ライフサイエンスコーパス: vitro

1 d other tissues were measured ex vivo and in vitro.

2 receptor (AHR) to limit ECM accumulation in vitro.

3 eptor expression on lung ILC2 in vivo and in vitro.

4 ion of BT2158 and either BT2156 or BT2157 in vitro.

5 or to that of the parent fragment peptide in vitro.

6 with target HLA/peptide on their surfaces in vitro.

7 were induced to differentiate to TM cells in vitro.

8 erates a stabilized cleavage intermediate in vitro.

9 s from pro- towards anti-tumor expression in vitro.

10 finity through its HMG DNA-binding domain in vitro.

11 d to multiple bioactive phosphoinositides in vitro.

12 BLAC2 is a substrate for purified zDHHC20 in vitro.

13 cardiomyocytes with adult-like phenotypes in vitro.

14 nts express invariably high levels of Ena in vitro.

15 sphate linked moiety X]-type hydrolase 3) in vitro.

16 easuring the genome-wide activity of Cas9 in vitro.

17 produced Langerhans cell (LC)-like cells in vitro.

18 ng the action of IRL201104 on human cells in vitro.

19 ffectively degrade and decolorize melanin in vitro.

20 Cellular crosstalk was investigated in vitro.

21 evaluated for its interactions with P-gp in vitro.

22 n to stimulate transcriptional elongation in vitro.

23 med for all 10 pause sites that we tested in vitro.

24 s, 10 of which can be simultaneously used in vitro.

25 so enhanced primary human T cell function in vitro.

26 f venom was also evaluated on macrophages in vitro.

27 EKs have distinct substrate specificities in vitro.

28 ontroller' prevents aggregation at pH 7.5 in vitro.

29 d paracrine-mediated immune cell function in vitro.

30 f Mn(2+) stimulates this coupled reaction in vitro.

31 xpanding the use of human neuronal models in vitro.

32 ating the antiangiogenic effects of IMiDs in vitro.

33 and migration of tumor cells in different in vitro 2D and 3D co-cultures.

34 muM] and inhibits tubulin polymerization in vitro; 4) had no effect upon the polymerization of the b

35 vage by recombinant DENV-2/ZIKV proteases in vitro A version of this sensor containing the flavivirus

36 combined models were parameterised using in vitro activities of carbonic anhydrase (CA), pyruvate, p

37 Cold-grown Miscanthus plants increased in vitro activities of RuBisCO and PPDK but decreased PEPc

38 In vitro activity measurements and functional mutagenesis s

39 splayed over threefold and 10-fold higher in vitro activity than ivermectin against hepatic and blood

40 PD-1 following P. falciparum stimulation in vitro Additionally, functional in vitro studies revealed

41 d higher amounts of leukotriene B4 (LTB4) in vitro after activation with zymosan or immune complexes,

42 -isoxazolepropionic acid (AMPA) receptors in vitro after exposure to patients' CSF antibodies or SSM5

43 mbranes to study lipid-lipid interactions in vitro, alongside optical microscopy techniques aimed at

44 ion of microsatellites in order to reduce in vitro amplification noise.

45 es in adherent and nonadherent conditions in vitro and analyzed changes in mRNA and protein levels to

46 erface residues blocks filament formation in vitro and autophagosome closure and HIV-1 release in hum

47 fective mast cell degranulation inhibitor in vitro and can be delivered topically for prolonged perio

48 This article discloses the in vitro and cellular activity profiles of GSK789, a potent

49 so replaced E. coli BioC both in vivo and in vitro and complemented biotin-independent growth of the

50 i-donor type T cell response was detected in vitro and conventional immunosuppressants targeting T ce

51 ly(ADP-ribose) polymerase inhibitors both in vitro and ex vivo These findings might pave a way for ne

52 pound with partial FXR agonistic activity in vitro and FXR-dependent gene modulation in vivo.

53 Studies in vitro and in affected joints demonstrated that A2AR liga

54 Moreover, we demonstrate in vitro and in cells that Fes1 oxidation is reversible and

55 integrity following oxidative stress both in vitro and in cells to elucidate details of the interacti

56 vely captured known CS-E-binding proteins in vitro and in cells.

57 existing CMV immunity against tumor cells in vitro and in mouse cancer models.

