ライフサイエンスコーパス: vmPFC

1 certainty in ventromedial prefrontal cortex (vmPFC).

2 pocampus and ventromedial prefrontal cortex (vmPFC).

3 activity in ventromedial prefrontal cortex (vmPFC).

4 een NAcc and ventromedial prefrontal cortex (vmPFC).

5 value within ventromedial prefrontal cortex (vmPFC).

6 ation is the ventromedial prefrontal cortex (vmPFC).

7 atum and the ventromedial prefrontal cortex (vmPFC).

8 g, exploratory-like) behavioral repertoires (vmPFC).

9 AIC) and the ventromedial prefrontal cortex (vmPFC).

10 LA) or the ventral medial prefrontal cortex (vmPFC).

11 s and in the ventromedial prefrontal cortex (vmPFC).

12 includes the ventromedial prefrontal cortex (vmPFC).

13 ce) were indiscriminately represented across vmPFC.

14 itatory connectivity between the IFG and the vmPFC.

15 a specific CeMA GABAergic projection to the vmPFC.

16 ess ratings, are specifically encoded in the VMPFC.

17 BDNF expression and calcium mobilization in vmPFC.

18 RS), and were increased by ketamine in mouse vmPFC.

19 riate scene imagery is strongly modulated by vmPFC.

20 terns in the ventromedial prefrontal cortex (vmPFC), a key node in the brain's valuation and decision

21 activity in ventromedial prefrontal cortex (vmPFC), a region involved in computing an integrative va

22 Increased vmPFC activation (for CS+ > CS-) during early conditioni

23 ically predicted by prediction-error related vmPFC activation during early extinction.

24 The effects of vmPFC activation on cue-induced reinstatement depended o

25 arning process, and prediction error-related vmPFC activation specifically predicted therapy outcome.

26 y initial hypoactivity followed by increased VmPFC activation, pointed to the VmPFC as a key locus of

27 amygdala and ventromedial prefrontal cortex (vmPFC) activation during early extinction learning with

28 There were also indications vmPFC activations during conditioned safety stimulus pro

29 ehavior, but the precise conditions by which vmPFC activity can be exploited to reduce cocaine relaps

30 ortex (vmPFC), with additional evidence that vmPFC activity leads that of the hippocampus.

31 That is, amygdala and vmPFC activity strongly tracked with population behavior

32 lysis showed that this SES-based increase in VMPFC activity was associated with greater co-activation

33 Here, we show that the vmPFC actually plays a causal role in the acquisition of

34 Intra-vmPFC administration of the glycine transport inhibitor

35 f glycine transport inhibitor ALX5407 in the vmPFC alleviated deficits in impulse control.

36 atings whereas lower dynamic activity in the VmPFC also predicted a higher level of maladaptive copin

37 Within vmPFC, anatomically distinct regions were dissociated in

38 sconnection experiments (Daun02 lesioning of vmPFC and acute dopamine D1-receptor blockade with SCH39

39 and olfactory (piriform) cortex and between vmPFC and amygdala revealed parallel pathways that suppo

40 esponses to the extinguished cues within the vmPFC and amygdala, but significantly increased function

41 the amygdala and insula and between the rACC/vmPFC and cognitive control network.

42 During decision making, separate signals in VMPFC and DMPFC encoded subjects' decision variable for

43 Neurons in the vmPFC and dmPFC exhibited phasic firing to EtOH lever pr

44 We find that vmPFC and dmPFC have distinguishable time courses and ti

45 Thus, our data show reward-related vmPFC and dmPFC responses have distinct time courses and

46 ivo electrophysiological recordings in mouse vmPFC and dmPFC to obtain neuronal correlates of footsho

47 as associated with structural differences in vmPFC and hippocampus, regions implicated in emotional p

48 re than women showed greater activity in the VMPFC and NAcc when forming impressions of high-SES (vs.

