ライフサイエンスコーパス: vitronectin

1 in serum-free conditions (in the absence of vitronectin).

2 ng with integrin alphavbeta3 comparable with vitronectin.

3 inhibitor-1 (PAI-1), which is potentiated by vitronectin.

4 ivate PAI-1 in the presence of its cofactor, vitronectin.

5 ompounds inactivate PAI-1 in the presence of vitronectin.

6 iated H1299 cell adhesion to fibronectin and vitronectin.

7 PAR increased cell adhesion and migration on vitronectin.

8 ind the arginine-glycine-aspartate domain of vitronectin.

9 interactions with plasminogen activators and vitronectin.

10 adhesion by acting as a binding protein for vitronectin.

11 is occupied by its ligands, fibronectin and vitronectin.

12 creased adhesion of cells to fibronectin and vitronectin.

13 molecules of PAI-1 are capable of binding to vitronectin.

14 ll adhesion and spreading on fibronectin and vitronectin.

15 suggested a second PAI-1-binding site within vitronectin.

16 f PAI-1 in solution and its interaction with vitronectin.

17 the F-prostanoid receptor (FPS) to adhere to vitronectin.

18 pping multiple substrate proteins, including vitronectin.

19 ved for the binding of purified integrins to vitronectin.

20 e significantly increased by fibronectin and vitronectin.

21 with PAI-039 blocked the binding of PAI-1 to vitronectin.

22 e previously identified interaction site for vitronectin.

23 e sulfation sites in mouse lumican and human vitronectin.

24 of paxillin and p130Cas in cells adhering to vitronectin.

25 ng alpha(v)beta(3)-mediated cell adhesion to vitronectin.

26 essed the RGDfV-induced loss of spreading on vitronectin.

27 CD63 inhibits MC adhesion to fibronectin and vitronectin.

28 totactic migration towards the matrix factor vitronectin.

29 d increased adhesion to and migration toward vitronectin.

30 d and the active serpin forms complexes with vitronectin.

31 PAI-1 circulates in blood as a complex with vitronectin.

32 gate suspension or as monolayers adherent to vitronectin.

33 ed to both FGF-2 and fibrinogen but not with vitronectin.

34 ing abrogated upon plating of the cells onto vitronectin.

35 ccal adhesin PspC and the human glycoprotein vitronectin.

36 I-1 binding to proteases and to its cofactor vitronectin.

37 ith the C-terminal heparin-binding domain of vitronectin.

38 lar matrix and integrin-mediated adhesion to vitronectin.

39 ral extracellular ligands, including uPA and vitronectin.

40 ace CEACAMs and to integrins, the latter via vitronectin.

41 lates the binding of uPAR to matrix-embedded vitronectin.

42 5)-Cys(31) connectivity is present in native vitronectin; 2) only the native disulfide connectivity i

43 90% cleavage, clusterin (50%), ADAM9 (54%), vitronectin (54%), and alpha2-macroglobulin (55%), as we

44 SAXS) measurements were used to characterize vitronectin, a circulatory protein found in human plasma

45 sensitive ligands: the physiologic cofactor, vitronectin; a monoclonal antibody, 33B8, that binds pre

46 Vitronectin acquisition conferred serum resistance to bo

47 Elevated levels of TIMP3 and vitronectin, acting downstream of Notch3(ECD) deposition

48 o the beta-propeller of alpha3beta1 empowers vitronectin adhesion by this integrin.

49 bent assay were used to measure fibronectin, vitronectin, alphaVbeta3 integrin, and IGF-I levels.

50 etal and adult beta-cells to collagen IV and vitronectin also results in the marked suppression of in

51 ated by vitronectin, we further propose that vitronectin alters the conformation of the RCL to allow

52 and apoptosis in HBMECs on poly-l-lysine or vitronectin, although cells detached only from vitronect

53 led a number of common factors, for example, vitronectin, an adhesion protein, dendritic cell-specifi

54 UTP also increased expression of vitronectin, an extracellular matrix protein that is a l

55 -ARs induced adhesion in three cell types to vitronectin, an interaction that was also integrin-, FGF

56 i-LIBS binding, but reduced cell adhesion to vitronectin and AP3.

