ライフサイエンスコーパス: vulnerability

1 also reinforcing the notion of selective DG vulnerability).

2 and led to increased inequality and climate vulnerability.

3 ivity, stability, cytopathicity and antibody vulnerability.

4 microhabitats can contribute to reduce their vulnerability.

5 could provide novel insights into selective vulnerability.

6 se velocities as novel biomarkers for plaque vulnerability.

7 n can also play a significant role in forest vulnerability.

8 ncer (PCa) and a promising novel therapeutic vulnerability.

9 , and Kenya) have variable capacity and high vulnerability.

10 traumatic stress disorder drives cocaine use vulnerability.

11 uently reducing tau-mediated neuronal stress vulnerability.

12 est rubber suitability and lowest extinction vulnerability.

13 nd stress responsivity relevant to addiction vulnerability.

14 ts with CHD, identifying areas of particular vulnerability.

15 as a putative mechanism for promoting stress vulnerability.

16 ding of how barriers to dispersal may impact vulnerability.

17 posures and common features may mediate this vulnerability.

18 stress, providing insight into mechanisms of vulnerability.

19 overlapping atmospheric pollution and social vulnerability.

20 sponding to the ages of differential disease vulnerability.

21 l approaches that underlie individual tumour vulnerabilities.

22 able genetic interactions by targeting tumor vulnerabilities.

23 fficking, potentially resulting in selective vulnerabilities.

24 ure and this can be enhanced by communities' vulnerabilities.

25 efficiently, including to many with medical vulnerabilities.

26 veral cancers, but may also expose druggable vulnerabilities.

27 developing therapies that exploit metabolic vulnerabilities.

28 rant cancer cells could expose new treatment vulnerabilities.

29 bber bioclimatic suitability with extinction vulnerability [4] in Africa, Asia, and New Guinea, where

30 We determined frogs' current vulnerability across habitats, elevations and microhabit

31 We explore multiple drivers of heterogeneous vulnerability across the distributions of 96 vegetation

32 questions about factors potentially shaping vulnerability across the region: (a) How does sensitivit

33 TNBC exploits lipid anabolism as a metabolic vulnerability against CSCs in primary tumors.

34 Weather shocks may exacerbate vulnerabilities among women in sub-Saharan Africa.

35 QMAP-Seq reveals clinically actionable drug vulnerabilities and functional relationships involving t

36 of intermediary metabolism as well metabolic vulnerabilities and plasticity.

37 ) pandemic exposes unexpected cardiovascular vulnerabilities and the need to improve cardiometabolic

38 and immune metabolism can uncover metabolic vulnerabilities and therapeutic windows upon which to in

39 more, interactions tend to have more similar vulnerability and contribution to feasibility across net

40 idence links disrupted circadian genes to SU vulnerability and drug-induced alterations to these gene

41 Cities with high levels of heat vulnerability and exposure must be prioritized for adapt

42 rks than expected by chance, suggesting that vulnerability and feasibility contribution may be intrin

43 Then, the coincidence of socio-economic vulnerability and flash flood hazard were investigated t

44 ample, substance use) that may alter disease vulnerability and illness course and neurobiological ass

45 t-herbivore networks showed higher values of vulnerability and lower modularity with fertiliser addit

46 undance was the highest for leaf miners, the vulnerability and modularity of flower-visitor networks

47 pulation distribution, income, exposure, and vulnerability and of CO(2) emissions and temperature inc

48 may contribute to individual differences in vulnerability and resilience following emotional disturb

49 ta suggest disparate mechanisms of cognitive vulnerability and resilience in depressed youth, which m

50 d causal determinants of cell type-selective vulnerability and to identify therapeutic targets.

51 the mechanisms of GIN in MM, the associated vulnerabilities, and therapeutic targeting strategies.

52 ries to share survey data, to assess species vulnerabilities, and to support management adaptation in

53 aps regarding indoor heat-health thresholds, vulnerability, and adaptive capacity persist.

