ライフサイエンスコーパス: voltage sensitivity

1 ce on voltage indicating a lack of intrinsic voltage sensitivity.

2 vely, indicating that Cx36 exhibits very low voltage sensitivity.

3 ge-dependent manner but with relatively weak voltage sensitivity.

4 te that ABA stimulates ICl and modulates its voltage sensitivity.

5 l conductance without significantly changing voltage sensitivity.

6 g time constants yet did not influence their voltage sensitivity.

7 ane potential at a level determined by their voltage sensitivity.

8 ow high conductance channels with asymmetric voltage sensitivity.

9 urrents with a much increased calcium and/or voltage sensitivity.

10 phore, achieving high brightness, speed, and voltage sensitivity.

11 rior, K12, is responsible for most of VDAC's voltage sensitivity.

12 ly) neural recording achieving unprecedented voltage sensitivity.

13 ntaining fluorescence quantum efficiency and voltage sensitivity.

14 d pore, reduced ATP interaction and weakened voltage sensitivity.

15 ganizing synaptic ribbons and setting CaV1.4 voltage sensitivity.

16 ylation of T848 and thereby for the shift in voltage sensitivity.

17 nidentified also contribute to the slow gate voltage sensitivity.

18 n to more depolarized values and reduced its voltage sensitivity.

19 GEVIs for 2P brightness, response speed, and voltage sensitivity.

20 le AT1R expression could decrease BK channel voltage sensitivity.

21 tate, causing a dramatic decrease in channel voltage sensitivity.

22 annels in IHCs primarily by increasing their voltage sensitivity.

23 Surprisingly, Trp substitution unmasks voltage sensitivity.

24 ven though they exhibited a complete loss of voltage sensitivity.

25 restin on its intracellular domain to confer voltage sensitivity.

26 annel isoforms that vary in their Ca(2+) and voltage sensitivities.

27 luorene molecular wire scaffold improves the voltage sensitivity 1.5- to 3.5-fold over fluorene-based

28 iles at greater than 700 nm, show a range of voltage sensitivities (13 to 43% F/F per 100 mV in HEK c

29 brane localization, cellular brightness, and voltage sensitivity (26% F/F per 100 mV), rivaling that

30 on (1P) illumination, RVF5 demonstrates high voltage sensitivity (28% DeltaF/F per 100 mV) and improv

31 amily channels, despite large differences in voltage sensitivity, activation rates, and activation th

32 a reduction in turnover number and a loss of voltage sensitivity, although there were no alterations

33 gating phenotype, a hyperpolarizing shift in voltage sensitivities and faster gating kinetics.

34 ubunit, which imprints unique kinetics, Ca2+/voltage sensitivities and pharmacology to the channel.

35 tinct effects on Kv channels: an increase in voltage sensitivity and a concomitant decrease in curren

36 Tubulin strikingly increases VDAC voltage sensitivity and at physiological salt conditions

37 r that interacts with a region that controls voltage sensitivity and enhances action potential firing

38 sfer as a voltage-sensing trigger offer high voltage sensitivity and fast-response kinetics, but targ

39 ith the exception of markedly reduced Ca(2+)/voltage sensitivity and faster activation kinetics.

40 P2Y receptors are capable of modulating the voltage sensitivity and inactivation gating of an endoge

41 e two voltage-sensing domains (VSD2) encodes voltage sensitivity and inhibition by luminal Ca(2+) and

42 tassium-selective channels but with variable voltage sensitivity and pH regulation.