57 igh-affinity alpha(v)beta(3) integrin ligand vitronectin and by antibodies to alpha(v)beta(3) integri

58 such as basic FGF, TGFbeta, fibronectin, and vitronectin and can serve as feeders for both autologous

59 tested only fibronectin and laminin but not vitronectin and collagen I stimulated trans-activation o

60 n expressed in Haemophilus influenzae, bound vitronectin and conferred serum resistance on this organ

61 of DsrA exhibited binding to fibronectin and vitronectin and conferred serum resistance to an H. ducr

62 as correlated with both increased binding of vitronectin and decreased binding of polymerized C9.

63 like pneumococcal surface protein, possesses vitronectin and factor H binding activity.

64 tween hTSP-1 and Hic differs from binding to vitronectin and factor H.

65 gands from the extracellular matrix ligands (vitronectin and fibronectin for alpha(v)beta(3) and alph

66 eractions via antibodies, exogenous ligands (vitronectin and fibronectin), and their RGD recognition

67 s, we found that whereas interaction between vitronectin and integrins diminished the ability of macr

68 reported, but also other ECM components like vitronectin and is an important regulator of cellular re

69 PAI-1 is inaccessible when PAI-1 is bound to vitronectin and may overlap with the PAI-1 vitronectin b

70 xtracellular matrix proteins fibronectin and vitronectin and mediates attachment of H. ducreyi to ker

71 ed alterations in adhesion and morphology on vitronectin and migration could be abolished by cultivat

72 B cells upregulate alphavbeta3 and adhere to vitronectin and milk-fat globule epidermal growth factor

73 econd, separate site for interaction between vitronectin and PAI-1.

74 MB) domain, mediates the interaction between vitronectin and plasminogen activator inhibitor 1 (PAI-1

75 Vitronectin and plasminogen activator inhibitor-1 (PAI-1

76 Vitronectin and plasminogen activator inhibitor-1 (PAI-1

77 We therefore hypothesized that IaI can bind vitronectin and promote vitronectin-induced epithelial r

78 exhibited migration and spreading defects on vitronectin and reduced sprouting in 3-dimensional fibri

79 integrin mediates adhesion to fibronectin or vitronectin and regulates various aspects of the inflamm

80 s with alpha(v)beta(3) upon cell adhesion to vitronectin and that this association requires beta(3) t

81 b-RPE deposits, such as complement factor H, vitronectin, and amyloid beta, revealed that HAP spherul

82 lation of the complement pathway (clusterin, vitronectin, and fibromodulin) and of amyloid deposition

83 IGF-I, vitronectin, and fibronectin RNA and protein levels were

84 es are able to bind to laminin, fibronectin, vitronectin, and hyaluronic acid, which are extracellula

85 were also observed to spread and migrate on vitronectin, and integrin alpha(v)beta(1) was found to b

86 ancer cell lines (C6, SNB75) on fibronectin, vitronectin, and laminin.

87 poietin-2 similarly to laminin, fibronectin, vitronectin, and more than to collagen-I, -III, and -IV.

88 nce to human serum, cosedimentation of human vitronectin, and pellicle formation.

89 actor beta-induced protein betaig-H3, DEL-1, vitronectin, and serine protease HtrA1 (P < 0.01).

