ライフサイエンスコーパス: wake

1 r groups will persist and diversify in their wake.

2 cephalography biotelemetry measures of sleep/wake.

3 inated during NREM sleep compared to resting wake.

4 asticity happened independently of sleep and wake.

5 ection: it occurred during sleep, not during wake.

6 front with rapidly decreasing density in the wake.

7 action, rather than just following in their wake.

8 eep events were interspersed with periods of wake.

9 n of breathing automaticity during sleep and wake.

10 es due to circadian misalignment or extended wake.

11 rovides a similar memory benefit compared to wake.

12 s to smoke the first joint within an hour of waking.

13 leep phase when the brain is as active as in waking.

14 n can be used to mitigate sleep inertia upon waking.

15 nd with hippocampal interictal spikes during waking.

16 at are subsequently reactivated during quiet waking.

17 in REM sleep (10 mW) compared to non-REM and waking (3 to 5 mW, P < 0.05), and the slopes of the regr

18 e dual role for both sleep and arousal/brief wake activation.

19 Wake-active sleep-promoting circuits may also be require

20 egans thus requires an additional component, wake-active sleep-promoting neurons that translate wakef

21 Wake-active wake-promoting neurons in turn shut down sle

22 ded p < 0.001) was found in the reduction of wake after sleep onset and latency to persistent sleep f

23 t relationships were observed for subjective wake after sleep onset and subjective latency to sleep o

24 dels, actigraphic sleep-disruption measures (wake after sleep onset, fragmentation, percentage sleep,

25 sting achieve estimates of total sleep time, wake after sleep onset, sleep efficiency, and number of

26 A formulation is proposed to predict wake amplitude on the basis of ship characteristics and

27 hin an hour of waking, known colloquially as wake and bake.

28 Sleep pressure increases during wake and dissipates during sleep, but the molecules and

29 amic neurons involved in regulation of sleep/wake and fast/feeding states.

30 at astroglial calcium signals are highest in wake and lowest in sleep and are most pronounced in astr

31 Disrupted sleep-wake and molecular circadian rhythms are a feature of ag

32 5-day-old rats with whisker movements during wake and myoclonic twitches of the whiskers during activ

33 LH(GABA) neurons indicate that they are both wake and rapid eye movement (REM)-sleep active.

34 essure and sleep depth are key regulators of wake and sleep.

35 tion that cortical synapses are larger after wake and smaller after sleep.

36 , synapses on average should be larger after wake and smaller after sleep.

37 rtical activation during active or attentive waking and paradoxical or rapid eye movement sleep.

38 ion, which occurs during active or attentive waking and paradoxical or rapid eye movement sleep.

39 firing also occurs during natural attentive waking and paradoxical sleep in association with theta a

40 ciation with theta activity during attentive waking and paradoxical sleep.SIGNIFICANCE STATEMENT Neur

41 Waking and rapid eye movement (REM) sleep are characteri

42 Theta sequences were preserved between waking and sleep, but appeared not to resemble the order

43 used body-attachment locations for 24 hours, waking and sleeping hours, and to test comparability of

44 tal IOP energy the eye must withstand during waking and sleeping hours, respectively.

45 nterictal hippocampal spike frequency during waking and the first cycle of NREM sleep and memory perf

46 vivo and computational analyses show that P(Wake) and P(Doze) are largely independent and control th

47 zed the increase in synaptic strength during waking, and compensatory downsizing of (presumably less

48 NHPs), and M(1) PAM BQCA (in rats) on sleep/wake architecture and arousal.

49 Changes in sleep/wake architecture are also present in normal aging and m

50 microbiota is suggested to affect the sleep/wake architecture by altering the intestinal balance of

51 ssociated with disruptions in arousal, sleep/wake architecture, and cognition.

52 hese neuronal subpopulations did alter sleep-wake architecture.

53 ed after 6-8 h of sleep (S = 6), spontaneous wake at night (W = 4) or wake enforced during the day by

54 farm through yaw misalignment that deflects wakes away from downstream turbines.