58 In a hypothesis-driven in vitro and in silico approach, we turn to early and lower

59 d composition, as the substrates of PfCRT in vitro and in situ, and show that PfCRT does not mediate

60 mary carcinoma cells to radiation therapy in vitro and in vivo (in immunocompetent syngeneic hosts).

61 MIB1 physically interacts with WRN in vitro and in vivo and induces ubiquitination and degrada

62 Both in vitro and in vivo assays showed that TubZIP28 bound to t

63 The peptide profile generated after in vitro and in vivo digestion showed clear similarities wi

64 thematical model was proposed to link the in vitro and in vivo evolution of prostate cancer.

65 any types of applications, including both in vitro and in vivo experiments.

66 In vitro and in vivo growth responses of Abi-/Enza-resistan

67 his effect is associated with a series of in vitro and in vivo immune abnormalities consistent with l

68 gregation, and inhibits its toxicity both in vitro and in vivo In this study, we investigate whether

69 ary LSCs from MLL-rearranged AML patients in vitro and in vivo in xenograft mice.

70 Several in vitro and in vivo mechanisms involved in PDAC metastases

71 Finally, in vitro and in vivo microdosimetry was modeled from experi

72 ntities of the mini-protein and permitted in vitro and in vivo SAR exploration of this modality.

73 ed along with its application to multiple in vitro and in vivo studies across species.

74 In vitro and in vivo studies demonstrated that 20 restored

75 ovel anticancer target based on extensive in vitro and in vivo studies with archazolids, complex poly

76 ded VP3 antagonizes RNase L activity both in vitro and in vivo These studies highlight an ever-evolvi

77 esterol efflux mediated by apoA-I or HDL3 in vitro and in vivo Using LC-MS/MS analysis, we analyzed t

78 s been reported across cancer types, both in vitro and in vivo, and implicated in multiple processes

79 Designs were tested in vitro and in vivo, demonstrating alteration of the E2 an

80 volved in the polarization of macrophages in vitro and in vivo, including the up-regulation of interl

81 ctivation by disturbed flow required Nck1 in vitro and in vivo, showing endothelial Nck1 and IRAK-1 s

82 ls, which are collectively effective both in vitro and in vivo, thereby inducing stem cell differenti

83 Both in vitro and in vivo, we find that RFX6 specifically labels

84 ghei development inside hepatocytes, both in vitro and in vivo.

85 ss their effects on c-MYC gene expression in vitro and in vivo.

86 rom MSCs, thus suppressing bone formation in vitro and in vivo.

87 tin-resistant GNB to multiple antibiotics in vitro and in vivo.

88 -4 labeled with IRDye 800CW, was examined in vitro and in vivo.

89 al and promotion of aggressive phenotypes in vitro and in vivo.

90 esis of T. gondii infection were examined in vitro and in vivo.

91 ated monocytes drive Th17 differentiation in vitro and induce cholangiocytes to produce chemokines me

92 pathway triggers human BTSC proliferation in vitro and influences PBG hyperplasia in vivo in the DDC-

93 SFMBT1 abolished ccRCC cell proliferation in vitro and inhibited orthotopic tumor growth in vivo.

94 CERBERUS has auto-ubiquitination activity in vitro and is localized within distinct motile puncta in

95 eds light on human airway differentiation in vitro and provides a single-cell atlas of the developing

96 aring islets that enhances islet function in vitro and reduces immunogenicity.

97 of PrimPol in tenofovir-induced toxicity in vitro and show that tenofovir-diphosphate incorporation

98 uman IgM affects C. neoformans morphology in vitro and suggest that the hypothesis that human immunog

99 n hydrolysis is fluorescent) was compared in vitro and their vaccine efficacy (antigen-specific antib

100 reduced tumor cell migration and invasion in vitro and tumor growth and metastasis in vivo.

101 are recruited by the CPSF30-hFip1 complex in vitro, and both hFip1 binding sites in CPSF30 can suppor

102 platform for advanced testing of implants in vitro, and demonstrate the scientific validity and predi

103 , exhibits decreased rates of acetylation in vitro, and is effective at lowering bacterial load in a

104 or PV(+) cells can trigger SWRs, as shown in vitro, and suggests that PV(+) cell-mediated short-term

105 ngs and directly blocks MRE11 degradation in vitro, and the DNA-binding ability of CST is required fo

106 Newly synthesized compounds were examined in vitro, and their mechanism of action was preliminarily i

107 Auranofin's in vitro antibacterial activity was stable in the presence

108 ainst E. coli, S. aureus, and S. typhi in in vitro antimicrobial tests, followed closely by AA/PA-MEs

109 dynamics of microtubule/motor assemblies in vitro as well as in diverse intracellular structures ran

110 ng cellular invasion and colony formation in vitro, as well as tumor growth and metastasis in vivo.