90 RGD-containing ligands, such as fibronectin, vitronectin, and the latency-associated peptides of tran

91 PE binds plasminogen and also vitronectin, and the two human plasma proteins compete f

92 TIMP3 and vitronectin are 2 extracellular matrix proteins that abn

93 lasminogen activator inhibitor-1 (PAI-1) and vitronectin are cofactors involved in pathological condi

94 igated whether increased levels of TIMP3 and vitronectin are responsible for aspects of CADASIL disea

95 es exclude proteolytic removal of PAI-1 from vitronectin as the mechanism, and show instead that cell

96 ame capacity to inhibit the binding of PE to vitronectin as those induced after PE immunization.

97 Our results demonstrate that PAI-1 and vitronectin assemble into higher order forms via a pathw

98 We show that IaI binds vitronectin at the arginine-glycine-aspartate site, ther

99 h Opc, Msf binds preferentially to activated vitronectin (aVn), engaging at its N-terminal region but

100 apoptotic vtn(-/-) neutrophils with purified vitronectin before intratracheal instillation decreased

101 ll adhesion, migration and signaling through vitronectin binding and interactions with integrins.

102 o vitronectin and may overlap with the PAI-1 vitronectin binding domain.

103 grins alpha5beta1 and alphavbeta6 and not on vitronectin binding integrins alphavbeta3 and alphavbeta

104 ncluded that neither fibronectin binding nor vitronectin binding is required for high-level serum res

105 The data imply that vitronectin binding may be an important strategy for the

106 Vitronectin binding required the R domains in the mature

107 inhibition by inactivators that bind at the vitronectin binding site.

108 -RGD constructs 10-13 inhibited biotinylated vitronectin binding to the purified alphaVbeta3 integrin

109 class II H. ducreyi strains mediated FN and vitronectin binding.

110 ase interactions with PAI-1 while conserving vitronectin binding.

111 say, expression of alphavbeta3 integrin, and vitronectin binding.

112 23K/R101A variant demonstrated an even lower vitronectin-binding ability.

113 that possessed either intact antiprotease or vitronectin-binding activity to bleomycin-injured mice g

114 n resonance experiments demonstrated reduced vitronectin-binding affinity of the (Q123K) variant (K(D

115 We found that the vitronectin-binding capacity of PAI-1 was the primary de

116 The critical role of the vitronectin-binding function of PAI-1 in fibrosis was co

117 We conclude that the vitronectin-binding function of PAI-1 is necessary and s

118 at inhibits the generation of plasmin, and a vitronectin-binding function that interferes with cell a

119 A vitronectin-binding mutant of PAI-1 was equipotent with

120 In this study, we identified PspC as a vitronectin-binding protein interacting with the C-termi

121 PAR form, exposing the uPAR88-92 region, and vitronectin, both involved in fibrosis and in the fibrob

122 Finally, vitronectin bound to PspC was functionally active and in

123 nt pharmacokinetics, potent activity against vitronectin-bound PAI-1 in vivo, and efficacy in a murin

124 on of PAI-1 by PAI-039 against free, but not vitronectin-bound PAI-1, suggesting for the first time a

125 d for pancreatic carcinoma cell migration on vitronectin but not on collagen.

126 ic ligands (urokinase plasminogen activator, vitronectin), but not via adjustment of the cholesterol

127 Preincubation of PAI-1 with vitronectin, but not bovine serum albumin, blocked PAI-0

128 rfaces after incubation with fibronectin and vitronectin, but not collagen or laminin.

129 induced transient loss of HBMEC spreading on vitronectin, but not their detachment, and induced apopt

130 PE-PilA was found to bind vitronectin by enzyme-linked immunosorbent assay, as iso

131 These results indicate that binding of vitronectin by UspA2 is involved in the serum resistance

132 infection can be reduced by fibronectin and vitronectin, by down-regulation of integrin alphav, or b

133 mals carrying excess RGD proteins, including vitronectin, CD40-ligand and thrombospondin-1.

134 g peptide RGDfV induces loss of spreading on vitronectin, cell detachment, and apoptosis.

135 dditional known drusen components, including vitronectin, clusterin, and serum amyloid P, thus sugges

136 We assessed five conditions and found that a vitronectin-coated substrate was the most efficient meth

137 o display a nonpolarized form of motility on vitronectin-coated substrates.