55 hways through which nutrient state and sleep/wake behavior affect central clock function.

56 its projections, and its regulation of sleep-wake behavior and addiction.

57 Rhythms of sleep/wake behavior were assessed via wrist-worn actigraphy, w

58 associated with circadian outputs and sleep/wake behavior.

59 h proteostatic pathways can affect sleep and wake behavior.

60 tween their circadian system and daily sleep-wake behaviors, with negative health consequences, we in

61 tanding of how orexin neurons regulate sleep-wake behaviour and the consequences of the loss of orexi

62 ian timing system and daily rhythms of sleep-wake behaviour or food intake as a result of genetic, en

63 rate during arousals may result from a sleep-wake boundary instability, suggesting a bidirectional re

64 onset, fragmentation, percentage sleep, and wake bouts) were associated with worse cognition.

65 We discovered that sleep-wake brain states and motor behaviors are coregulated by

66 Most brain neurons are active in waking, but hypothalamic neurons that synthesize the neu

67 current asthma (past 12 months), defined as: woken by shortness of breath, asthma attack, or asthma m

68 ngle-cycle pulse within the nearly evacuated wake cavity.

69 ep-active neurons that depolarize to inhibit wake circuits.

70 ful cognitive processing-the sole purview of waking consciousness.

71 propose an arousal-action circuit for sleep-wake control in which wakefulness is supported by separa

72 exert their effects through endogenous sleep-wake control systems and accordingly GA and sleep share

73 the neuronal populations implicated in sleep-wake control, the ventrolateral preoptic (VLPO) nucleus

74 e dual role for both sleep and arousal/brief wake control.

75 halamic-hindbrain neuronal circuit for sleep/wake control.

76 vironmental implications of SWM policies for Wake County, North Carolina using a life-cycle approach.

77 f this study was to establish baseline sleep-wake cycle and activity patterns using actigraphy and fu

78 g and spreading were influenced by the sleep-wake cycle and SD.

79 es experience radical changes in their sleep-wake cycle and sleep difficulties after exposure to a ro

80 bidirectional relationship between the sleep-wake cycle and tau have not been previously discussed in

81 mportant role in the regulation of the sleep-wake cycle and the regulation of feeding and emotions.

82 in other brain cells (glia) across the sleep-wake cycle and their role in sleep regulation are compar

83 epsy is a neurological disorder of the sleep-wake cycle characterized by excessive daytime sleepiness

84 ted data which specific changes of the sleep/wake cycle play the most important role in this associat

85 Thus, the sleep-wake cycle regulates ISF tau, and SD increases ISF and C

86 micro-architecture characterizing the sleep-wake cycle results from an underlying non-equilibrium cr

87 In mammals, the clock regulates the sleep-wake cycle via 2 basic helix-loop-helix PER-ARNT-SIM (bH

88 critical dynamics observed across the sleep-wake cycle, and indicate that VLPO neurons may have dual

89 he processing of visual input over the sleep-wake cycle, sensory gain control during wakefulness, and

90 lly dependent on the regulation of the sleep-wake cycle, thereby indicating the importance of good sl

91 ations sculpt critical features of the sleep-wake cycle.

92 progression due to a disruption in the sleep-wake cycle.

93 ta and tau fluctuate during the normal sleep-wake cycle.

94 timately linked with regulation of the sleep/wake cycle.

95 icing in beta-cell function across the sleep/wake cycle.

96 g evoked cortical responses during the sleep-wake cycle.

97 d its hypothetical relationship to the sleep-waking cycle, blood flow, and brain temperature in speci

98 avior of individual neurons across the sleep-wake-cycle.