54 Altered metabolism is a cancer vulnerability, and several metabolic pathways have been

55 the genetic substrates that underlie disease vulnerability, and the interaction of genes, early-life

56 ors of neuroticism-anxiety/tension and worry/vulnerability-and how they contrast with that of general

57 of anxiety/tension, and high levels of worry/vulnerability are associated with genetic variants linke

58 Among the factors that confer heightened vulnerability are the substantial energy requirements, a

59 r (Juniperus californica), examining drought vulnerability as a function of climate, lithology and hy

60 assess how conservation goals were defined, vulnerability assessments performed and adaptation strat

61 n pressure is essential for accurate species vulnerability assessments under climate change, as prior

62 d the polygenic architecture underlying DILI vulnerability at the level of hepatocytes, thus facilita

63 re and plaque composition as signs of plaque vulnerability, but few studies have analyzed hemodynamic

64 Nerve terminals are a locus of this vulnerability, but how they regulate ATP synthesis as fu

65 C starvation may lead to increased mortality vulnerability, but hydraulic failure or biotic attack ma

66 m-directed antibody responses to the site of vulnerability by glycan repositioning may be a step towa

67 tive border policy can increase exposure and vulnerability, by trapping people in areas where they ar

68 We additionally found that chemical vulnerabilities changed as cancer cells expanded ex vivo

69 nce use disorder experience enhanced relapse vulnerability compared with males, particularly during s

70 We propose that redox vulnerabilities could be exploited for therapeutic benef

71 und publicly available hazard, exposure, and vulnerability data.

72 aken together, our findings define metabolic vulnerabilities due to EAE and provide evidence that beh

73 risks onto behaviors related to psychiatric vulnerability (e.g., marijuana, alcohol, and caffeine mi

74 r researchers feel discouraged from exposing vulnerability even during a global crisis.

75 As part of NASA's Arctic-Boreal Vulnerability Experiment, we sampled 79 stands (47 burne

76 Our maps highlight an additional vulnerability faced by poorer individuals in remote area

77 ial dysfunction was highlighted as a crucial vulnerability factor for the development of depression.

78 pring DHCR7 heterozygosity might represent a vulnerability factor to medications that interfere with

79 risk factors, pathophysiological mechanisms, vulnerability factors for specific types of behaviour an

80 stratification on individual- and area-level vulnerability factors.

81 rations leading to CRPC may reveal potential vulnerabilities for cancer therapy.

82 2 scenarios (#59 and 60) displayed increased vulnerability for CR-POPF relative to the moderate-risk

83 ndscape resistance influences climate change vulnerability for many species is needed, as is an under

84 n synapses, leading to an extended window of vulnerability for memory disruption.

85 effects of childhood maltreatment on disease vulnerability for mood disorders, specifically summarizi

86 in cancer cells, representing an exploitable vulnerability for the development of effective therapeut

87 Key indicators of vulnerability for the syndemic of opioid overdose, human

88 thway, and uncover an accompanying metabolic vulnerability for therapeutic targeting in SLC7A11(high)

89 M1 and EGFR/ERBB2 pathways are key points of vulnerability for therapy to disrupt peritoneal spread a

90 plexities of sexuality and gender affect HIV vulnerability for this group, including not identifying

91 While sex differences in vulnerability have been identified with a clear need for

92 limate change(3,4), yet their importance and vulnerability have not been quantified at the global sca

93 Cancer cell metabolism is a targetable vulnerability; however, a precise understanding of metab

94 This crisis exposed vulnerabilities in graduate medical education (GME).

95 To identify potential vulnerabilities in KRAS-mutated CRC, we characterize the

96 development and oncogenesis may identify new vulnerabilities in malignancies that currently lack effe

97 To identify targetable vulnerabilities in MBC, we examined steroid hormone rece

98 Further vulnerabilities in supply chains have been revealed by e

99 ter the cell state, unwittingly exposing new vulnerabilities in the infected cell.

100 Here we examine adversarial vulnerabilities in the processes responsible for learnin

101 breast cancer model, highlighting metabolic vulnerabilities in these pathways as promising targets f

102 hybrid imaging to define regions of amyloid vulnerability in 5xFAD mice.

103 (DLBCL) and identify a potential therapeutic vulnerability in a subtype of the disease.