138 Using this new medium (E8) and vitronectin-coated surfaces, we demonstrate improved der

139 of endothelial cells cultured on Matrigel or vitronectin-coated surfaces.

140 ogen but not on other matrices (fibronectin, vitronectin, collagen 1, and von Willebrand factor), str

141 concentration dependence of EPC adhesion (to vitronectin-, collagen type I-, fibronectin-, and lamini

142 e isolated, characterized, and cultured on a vitronectin/collagen scaffold and primed with SDF to gen

143 , the other 3 reactivity clusters (histones, vitronectin/collagen/chondroitin sulphate, and entactin/

144 xhibit reduced adhesion and migration toward vitronectin compared with wild-type cells.

145 Analytical ultracentrifugation on the PAI-1-vitronectin complex demonstrated that increasing NaCl co

146 This 2:1 PAI-1-vitronectin complex, with a sedimentation coefficient of

147 Cl concentration favors 1:1 versus 2:1 PAI-1-vitronectin complexes and hampers formation of higher or

148 We hypothesize that PAI-1-vitronectin complexes form in a stepwise and concentrati

149 model for the assembly of higher order PAI-1-vitronectin complexes via two distinct binding sites in

150 e were performed to identify different PAI-1-vitronectin complexes.

151 Vitronectin concentrations were significantly increased

152 in (residues 1-44) of the human glycoprotein vitronectin contains the high-affinity binding sites for

153 psin, pancreatic polypeptide, complement C3, vitronectin, cortisol, AXL receptor kinase, interleukin-

154 at allows activation of proteins, among them vitronectin, critical for thrombus formation.

155 reduced in bronchoalveolar lavage fluid from vitronectin-deficient (vitronectin(-/-)) mice, as compar

156 ound in bronchoalveolar lavage obtained from vitronectin-deficient (vtn(-/-)) mice compared with wild

157 eurones in slices derived from wild-type and vitronectin-deficient mice.

158 These findings provide a novel vitronectin-dependent mechanism contributing to the deve

159 PAI-1 inhibition enhanced vitronectin-dependent transendothelial migration of huma

160 Furthermore, vitronectin-depleted NHS exhibited bactericidal activity

161 her, this work suggests that fibronectin and vitronectin deposition during demyelinating disease is a

162 a close relationship between fibronectin and vitronectin deposition, microglial activation, and micro

163 Furthermore, studying vitronectin-directed migration using (a) Fyn small inter

164 Plasma vitronectin does not bind to alphavbeta3 or alphaIIbbeta

165 this molecule does not modulate migration on vitronectin, does not associate with the major vitronect

166 leased PDI reduces disulfide bonds on plasma vitronectin, enabling vitronectin to bind to alphaVbeta3

167 vely larger contribution to total current in vitronectin-exposed cells contributing to the accelerati

168 n rate of I(h) between neurones in naive and vitronectin-exposed slices (10 microg ml(-1) added to se

169 , HCN1 immunoreactivity appeared elevated in vitronectin-exposed slices, while HCN2 levels appeared u

170 Timp3 and vitronectin expression were genetically reduced in TgNot

171 proximately 1 nm) but does not interact with vitronectin, fibronectin, laminin, fibrinogen, and von W

172 is of endothelial cells cultured on gelatin, vitronectin, fibronectin, or laminin but not collagen ty

173 nhibits the binding of purified integrins to vitronectin; however, its inhibition of endothelial and

174 ithin the N-terminal somatomedin B domain of vitronectin; however, several studies have suggested a s

175 ition of the plasma proteins fibronectin and vitronectin in cerebral parenchyma.

176 n acute lung injury, we examined the role of vitronectin in LPS-induced pulmonary inflammation.