99 the endogenous circadian pacemaker and sleep/wake cycles (circadian misalignment), while environmenta

100 Sleep-wake cycles and exercise levels were held constant.

101 g patterns were stable across multiple sleep-wake cycles and were independent of ambient lighting con

102 e prominent behavioural states such as sleep-wake cycles but also a host of less conspicuous oscillat

103 ter group were inactive during regular sleep/wake cycles but were specifically activated by predator

104 Human sleep/wake cycles follow a stable circadian rhythm associated

105 travel across time zones or irregular sleep-wake cycles has long-term consequences for our health an

106 hat FLM can be used to describe normal sleep-wake cycles of healthy adult dogs and the effects of phy

107 t rate(6), pulmonary artery tone(5,7), sleep/wake cycles(8) and responses to volatile anaesthetics(8-

108 rupted circadian rhythms (for example, sleep-wake cycles) and disorders of the CNS.

109 hich have a central role in regulating sleep/wake cycles, impact activity, feeding, and immunity.

110 d with disrupted cognitive control and sleep-wake cycles.

111 ns PDF release orchestrating phases of sleep-wake cycles.

112 its how much time can be devoted to critical wake-dependent activities [1].

113 we assessed endogenous circadian rhythms and wake-dependent changes in plasma metabolites in 13 parti

114 Establishing circadian and wake-dependent changes in the human metabolome are criti

115 ions, with consequences on metabolism, sleep/wake disorders and progression of neurodegenerations.

116 Experimental sleep-wake disruption in rodents and humans causally modulates

117 Yet mechanisms by which wakes dissipate their energy into surrounding plasma rem

118 sessments), psychomotor changes (46%), sleep-wake disturbances (46%), and impaired arousal (37%) had

119 the interaction between a homeostatic sleep-wake-driven process and a periodic circadian process, an

120 S = 6), spontaneous wake at night (W = 4) or wake enforced during the day by novelty exposure (EW = 4

121 The wake-enhancing and REM-suppressing effects of R05263397

122 isual perception of light in the bedtime and waking environments were added to the Consensus Sleep Di

123 large dataset of approximately 600 measured wake events associated to specific ships whose data are

124 ding of memories in sleep would require that waking events are faithfully transferred to and reproduc

125 STATEMENT Rodent hippocampal neurons replay waking events during sharpwave ripples (SWRs) in NREM sl

126 brain may instead reflect the quality of the waking experience itself.

127 on the recovery of neural representations of waking experience.

128 owever, this has never been demonstrated, as waking experiences are never truly replicated in sleep b

129 rough the reactivation of previously encoded waking experiences.

130 h REMS may mediate the response to stressful waking experiences.

131 f fundamental behaviors, including sleeping, waking, feeding, stress and motivated behavior.

132 particle, caused by its thermal motion in a wake field of another particle, can lead to a significan

133 In rodents, waking firing patterns replay in NREM sleep during hippo

134 dation, mark when hippocampal neurons replay waking firing patterns.

135 zation of the events that underlie entry and waking from persistence may lead to lasting breakthrough

136 k cycle are associated with changes in sleep/wake has not been tested.

137 able with dynamics dependent on global sleep-wake history, and reflected in electroencephalogram (EEG

138 me series of mRNA expression data with sleep-wake history, which established that a large proportion

139 for women) accounted for 59.4% and 57.3% of waking hours in men and women, respectively; 73.8% of sa

140 ive and control groups in the mean number of waking hours per day with good symptom control and no tr

141 ng at least 6 full days of wear (at least 10 waking hours).

142 day and lower activity levels during typical waking hours, reflecting low physiologic functioning.

143 rapid eye movement (NREM) sleep, followed by waking immobility.

144 The environment changes sleep and wake in flies, e.g., starvation induces waking in Drosop

145 dex associated with laser-produced nonlinear wakes in a suitably designed plasma density structure ra

146 s were subsequently reactivated during quiet waking in darkness, with higher reactivation rates durin

147 and wake in flies, e.g., starvation induces waking in Drosophila as it does in many animals.

148 (2.17, 1.10-4.27; p=0.025), sleep problems (waking in the night 1.91, 0.95-3.84, p=0.069; insufficie

149 We previously identified WIDE AWAKE (WAKE) in Drosophila, a clock output molecule that mediat

150 s to smoke the first joint within an hour of waking, known colloquially as wake and bake.

151 formance and lowering of alertness following waking, lasts for durations ranging between 1 min and 3

152 aptic strength after ongoing learning during waking leads to net synaptic potentiation.