49 These effects were specific to vmPFC and not to striatum.

50 Instead, changes in connectivity between vmPFC and OFC are correlated with learning-related chang

51 value, whereas connectivity changes between vmPFC and PC predict changes in perceived odour similari

52 larly predicted decreased dorsal striatal to vmPFC and presupplementary motor area connectivity, whic

53 hlights the heterogeneity of function within vmPFC and reveals how the effects of area 14 overactivat

54 for the investigation of the function of the vmPFC and show that taking into account the sulcal varia

55 that the functional connectivity between the vmPFC and the right inferior frontal gyrus (IFG) was red

56 gen-level-dependent activity patterns of the vmPFC and the striatum that coexist with value signals.

57 mages, but significant hypoactivation in the vmPFC and ventral striatum in response to stress images

58 idence on the causal mechanisms by which the vmPFC and ventral striatum interact during the anticipat

59 In vmPFC and ventral striatum, representations of predictio

60 Nonetheless, the close match between vmPFC and VS suggests that cortex and its striatal targe

61 gene delivery of an activating Gq-DREADD to vmPFC and/or vmPFC projections to the nucleus accumbens

62 sured in the ventromedial prefrontal cortex (vmPFC) and dorsal raphe nucleus (DRN).

63 The ventromedial prefrontal cortex (vmPFC) and dorsomedial prefrontal cortex (dmPFC) are pos

64 ncluding the ventromedial prefrontal cortex (vmPFC) and hippocampus.

65 thicker cortex in the left ventromedial PFC (vmPFC) and left precentral gyrus.

66 ng amygdala, ventromedial prefrontal cortex (vmPFC) and nucleus accumbens (NAc)).

67 of interest (ventromedial prefrontal cortex (vmPFC) and nucleus accumbens).

68 (dACC), the ventro-medial prefrontal cortex (vmPFC) and the anterior insula.

69 (ACC), and ventral medial prefrontal cortex (vmPFC)) and this stress diathesis, in maltreated youth w

70 rtex (dACC), ventromedial prefrontal cortex (VMPFC), and intraparietal sulcus (IPS) predicted individ

71 prefrontal-limbic model comprising the IFG, vmPFC, and amygdala.

72 r competition-based choice dynamics in human vmPFC, and introduce computational neurostimulation as a

73 l anterior cingulate cortex (rACC), anterior vmPFC, and subgenual cingulate significantly decreased f

74 the striatum, the DLPFC, the insula and the vmPFC appeared to be central 'nodes' or hubs of the fati

75 As in macaques, human lOFC and mOFC/vmPFC are necessary for contingent learning and value-gu

76 striatum and ventromedial prefrontal cortex (vmPFC) are two central nodes of the "reward circuit" of

77 to those of ventromedial prefrontal cortex (vmPFC) Area 14 neurons, recorded in a risky choice task.

78 threat processing of 2 major regions of the vmPFC, areas 25 and 32 in NHPs and their anatomical homo

79 y increased VmPFC activation, pointed to the VmPFC as a key locus of the emotional and behavioral con

80 These results establish VMPFC as the neurocomputational substrate shared between

81 area 14 (a putative macaque homolog of human vmPFC) as 2 male macaques performed a novel foraging sea

82 inhibitory functional connectivity with the vmPFC at the time of children's own choice.

83 gnitive processes along a posterior-anterior vmPFC axis.

84 tional possibilities for clinical studies of vmPFC-based circuits, including neuropsychological asses

85 reduction in rearing were mimicked by intra-vmPFC blockade of AMPA-type but not NMDA-type glutamate

86 s with higher HRV showed both higher overall vmPFC blood-oxygen-level-dependent activity and attenuat

87 lf-administration and extinction comingle in vmPFC but have distinct outputs to the NAc core and shel

88 ing into the ventromedial prefrontal cortex (vmPFC) but unlike regular CFC extinction not in the CA1

89 nd 32 of the ventromedial prefrontal cortex (vmPFC), but a causal relationship between dysregulation

90 icits in the ventromedial prefrontal cortex (vmPFC), but the underlying molecular pathways are incomp

91 pocampus and ventromedial prefrontal cortex (vmPFC), but their respective roles are debated.