43 ion patterns responsible for ligand-specific voltage sensitivity and present new insights into their

44 annel activity is correlated with diminished voltage sensitivity and slowed activation kinetics of th

45 The voltage sensitivity and strong dependence of the flecain

46 The steep voltage-sensitivity and rapid recovery of K(V)4 channels

47 lization, negligible cytotoxicity, promising voltage sensitivities, and photostabilities that are 4 t

48 xpression near 70% without affecting channel voltage sensitivity, and deletion of 1007YNMLCFGIY1015 m

49 the fluorescence brightness, photostability, voltage sensitivity, and kinetics of wildtype heliorhodo

50 essing cell-surface SpyCatcher, display good voltage sensitivity, and maintain fast-response kinetics

51 current amplitude, hyperpolarizing shift in voltage sensitivity, and slowing of deactivation in resp

52 Voltage sensitivity apparently depends in part on the ab

53 ed with native calmodulin, and the decreased voltage sensitivity are only observed when the mutant is

54 We hypothesize that the mechanism of voltage sensitivity arises from acceptor PeT (a-PeT) fro

55 This gave values for the voltage sensitivity at the cell's resting potential, the

56 e strongly dependent on axonal ion channels' voltage sensitivity, but not their number or exact locat

57 urrent was due to an increase in the channel voltage sensitivity by approximately 20 mV and was rever

58 in which the N-terminus determines the KAT1 voltage sensitivity by contributing to the electric fiel

59 , and supports mechanistic interpretation of voltage sensitivity by fractional amino acid contributio

60 d emission, mono-exponential decay, and high voltage sensitivity enable fast FLIM recording of APs in

61 h systematic chemical substitution modulates voltage sensitivity, estimate (DeltaGPeT + w) values fro

62 f 14 pS, flickery kinetics and showed little voltage sensitivity except at extreme positive potential

63 Surprisingly, the voltage sensitivity, expressed as a slope of the logarit

64 those of rat Ca(V)1.2 but with left-shifted voltage sensitivity for activation and inactivation.

65 Voltage-gated ion channels derive their voltage sensitivity from the movement of specific charge

66 We discuss their mechanisms of voltage sensitivity, from reorientation, electrochromic,

67 emission profiles of >560 nm, displays high voltage sensitivity (>30% Delta F/ F per 100 mV), and ca

68 Two additional BODIPY VFs show good voltage sensitivity (>=24% DeltaF/F) and excellent brigh

69 QuasAr2, which show improved brightness and voltage sensitivity, have microsecond response times and

70 measured redox potentials, and validate the voltage sensitivities in patch-clamped HEK cells for 10

71 of designer channels, which accounts for low-voltage sensitivity in all known temperature-gated ion c

72 d reduces both CaV1.2 channel expression and voltage sensitivity in arterial myocytes.

73 ng cells, high photostability, and excellent voltage sensitivity in neurons.

74 Voltage sensitivity in PHA-1 mutants stems from the disr

75 reen (ICG), which has FDA approval, exhibits voltage sensitivity in various tissues, thus raising hop

76 Voltage sensitivity is conferred by charged residues loc

77 The voltage sensitivity is conferred through four voltage-se

78 Prestin's voltage sensitivity is influenced by intracellular chlor

79 Voltage sensitivity is not influenced by divalent cation

80 s affect channel function, including loss of voltage sensitivity, loss of ion selectivity, and reduce

81 into these components revealed two different voltage-sensitivity mechanisms for ICG.

82 s that may gate their opening state, such as voltage-sensitivity, modulation by second messengers and

83 ix, but neither motion produced the observed voltage sensitivity, nor did either model result in a ca

84 that the previously reported negative-going voltage sensitivities of both GEVIs came from photocycle

85 The voltage sensitivities of both GEVIs were nonlinear funct

86 ve detection of local electric fields with a voltage sensitivity of a few microvolts, a spatial resol

87 electrode damage or perhaps the asymmetrical voltage sensitivity of a heterotypic gap junction.

88 the re-entrant loop in coupling calcium and voltage sensitivity of ANO1 and hence in regulating ANO1

89 ith the reciprocal relationship based on the voltage sensitivity of approximately 20 nm/mV for 50-mic

90 When the voltage sensitivity of axonal currents was increased we

91 However, the voltage sensitivity of bipolar channels correlates with

92 l potential but no change in the kinetics or voltage sensitivity of channel activation.