153 als awake suggests that sleep (compared with wake) leads to widespread reductions in net synaptic str

154 light on how this processing influences our waking life, which can further inspire the development o

155 tic activation of the dFB promotes sustained wake-like levels of neural activity even though flies be

156 acaques and effectively restored arousal and wake-like neural processing.

157 sleep typically transitions from an active "wake-like" stage to a less active stage.

158 s, it is characterized by a desynchronized, 'wake-like' EEG.

159 of power production through the reduction of wake losses.

160 Wake maintenance tests were not improved.

161 equent alertness prior to dawn (a circadian "wake maintenance zone").

162 Probability of initiating activity, P(Wake), measures sleep depth while probability of ceasing

163 vity was again greater after a twitch than a wake movement.

164 gy density that the driver deposits into the wake must be removed efficiently between shots.

165 uss its functional significance in the sleep-wake network.

166 ge involves attribution: determining, in the wake of a human-caused biological event, who was respons

167 cell populations generated in the immediate wake of an acute pathogen challenge, is in part controll

168 In the wake of community coronavirus disease 2019 (COVID-19) tr

169 isk of collapse or reduced efficiency in the wake of COVID-19 include food systems, incomes, and soci

170 ng state of neurovascular malfunction in the wake of CSDs.

171 In the wake of repeated coral bleaching mortalities in Lakshadw

172 owing ever more complex and plentiful in the wake of substantive advances in experimental and computa

173 In the wake of the announced development of Arctic shipping, th

174 ogical transformations and innovation in the wake of the Arab conquest in the seventh and eighth cent

175 In the wake of the COVID-19 pandemic many countries implemented

176 bout the future of radiology research in the wake of the COVID-19 pandemic.

177 can anticipate an increase in suicide in the wake of the COVID-19 pandemic.

178 shop, as well as follow-up discussion in the wake of the current pandemic.

179 is disassembled and then reassembled in the wake of the DNA replication fork.

180 on is linked to defective gap-filling in the wake of the replication fork and incomplete Okazaki frag

181 rental and newly synthesized histones in the wake of the replication fork through the activity of the

182 In the wake of the success of modern immunotherapy, oncolytic v

183 In the wake of the surge establishing a new normal for hospital

184 els to evaluate dinosaur habitability in the wake of various asteroid impact and Deccan volcanism sce

185 tion and confinement of plasma tracks in the wakes of laser field.

186 Psychological surveys were conducted in the wakes of mass shootings in the United States, New Zealan

187 mins of post-learning sleep, rest, or active wake on concept learning (dot pattern classification) an

188 estion, we compared the effects of sleep and wake on psychophysiological and subjective reactivity du

189 ssessing the relative impact of sleep versus wake on the brain may instead reflect the quality of the

190 test the effect of delay activity (sleep vs. wake) on the consolidation of statistical knowledge.

191 ences that received stimulations only during wake or not at all.

192 ) marked reductions in neural activity (from waking) over widespread regions of the cortex, most pron

193 The sleep-wake pattern was monitored by EEG and neck EMG recording

194 (beta = 0.073; p < 0.001) and specific sleep-wake patterns (p < 0.01).

195 er on individual circadian rhythms and sleep-wake patterns in adult subjects.

196 Sleep/wake patterns were measured with wrist actigraphy and in

197 hat caused age-dependent disruption of sleep-wake patterns.

198 city resulting from novel experiences versus wake per se has unique and distinct features.

199 is not known whether they have a role during waking perception.

200 tic demand throughout the day as a result of waking, physical activity, and food intake patterns.

201 portantly, we demonstrate that both the Doze/Wake probabilities and the sleep/wake substates are tied

202 both GNRR-3 and GNRR-6 are required for the wake-promoting action of NLP-2 neuropeptides.

203 avior, and neonicotinoids directly stimulate wake-promoting clock neurons in the fruit fly brain.

