombin, FVII,

132 ults suggest features of membrane binding by vitamin K-dependent proteins and provide reagents that m

133 physiological consequences in the levels of vitamin K-dependent proteins and the biochemical mechani

134 Overall, membrane binding by vitamin K-dependent proteins appeared consistent with th

135 Propeptides of the vitamin K-dependent proteins bind to an exosite on gamma

136 ities of synthetic propeptides of nine human vitamin K-dependent proteins by determining the inhibiti

137 The propeptides of the vitamin K-dependent proteins contain a gamma-carboxylati

138 l implications for overproducing recombinant vitamin K-dependent proteins for therapeutic use.

139 Vitamin K-dependent proteins function as calcification i

140 TAM receptors can be activated by the vitamin K-dependent proteins Gas6 and protein S.

141 Comparison of naturally occurring vitamin K-dependent proteins has provided possible bases

142 in individuals with combined deficiencies of vitamin K-dependent proteins have a mutation, L394R, in

143 Two human cDNAs that encode novel vitamin K-dependent proteins have been cloned and sequen

144 itamin K actions, the potential functions of vitamin K-dependent proteins in cancer, and observationa

145 Severe deficiency of vitamin K-dependent proteins in patients not maintained

146 e cancer cells, and an altered expression of vitamin K-dependent proteins in prostate tumors has been

147 presence of activation peptides (AP) of the vitamin K-dependent proteins in the phlebotomy blood of

148 Vitamin K-dependent proteins in vascular tissue affect v

149 r gamma-carboxyglutamic acid modification of vitamin K-dependent proteins includes gamma-carboxylase

150 dent carboxylase modifies and renders active vitamin K-dependent proteins involved in hemostasis, cel

151 Gamma-carboxylation of vitamin K-dependent proteins is dependent on formation o

152 modification of the membrane contact site of vitamin K-dependent proteins may enhance the membrane af

153 ic acid to gamma-carboxyglutamic acid in the vitamin K-dependent proteins of blood and bone.

154 All known vitamin K-dependent proteins possess a conserved eightee

155 gamma-Carboxylation of vitamin K-dependent proteins requires a functional vitam

156 The enzymatic activity of the vitamin K-dependent proteins requires the post-translati

157 peptide and the propeptides of the mammalian vitamin K-dependent proteins show no obvious sequence ho

158 The propeptides of vitamin K-dependent proteins stimulate gamma-carboxylase

159 istent with studies on prothrombin and other vitamin K-dependent proteins that have been modified or

160 and dissociation kinetics relative to other vitamin K-dependent proteins that have been tested.

161 Therefore, the five vitamin K-dependent proteins that were examined were equ

162 ropeptide is the primary binding site of the vitamin K-dependent proteins to carboxylase.

163 Binding of vitamin K-dependent proteins to cell membranes containin

164 tion is strongly dependent on the binding of vitamin K-dependent proteins to cell membranes containin

165 The vitamin K-dependent proteins undergo a conformational tr

166 hat the affinities of the propeptides of the vitamin K-dependent proteins vary over a considerable ra

167 No binding of PTX2 to other vitamin K-dependent proteins was observed.

168 raction by prothrombin, protein Z, and other vitamin K-dependent proteins were studied to determine t

169 tion of select glutamic acid residues of the vitamin K-dependent proteins which are important for coa

170 ated Glu (Gla) to activate a large number of vitamin K-dependent proteins with diverse functions, and

171 ding properties of human and bovine forms of vitamin K-dependent proteins Z, S, and C were characteri

172 ree new factors interpreted as inflammation, vitamin K-dependent proteins, and procoagulant activity.

173 s involved in the gamma-carboxylation of the vitamin K-dependent proteins, and vitamin K epoxide is a

174 e carboxylation and consequent activation of vitamin K-dependent proteins, but the mechanism of reduc

175 e to the analogous sequence present in other vitamin K-dependent proteins, contains a disproportionat

176 sible for post-translational modification of vitamin K-dependent proteins, converting them to Gla-con

177 shared to some degree by factor X and other vitamin K-dependent proteins, most notably prothrombin.

178 , a required cofactor for g-carboxylation of vitamin K-dependent proteins.

179 is not attributable to the Gla domain of all vitamin K-dependent proteins.

180 amino acid propeptide sequence found in all vitamin K-dependent proteins.

181 ed for the posttranslational modification of vitamin K-dependent proteins.

182 underlie membrane binding behaviors of other vitamin K-dependent proteins.

183 tamin K that is required for modification of vitamin K-dependent proteins.

184 n/phospholipid binding) for a Gla residue in vitamin K-dependent proteins.

185 ylation of certain glutamic acid residues in vitamin K-dependent proteins.

186 in post-translational gamma-carboxylation of vitamin K-dependent proteins.

187 t-translational modification of a variety of vitamin K-dependent proteins.

188 he sea squirt Ciona intestinalis that encode vitamin K-dependent proteins.

189 increased cellular production of recombinant vitamin K-dependent proteins.

190 ey regulatory protein in synthesis of active vitamin K-dependent proteins.

191 erent than in Gla domain structures of other vitamin K-dependent proteins.

192 cerning regulation of gamma-carboxylation of vitamin K-dependent proteins.

193 propeptide cleavage site, as occurs in other vitamin-K-dependent proteins.

194 activated by gamma-glutamyl carboxylation, a vitamin K-dependent reaction, to serve in an anti-minera

195 Central to this pathway is the vitamin K-dependent serine protease, APC, and its precur

196 nd 2 are the founding members of a family of vitamin K-dependent single-pass integral membrane protei

197 fication of select glutamate residues of its vitamin K-dependent substrates to gamma-carboxyglutamate

198 terrogans genome revealed an ortholog of the vitamin K-dependent (VKD) carboxylase as one of several

199 The vitamin K-dependent (VKD) carboxylase binds VKD proteins

200 The vitamin K-dependent (VKD) carboxylase converts clusters

201 The vitamin K-dependent (VKD) carboxylase converts Glu's to

202 The vitamin K-dependent (VKD) carboxylase uses the oxygenati

203 Vitamin K-dependent (VKD) proteins are modified by the V

204 Vitamin K-dependent (VKD) proteins become activated by t

205 nts governing the modification of individual vitamin K-dependent (VKD) proteins by the carboxylase ha

206 sttranslational carboxylation of a number of vitamin K-dependent (VKD) proteins involved in a wide va

207 Carboxylation of vitamin K-dependent (VKD) proteins is required for their

208 Vitamin K and vitamin K-dependent (VKD) proteins may be involved in re

209 Vitamin K-dependent (VKD) proteins require carboxylation

210 Vitamin K-dependent (VKD) proteins require modification

211 nerates multiple carboxylated Glus (Glas) in vitamin K-dependent (VKD) proteins that are required for

212 For 16 known vitamin K-dependent (VKD) proteins, we evaluated the rel

213 ycles vitamin K to support the activation of vitamin K-dependent (VKD) proteins, which have diverse f

214 a-carboxylase for gamma-carboxylation of all vitamin K-dependent (VKD) proteins.

215 Factor VII is a vitamin K-dependent zymogen of a serine protease that pa

216 of the coagulation cascade, the multidomain vitamin-K-dependent zymogen prothrombin is converted to