ライフサイエンスコーパス: wakefulness

1 matergic neurons causes a strong increase in wakefulness.

2 impairment in settings that involve extended wakefulness.

3 z) and gamma-band activity (30-80 Hz) during wakefulness.

4 pants (4 females) studied during 40-hours of wakefulness.

5 ation of this pathway in vivo rapidly drives wakefulness.

6 relative to wild-type controls during quiet wakefulness.

7 responsive, then reversed upon emergence to wakefulness.

8 ularly after more than 10 hours of scheduled wakefulness.

9 , the VTA has a role in regulating sleep and wakefulness.

10 eep-wake cycles with highest activity during wakefulness.

11 ep onset, sleep fragmentation, and increased wakefulness.

12 internal clock and by the duration of prior wakefulness.

13 ctivity changes during transitions to active wakefulness.

14 stabilized after sleep but diminished after wakefulness.

15 onset of muscle weakness or paralysis during wakefulness.

16 uction or loss, and REM sleep instruction in wakefulness.

17 g of synapses that have been built up during wakefulness.

18 rement for the maintenance of arousal during wakefulness.

19 le to study somnambulism behaviorally during wakefulness.

20 strength of the peaks with EEG-defined sleep/wakefulness.

21 with impaired behavioral performance during wakefulness.

22 onnected to mental ability both in sleep and wakefulness.

23 hown to depend on EEG-defined stage of sleep/wakefulness.

24 y young and older volunteers under extendend wakefulness.

25 urons and their specific role in maintaining wakefulness.

26 REM sleep, nor of theta power during resting wakefulness.

27 rousal and promote the maintenance of normal wakefulness.

28 d was observed, even after 4 days of induced wakefulness.

29 nic REM sleep, the latter resembling relaxed wakefulness.

30 ans, this occurs during sleep but not during wakefulness.

31 delta power spectrum and slightly decreased wakefulness.

32 he decisive role of the LTD and PPT in sleep-wakefulness.

33 ice increases local acetylcholine levels and wakefulness.

34 ffects on spiking activity across periods of wakefulness.

35 ral cortex, rather than to induce behavioral wakefulness.

36 emporal reactivated patterns in SWS or quiet wakefulness.

37 e and acetylcholine are highly active during wakefulness.

38 oral functions, such as control of sleep and wakefulness.

39 dividual neurons and the cortical LFP during wakefulness.

40 hcrt) are necessary for normal regulation of wakefulness.

41 e performance of a voluntary movement during wakefulness.

42 normal waking day, but also during overnight wakefulness.

43 e EEG and metabolic consequences of extended wakefulness.

44 , but not to the thalamus, mediate PB-driven wakefulness.

45 aracterized by hypersomnolence during normal wakefulness.

46 mice with an exceptional amount of sustained wakefulness.

47 paralysis, hallucinations) that intrude into wakefulness.

48 ring sleep and 'desynchronized' state during wakefulness.

49 in 11 healthy volunteers during 1 h of quiet wakefulness.

50 ntal or parietal cortices, failed to restore wakefulness.

51 exin signals, which rapidly fluctuate during wakefulness.

52 e changes in our nighttime sleep and daytime wakefulness.

53 on, compared to comparable amounts of active wakefulness.

54 g postsleep EEG were recorded during resting wakefulness.

55 vel circuits in the mouse brain that promote wakefulness.

56 some fragments are eliminated slowly during wakefulness.

57 e preserved after sleep but diminished after wakefulness.

58 lutamate cells impaired the consolidation of wakefulness.

59 ve during rapid eye movement (REM) sleep and wakefulness.

60 sleep, whereas their inactivation increased wakefulness.

61 generators of the alpha rhythm during quiet wakefulness.

62 ds relative to each other, ranging from full wakefulness (2.5) to deep sleep (0).

63 (5-HT or serotonin), and modulates sleep and wakefulness(5) by activating two high-affinity G-protein

64 integrin activation compared with nocturnal wakefulness, a mechanism possibly underlying some of the

65 e known to promote forward locomotion during wakefulness, act as major activators of RIS.

66 ifically, the same neurons shaping sleep and wakefulness actually do influence the anesthetic state i

67 Disturbed sleep and increased wakefulness acutely lead to increased Abeta production a

68 and month 3 by polysomnography end points of wakefulness after persistent sleep onset and latency to

69 o placebo on subjective total sleep time and wakefulness after persistent sleep onset at night 1/week

70 Prolonged wakefulness alters cortical excitability, which is essen

71 ross the circadian cycle, during 42 hours of wakefulness and after recovery sleep, in 33 healthy part

72 ess, whereas TAAR1 partial agonism increases wakefulness and also reduces NREM and also REM sleep.

73 system are elevated in schizophrenia during wakefulness and are also induced in the N-methyl-D-aspar

74 Sleep, wakefulness and body temperature rhythm were monitored t

75 he laboratory, the operational way to assess wakefulness and consciousness is through responsiveness.

76 ng been thought to be involved in behavioral wakefulness and cortical activation.