111 Here, we developed a novel in vitro assay to characterize the length and position of i

112 In vitro assays indicated that Sl-LIP8 can cleave 18:2 and

113 been hampered by inappropriately tailored in vitro assays of drug response.

114 In vitro assays with human enzymes show that PCNA and its l

115 and its suppression by PI3K activation in in vitro assays with SH-SY5Y human neuroblastoma cell cultu

116 protein exhibited high enzyme activity in in vitro assays.

117 e such structures by negative stain EM of in vitro assembly reactions.

118 examined the priming of naive CD4 T cells in vitro at fever temperatures, and we report notable fever

119 e and spinach were subjected to digestion in vitro at pH 2.0 and pH 7.5 and analysed using SEC-ICP-MS

120 its aragonite precipitation from seawater in vitro, at the pH, saturation state and approximate aspar

121 In vitro bactericidal efficacy studies were carried out usi

122 of this EVG nanoformulation to cross the in vitro BBB model and suppress the HIV-1 in macrophage cel

123 Here, through the use of in vitro biochemical assays, we demonstrate that the amide

124 their consensus binding sequence, both in in vitro biochemical binding assays and in vivo studies of

125 riments with CSLD-CESA chimeric proteins, in vitro biochemical reconstitution, and supporting computa

126 Recent in vitro biomechanical measurements found increased oligome

127 In vitro, both tracers displayed preferential binding to ac

128 30CAS mediates VEGF-A and PDGF signalling in vitro, but its cardiovascular function in vivo remains r

129 Ischemia-reperfusion injury was modeled in vitro by placing human umbilical vein endothelial cells

130 This mAb neutralizes virus in vitro by preventing virus entry and spread and is protec

131 frican mosquitoes do not prevent cleavage in vitro by the Cas9/guide RNA complex.

132 m cell-derived cardiomyocytes (hiPSC-CMs) in vitro can expand CMs modestly (<5-fold).

133 And finally, in vitro capillary sprouting assays revealed that inhibitio

134 ther, single-cell analysis of in vivo and in vitro cardiomyocyte maturation trajectories identify hig

135 bolite class are strong predictors of the in vitro cardiovascular effects of PCBs.

136 Yet, many current in vitro chemical assays to characterize antioxidant potent

137 ur human and mouse cell lines we examined in vitro cisplatin/JH-RE-06 treatment does not increase apo

138 ysis of variant proteins both in vivo and in vitro confirmed that residues in sequence motifs conserv

139 ne dimers were synthesized and tested for in vitro cytotoxicity against a panel of cancer cell lines.

140 IRIS related to mycobacterial infection, in vitro data demonstrate the emergence of pathogen-specifi

141 In vitro data showed that SC-Exos promoted neurite outgrowt

142 Currently no approaches for using in vitro data to anticipate such in vivo effects exist.

143 s are put into the context of in vivo and in vitro data.

144 nterrogation of USP22-regulated functions in vitro demonstrated critical roles for USP22 in prostate

145 cterization analysis showed that although in vitro derived effective concentrations exceeded the leve

146 We show that in vitro development of tamoxifen-resistance is associated

147 In vitro, Dgkzeta deficiency results in reduced production

148 ) system has an array of highly sensitive in vitro diagnostic (IVD) real-time PCR assays for respirat

149 ting, to food safety to the most frequent in vitro diagnostic tests, partially conducted in automated

150 ve characterized the epigenome during the in vitro differentiation of human mesenchymal stem cells (h

151 g perturbed UPR in myeloid precursors and in vitro differentiation of primary CD34(+) cells revealing

152 Moreover, in an in vitro digestive pepsin-trypsin treatment, 30% of quinoin

153 ned by single molecule force spectroscopy in vitro displays the properties of a random coil and acts

154 In vitro, DMOG had no proliferative effect on HC, but condi

155 Here, we demonstrate that high-throughput in vitro DNA binding assays coupled with unbiased computati

156 In vitro DNA-binding experiments and structural prediction

157 ed with optimization of cellular potency, in vitro drug-target residence times, and in vivo PK proper

158 Before the WWTP replacement, in vitro ER (24 ng 17beta-estradiol equivalents/L)-, GR (60

159 (63)-, and Met(1)-linked ubiquitin chains in vitro, establishing UBA(Cez) as a functional ubiquitin-b

160 haustive dialysis, mass spectrometry, and in vitro evaluation against the C165S mutant.