104 ravel the mechanisms underlying sex-specific vulnerability in ALS-FTD.

105 s were MU type dependent, thus reflecting MU vulnerability in ALS.

106 en and identify WEE1 kinase as a therapeutic vulnerability in cells depleted of the ATRX chromatin re

107 ks indicates that they represent a tractable vulnerability in homologous recombination-deficient tumo

108 Selective neuronal vulnerability in neurodegenerative disease is poorly und

109 rcuits, making them a potential key point of vulnerability in neurodevelopmental disorders.

110 all significant indicators of opioid-related vulnerability in our analysis are structural and potenti

111 The strong signal of genomic vulnerability in P. densata may be representative for ot

112 e context of enhanced monitoring of outbreak vulnerability in Scott County and similar rural contexts

113 ure to circadian misalignment underpins mood vulnerability in simulated shift work.

114 attention impairment can be dissociated from vulnerability in terms of other cognitive processes such

115 owever, this phenotype is multi-dimensional; vulnerability in terms of vigilant attention impairment

116 These findings point toward a predisposing vulnerability in the causation of addiction, related to

117 Here, we assess flood vulnerability in the US using >2 million claims from the

118 evolution and to target the APOBEC3A-induced vulnerability in therapy.

119 nxiety-like behavior and identify markers of vulnerability in this neural signal, with elevated prest

120 ggest that ODC may be a targetable metabolic vulnerability in TNBC.

121 Tau vulnerability in women is not just limited to the medial

122 Medicare database, which was merged with CDC vulnerability index (SVI) dataset at the beneficiary lev

123 A socio-economic vulnerability index is developed at the county level acr

124 vulnerability, using the Infectious Disease Vulnerability Index.

125 PCA-derived HVIs address correlation among vulnerability indicators, although the resulting output

126 Heat vulnerability indices (HVIs), commonly developed using p

127 Emerging evidence suggests that disease vulnerability is expressed throughout the airways, the s

128 One potential vulnerability is the endosymbiotic bacteria Wolbachia-pr

129 cancers, however, the basis of this sporadic vulnerability is unknown.

130 e neuroticism was characterized by worry and vulnerability lived longer lives.

131 en employing this methodology for fine-scale vulnerability mapping.

132 The previous reports on an addiction vulnerability marker in the human SLC4A7 gene encoding t

133 anding of information processing deficits as vulnerability markers for emerging psychosis and as indi

134 reclinical models demonstrating sex-specific vulnerability may help to understand female resistance t

135 fferences that account for this differential vulnerability may provide a key for developing new treat

136 Investigations of this shared vulnerability may provide insight into the genetic mecha

137 ssue scales to expose fundamental arrhythmia vulnerability mechanisms and complex interactions underl

138 The resulting "vulnerability network" is shown to mediate the influence

139 This vulnerability occurs despite their responsiveness to mos

140 to design therapeutic strategies exploiting vulnerabilities of cancer cells rooted in their ability

141 is, and characterize intrinsic and extrinsic vulnerabilities of cancer cells that can be therapeutica

142 antial prognostic power and suggest specific vulnerabilities of different cancers that might have the

143 the mechanisms that determine the metabolic vulnerabilities of each cancer.

144 dependencies on NRF2 and reveal exploitable vulnerabilities of NRF2-hyperactivated tumors.

145 certain nutrients that target the metabolic vulnerabilities of the tumour, or enhance the cytotoxici

146 d therapeutic exploitation of the amino acid vulnerabilities of tumourigenesis in the context of a pe

147 The vulnerability of a particular location to pollution from

148 ches to investigate the potential mechanical vulnerability of axons that span the gray-white tissue i

149 tifying the factors driving the exposure and vulnerability of biodiversity to land use change, and th

150 iomarker studies addressing the differential vulnerability of brain areas to tau pathology, its cell-

151 id changes, which raises questions about the vulnerability of contemporary forests to future climate

152 AT2 loss being a therapeutically exploitable vulnerability of CRC tumors.

153 In future studies, the similar chemical vulnerability of DNA between the somatic and germline se

154 al signaling was identified as a therapeutic vulnerability of ER(+)SEMA7A(+) tumors.