92 Closed-loop vmPFC, but not dmPFC, photosilencing on a postpunishment

93 optogenetic activation of the VGat-Cre(CeMA-vmPFC) circuit in awake, behaving animals produced a pos

94 We further provide evidence that the vmPFC codes for representations of those elements (i.e.,

95 lar for patients with lesions in DMF or mOFC/vmPFC, compared with Controls.

96 rs, it is essential to characterize amygdala-vmPFC connectivity changes during typical development.

97 rror responses in anterior insula and insula-vmPFC connectivity during self-esteem updates.

98 Enhanced insula-vmPFC connectivity during updating of those beliefs may

99 rthermore, age positively predicted amygdala-vmPFC connectivity in healthy youth, but negatively pred

100 is model indicated that the parental caudate-vmPFC connectivity in infancy predicted lower child exte

101 t decreases in dmPFC activation and amygdala-vmPFC connectivity may indicate abnormal developmental p

102 NAcc-vmPFC connectivity strength was negatively correlated wi

103 parental behavioral styles; stronger caudate-vmPFC connectivity was associated with more collaborativ

104 ter amygdala-ventromedial prefrontal cortex (vmPFC) connectivity when processing threat-related cues.

105 ase in the ventral medial prefrontal cortex (vmPFC) contributes to increased motor impulsivity during

106 striatum and ventromedial prefrontal cortex (vmPFC) (corrected P<0.05), which in turn correlated with

107 tters in the ventromedial prefrontal cortex (vmPFC) cortex in rats following long-term alcohol exposu

108 tofrontal (OFC) and ventromedial prefrontal (vmPFC) cortices, respectively.

109 oach to test whether participants with focal vmPFC damage (n = 6) would show a reduced influence of s

110 ngly opposite response pattern to those with vmPFC damage when making moral judgements.

111 In patients with vmPFC damage, visualization might also be reduced alongs

112 urbed in patients with either hippocampal or vmPFC damage.

113 neurosurgical patients with focal, bilateral vmPFC damage.

114 normal FPCN connectivity during WM, whereas vmPFC deactivation differences persisted regardless of W

115 cover that a value-anticipation mechanism in vmPFC declines in aging, and that this mechanism is asso

116 We found that a hippocampal-vmPFC dialog existed and that it took the form of vmPFC

117 When rating fear, activation in the vmPFC differed between the anxiety and healthy groups at

118 to assess the functional contribution of the vmPFC, dmPFC, vmPFC projections to NAcS, or vmPFC projec

119 ecent work (McCormick et al.) has shown that vmPFC drives the hippocampus during memory retrieval, ir

120 dialog existed and that it took the form of vmPFC driving the hippocampus.

121 l modeling of this interaction revealed that vmPFC drove activity in hippocampus during novel scene c

122 g, greater neural flexibility signals in the VmPFC during stress correlated with active coping rating

123 neurotransmitters were monitored in the rat vmPFC during the performance of a challenging variant of

124 responding and glycine and serine levels in vmPFC during the performance of the standard 5-CSRTT.

125 ns this view by also showing activity in the vmPFC during threat acquisition.

126 ation of the ventromedial prefrontal cortex (vmPFC) during correct and error trials.

127 ation of the ventromedial prefrontal cortex (vmPFC) during extinction recall (etap2 = 0.178, P = .02)

128 al (OFC) and ventromedial prefrontal cortex (vmPFC), during two-option choice with asynchronous offer

129 l tasks, the ventromedial prefrontal cortex (VMPFC) encoded an explicit representation of subjects' U

130 t that the ventral medial prefrontal cortex (vmPFC) encodes both operant drug self-administration and

131 ind that the ventromedial prefrontal cortex (vmPFC) encodes children's own preferences and the left d

