ライフサイエンスコーパス: w(as|ere) discovered

1 ich was retracted after an inadvertent error was discovered.

2 es, employing picolinamide 16 as the ligand, was discovered.

3 ator, poly(ADP-ribose) polymerase 1 (PARP1), was discovered.

4 in lengths of ethylene-bridged BODIPY motifs was discovered.

5 scientists for more than a century since it was discovered.

6 drogen-bonding network between Man3 and CV-N was discovered.

7 notriazolopyrimidinone-based PDE1 inhibitors was discovered.

8 to target rapid evolution to specific genes was discovered.

9 related to the early detection of mycotoxins was discovered.

10 of aldehydes requiring neither metals nor O2 was discovered.

11 tion an overexpression of phosphatidic acids was discovered.

12 volved in adipocyte triglyceride homeostasis was discovered.

13 an archetype-like noncoding cont rol region was discovered.

14 olines or 2-aryl-3-trifluoroacetylquinolines was discovered.

15 h evolidine, the first plant cyclic peptide, was discovered.

16 elated VRE (Enterococcus faecium) infections was discovered.

17 ecies formed in solution during the reaction was discovered.

18 le for DCs in suppressing myeloproliferation was discovered.

19 agonists or as inverse agonists/antagonists were discovered.

20 ng the human melanocortin-4 receptor (hMC4R) were discovered.

21 AR of this new core, two promising analogues were discovered.

22 r, 2 unexpected functions of the HG in H(V)1 were discovered.

23 cillary P2X4 and/or P2X7 receptor inhibition were discovered.

24 presenting disease-causing mutations (OMIM) were discovered.

25 n has remained a mystery since these enzymes were discovered.

26 ly reduced the amount of cytoplasmic HBV DNA were discovered.

27 Genotype specific 45S rDNA sequences were discovered.

28 mples and illegal proportions of ingredients were discovered.

29 , and selective noncovalent AChE1 inhibitors were discovered.

30 ntake among female participants and athletes were discovered.

31 and novel recurrent ADHD-associated SV loci were discovered.

32 ately 45 strains capable of increasing GLP-1 were discovered.

33 AT with their IC(50) values as low as 620 nM were discovered.

34 rded and some new chemical reaction pathways were discovered.

35 Although this organelle was discovered 120 years ago, such basic questions as wh

36 dataset of MCH neurons where no connections were discovered [15], we used quadruple whole-cell recor

37 n the hippocampal samples of the argon group was discovered 24 hours after subarachnoid hemorrhage.

38 e AKT, also known as protein kinase B (PKB), was discovered 25 years ago and has been the focus of te

39 EB1 was discovered 25 years ago as a binding partner of the

40 In the laboratory the ion was discovered(3) as long ago as 1925, but only in the l

41 NF-kappaB was discovered 30 years ago as a rapidly inducible trans

42 Although IgE was discovered 50 years ago, the ultimate evidence for i

43 f the chirp z-transform (CZT) algorithm that was discovered 50 years ago.

44 eptins are a unique family of GTPases, which were discovered 50 years ago as essential genes for the

45 cate mineral [NaSi(7)O(13)(OH)(3).4(H(2)O)], was discovered about 50 years ago in sediments around La

46 One such factor, viperin, was discovered almost two decades ago based on its induc

47 DCl and DBr using a controlled amount of D2O was discovered along with the critical role of hydrolysi

48 lifornian rock art site called Pinwheel Cave was discovered alongside fibrous quids in the same ceili

49 No such difference in outcomes was discovered among male recipients.

50 Similarly, close correlations were discovered among plasma cortisol levels, TSC22D3 ex

51 ted before this "host-induced" unique vertex was discovered and before DNA sequencing became routine.

52 ovel cocrystal form with superior solubility was discovered and determined to be suitable for develop

53 These results suggest that each time a CAA was discovered and embedded during evolution, it provide

54 owth factor (IGF) binding protein 2 (IGFBP2) was discovered and identified as an IGF system regulator

55 lanta, auxin is the first hormone group that was discovered and it is also the most studied phytohorm

56 t flask-to-flask morphological heterogeneity was discovered and overcome to support network generaliz

57 /z = 265.1188) phenylacetylglutamine (PAGln) was discovered and then shown in an independent cohort (

58 ociated locus on CFA28 (P(raw) = 2.87E(-06)) was discovered and validated in a closely related popula

59 ew phenylalanine ammonia lyase (PAL) enzymes were discovered and characterised with respect to their

60 tact histidine, lysine, or cysteine residues were discovered and characterized from high-molecular we

61 ously unrecognized inhibitors of Wee kinases were discovered and characterized.