155 istribution and storage enhance the inherent vulnerability of FMP to fraud and stability.

156 atic stressors of trees, contributing to the vulnerability of forest landscapes to climate-induced pr

157 , suggesting this configuration may increase vulnerability of genes in sperm to disrupted methylation

158 ld be given consideration when assessing the vulnerability of groundwater aquifers to climate change.

159 ave repeatedly underscored, for example, the vulnerability of groups such as pregnant women and taugh

160 These results expose the vulnerability of heme metabolism to genetic perturbation

161 prevent viral escape by exposing a universal vulnerability of HIV-1: the requirement to bind CD4 on a

162 colonial legacies, which have heightened the vulnerability of human and other biotic communities.

163 Our findings suggest differential vulnerability of inhibitory neurons to LFPI in the diffe

164 rwise obstructs predator access, enhance the vulnerability of macrobenthic invertebrates to predation

165 odalities is not justified and increases the vulnerability of patients.

166 tion within important supply regions and the vulnerability of peripheral regions believed to have bee

167 dict wildlife reservoirs of zoonoses and the vulnerability of populations to disease-induced extincti

168 basis for ven/aza resistance and a metabolic vulnerability of R/R LSCs.

169 w treatments to exploit the eco-evolutionary vulnerability of small and/or declining populations.

170 an larger species, likely reflecting greater vulnerability of smaller species.

171 ution in tropical regions may result in high vulnerability of species in these regions to climate cha

172 oth 2D- and 3D-culture systems, uncovering a vulnerability of spheroid cancer cells deprived of extra

173 ificant and progressive glial activation and vulnerability of spinal interneurons.

174 vivo, this translated into a tissue-specific vulnerability of the bone marrow that caused depletion o

175 activity by the 5-HT system and unravels the vulnerability of the CeA 5-HT system to chronic alcohol

176 ng, pose a challenge to BIR and increase the vulnerability of the D-loop to dissociation by helicases

177 neurodegeneration in female mice, to examine vulnerability of the diseased brain to acute stressors,

178 The second mechanism centers on the vulnerability of the male germline to oxidative stress a

179 hat the proposed mechanism predicts a higher vulnerability of the metabolic layer to perturbations ap

180 ossible molecular correlates of the specific vulnerability of the VLS, we analyzed the expression of

181 y gene ontology categories, underscoring the vulnerability of these corticocortical projection neuron

182 =10%) proportion of RBF, indicating a higher vulnerability of those communities to wildfire.

183 ong species, broad generalizations about the vulnerability of tropical ectotherms should be made more

184 d the loss of crop diversity suggest greater vulnerability of US food systems to environmental and ec

185 umors, identifying FTO as an HIF-independent vulnerability of VHL-deficient cancers.

186 Here, we report an age-dependent vulnerability of wild-type (WT) mice of either sex towar

187 ort-term resiliency (and potential long-term vulnerability) of barrier islands to external stresses.

188 The studies reveal diverse sites of vulnerability on RBP recognized by potent human mAbs tha

189 This work defines sites of vulnerability on SARS-CoV-2 S and demonstrates the speed

190 eveloping addiction, whether due to familial vulnerability or drug use, was associated with significa

191 n about how this pathway might encode future vulnerability or specific behavioral phenotypes.

192 traded greater productivity for higher crop vulnerability outside specialized cultivation conditions

193 tterns according to three widely implemented vulnerability paradigms-niche novelty (decline in modele

194 changes that produce potential mental health vulnerabilities, particularly (but not exclusively) in a

195 To discover epidermal vulnerabilities, patient-derived pluripotent stem cells

196 (c) How different are these vulnerability patterns according to three widely impleme

197 nd supervised HVIs yielded differing spatial vulnerability patterns, depending on selected land cover

198 ontribute to heterogeneity in climate change vulnerability, predicting these features at macroecologi

199 digms diverge widely in their climate change vulnerability predictions.