93 Surprisingly, the voltage sensitivity of closing kinetics changed with cal

94 depolarization, a value consistent with the voltage sensitivity of DHPR-mediated VICaR in skeletal m

95 Notably, the anion selectivity and voltage sensitivity of dVGACs can be tuned through targe

96 bal SR Ca(2+) release over the full range of voltage sensitivity of EC coupling.

97 utamate uptake by EAAT2, we predict that the voltage sensitivity of exchange is caused by the voltage

98 The macroscopic voltage sensitivity of homotypic Cx46 conformed to the t

99 The voltage sensitivity of hSlo was right-shifted by approxi

100 ysical association, 8-bromo-cAMP shifted the voltage sensitivity of I(h) less than that of HCN4 chann

101 suggests that elevation of I(Kr) by reducing voltage sensitivity of inactivation, not via slowing of

102 The voltage sensitivity of inhibitors was also examined.

103 brane hyperpolarization, thus increasing the voltage sensitivity of internal alkalization.

104 The implication is that the voltage sensitivity of K(+) channels is not solely encod

105 BDM (5 mM) shifted the range of voltage sensitivity of membrane capacitance and cell len

106 However, the voltage sensitivity of most FRET-opsin GEVIs has been re

107 most recent concepts regarding the intrinsic voltage sensitivity of muscarinic receptors and the cons

108 tiated by a specific interaction between the voltage sensitivity of NMDA receptors and voltage-gated

109 acteristics, including inward rectification, voltage sensitivity of open probability, sensitivity of

110 stitution at this locus reduced the apparent voltage sensitivity of open- and closed-state fast inact

111 rast, we find that CPZ and TNP influence the voltage sensitivity of prestin via membrane bending, dem

112 to a positive charge (R399), can promote the voltage sensitivity of prestin.

113 as auxiliary gamma subunits that elevate the voltage sensitivity of recombinant and prostate adenocar

114 The high photostability and voltage sensitivity of RVF5 is recapitulated under 2P il

115 ression with the beta4 subunit increased the voltage sensitivity of the alpha2, alpha3 and slow alpha

116 The lack of voltage sensitivity of the blocking protein suggests tha

117 unclear whether this is due to an increased voltage sensitivity of the Cav1.3 voltage-sensing domain

118 of these different loop substitutions on the voltage sensitivity of the channel and compared these ex

119 The voltage sensitivity of the channels was also reduced dur

120 low as 50 microM, and both the amplitude and voltage sensitivity of the current depended upon Zn2+ co

121 The lack of voltage sensitivity of the discharge of membrane noise i

122 han a factor of four better than the nominal voltage sensitivity of the dyes under "one-photon" fluor

123 ervals, suggest mefenamic acid decreases the voltage sensitivity of the I (Ks) channel and shifts cha

124 Comparison of the kinetic properties and the voltage sensitivity of the isolated components of evoked

125 C-terminal deletions altered the voltage sensitivity of the KAT1 channel with greater del

126 adaic acid (1 microM, 30-60 min) shifted the voltage sensitivity of the membrane capacitance in the h

127 The second pathway shifts the voltage sensitivity of the OHC electromotile mechanism a

128 observation that sugar transport alters the voltage sensitivity of the OHC motor mechanism.

129 r, the deletions paradoxically increased the voltage sensitivity of the R176S mutant channel, but not

130 ior of KACh channels is due to the intrinsic voltage sensitivity of the receptor that activates KACh

131 at they resembled those of Cx46, reduced the voltage sensitivity of the steady-state junctional condu

132 iophysical mechanism responsible for the SHG voltage sensitivity of the styryl dye FM 4-64 in pyramid

133 ulation of inner segment conductances or the voltage sensitivity of the synaptic Ca(2+) current, sugg

134 We find that voltage sensitivity of the tubulin-VDAC blockage practic

135 The voltage sensitivity of these channels arises from the mo

136 eptor R295(7.40), which showed alteration of voltage sensitivity of TP receptor upon mutation.