62 uses that likely belong to three new species were discovered and full genome sequences of these were

63 A large proportion of the BP loci were discovered and reported simultaneously by multiple

64 , we discuss how these CRISPR-Cas inhibitors were discovered and their modes of action were elucidate

65 el anionic, zwitterionic, and cationic PFASs were discovered, and an additional 17 previously reporte

66 Four candidate CPPs were discovered, and further study on one peptide (PepB2

67 sent a historical perspective on how barrels were discovered, and how thereafter, they became a workh

68 Two ligands of each receptor were discovered, and the most potent had sub-micromolar

69 ons involving wild dogs, jackals, and hyenas were discovered; and our results suggest that mutations

70 It was discovered approximately 20 years ago by yeast genet

71 Compound 12 (CTW0415) was discovered as a 5-HT(2C)R PAM with improved pharmaco

72 A decade after LUBAC was discovered as a cellular activity of unknown functio

73 A bicyclic olefin was discovered as a cocatalyst in a Cp*Rh(III)-catalyzed

74 The cytokine IL-2 was discovered as a growth factor for T cells and thus a

75 Rhizolutin (1) was discovered as a natural product of ginseng-rhizosphe

76 Recently, stanniocalcin-2 (STC2) was discovered as a novel inhibitor of the enzyme pregna

77 PrimPol was discovered as a primase-polymerase localized to the

78 Since ghrelin was discovered as a pro-hunger hormone, many additional

79 the cuprate high-temperature superconductors was discovered as a suppression of the Knight shift and

80 Hydrogen sulfide (H2S) was discovered as a third gasotransmitter in biological

81 yejM was discovered as an essential gene in E. coli and S. ty

82 The indole-3-glyoxamide 6 was discovered as an inhibitor of HIV-1 infectivity usin

83 noid Receptor Interacting Protein 1 (Cnrip1) was discovered as an interactor with the intracellular r

84 (RasGAP), DAB2 interacting protein (DAB2IP), was discovered as an miR-431 target.

85 Shortly after HIV-1 was discovered as the cause of AIDS, the search for epit

86 Apelin-36 was discovered as the endogenous ligand for the previous

87 Epstein-Barr virus (EBV) was discovered as the first human tumor virus more than

88 2017, Swope Supernova Survey 2017a (SSS17a) was discovered as the optical counterpart of the binary

89 The six major mammalian DNA repair pathways were discovered as independent processes, each dedicated

90 anilino)thieno[3,2- d]pyrimidine derivatives were discovered as novel dual tubulin polymerization and

91 anesulfonic acid, eight other AFFF chemicals were discovered as novel ligands, including four C(14)-

92 a" or "FAM150A" and "FAM150B," respectively) were discovered as physiological ligands of Alk and Ltk.

93 d indolinyl propanamides (series II and III) were discovered as selective androgen receptor degraders

94 The ARPP-16/19 proteins were discovered as substrates for PKA, but the function

95 Two meaningful dimensionless groups were discovered as the light use efficiency number (LUE

96 d bottom-up proteomics, hundreds of proteins were discovered at each locus in each condition.

97 high-specificity for detection of diazinon, was discovered, based on fluorescence resonance energy t

98 ro and in vivo, and a negative feedback loop was discovered between DGAT1, PEDF, and GM130.

99 Furthermore, a quadratic relationship was discovered between impact force and stiffness in the

100 A further 8 nests were discovered between 2016 and 2019.

101 Positive associations were discovered between airborne 10:2 FTOH and serum PFO

102 Significant differences in CTRP1 levels were discovered between the single- and triple-vascular-

103 ion of end wall resistance with plant height was discovered, but found to be independent of end wall

104 antisense-to-latency transcript (ALT) lncRNA was discovered by genome-tiling microarray.