161 This in vitro evidence was corroborated by docking results demon

162 this model, and functionally validated by in vitro, ex vivo and in vivo techniques.

163 1 (SR-B1) and CD15 on brain SHH MB cells in vitro, ex vivo, and in vivo.

164 r synaptic plasticity rules inferred from in vitro experiments are correct in physiological condition

165 We mimic parameter uncertainty in in vitro experiments by incorporating model error that shif

166 Here, in vitro experiments demonstrate that TAN1 directly binds m

167 Our in vitro experiments reveal that this feature stems mainly

168 In vitro experiments showed that human embryonic stem cell-

169 mics simulations were used in tandem with in vitro experiments to investigate changes in depolymeriza

170 During in vitro fertilisation (IVF), pharmacological activation of

171 We refined ovarian stimulation and in vitro fertilization (IVF) methods established for Chines

172 In vitro findings were confirmed in vivo with an angiotensi

173 nability to efficiently culture the virus in vitro for neutralization assays.

174 This paper outlines the in vitro formulation development for hydrogel-forming micro

175 elopmental stages and RGCs differentiated in vitro from embryonic retinal progenitors for the effects

176 In vitro FTY720 treatment downregulated CCR7 on Y. enteroco

177 S6K1 in TKI resistance was determined in in vitro gain-and-loss of function studies and confirmed in

178 pared at designated timepoints throughout in vitro gastric and intestinal digestion for differences i

179 indings resulted in a profound insight in in vitro gastric molecular lipolysis mechanisms.

180 20:80, 50:50 and 80:20) were subjected to in vitro gastro-intestinal digestion using a semi-dynamic g

181 y the evolution of oleuropein (OE) during in vitro gastrointestinal digestion, its bioaccessibility a

182 databases, methylated TFBSs derived from in vitro high-throughput EpiSELEX-seq binding assays and in

183 emonstrate massive expansion of hiPSC-CMs in vitro (i.e., 100- to 250-fold) by glycogen synthase kina

184 Characterization of defined mutations in vitro identified defects in intracellular survival and p

185 In vitro IFNgamma treatment increased PD-L1 expression in t

186 In vitro, IL6 treatment of MDSC-like cells activated STAT3,

187 of GSCs towards low concentrations of S1P in vitro In addition, inhibiting phospholipase A2 (PLA2) or

188 form paired helical filament-like fibres in vitro in the absence of additives such as heparin.

189 and neuronal excitability of BLA neurons in vitro in the left and right amygdala of postnatal days 2

190 surements made by an eyemate(R)-IO sensor in-vitro, in an artificial and controlled environment.

191 ecies, or model conditions such as growth in vitro, in macrophages and in the mouse.

192 own to be individually efficacious in RA (in vitro, in vivo, and/or in humans) and provide a strong r

193 al to differentiate into various lineages in vitro, including osteogenic, chondrogenic, and adipogeni

194 ptibility to HIV-2 infection by combining in vitro infection of tonsillar Tfh with the ex vivo study

195 rum albumin, the potency of JMS-053 as an in vitro inhibitor of PTP4A3 and human A2780 ovarian cancer

196 Here, we performed in vitro integration assays, finding that for G1 and G2, th

197 Generating insulin-expressing cells in vitro is no exception, with the guided series of differe

198 In vitro, knockdown of GPRC5B in human aortic SMCs resulted

199 m to temozolomide (TMZ)-induced apoptosis in vitro Likewise, in in vivo human GBM xenograft experimen

200 r Chinese cynomolgus macaques to generate in vitro MCM embryos.