137 is condition of -45 +/- 5 mV at 60 mmHg, the voltage sensitivity of wall [Ca2+] and diameter were 7.5

138 Like ABA, OA and CA shifted the voltage-sensitivities of the Ca2+ current and [Ca2+]i in

139 s in its single channel conductance, lack of voltage-sensitivity of activation, inward rectification,

140 indicated that in L529I, NS1643 reduces the voltage-sensitivity of S4 movement.

141 cells, promoting Ca2+ entry by shifting the voltage-sensitivity of the channels.

142 he PIP2-dependent gating, in addition to the voltage sensitivity, of KCNQ1.

143 We find a dependence of voltage sensitivity on excitation wavelength that is con

144 ce, and there is a significant dependence of voltage sensitivity on the structure of the nonchromopho

145 otential, we further analyzed the effects of voltage sensitivity on this receptor.

146 ctivity as well as inactivation kinetics and voltage sensitivity, only little is known about intrapro

147 is common to most K2P channels and that this voltage sensitivity originates from the movement of thre

148 r, the mechanism to explain this increase in voltage sensitivity remains unknown.

149 bunit modification of Kv1.5 inactivation and voltage sensitivity require phosphorylation by protein k

150 as a sodium "background" current with little voltage sensitivity, revealed by NMDG replacement for so

151 contain high threshold Kv2.1 channels whose voltage sensitivity shifts upon declustering; nor are th

152 stituted voltage indicators exhibit improved voltage sensitivity should be broadly applicable to othe

153 The unique combination of weak voltage sensitivity, small unitary conductance, and perm

154 evertheless conserve both the charge and its voltage sensitivity suggest a primary action upon the Ry

155 reduced channel activity and alterations in voltage sensitivity that are best explained by a physica

156 bit a unique, agonist-dependent mechanism of voltage-sensitivity that modulates downstream receptor s

157 re, we demonstrate the possibility to confer voltage sensitivity to cytosolic enzymes.

158 he rhodamine aryl ring, exhibits the highest voltage sensitivity to date for red-shifted PeT-based vo

159 A number of studies link voltage sensitivity to interactions of S4 charges with m

160 ur transmembrane segments (S1-S4) and confer voltage sensitivity to many ion channels.

161 ecialized transmembrane segments that confer voltage sensitivity to many proteins such as ion channel

162 e membrane-bound protein modules that confer voltage sensitivity to membrane proteins.

163 raversing the channel from the inside confer voltage sensitivity to the Hui1 off-rate via Arg23, indi

164 channels (VGKC), voltage sensors (VSD) endow voltage-sensitivity to pore domains (PDs) through a not

165 RhoVR-Halo dyes maintain high voltage sensitivities-up to 34% DeltaF/F per 100 mV-and

166 The voltage sensitivity was DeltaF/F = 40 +/- 1.7% per 100 m

167 Voltage sensitivity was not limited to TP receptor becau

168 oop linking the S3 helix and the S4 helix in voltage sensitivity, we have constructed a set of mutant

169 cal to the 130 pS channel in conductance and voltage sensitivity were activated in the absence of opi

170 e mice, the Ca(V)1.1 channel conductance and voltage sensitivity were increased by splice-shifting ol

171 s the voltage of half-maximum activation and voltage sensitivity, were altered, indicating that Cav1.

172 t alter Ca(2+) sparks but reduced BK channel voltage sensitivity, which decreased channel apparent Ca

173 y, though, such substitution also results in voltage sensitivity with greater activity at hyperpolari

174 BK displays shallow voltage sensitivity with very fast gating charge kinetic

175 The channel displays an unusual voltage sensitivity, with an abrupt increase in open-sta