177 In contrast, haploinsufficiency or loss of vitronectin in TgNotch3(R169C) mice ameliorated white ma

178 cell, but not smooth muscle cell adhesion to vitronectin in the presence of PAI-1 requires both polym

179 l adhesion assembly reduces cell adhesion to vitronectin in the presence of PAI-1 to levels similar t

180 a significant increase in the expression of vitronectin in the retina of the experimental mice.

181 the high-affinity association of PAI-1 with vitronectin in vivo have made it difficult to identify p

182 scover that GNPs respond to laminin, but not vitronectin, in the GZ microenvironment via integrin bet

183 tronectin, although cells detached only from vitronectin, indicating that cell detachment was not req

184 Fura-2 microfluorimetry revealed that vitronectin induced a significant and sustained increase

185 n intracellular Ca2+ concentration, although vitronectin-induced Ca2+ current could not be detected.

186 ed that IaI can bind vitronectin and promote vitronectin-induced epithelial repair after injury.

187 of fetal beta-cells to both collagen IV and vitronectin induces significant glucose-independent insu

188 Collagen IV, but not vitronectin, induces comparable responses in adult beta-

189 prouting is known to involve the alphaVbeta3 vitronectin integrin on endothelium.

190 C molecules, did not interfere with the PspC-vitronectin interaction.

191 However, the factors that modify cell-vitronectin interactions after injury and help promote e

192 Vitronectin is a major ECM component that promotes epith

193 n of microglial activation by fibronectin or vitronectin is an important regulatory mechanism in vivo

194 dothelial and smooth muscle cell adhesion to vitronectin is at most 50-75%.

195 Vitronectin is present in large concentrations in serum

196 nectin (Kd = 10.19 nM), but slightly less to vitronectin (Kd = 16.51 nM).

197 id residues of the human plasma glycoprotein vitronectin, known as the somatomedin B (SMB) domain, me

198 y of PAI-1 mutants to bind to the engineered vitronectin lacking the SMB domain.

199 In addition to fibrillin-1, fibronectin, vitronectin, laminin, and amyloid P-component, which are

200 he ECM protein, fibronectin, but adhesion to vitronectin, laminin, collagen-I, and collagen-IV was no

201 yptase epsilon could not cleave fibronectin, vitronectin, laminin, single-chain tissue-type plasminog

202 ited increased haptotaxis on fibronectin and vitronectin matrices that correlated with decreased adhe

203 nsity of 5 x 10(6) cells/cm(2) on a collagen/vitronectin matrix.

204 rhalis; this represents the first example of vitronectin-mediated serum resistance on a microbe.

205 ressor protein 4E-BP1, which is required for vitronectin-mediated tumor cell invasion.

206 nt (vitronectin(-/-)) mice, as compared with vitronectin(+/+) mice, after LPS exposure.

207 chemotaxis as compared with neutrophils from vitronectin(+/+) mice, and incubation of vitronectin(+/+

208 e concentrations were significantly lower in vitronectin(-/-) mice.

209 lar lavage fluid from vitronectin-deficient (vitronectin(-/-)) mice, as compared with vitronectin(+/+

210 To investigate this secondary site, a vitronectin mutant lacking the somatomedin B domain (rDe

211 -2, and IL-1beta after LPS exposure than did vitronectin(+/+) neutrophils and also showed greater deg

212 rom vitronectin(+/+) mice, and incubation of vitronectin(+/+) neutrophils with vitronectin was associ

213 lear accumulation of NF-kappaB compared with vitronectin(+/+) neutrophils.

214 Vitronectin(-/-) neutrophils consistently produced more

215 Vitronectin(-/-) neutrophils demonstrated decreased KC-i

216 s demonstrate that the inhibitory effects of vitronectin on efferocytosis involve interactions with b

217 und specifically to fibronectin (Fn) but not vitronectin or collagens.