201 When cocultured with breast cancer cells in vitro, MCs hindered activation of cMET, a master regulat

202 However, in vitro measurements fail to capture the viscoelastic modu

203 validated blood flow simulations against in vitro measurements in 3D-printed phantoms representing t

204 Recent genomic studies together with in vitro measurements suggest that the nucleosome barrier t

205 Motivated by the fact that in vitro membrane protein studies often require additives s

206 e energy with a sensitivity comparable to in vitro methods, enabling the measurement of energy landsc

207 Using in vitro mineralization assays we showed that both recombin

208 between gene signatures obtained from the in vitro model (CS vs. air) with a published data set from

209 We established an in vitro model for the induction of these structures in mou

210 on of the derivatives was evaluated in an in vitro model of cellular injury on cortical neurons.

211 As an in vitro model of haematopoietic dysfunction, the BM chip m

212 We validated its effects in an in vitro model of MI/IRI in mammalian cardiac cells.

213 ariants that were predicted to be benign, in vitro modeling demonstrated that these mutations conferr

214 ally effective at restraining in vivo and in vitro models expressing MET(N375S).

215 nerative diseases, using both in vivo and in vitro models.

216 ression and functional screening using an in vitro mouse oocyte development system, we identified eig

217 rmed a transcriptome-wide analysis during in vitro mucociliary differentiation of human adult BSCs fr

218 anel of group 1 HAs and F0045(S) exhibits in vitro neutralization activity against multiple H1N1 and

219 Partial depolymerization in vitro of nonphosphorylated smooth muscle myosin filament

220 darG(Mtb) does not alter viability of Mtb in vitro or in mice.

221 ell cytotoxicity but was not required for in vitro or in vivo leukemia clearance.

222 mmation or NRF2 activation in macrophages in vitro or in vivo.

223 yos were cultured to the blastocyst stage in vitro or transferred to diabetic and non-diabetic recipi

224 We report here that in vitro osteoclastogenesis is greatly suppressed by solubl

225 Tested against a panel of GBM cell lines in vitro, paclitaxel was found to be effective at nanomolar

226 In the clinical study, 24 in vivo-in vitro pairs were eligible for further analysis, with 4 h

227 Although TMUV can be attenuated by in vitro passaging, experimental evidence supporting the ro

228 measured drug combination efficacies both in vitro (Pearson's correlation = 0.93 when comparing predi

229 tically inactive mutant in vivo (based on in vitro peptide studies) actually retains substantial H3K4

230 igated microwave catheters were tested in in vitro phantom models and in 15 sheep.

231 ing serum pharmacokinetics (HVTN 104) and in vitro pharmacodynamics (LANL CATNAP database).

232 of 19 physicochemical descriptors and 36 in vitro phenotypes revealed that chlorination status and m

233 in may be relevant targets for increasing in vitro platelet manufacturing and for managing quantitati

234 caque trophoblast stem cells (TSCs) as an in vitro platform for future assessment of primate trophobl

235 approach, starting with a high-throughput in vitro primary screen to identify inhibitors, building in

236 In addition, in vitro produced intracellular-derived particles were infe

237 fish-free feed had the highest degree of in-vitro protein hydrolysis and protein digestibility.

238 ABM300 was characterized in vitro (receptor binding, beta-arrestin2 recruitment, ERK

239 In vitro, recombinant Crm proteins from different orthopoxv

240 Using an in vitro reconstitution system, we describe a mechanism for

241 both patients' cells with JAK inhibitors in vitro reduced phosphorylated STAT1 to normal.

242 sceptibility (9- to 116-fold) but also on in vitro replicative fitness.

243 proteins: the DHX30N-NS1 RBD interaction in vitro requires the presence of a dsRNA platform that bin

244 ion of CD4(+) T cells to MAdCAM-1 and the in vitro response to vedolizumab before treatment initiatio

245 In vitro restoration of TET expression by ascorbic acid was

246 In-vitro results demonstrated that TMNP exhibited excellent

247 This should be considered when comparing in vitro results to in vivo systems.

248 I and II HLA molecules were selected for in vitro screening against PBMC samples from a cohort of ch

249 new antigen receptor (VNAR) was used for in vitro selection against recombinant human TfR1 ectodomai

250 In vitro, selumetinib downregulated cellular and membrane l

251 ctors, or AH50 less than median, impaired in vitro serum control of KP that was restored by adding he

252 rs to HIO ECs, we find that HIO ECs grown in vitro share the highest similarity with native intestina

253 n bioavailability was determined using an in vitro simulated peptic-pancreatic digestion, followed by

254 In vitro single-molecule experiments confirmed that yeast c

255 d trans-A(2)B(2) porphyrins showed decent in vitro singlet oxygen generation, which was supported by

256 f the aging hippocampus, together with an in vitro site-directed mutagenesis approach, we identify lo

257 We show that genetic ablation of IFT20 in vitro slows keratinocyte migration during wound healing.

258 accharides, phenolic compound content and in vitro starch digestion.