132 SCH39166 in NAc core or shell) confirm that vmPFC ensembles interact with NAc core versus shell to p

133 The vmPFC exhibited inhibitory influence on the amygdala.

134 of human vmPFC) of MDD patients and in mouse vmPFC following chronic restraint stress (CRS), and were

135 Analyses focused on the VMPFC, following research implicating this region in pos

136 pocampus and ventromedial prefrontal cortex (vmPFC) for object-word pairs, and posterior hippocampus

137 addition, it uncovers an altered pattern of vmPFC-frontoparietal connectivity in impulsive people wi

138 In nonpsychiatric controls, vmPFC-frontoparietal connectivity was negatively moderat

139 Moderating effects of impulsivity on vmPFC-frontoparietal connectivity were assessed in nonps

140 We investigated vmPFC value signals, vmPFC-frontoparietal connectivity, and the impact of imp

141 uicide attempts showed a disrupted effect of vmPFC-frontoparietal connectivity, impulsivity, and rein

142 diated by the degree of anterior hippocampal-vmPFC functional connectivity.

143 s showed blunted task-related recruitment of vmPFC glycine and serine release, and the loss of an inv

144 processes and perspectives that propose the vmPFC guides the construction of context-relevant repres

145 d nucleus accumbens, however its function in vmPFC has not been investigated.

146 Since the vmPFC has strong anatomical and functional links with th

147 The ventromedial prefrontal cortex (vmPFC) has been implicated in a variety of social, cogni

148 The ventromedial prefrontal cortex (vmPFC) has been shown to negatively regulate cocaine-see

149 ANCE STATEMENT Neuronal ensembles within the vmPFC have recently been shown to play a role in self-ad

150 ofrontal cortex (OFC), and ventromedial PFC (vmPFC) have been linked to the regulation of anxiety dur

151 of the amygdala (CeMA) and ventromedial PFC (vmPFC) have critical roles for emotional regulation.

152 ly increased functional coupling between the vmPFC, hippocampus, and dorsal anterior cingulate cortex

153 rieval and scene imagination rely on similar vmPFC-hippocampus neural dynamics.

154 eys (a nonhuman primate that has far greater vmPFC homology to humans than rodents), areas 25 and 32

155 The vmPFC hypoactivation was associated with anxiety symptom

156 e novel evidence for a critical role for the vmPFC in contributing to reward-related activity of the

157 of stimulus meaning, which then informs the vmPFC in inhibiting the amygdala.

158 surements implied greater myelination within vmPFC in misophonic individuals.

159 rack of research shows the importance of the vmPFC in multiple aspects of social cognition, such as f

160 ning task-related hyperconnectivity with the vmPFC in OCD, consistent with biased processing of the C

161 maging studies of the human brain and of the vmPFC in particular.

162 Consistent with the role of the vmPFC in providing access to details that are typical fo

163 unique evidence for the critical role of the vmPFC in regulating activity of the amygdala in humans a

164 hese findings demonstrate a key role for the vmPFC in regulating EtOH-SA after punishment, with impli

165 Given the role of the vmPFC in schema-related processing and latent structure

166 oth nodes were functionally coupled with the vmPFC in support of the human coparental bond and this c

167 Here we investigate the casual role of vmPFC in the acquisition of pavlovian threat conditionin

168 nce was observed between the hippocampus and vmPFC in the scene compared with the object condition.

169 role of the ventromedial prefrontal cortex (vmPFC) in human pavlovian threat conditioning has been r

170 ted with the ventromedial prefrontal cortex (vmPFC) in humans, and damage to this region significantl

171 ivity in the ventromedial prefrontal cortex (vmPFC) in response to neutral images, but significant hy

172 role of the ventromedial prefrontal cortex (vmPFC) in the acquisition of pavlovian threat conditioni

173 eficits induced by CRS, and VGF knockdown in vmPFC increased susceptibility to subchronic variable st

174 ted into NAc combined with Fos colabeling in vmPFC indicated that vmPFC self-administration ensembles

175 e provide new evidence for bottom-up CeMA to vmPFC influence on reward-related behaviors.