204 However, the circuitry controlling these wake-promoting DA neurons is unknown.

205 PDM3 controls the wiring of wake-promoting dopaminergic (DA) neurites to a sleep-pro

206 In general, the wake-promoting effects observed were not accompanied by

207 onstrated high receptor occupancy and marked wake-promoting effects with decreased rapid-eye-movement

208 ective histamine H3 receptor antagonist with wake-promoting effects, for the treatment of daytime sle

209 but eventually the paradigm shifted toward a wake-promoting function for the serotonergic raphe.

210 Histamine (HA), a wake-promoting monoamine implicated in stress-related ar

211 neurons drive broad GABAergic inhibition of wake-promoting neuronal populations.

212 ording to the most conventional sleep model, wake-promoting neurons (WPNs) and sleep-promoting neuron

213 Wake-active wake-promoting neurons in turn shut down sleep-active ne

214 mulated subthreshold voltage fluctuations in wake-promoting neurons to account for stochasticity in s

215 d in fly astrocytes and in a specific set of wake-promoting neurons-the mushroom body (MB) alpha'beta

216 at changes in PERK signaling directly impact wake-promoting neuropeptide expression, revealing a mech

217 major source of GABAergic inputs to multiple wake-promoting populations; gene profiling revealed NTS

218 onsistent with C1's projections to brainstem wake-promoting structures.

219 ow that ions and electrons that the original wake propels outward, carrying 90 percent of its energy,

220 grid cell pair and collectively, and across waking, rapid eye movement sleep and non-rapid eye movem

221 ess this, we employed a combination of sleep/wake recordings, fast scan cyclic voltammetry, and weste

222 sleep (red light mask) and to eyes open upon waking (red light goggles) reduced sleep inertia.

223 d represent a general mechanism of sleep and wake regulation and provide greater insight into the rel

224 d the effects of the gut microbiota on sleep/wake regulation.

225 cific neural pathway separate from the sleep-wake regulatory pathway induce behavioral quiescence and

226 These results suggest that multiple sleep-wake regulatory systems exist in a brain region-specific

227 he uncovered critical behavior in sleep- and wake-related cortical rhythms indicates a mechanism esse

228 f-organization and criticality in sleep- and wake-related cortical rhythms; a mechanism essential for

229 for the EEG, EMG, and autonomic profiles of wake, REM, and NREM states and several key features of t

230 a post-encoding period of quiet, eyes-closed waking rest benefits memory consolidation, others have r

231 moderately sized and significant benefit of waking rest for verbal memory (d = 0.38, p < 0.001).

232 ver, the relative benefits of sleep vs quiet waking rest on memory remain poorly understood.

233 it, above and beyond that conferred by quiet waking rest.

234 areas involved in circadian timing and sleep-wake rhythms showed the lowest redistribution of contras

235 dicts cognitive effectiveness based on sleep/wake schedule.

236 pared with not drinking, was associated with waking several times a night (odds ratio 1.30, confidenc

237 sleep profiles in terms of waking tired and waking several times.

238 on and their number increases after extended wake.SIGNIFICANCE STATEMENT Sleep benefits learning, mem

239 , and patterned tachycardia conserved across wake, sleep, and arousal states.

240 d hindbrain that are known to be involved in wake-sleep control in mammals(4-6).

241 primarily function to enhance flexibility in wake-sleep preference, a behavioral plasticity that is c

242 model to study sleep [3], we identify a new wake-sleep regulator that we term daywake (dyw).

243 icates a less recognized class of modulatory wake-sleep regulators that primarily function to enhance

244 t altering duration of time across all sleep/wake stages.

245 ctivation of Tac1 POA neurons stabilizes the wake state against both isoflurane- and sevoflurane-indu

246 nd western blotting to examine whether sleep/wake state and/or light/dark phase impact DA terminal ne

247 These findings suggest that sleep/wake state influences DA neurotransmission in a manner t

248 TN) are considered to be important for sleep-wake state-dependent control of breathing.

249 aine at inhibiting the DAT vary across sleep/wake state.

250 hostimulant abuse, and, more recently, sleep/wake state.