77 tive in blocking spindles but increased both wakefulness and cortical delta/gamma activity, as well a

78 visual cortical neurons, even during active wakefulness and decision making.SIGNIFICANCE STATEMENT A

79 d-EEG recordings of 12 healthy adults during wakefulness and deep (N3-)sleep, characterised by differ

80 Cortical state changes also occur at full wakefulness and during rapid cognitive acts, such as per

81 OX-A is crucial for the control of wakefulness and energy homeostasis and promotes, in OX-1

82 apeutic option for the treatment of impaired wakefulness and excessive sleepiness in patients with na

83 duced silencing of Kiss1(ARH) neurons shifts wakefulness and food consumption to the light phase and

84 regulator of behavioral arousal, sleep, and wakefulness and has been an area of intense research eff

85 tamine (HA) system, implicated in supporting wakefulness and higher brain function, but has been diff

86 ergic projections to cortex directly control wakefulness and illustrates the utility of "opto-dialysi

87 ly, in mice, ablation of the raphe increases wakefulness and impairs the homeostatic response to slee

88 oral wakefulness, whereas inhibition reduced wakefulness and increased non-REM (NREM) sleep.

89 s continue to live under extended periods of wakefulness and ingestion events, daily eating pattern o

90 itical for maintaining normal daily cycle of wakefulness and involving astrocyte-neuron metabolic int

91 and single-unit activity in patients during wakefulness and light anesthesia.

92 hat occur to a different extent during quiet wakefulness and light general anesthesia.

93 on requires neurons that have known roles in wakefulness and locomotion behavior.

94 cortical processing hierarchy of rats during wakefulness and natural sleep.

95 riment 1, n = 39), and during sleep-deprived wakefulness and non-rapid eye movement sleep (experiment

96 vioral task remained segregated during quiet wakefulness and NREM sleep.

97 ne its effects on breathing during sleep and wakefulness and on HVR.

98 from non-rapid eye movement (NREM) sleep to wakefulness and produces sustained arousal, higher locom

99 Conversely, chemogenetic inhibition opposed wakefulness and promoted NREM sleep, even in the face of

100 py for narcolepsy primarily aims to increase wakefulness and reduce cataplexy attacks.

101 off, when sleep pressure was high, promoted wakefulness and reduced both REM and non-REM sleep witho

102 usions: Solriamfetol significantly increased wakefulness and reduced sleepiness in participants with

103 ereas chemogenetic stimulation promotes both wakefulness and REM sleep, optogenetic stimulation of th

104 onally, FAA was positively correlated across wakefulness and REM sleep.

105 ng been considered a key site for regulating wakefulness and REM sleep.

106 cient obese db/db mice increased V(E) during wakefulness and sleep and augmented the HVR.

107 While responses are comparable across wakefulness and sleep in auditory cortex (AC), neuronal

108 pace function in intact rodent models during wakefulness and sleep, and MRI in humans has enabled per

109 Genioglossus activity during wakefulness and sleep, genioglossus muscle responsivenes

110 point to a novel target to improve disturbed wakefulness and sleep.

111 the neocortex and hippocampus of rats during wakefulness and sleep.

112 nd in AC of freely behaving male rats across wakefulness and sleep.

113 maged brain-wide hemodynamics in rats during wakefulness and sleep.

114 oratory behavior and REM sleep than in quiet wakefulness and slow wave sleep, behavioral states that

115 ny of fMRI activity in healthy humans during wakefulness and slow-wave sleep.

116 parameter for all brain nodes to best match wakefulness and slow-wave sleep.

117 e modifications and medications that promote wakefulness and suppress cataplexy.

118 AAR1 partial agonist RO5263397 also promoted wakefulness and suppressed nonrapid eye movement sleep.

119 ation, in contrast, initiated and maintained wakefulness and suppressed sleep and sleep-related nesti

120 TAAR1 agonism also increases wakefulness and suppresses rapid-eye movement (REM) slee

121 strated that these state transitions between wakefulness and unconsciousness were rapid and unstable.

122 been typically observed following prolonged wakefulness and widely used as a sleep homeostasis indic

123 inked with traumatic brain injury, prolonged wakefulness, and aging.

124 leep-wake cycle, sensory gain control during wakefulness, and consider evidence for cholinergic suppo

125 Dopamine (DA) promotes wakefulness, and DA transporter inhibitors such as dextr

126 p paralleled decreased NREM sleep, increased wakefulness, and more frequent awakenings.

127 l- and reward-directed and social behaviors, wakefulness, and sleep.

128 ty: locomotion, nonlocomotor movement, quiet wakefulness, and sleep; transitions occurred not randoml

129 Activating these neurons can lead to wakefulness, and the activity of these neurons is affect

130 neurons is necessary for the maintenance of wakefulness, and their silencing not only impairs arousa

131 y cortical substates during quiet and active wakefulness, and transitions in population activity duri

132 We show that sleep and wakefulness are accompanied by state-dependent changes i

133 Sleep and wakefulness are fundamental behavioral states of which t

134 Sleep and wakefulness are greatly influenced by various physiologi

135 wing exposure to intermittent hypoxia during wakefulness are positively associated with loop gain and

136 quences of place cell firing observed during wakefulness are reinstated ("replay") [3-5].