176 or-expressing medium spiny neurons receiving vmPFC input to examine punishment-related plasticity in

177 nt was associated with altered plasticity at vmPFC inputs to D(1) receptor-expressing medium spiny ne

178 The ventromedial prefrontal cortex (vmPFC), insula, amygdala, hypothalamus, and periaqueduct

179 However, the CeMA and ventromedial PFC (vmPFC) interaction in reward regulation remains poorly u

180 how that the ventromedial prefrontal cortex (vmPFC) inversely and ventral tegmental area directly tra

181 We argue that the vmPFC is a core element of a network that represents str

182 an and animal studies demonstrating that the vmPFC is a key node of cortical and subcortical networks

183 The vmPFC is closely connected with another brain region-the

184 cond track of research demonstrates that the vmPFC is critical for the generation and regulation of n

185 One track of research indicates that the vmPFC is critical for the representation of reward- and

186 mPFC lesions to test the hypothesis that the vmPFC is necessary for enhancing ventral striatum respon

187 ts that representation of decision values in vmPFC is suborganized according to the underlying comput

188 The ventromedial prefrontal cortex (vmPFC) is a key brain structure implicated in mood and a

189 ction in the ventromedial prefrontal cortex (vmPFC) is believed to play a pivotal role in the pathoge

190 The ventromedial prefrontal cortex (vmPFC) is closely associated with the ability to make co

191 amygdala and ventromedial prefrontal cortex (vmPFC) is compromised in multiple psychiatric disorders,

192 The ventromedial prefrontal cortex (vmPFC) is consistently implicated in the cognitive and e

193 TATEMENT The ventromedial prefrontal cortex (vmPFC) is one of the main hubs of the Default Mode Netwo

194 cortex/ventromedial prefrontal cortex (rACC/vmPFC) is the most consistent finding across studies, di

195 sion making, ventromedial prefrontal cortex (vmPFC) is thought to support choices by tracking the exp

196 abnormal connectivity among regions such as vmPFC, lateral orbitofrontal cortex, and parahippocampal

197 Results showed that patients with vmPFC lesion failed to produce a conditioned SCR during

198 paradigm in eight patients with a bilateral vmPFC lesion, 10 with a lesion outside PFC and 10 health

199 Furthermore, we observed that the vmPFC-lesioned patients had decreased volumes of the acc

200 matched neurologically healthy subjects, the vmPFC-lesioned patients had reduced ventral striatal act

201 By contrast, mOFC/vmPFC-lesioned patients made more stochastic choices tha

202 osite approach to moral decision making than vmPFC-lesioned patients.

203 RI in five neurosurgical patients with focal vmPFC lesions to test the hypothesis that the vmPFC is n

204 ation of the ventromedial prefrontal cortex (VmPFC), marked by initial hypoactivity followed by incre

205 fy to what extent the deviations in amygdala-vmPFC maturation contribute to the onset of psychiatric

206 arable data in humans to address whether the vmPFC may be critical for the reward-related response pr

207 Alterations of the vmPFC may be one mechanism that mediates the pathway fro

208 rocessing and latent structure learning, the vmPFC may be required to construct a detailed representa

209 ex (EC), and ventromedial prefrontal cortex (vmPFC)/medial orbitofrontal cortex (mOFC) organize abstr

210 nd animal studies have demonstrated that the vmPFC modulates ventral striatum activity.

211 In contrast, vmPFC/mOFC damage abolished neither scaling nor asymptot

212 us results regarding temporal discounting in vmPFC/mOFC patients and 2) showed in a previously unpubl

213 ly unpublished data set on risky choice that vmPFC/mOFC patients exhibit increased risk-taking relati

214 both behavior and neural activity in EC and vmPFC/mOFC reflected the Euclidean distance to the retri

215 ultivariate activity patterns in HC, EC, and vmPFC/mOFC were linearly related to the Euclidean distan

216 rontal cortex / medial orbitofrontal cortex (vmPFC/mOFC) and nineteen age- and education-matched cont

217 as ventromedial prefrontal cortex in humans; vmPFC/mOFC) is involved in constraining the decision to

218 In contrast, intra-vmPFC muscimol infusions did not alter the overall intak

219 the stress response, and a specific role for VmPFC neuroflexibility in stress-resilient coping.