251 fined set-point, independent of global sleep-wake state.

252 ment (REM) sleep, strongly consolidating the waking state for hours, even during a period of elevated

253 Moment-to-moment fluctuations in waking state or arousal can account for much of this var

254 the understanding of rapid variations in the waking state, how variations are generated, and how they

255 d traits as well as affect regulation in the waking state.

256 PO) of the hypothalamus would modulate sleep/wake states and alter the time to loss and resumption of

257 ificant association between individual sleep/wake states and DA terminal neurotransmission, with high

258 error and bias values when quantifying sleep/wake states as compared to sleep staging durations.

259 ersonalized machine learning models of sleep-wake states outperform their generalized counterparts in

260 Thus, sleep and wake states temporally segregate upward and downward FRH

261 underscore the necessity of monitoring sleep-wake states to ensure accurate assessments of the contri

262 ey interact with each other to control sleep/wake states.

263 are indistinguishable from PSG labeled sleep-wake states.

264 neuronal responsiveness and the continuum of waking states, and suggest new complexities in the relat

265 Wake steering also decreased the variability in the powe

266 t this farm, these statistically significant wake steering results demonstrate the potential to incre

267 th the Doze/Wake probabilities and the sleep/wake substates are tied to specific biological processes

268 that allows visualization of distinct sleep/wake substates.

269 predictable relationship with P(Doze) and P(Wake), suggesting that the methods capture the same beha

270 Sleep and wake summary outcomes as well as sleep staging metrics w

271 hat Abeta can trigger a bi-directional sleep/wake switch.

272 lations of ion channels emerging from broken wakes that electron bunches from the SLAC linac generate

273 During periods of sleep and inactive waking, the extracellular activity of the hippocampus is

274 to in-situ probe the transient and nonlinear wakes themselves.

275 ve their first joint within 60 minutes after waking: those who smoked tobacco and used spliffs (95%CI

276 Total sleep time (TST), total wake time (TWT), and sleep efficiency (SE) were measured

277 e primary efficacy outcome was the change in wake time after sleep onset from baseline to days 1 and

278 seline to days 1 and 2, change in subjective wake time after sleep onset, and subjective latency to s

279 homozygous Sik1(S577A) mice showed a shorter wake time, longer NREMS time, and higher NREMS delta den

280 were brief and only slightly increased total wake time, reminiscent of clinical findings in sleep apn

281 DP(+) (and hence the record of sleep debt or waking time) represent prototypes of potential sleep-reg

282 ded to have worse sleep profiles in terms of waking tired and waking several times.

283 eep can repair DNA breaks accumulated during wake to maintain genome integrity and likely slow down n

284 nism coordinating these changes during sleep-wake transitions remains poorly understood.

285 conditioning, social interaction, and sleep/wake transitions.

286 riences will occur and what prevents us from waking up during these episodes.

287 d awakening protocol where participants were woken up at various points throughout the night, includi

288 of nonsedation versus sedation with a daily wake-up call during mechanical ventilation on cognitive

289 ent analgesia or light sedation with a daily wake-up call during mechanical ventilation.

290 Threat probability (predator wake-up rate) and magnitude (amount of token loss) varie

291 A significant proportion of patients with wake-up stroke exhibit low NWU and may therefore be pote

292 Among 87 patients with wake-up stroke, 46 patients (53%) showed low NWU (< 11.5

293 zed in a consecutive cohort of patients with wake-up stroke.

294 uated inversion recovery (FLAIR) mismatch in WAKE-UP who underwent PWI.

295 met our eligibility criteria for inclusion: WAKE-UP, EXTEND, THAWS, and ECASS-4.

296 making drag, generates a stationary internal wake which produces a kinematic drag with a noticeable h

297 e gas slug bursts, liquid is drawn up in its wake, which exsolves the more soluble volatile component

298 Corroborating the increased waking with RluD, production of RluD increased the numbe

299 the sound cues that were associated (during wake) with left- and right-hand movements before bringin

300 considerably increased in sleep compared to waking, with larger responses during SWS than during REM