259 ls, implying that pDCs were refractory to in vitro stimulation after IFNalpha production in vivo.

260 Additional phenotyping and in vitro studies enabled reclassification of a KCNQ1 varian

261 eview various forms of recent 3D MEAs for in vitro studies in context of their geometry, materials, a

262 ulation in vitro Additionally, functional in vitro studies revealed that PD-1 expression on NK cells

263 Human and experimental in vivo and in vitro studies show that the adventitia is a dynamic micr

264 In vitro studies showed that rhIGF-1/BP3 treatment increase

265 Despite recent in vivo and in vitro studies supporting this function, a mechanistic un

266 Preclinical studies, in vivo, and in vitro studies, in combination with mathematical modeling

267 In vitro study confirmed that VPS35 up-regulation by reduci

268 nfirmed that some of these compounds were in vitro substrates of the transporter and validated the di

269 HK phosphorylation in biochemical assays in vitro suggest negative cooperativity, whereby phosphoryl

270 d zebularine also did not disrupt editing in vitro, suggesting that PPR65 cannot bind modified bases

271 To determine whether the in vitro susceptibility of multi-NAI-resistant AIVs is asso

272 N8(Q136K)) NA substitutions, which impart in vitro susceptibility only to LAN or OS, respectively.

273 he capsule polymerase Cps1B of App1 as an in vitro synthesis tool and an alternative for capsule poly

274 ico tests using known stability data, and in vitro tests using three membrane protein targets with 7,

275 n of Rep) display G4 unwinding activities in vitro that are significantly higher than the closely rel

276 short transient burst of competent state in vitro, the naturally developed competent state was prolo

277 at active K-Ras4B dimerizes in silico and in vitro through two major interfaces: (i) beta-interface,

278 Human subcutaneous fat was cultured in vitro to promote blood vessel outgrowth prior to implant

279 we overexpressed BC200 by transfection of in vitro transcribed RNA and transient expression from tran

280 Ensemble in vitro transcription assays indicate that PQS in the non-

281 Several essential conditions for in vitro transcription by T7 RNAP were confirmed with this

282 , using recombinantly expressed proteins, in vitro transcription, kinetic analyses, and in vivo cell

283 followed by linear amplification through in vitro transcription.

284 ors of translation in both cell-based and in vitro translation assays.

285 In vitro transport assays confirmed that some of these comp

286 ubstrate commonly used in high-throughput in vitro transporter inhibition assays in the early ADME pr

287 In vitro treatment of IEC organoids with type III IFN resul

288 d that increased cellular metabolic rates in vitro using changes in oxygen consumption rate as a read

289 Further analysis and in vitro validation revealed that metformin optimally rever

290 In vitro, VE-cadDEE mutant cells displayed defects in polar

291 asma anti-RBD and anti-ECD IgG titers and in vitro VN titers.

292 CCL7, CCL2, and CCL3 chemotactic function in vitro We show that local as well as systemic administrat

293 l cells are exposed to hypoxic conditions in vitro, we observed a striking enhancement in HIF2alpha e

294 This in vivo MT phenotype was reproduced in vitro when cells were co-cultured with IL4-polarized MPh

295 n the ability of pDCs to produce IFNalpha in vitro, which correlated with decreased phosphorylation o

296 ents PDGF-induced Akt and STAT3 signaling in vitro, while next generation sequencing broadly implicat

297 classic model for studying primary cilia in vitro, with a genetic dissection of the protein-protein

298 micelles and was monodisperse and stable in vitro, with sufficient structural definition to support

299 rats SCI decreases opioid responsiveness in vitro within a specific subset of small-diameter nocicep

300 Subsequent in vitro wound-healing assays also confirmed that M2 and M1