105 Recently, a novel bacteriophage, crAssphage, was discovered by metagenomic data mining and reported t

106 log x, also known as B7-H4, B7S1, and VTCN1) was discovered by ourselves and others in 2003 as the se

107 The compound series was discovered by repurposing hits from a screen against

108 The seminal hit molecule was discovered by virtual screening and confirmed throug

109 Several interesting metabolites were discovered by accurate mass and comparing MS2 spect

110 on clinical features of autoimmune disorders were discovered by chance during World War II.

111 molecules representing two unique scaffolds were discovered by HTS and disrupt surface protein displ

112 s with dual activity on these receptors that were discovered by rational design.

113 They were discovered by serendipitous observations on weed gr

114 ous mutations in the mouse Zpld1 gene, which were discovered by the circling behavior of mutant mice,

115 Further, multipotent compounds were discovered, characterized, and for example, assigne

116 A potent hit compound was discovered containing a (R)-N-(piperidin-3-yl) linke

117 ys that acutely regulate Glut4 translocation were discovered: de novo protein synthesis and endocytic

118 /2), which form the ancient ribosomal stalk, were discovered decades ago but their functions remain m

119 Two monomeric variants were discovered, deemed mRhubarb719 and mRhubarb720, wit

120 ies of nine polyfluorinated carboxylic acids was discovered, each differing by CF2CH2.

121 ion used for controlling optomotor responses was discovered early.

122 Two promoter variants, EP01rec and EP14rec, were discovered exhibiting enhanced protein expression.

123 rol, piceatannol, astringin and isorhapontin were discovered, explaining 22-59% of phenotypic variati

124 The functionality was discovered for a ruthenium catalyst, but since there

125 Finally, no immunogenicity was discovered for Esc peptides, suggesting their potent

126 Significant associations were discovered for all phenotypes and are indicative th

127 activity and stability in alkaline solution were discovered for mixed nickel/cobalt hydroxide electr

128 ionally, new potentially pathogenic variants were discovered for two disorders, including IGF2/INS-IG

129 , the smallest representative of this genus, was discovered from the Ayeyarwady and Chindwin rivers.

130 rid, Kamuysaurus japonicus gen. et sp. nov., was discovered from the outer shelf deposits of the Uppe

131 skull caps) and two tibiae (lower leg bones) were discovered from a bone bed located about 20 m above

132 These compounds were discovered from a TNBC phenotypic screen and posses

133 istone-modification marks in several tissues were discovered from multiomics data of over 400 cattle.

134 ormation, four additional putative CCR genes were discovered from sorghum genomic data.

135 ic acid A (1) and iodocallophycols A-D (2-5) were discovered from the Fijian red alga Callophycus sp.

136 egal addition and replacement of ingredients were discovered, i.e. undeclared addition of pork and eg

137 and controversial history since its activity was discovered in 1939, has long been thought to be mono

138 cations especially since their photochromism was discovered in 1952.

139 Although Lands' cycle was discovered in 1958, its function and cellular regula

140 st (C-MFC based on N-doped carbon nanotubes) was discovered in 2009.

141 Asteroid 2015 BZ509 was discovered in 2015, but with too much uncertainty in

142 A particularly large set of C-degrons was discovered in 2018.

143 samples derived before the SARS-CoV-2 virus was discovered in 2019, we mapped 142 T cell epitopes ac

144 with Ehlers Danlos Syndrome whose diagnosis was discovered in a neuro-ophthalmic clinic for brain in

145 A new KCNA2 missense variant was discovered in a patient with epilepsy, causing amino

146 domain missense mutation, LAMB2-S80R, which was discovered in a patient with Pierson syndrome and un

147 e biosynthesis of the antibiotic valanimycin was discovered in a Streptomyces strain.

148 n 800 million years after the Big Bang) that was discovered in a wide-field survey.