218 However, cells maximally spread on vitronectin or fibronectin still responded to the fibron

219 lls expressing gB and gHgL can be blocked by vitronectin or triggered by addition of soluble truncate

220 1 collagen matrices, but not to fibronectin, vitronectin, or laminin, demonstrated a significant incr

221 alpha-helices D and E in PAI-1 and a site in vitronectin outside of the SMB domain.

222 ea that may promote assembly of higher order vitronectin-PAI-1 complexes.

223 tion using a surface plasmon resonance based vitronectin-PAI-1-SMB competition assay allowed us to co

224 In addition, using vitronectin peptides to block Msf-aVn interactions, aVn-

225 Using a series of vitronectin peptides, the C-terminal heparin-binding dom

226 Deposits were rich in vitronectin, photoreceptor-associated proteins, and Iba1

227 eta3 with extracellular matrix ligands (e.g. vitronectin) plays a critical role in insulin-like growt

228 le, immobilized, as well as cellularly bound vitronectin possesses different conformations.

229 isulfide topology in the SMB domain of human vitronectin, providing biochemical as well as functional

230 segment of 51 amino acid residues of intact vitronectin purified from human blood.

231 thrombus generation in mice demonstrate that vitronectin rapidly accumulates on the endothelium and t

232 The role of the vitronectin receptor (alpha(v)beta(3)-integrin) as a tum

233 osphatidylserine (PS)-exposing cells and the vitronectin receptor (VR) on phagocytes.

234 Therefore, the vitronectin receptor might not be an appropriate therape

235 pidermal growth factor-8, and its microglial vitronectin receptor was sufficient to rescue up to 90%

236 tronectin, does not associate with the major vitronectin receptor, alpha(v)beta(3) integrin, and does

237 own about kindlin regulation of the related "vitronectin receptor," alphaVbeta3.

238 s of phenylbutyrate-based antagonists of the vitronectin receptors alphavbeta3 and alphavbeta5 signif

239 in polymerization) or cyclo(RGDfV) (to block vitronectin receptors) significantly prevented neuronal

240 Among the two vitronectin receptors, alphavbeta3 and alphavbeta5 integ

241 nificantly reduced binding to fibrinogen and vitronectin, relative to non-risk, both in purified prot

242 immobilized integrins, using fibronectin and vitronectin, respectively, as competitors.

243 ter understanding of the domain structure of vitronectin resulted from low-resolution models develope

244 -mediated adhesion of hematopoietic cells to vitronectin results in activation of the Rho GTPases.

245 domain demonstrates that this mutant form of vitronectin retains PAI-1 binding.

246 ite that is located directly adjacent to the vitronectin RGD integrin binding sequence.

247 The plasma adhesion proteins fibronectin and vitronectin serve as cofactors for these three antiangio

248 The somatomedin B domain of vitronectin (SMBD) did not affect SI for any proteinase

249 The binding of PAI-1 to vitronectin sterically blocks integrin access to this si

250 aging the extracellular matrix (ECM) protein vitronectin, strongly upregulate both mTOR activity and

251 and facilitates the migration of cells on a vitronectin substrate by regulating alpha v integrin cel

252 Binding experiments with immobilized vitronectin suggested a region N-terminal to the identif

253 ascular endothelial cells (HBMECs) plated on vitronectin, suggesting that sphingomyelin hydrolysis co

254 hese same three wild-type strains bound more vitronectin than did their uspA2 mutants.

255 in 35000HP bound more C4 binding protein and vitronectin than FX517 but not factor H.

256 Pneumococci engage vitronectin, the human adhesive glycoprotein and complem

257 g the first 51 amino acids from human plasma vitronectin, the somatomedin B (SMB) domain, has been de

258 ulfide bonds on plasma vitronectin, enabling vitronectin to bind to alphaVbeta3 and alphaIIbbeta3.

259 saturation of the two PAI-1-binding sites of vitronectin to form the 2:1 complex.