220 of designer receptors (DREADDs) to activate vmPFC neurons and examine the consequences on cocaine se

221 -DREADD approach to confine the Gq-DREADD to vmPFC neurons that project to the medial nucleus accumbe

222 Activation of vmPFC neurons with the Gq-DREADD reduced reinstatement o

223 ted and isolated modulation of ventral mPFC (vmPFC) neurons that project to the NAcSh.

224 ncluding the ventromedial prefrontal cortex (vmPFC), nucleus accumbens, caudate nucleus, and putamen.

225 uced in Brodmann area 25 (a portion of human vmPFC) of MDD patients and in mouse vmPFC following chro

226 As it has been suggested that the vmPFC operates as a pivotal point that mediates between

227 lOFC (predominantly right hemisphere), mOFC/vmPFC, or dorsomedial prefrontal (DMF), and a comparison

228 noncarriers, contributions of an additional VMPFC pathway best characterized deletion carriers.

229 OFC patients compared with Controls and mOFC/vmPFC patients.

230 organization influences the location of the vmPFC peak of the Default Mode Network, demonstrating th

231 erving as specialized economic value center, vmPFC plays a broad role in integrating relevant environ

232 These results suggest that the vmPFC plays a causal role in the acquisition of new lear

233 We conclude that vmPFC plays a rich role in encoding and integrating mult

234 s, including ventromedial prefrontal cortex (vmPFC), posteromedial cortex (PMC), hippocampus, and amy

235 Additionally, theta power changes in the vmPFC preceded those observed in the hippocampus.

236 value coding ventromedial prefrontal cortex (vmPFC) predicted choice behavior.

237 ue coding in ventromedial prefrontal cortex (vmPFC) predicted individual differences in satiety-relat

238 VGF overexpression in vmPFC prevented behavioral deficits induced by CRS, and

239 The extent to which vmPFC processes safety signals may additionally be predi

240 These results support the idea that vmPFC processes self-relevant information, and suggest t

241 escribed here suggest that the VGat-Cre(CeMA-vmPFC) projection acts to modulate existing reward-relat

242 The ventromedial prefrontal cortex (vmPFC) projection to the nucleus accumbens shell is impo

243 vmPFC, dmPFC, vmPFC projections to NAcS, or vmPFC projections to basolateral amygdala, to punished E

244 functional contribution of the vmPFC, dmPFC, vmPFC projections to NAcS, or vmPFC projections to basol

245 Photosilencing vmPFC projections to the NAcS, but not to the basolatera

246 y of an activating Gq-DREADD to vmPFC and/or vmPFC projections to the nucleus accumbens shell allows

247 inction memory with social support relies on vmPFC rather than hippocampus gene expression and riboso

248 valuation, and how functional connections to vmPFC reflect the current value of outcomes and guide go

249 such as the ventromedial Prefrontal Cortex (vmPFC), reflected the strength of prior preferences.

250 In conclusion, VGF in the vmPFC regulates susceptibility to stress and the antidep

251 torhinal and ventromedial prefrontal cortex (vmPFC) representations perform a much broader role in ge

252 in humans, we demonstrate that damage to the vmPFC results in decreased ventral striatum activity dur

253 e combination of these signals reconstructed VMPFC's valuation function.