200 For each water tower, we assess its vulnerability related to water stress, governance, hydro

201 Ds), yet the mechanisms responsible for this vulnerability remain largely unknown.

202 vironmental influences interact with genetic vulnerability remains obscure.

203 A fundamental gap in climate change vulnerability research is an understanding of the relati

204 ith the development of stress resilience and vulnerability, respectively.

205 a clinically recognizable state of increased vulnerability resulting from aging-associated decline in

206 levels contribute to selective brain region vulnerability (SBRV) in ADHD.

207 ts reveal a diverse mosaic of climate change vulnerability signatures across the region's plant commu

208 could serve as a novel target for addiction vulnerability.SIGNIFICANCE STATEMENT Cocaine produces we

209 IN drives disease evolution, it also creates vulnerabilities such as dependencies on 'superfluous' re

210 ered novel malignant-cell-specific metabolic vulnerabilities targetable by small molecule compounds.

211 The high temporal resolution of the optical vulnerability technique revealed that in current year br

212 entifies flooding extents and infrastructure vulnerabilities that are likely to result from alternate

213 To identify vulnerabilities that arise when Und-P metabolism is defe

214 e opportunity to uncover potential molecular vulnerabilities that can be exploited therapeutically.

215 ns and offer insights into additional cancer vulnerabilities that can be investigated for potential t

216 t copper bioavailability is a KRAS-selective vulnerability that could be exploited for the treatment

217 etabolism, uncovering a targetable metabolic vulnerability that largely depends on dietary fat restri

218 mmon principles of resistance and persistent vulnerabilities to overcome resistance.

219 leterious to brain health, and it results in vulnerability to a range of brain disorders, including m

220 disorder (GD) could reflect transdiagnostic vulnerability to addiction or neuroadaptive consequences

221 ance, overall life expectancy, and increases vulnerability to Alzheimer's disease-related dementias.

222 A rodent model of resilience and vulnerability to AN would be valuable to research.

223 ring sinus rhythm and may explain the higher vulnerability to atrial fibrillation of obese patients.

224 we quantified among-individual variation in vulnerability to cause-specific mortality resulting from

225 on of the immune environment and ultimately, vulnerability to CBT.

226 tokines, elevated phagocytosis and increased vulnerability to cellular stress.

227 niles of small-bodied species showing higher vulnerability to changes in coral morphology.

228 tion to historical conditions could increase vulnerability to climate change, even for geographically

229 latory behaviours for understanding species' vulnerability to climate change.

230 nt degrees of aridity, land degradation, and vulnerability to climate change.

231 ough which to interpret these differences in vulnerability to climatic drought and climate change.

232 that were associated with greatly increased vulnerability to clonal haematopoiesis with specific acq

233 and North American countries increase their vulnerability to COVID-related deaths in general.

234 ect of protein restriction, as well as their vulnerability to deleterious diet effects at different l

235 on or deletion of p11 in these cells induced vulnerability to depressive behavior, whereas upregulati

236 recently related to hierarchical status and vulnerability to develop depression-like behavior.

237 e suggests that hierarchical status provides vulnerability to develop stress-induced depression.

238 particularly when individuals vary in their vulnerability to different causes of mortality due to tr

239 ding habitat loss, climate change, increased vulnerability to disease and parasites, and pesticide us

240 ogeneity of patients that might modify their vulnerability to disease.

241 t system as a source of sexual dimorphism in vulnerability to diverse illnesses.

242 Forest vulnerability to drought is expected to increase under a

243 between genetic predisposition and increased vulnerability to early environmental insults.

244 of mTORC1 rescues the lysosomal defects and vulnerability to energetic stress and prolongs the survi

245 The elevated ROS levels suggest a vulnerability to excess prooxidant loads leading to sele

246 a comprehensive assessment of socio-economic vulnerability to flash floods and investigates the main

247 uripotent stem cells (iPSCs), to study their vulnerability to flow shear stress.

248 ing these markers may represent pre-existing vulnerability to GD.

249 out how this dynamism may influence species' vulnerability to global environmental change.

250 in their habitats is crucial to determining vulnerability to global warming.

251 that KMT2D deficiency confers a therapeutic vulnerability to glycolytic inhibitors.