149 Recently, a quality control pathway was discovered in Bacillus subtilis which monitors the a

150 Zika virus was discovered in East Africa in 1947 by the Rockefeller

151 In 2015, the mcr-1 gene was discovered in Escherichia coli in domestic swine in

152 Schmallenberg virus (SBV) was discovered in Germany in late 2011 and then spread r

153 A fossil hominin cranium was discovered in mid-Pliocene deltaic strata in the God

154 Peak editing activity for four sites was discovered in size-exclusion chromatography (SEC) fr

155 t wolf (Canis lupus) pup (specimen YG 648.1) was discovered in thawing permafrost in the Klondike gol

156 BD monomer, the natural product anthramycin, was discovered in the 1960s, and the best known PBD dime

157 5-protein signature, TB Risk Model 5 (TRM5), was discovered in the ACS training set and verified by b

158 form of diamond, also known as lonsdaleite, was discovered in the Canyon Diablo meteorite where its

159 Abundant molecular oxygen was discovered in the coma of comet 67P/Churyumov-Gerasi

160 y involving methylerithritol phosphate (MEP) was discovered in the early 1990s.

161 For (Asym)CDTb, a Ca(2+) binding site was discovered in the first receptor-binding domain that

162 new icosahedral mineral formed naturally and was discovered in the Khatyrka meteorite, a recently des

163 he Nozaki-Hiyama-Takai-Kishi (NHTK) reaction was discovered in the late 1970s and, since then, its ma

164 It was discovered in the mid-1990s and has been intensively

165 n that same year a second human polyomavirus was discovered in the urine of a kidney transplant patie

166 Recently, superconductivity was discovered in thin films of the infinite-layer nicke

167 A higher rate of pump-specific malfunctions was discovered in those implanted with an HM II versus a

168 Zika virus was discovered in Uganda in 1947 and is transmitted by A

169 operty of Rhodotorula mucilaginosa (NCYC 65) was discovered in which sugar substrate is cleaved but t

170 Although microscopic nodes were discovered in 27.6% of pCND patients, oncologic out

171 t met 1 or more and >/=3 of the new criteria were discovered in 87% and 54% of patients, respectively

172 Proteomic TB risk signatures were discovered in a longitudinal cohort of 6,363 Mycoba

173 Although these phases were discovered in a solid-state setting, recent innovat

174 Leading severity-related genes were discovered in an unbiased, system-wide analysis, re

175 es that are related to SARS-CoV and MERS-CoV were discovered in bats worldwide.

176 19a, miR-19b, miR-20a, miR-451a and miR-92a) were discovered in both humans and mice.

177 Mask family proteins were discovered in Drosophila to promote the activity of

178 Rare and common associations were discovered in eight genes involved in cell wall bio

179 Many genetic pathways that regulate aging were discovered in invertebrates.

180 f common and strain-specific genetic changes were discovered in MIL-adapted parasites, including dele

181 to histidine-histidine (His-His) cross-links were discovered in monoclonal antibody HMW species.

182 rcokinin (OK) are related neuropeptides that were discovered in protostomian invertebrates (mollusks,

183 interacting single-nucleotide polymorphisms were discovered in relation to superoxide dismutase 2, A

184 year, three candidates for bacterial actins were discovered in silico.

185 While nitroimidazoles were discovered in the 1950s, there has been renewed int

186 idima 2) from Apidima Cave, southern Greece, were discovered in the late 1970s but have remained enig

187 nts with gallbladder cancer, 207 cases (46%) were discovered incidentally and underwent reoperation a

188 onse that are associated with poor prognosis were discovered including HMGCS2, GPX2 and CD36, which m

189 scale matter specific to inorganic materials were discovered, including three-dimentional lithography

190 conformational changes of the viral protein was discovered, indicating GP10 may not be a static chan

191 MmpL3 ligand, phosphatidylethanolamine (PE), was discovered inside this transporter.

192 Three heat storage-release schemes were discovered involving different activation methods (

193 1990s, two "alternative nitrogenase" systems were discovered, isolated, and found to incorporate V or

194 Five inhibitors of human PYCR1 were discovered: l-tetrahydro-2-furoic acid, cyclopentan

195 Although oncoproteins were discovered many years ago and have been widely stud

196 contains an additional large exon termed 4a was discovered more than 25 years ago.

197 -loving) fungus Pseudogymnoascus destructans was discovered more than a decade ago to be the pathogen

198 Although this pattern was discovered more than sixty years ago, it remains an

199 tion, poly(ADP-ribose) polymerase 1 (PARP1), were discovered more than 50 years ago.