260 ly, we have shown that Nm Opc binds to serum vitronectin to inhibit complement-mediated killing.

261 and alpha(v)beta(5) engagement with adsorbed vitronectin to promote colony formation.

262 etory IgA competitively inhibited binding of vitronectin to purified PspC and to PspC-expressing pneu

263 -I, whereas addition of the active region of vitronectin to RECs grown in normal glucose enhanced the

264 tant wild-type strains; addition of purified vitronectin to this serum restored serum resistance.

265 Conversely, supplying an integrin ligand, vitronectin, to the ECM rescued the enhanced ciliation o

266 hich comprises the N-terminal 44 residues of vitronectin, to the flexible joint region of PAI-1, incl

267 tion of luminal alpha(v)beta(3) receptors by vitronectin triggers Ca2+ influx.

268 gher on fibronectin and VCAM-1 compared with vitronectin, types I or IV collagen.

269 ted chemotaxis, Rac and Vav2 activation, and vitronectin up-regulation were inhibited by pretreatment

270 s (fibronectin, types I and IV collagen, and vitronectin), vascular cell adhesion molecule (VCAM)-1,

271 s that bind beta3 integrins (fibronectin and vitronectin) versus substrates that only bind beta1 inte

272 demonstrate meningococcal interactions with vitronectin via a novel adhesin, Msf (meningococcal surf

273 The high-affinity binding site in human vitronectin (VN) for plasminogen activator inhibitor-1 (

274 en uPAR and the extracellular matrix protein vitronectin (VN) for the signaling activity of the recep

275 Vitronectin (VN) in provisional extracellular matrix (EC

276 leavage of ECM proteins fibronectin (FN) and vitronectin (Vn) into small fragments and increased bind

277 The human blood protein vitronectin (Vn) is a major component of the abnormal de

278 , we revealed that PH is also a receptor for vitronectin (Vn), an abundant plasma protein that regula

279 lasts (HCFs) were grown on fibronectin (FN), vitronectin (VN), or collagen (CL) in supplemented serum

280 en identified previously as a staphylococcal vitronectin (Vn)-binding protein.

281 the plasma and extracellular matrix protein vitronectin (Vn).

282 as factor H, C4b-binding protein (C4BP) and vitronectin (Vn).

283 ubation of vitronectin(+/+) neutrophils with vitronectin was associated with increased chemotaxis.

284 Adhesion to fibronectin, collagens, and vitronectin was compromised.

285 ation was also noted: macrophage adhesion to vitronectin was enhanced by uPA and blocked by plasminog

286 showed that the influence of fibronectin and vitronectin was mediated by the alpha(5)beta(1) and alph

287 entation of the extracellular matrix protein vitronectin, we accomplished reversible differentiation

288 king peptides into wtPAI-1 is accelerated by vitronectin, we further propose that vitronectin alters

289 itro is strongly promoted by fibronectin and vitronectin, we set out to examine the possibility that

290 ation, total brain levels of fibronectin and vitronectin were strongly increased and there was a clos

291 , we found that SEMA3F decreased adhesion to vitronectin, whereas integrin-linked kinase (ILK) kinase

292 adhesion to the extracellular matrix protein vitronectin, which is a naturally occurring ligand for a

293 Because PAI-1 binds vitronectin with approximately 10-100-fold higher affini

294 ype-1 (PAI-1), binds to the adhesion protein vitronectin with high affinity at a site that is located

295 Interaction of vitronectin with integrin alphavbeta3 results in the con

296 Preincubation of vitronectin with plasminogen activator inhibitor-1 elimi

297 be essential for the interaction of soluble vitronectin with PspC.

298 in and C-terminal heparin-binding domains of vitronectin with respect to the N-terminal somatomedin B

299 ingest apoptotic cells, interaction between vitronectin with urokinase-type plasminogen activator re

300 nt amplitude was preferentially sensitive to vitronectin, with its relatively larger contribution to