252 Results show an increase in shoreline vulnerability to hardening with SLR governed by backshor

253 Expanding the concept of vulnerability to HIV outbreaks and other lessons learned

254 critical to informing future models of coral vulnerability to inevitable global change, particularly

255 Vulnerability to infection was not associated with basel

256 ty underlies its computational abilities and vulnerability to injury and disease.

257 ly half of the heart still allows for marked vulnerability to injury.

258 Chronic stress exposure increases vulnerability to mental illness, so the ECSS has attract

259 epitope exposure as a mechanism of enhanced vulnerability to neutralization.

260 vating the same IHC differ in their relative vulnerability to noise.

261 pwelling exhibited significant mortality and vulnerability to OA.

262 ties, mechanosensory channel expression, and vulnerability to ototoxin in a high-content phenotypic s

263 PFL is a glycyl-radical enzyme whose vulnerability to oxygen is already understood.

264 duces immunosuppression which could increase vulnerability to pathogens.

265 responsible in part for the mammalian ear's vulnerability to permanent balance and hearing deficits.

266 of I(K1) during terminal repolarization and vulnerability to phase 3 early afterdepolarizations.

267 RIM37 is an essential determinant of mitotic vulnerability to PLK4 inhibition.

268 Adolescence is a period of increased vulnerability to psychiatric disorders, including depres

269 tical and transdiagnostic concept to explain vulnerability to psychopathology and its treatment.

270 pecific developmental mechanisms that impart vulnerability to psychosis and the possibility of interv

271 ritical role for dMSNs and iMSNs in encoding vulnerability to reinstatement of heroin-seeking and pro

272 SLE and Sjogren's syndrome and men's greater vulnerability to schizophrenia.

273 ed the effects of adolescent-stress on adult vulnerability to severe stress using the single-prolonge

274 re are large inter-individual differences in vulnerability to sleep loss, and these inter-individual

275 ) to ventral tegmental area (VTA) influences vulnerability to social stress.

276 The role of BDNF in vulnerability to stress and stress-related disorders, su

277 ergic system contributes to the differential vulnerability to stress displayed by susceptible and res

278 ltered set points may relate to differential vulnerability to stress exposure later in life.

279 dy mechanisms associated with resilience and vulnerability to stress in BLA.SIGNIFICANCE STATEMENT Wi

280 We identified intrinsic cellular vulnerability to stress in PS1 mutants associated simult

281 This molecular signature of vulnerability to stress-induced anhedonia and the active

282 the commensal gut microbiome and reduce host vulnerability to stress-induced disruptions in complex b

283 tes sensitivity to stress and, by extension, vulnerability to stress-inducible illnesses.

284 However, stress induces vulnerability to such disorders only in a sub-population

285 lucidate common neural mechanisms conferring vulnerability to such symptoms in the general population

286 e, we investigated whether this differential vulnerability to tau deposition may predict different co

287 istics of tau filaments, along with regional vulnerability to tau pathology, account for the distinct

288 d emotional regulation in humans, increasing vulnerability to the development of psychopathologies.

289 c characteristics of the societies and their vulnerability to these extreme events.

290 lcholine receptor (nAChR) subunit, increases vulnerability to tobacco dependence and smoking-related

291 Stress in adolescence can regulate vulnerability to traumatic stress in adulthood through r

292 to project tree growth and forest ecosystem vulnerability under future climate conditions.

293 ons Monitoring and Evaluation Framework; and vulnerability, using the Infectious Disease Vulnerabilit

294 We ask how species' vulnerability varies across habitats and elevations, and

295 ts accounting for phylogeny and then ask how vulnerability varies under four warming scenarios: +1.5,

296 present, as well as the increased permafrost vulnerability when sea ice is absent, can be explained b

297 The results show the scale of vulnerability when we have dependent tuples in the datas

298 rentiated according to each adolescent's HIV vulnerability, which was reassessed every 3 months.

299 a greater understanding of social-ecological vulnerabilities within hazard and exposure areas.

300 ace processes explained variation in drought vulnerability within and across species at both scales.