200 Two new protein densities were discovered near the decoding center and the peptidy

201 Lysine fatty acylation in mammalian cells was discovered nearly three decades ago, yet the enzymes

202 erto unknown Indian Ocean pathway of the ITF was discovered off Sumatra associated with prolonged nor

203 Clusters of HCW infection were discovered on two independent wards.

204 of inflammatory diseases including psoriasis were discovered only relatively late in the early 2000s.

205 Zika virus (ZIKV) was discovered over 70 years ago in East Africa, but lit

206 Bacterial membrane vesicles were discovered over 60 years ago and have been extensiv

207 Ras-oncogenes were discovered over three decades ago, but there are st

208 ed on endothelial cells in colon tumors that was discovered recently to be upregulated in TNBC.

209 Giant viruses of amoebae were discovered serendipitously in 2003; they are visibl

210 Traditional covalent drugs were discovered serendipitously; the presented tool, whi

211 Striosomes were discovered several decades ago as neurochemically i

212 lthough many of these chemical modifications were discovered several decades ago, their functions wer

213 Neutralization escape variants were discovered shortly thereafter, and, after almost th

214 n,Mn)2As2 (BZA), with high Curie temperature was discovered, showing an independent spin and charge-d

215 Soon after these radiation belts were discovered six decades ago, it was recognized that

216 Although viperin was discovered some 20 years ago, only recently was the

217 he inhibitory function of sulfonamides on CA was discovered some 80 years ago.

218 nd fullerene-like nanoparticles (NPs) of WS2 were discovered some 25 years ago and are produced now o

219 Although the ferrocenium cation was discovered soon afterwards, a derivatized ferroceniu

220 In 2002 it was discovered that a lightning discharge can rise out o

221 It was discovered that a new and serendipitously formed Ag(

222 -hydroxy-L-proline (Hyp) dehydratase (HypD), was discovered that catalyzes the dehydration of Hyp to

223 a special group of anaerobic microorganisms was discovered that could conserve energy by reducing or

224 Recently, it was discovered that exposure to mainstream antibiotics a

225 It was discovered that forced convective flow of electrolyt

226 osmolality-sensing ion channel called OSCA1 was discovered that functions in sensing hyperosmolality

227 Recently, it was discovered that Gram-positive pathogens use a unique

228 It was discovered that in order to maximize the response, t

229 me positioning maps for the human genome, it was discovered that in our genome, unlike in that of yea

230 Recently, a schistosome ion channel was discovered that is activated by PZQ and displays cha

231 the ligand-binding domain (LBD) of RORgammat was discovered that is amenable to small-molecule drug d

232 An unusual diastereodivergent NCAL process was discovered that leads to two different products; a t

233 Theranostic agent 1a was discovered that localized in glioblastoma tumor cell

234 Recently, it was discovered that MCR enzymes require zinc for activit

235 585 F2 plants segregating for the Ptr1 locus was discovered that narrowed the Ptr1 candidates to eigh

236 Recently, it was discovered that PEG10 isoforms promote the progressi

237 However, more recently it was discovered that peroxisomes can also benefit the vir

238 to azetidine nitrones from N-alkenylnitrones was discovered that provides facile access to these unsa

239 It was discovered that rats with chronically indwelling int

240 It was discovered that some lung cancer cell lines release

241 It was discovered that the 1D topological edge states are p

242 About two decades ago, it was discovered that the aurora is also controlled by sol

243 adjuvant (IFA) as a co-delivery vehicle, it was discovered that the controlled release of autoantige

244 It was discovered that the sulfur in sodium chromium sulfid

245 through a guided clinical re-evaluation, it was discovered that they share signs with the BioVU-asso

246 It was discovered that this seaweed was high in dietary fib

247 e than 30 years ago, two unexpected findings were discovered that challenged conventional thinking in

248 Recently, four small molecules were discovered that inhibit efflux in Escherichia coli

249 rms of ATP-PRT, namely long and short forms, were discovered that show different arrangements of thei

250 o anaerobic methane-oxidizing archaea (ANME) were discovered that use MCR enzymes to activate methane

251 ing between the first three unfolding states was discovered, the two transitions corresponded to the

252 Overall, it was discovered there was some variation between the diff

253 ssociated with glycyl radical enzymes (GREs) were discovered; these are widespread and comprise at le