254 Our findings reveal an absence of vmPFC safety signaling in OCD, undermining flexible thre

255 ese results promote further investigation of vmPFC safety signaling in other anxiety disorders, with

256 To investigate the importance of vmPFC safety signaling, we used neuroimaging of Pavlovia

257 ion in OCD patients during reversal, whereas vmPFC safety signals were absent throughout learning in

258 g can occur to some extent in the absence of vmPFC safety signals, effective CS- signaling becomes cr

259 with Fos colabeling in vmPFC indicated that vmPFC self-administration ensembles project to NAc core

260 ss, with the ventromedial prefrontal cortex (VMPFC) showing greater modulation by EEV.

261 Specifically, VMPFC signaled the subjective likability of artificial a

262 whereas the ventromedial prefrontal cortex (vmPFC) signaled the level of redress incurred by a choic

263 The vmPFC signals a multiplicity of decision variables, the

264 nce that the ventromedial prefrontal cortex (vmPFC) signals the satisfaction we expect from imminent

265 ally restructuring memory representations in vmPFC.SIGNIFICANCE STATEMENT How new experiences are tra

266 erized developmental changes of the amygdala-vmPFC subregion functional and structural connectivity u

267 Some accounts of ventromedial PFC (vmPFC) suggest that it has a narrow role limited to eval

268 mined the interindividual variability in the vmPFC sulcal morphology in 57 humans (37 females) and de

269 ntations in the brain, located mainly in the vmPFC, temporal and parahippocampal cortices, thalamus,

270 ata revealing distinct subregions within the vmPFC that correspond to each of these three functions,

271 p, across individual object-word memories in vmPFC the next day.

272 xperimental studies that have focused on the vmPFC, the preferred animal model for such research has

273 Acute intra-vmPFC TLQP-62 infusion induced behavioral phenotypes tha

274 iors and emphasized top-down processing from vmPFC to CeMA.

275 and thereby alters general value signals in vmPFC to guide goal-directed behavior.

276 ity and binge-like eating are linked and the vmPFC to NAcSh pathway serves as a 'brake' over both beh

277 Chemogenetic activation of the vmPFC to NAcSh pathway significantly suppressed motor im

278 We show that vmPFC uniquely contributes a sustained activation profil

279 A and terminates in the vmPFC (VGat-Cre(CeMA-vmPFC)) using viral-vector-mediated, cell-type-specific

280 VmPFC value activation was compared between groups.

281 The findings anatomically decompose vmPFC value representations according to computational r

282 VmPFC value responses in participants with a history of

283 gs from this study largely support disrupted vmPFC value signals in suicidal behavior.

284 We investigated vmPFC value signals, vmPFC-frontoparietal connectivity,

285 Disrupted ventromedial prefrontal cortex (vmPFC) value signals may underlie this behavioral phenot

286 originates in the CeMA and terminates in the vmPFC (VGat-Cre(CeMA-vmPFC)) using viral-vector-mediated

287 youth with PTSD demonstrated decreased right vmPFC volumes compared with both maltreated youth withou

288 Finally, connectivity between striatum and vmPFC was associated with increased plasma interleukin (

289 ndle density and representational overlap in vmPFC was mediated by the degree of anterior hippocampal

290 The VMPFC was sensitive to the (1) availability of person-kn

291 extinction procedures, we demonstrated that vmPFC was similarly activated (indexed by Fos) during co

292 OH lever presses and aborts, but only in the vmPFC was there a population-level shift in coding from

293 (dmPFC) and ventromedial prefrontal cortex (vmPFC) was consistently modulated by relative subjective

294 D) signal in ventromedial prefrontal cortex (vmPFC) was parametrically modulated by the affective val

295 e signals in ventromedial prefrontal cortex (vmPFC) were attenuated in older adults.

296 The ventromedial prefrontal cortex (vmPFC), which comprises several distinct cytoarchitecton

297 dominantly determine the organization of the vmPFC, which in turn affects the location of the functio

298 nnectivity in centromedial amygdala-anterior vmPFC white matter was associated with greater anxiety/d

299 ed by distinct neuronal ensembles within the vmPFC with different outputs to the nucleus accumbens (N

300 pocampus and ventromedial prefrontal cortex (vmPFC), with additional evidence that vmPFC activity lea