254 D-D fusions has remained unknown since they were discovered three decades ago.

255 Another "bug" was discovered through proteomic analysis, associated wi

256 This pathway was discovered through the creation and analysis of Hmmr

257 The fact that our VRE outbreak was discovered through WGS surveillance and the manufact

258 The region was discovered through whole genome resequencing focused

259 Key structural features interacting with KHK were discovered through fragment-based screening and sub

260 Most of the classic selfish genetic elements were discovered through their biasing of transmission, b

261 Sixteen months later, it was discovered to be a complication of coccidioidal meni

262 CF(3)Boc-group that caps the P3 amino moiety was discovered to be an essential contributor to metabol

263 e interplay between superconductivity (MoTe2 was discovered to be superconducting recently) and their

264 Borrelia burgdorferi was discovered to be the cause of Lyme disease in 1983,

265 After a strategic investigation, silica gel was discovered to be the cause of the byproduct formatio

266 he cytoplasmic dynein heavy chain (DHC) gene was discovered to cause an autosomal dominant form of th

267 Recently, a cytochrome P450 system, GcoAB, was discovered to demethylate guaiacol (2-methoxyphenol)

268 Interestingly, A. thaliana was discovered to have a recognition system for the effe

269 A three-year-old male was discovered to have nanophthalmos after first present

270 In transfected cells, the HSV-1 gI was discovered to induce rod-shaped structures that were

271 conserved and disordered protein called SERF was discovered to modify amyloid formation in Caenorhabd

272 However, the golden SNP was discovered to not affect PSY protein levels and caro

273 cial rhizobacterium Bacillus velezensis SQR9 was discovered to produce novel antibacterial fatty acid

274 of the left dorsal anterior cingulum bundle was discovered to reliably evoke positive affect and anx

275 2,2-dimethyl-pyrrolidin-5-ylidene ((Et)CAAC) were discovered to afford three different types of react

276 o[1,2- b]pyridazin-8-amine kinase inhibitors were discovered to allosterically inhibit the endoribonu

277 However, it was not until 1999 that BAs were discovered to be endogenous ligands for the nuclear

278 Thus, RIP9 complexes were discovered to be highly associated with C-to-U RNA

279 Recently, gold nanoparticles (AuNPs) were discovered to inhibit cancer cell migration and pre

280 of the Ig superfamily (IgSF) in fruit flies were discovered to label different subsets of neurons in

281 d (33)) are relaxor-PbTiO(3) crystals, which were discovered two decades ago.

282 lta1 and TCRVdelta2 gammadelta T lymphocytes were discovered, unveiling in both subsets an unattended

283 ive Tyr-to-Cys substitution at amino acid 42 was discovered using error-prone PCR to generate additio

284 onment in promoting anthralin/O(2) reactions was discovered using neat solvents to model the amino ac

285 ality single nucleotide polymorphisms (SNPs) were discovered using a minimum allele frequency of 1% a

286 ted Alternative Open reading frame (AltORFs) were discovered using customized databases.

287 ely called the hypocretins or orexins, which were discovered using two different approaches.

288 A novel mechanism of BRCA1 abrogation was discovered via germline SINE-VNTR-Alu retrotransposi

289 Several mechanisms were discovered via which the initially sigma-bonded sub

290 ochemically inactive, and a unique mechanism was discovered which allows for radical polymerization.

291 H244 (13m), OFH3911 (14n), and OFH3912 (14m) were discovered, which display two-digit picomolar affin

292 ciated with flavonoid metabolic biosynthesis were discovered, which enhance catechin production, terp

293 Novel DNA sequences were discovered, whose repeat structures, gene contents,

294 racemic screening hit from HTS campaign 11a was discovered with an enzymatic IC(50) of 150 nM.

295 An unexpected acidanion heterodimer was discovered with weaker picric acid, which helped rev

296 show that two putative PORCN inhibitors that were discovered with cell-based assays indeed target hum

297 ChoK inhibitor leads RSM-932A and MN58b that were discovered with IC50 of 0.5 and 150 muM, respective

298 Gravitational waves were discovered with the detection of binary black-hole

299 f three bilayer thick PbSe-SnSe alloy layers was discovered within [(Pbx Sn1-x Se)1+delta ]n (TiSe2 )

300 st-degree incestuous union from remains that were discovered within the most elaborate recess of the