137 However, MCH cell dynamics during wakefulness are unknown, leaving it unclear if they diff

138 SBT and are extubated reach higher levels of wakefulness as indicated by the ORP, suggesting abnormal

139 lated brain regions that mediate arousal and wakefulness as well as the effect of opioids in sleep-re

140 Key secondary endpoints were maintenance of wakefulness assessed on the basis of the Oxford Sleep Re

141 relative to wild-type controls during quiet wakefulness at baseline and at elevated core body temper

142 ng the heterogeneities of stage N1 sleep and wakefulness before and after sleep.

143 es during rapid-eye movement (REM) sleep and wakefulness-behavioral states that do not naturally expr

144 However, besides prior wakefulness, brain function and cognition are also affec

145 EMENT We experience emotions not only during wakefulness but also during dreaming.

146 mation from the cortex to hippocampus during wakefulness, but in the reverse direction during slow-wa

147 ila, where brain activity appears similar to wakefulness, but responsiveness to external sensory stim

148 n-class agent utilizing histamine to improve wakefulness by acting as an antagonist/inverse agonist o

149 sistently dysregulated patterns of sleep and wakefulness by blunting serotonergic signaling in the la

150 suggest that GABAergic VTA neurons may limit wakefulness by inhibiting the arousal-promoting VTA glut

151 reotypical electroencephalography pattern of wakefulness by simply imposing a change in the extracell

152 two dominant mutations that affect sleep and wakefulness by using an electroencephalogram/electromyog

153 homeostatic recovery sleep, indicating that wakefulness can be dissociated from accrual of sleep nee

154 ed with different brain states (coma, sleep, wakefulness) can coexist within the same brain.

155 Surprisingly, the enhanced wakefulness caused by cholinergic stimulation was abolis

156 neurons depolarize during sleep to suppress wakefulness circuits.

157 Sleep and wakefulness control in the mammalian brain requires the

158 strate that hippocampal astrocytes sense the wakefulness-dependent activity of septal cholinergic fib

159 delivery to prefrontal cortex (PFC) restored wakefulness despite continuous administration of the gen

160 hich cholinergic stimulation of PFC produced wakefulness despite continuous exposure to a general ane

161 luding Arntl/Bmal1, suggesting that enforced wakefulness directly impacts the molecular clock machine

162 ured subjects in various states of conscious wakefulness, disconnected consciousness, and unconscious

163 glutamatergic neurons that increase sleep or wakefulness does not substantively influence anesthetic

164 : 63.6 (1.3) y)] underwent 40-h of sustained wakefulness during 3 balanced crossover segments, once u

165 Patient tolerance, wakefulness during sedation, and cooperation were simila

166 n causes excessive sleepiness and fragmented wakefulness during the nocturnal active phase.

167 For instance, compared to wakefulness, during non-rapid eye movement (NREM) sleep

168 o non-rapid eye movement (non-REM) sleep and wakefulness (each P < 0.05, n = 7).

169 Measurements were made during wakefulness, escalating and constant levels of two anest

170 arousal and that their inhibition suppresses wakefulness, even in the face of ethologically relevant

171 Human ventilatory activity persists, during wakefulness, even when hypocapnia makes it unnecessary.

172 Prolonged wakefulness exacerbates the production of amyloid-beta (

173 Rationale: Abnormal patterns of sleep and wakefulness exist in mechanically ventilated patients.

174 rapid eye movement sleep, and during evening wakefulness, experience more anger in dreams.

175 afish that generates short-term increases in wakefulness followed by sustained rebound sleep after wa

176 ypothalamus, which promote the transition to wakefulness from non-rapid eye movement (NREM) and rapid

177 BF-PV neurons produced rapid transitions to wakefulness from non-rapid eye movement (NREM) sleep but

178 ree component of neural activity, delineates wakefulness from propofol anesthesia, NREM and REM sleep

179 Critically, the spectral slope discriminates wakefulness from REM sleep solely based on the neurophys

180 nder homeostatic control, whereby increasing wakefulness generates sleep need and triggers sleep driv

181 In contrast, SW(opto) during wakefulness had no effect.

182 Rapid variations in cortical state during wakefulness have a strong influence on neural and behavi

183 increases transitions between NREM sleep and wakefulness, implicating cholinergic projections to cort

184 ingly, burst optogenetic stimulation induces wakefulness in accordance with previously described burs

185 deposition is enhanced by chronic increased wakefulness in animal models.

186 d eye movement sleep, and slightly increased wakefulness in both light and dark phases, whereas inhib

187 leep, which was consistent with decreases in wakefulness in C57BL/6Slac mice compared with their own

188 ation) before and after periods of sleep and wakefulness in humans (female and male participants).

189 Chemogenetically driven wakefulness in mice also significantly increased both IS

190 amine-associated receptor 1 (TAAR1) promote wakefulness in mice and rats, we evaluated whether TAAR1

191 increased acetylcholine levels and increased wakefulness in mice.

192 as indicated by the ORP, suggesting abnormal wakefulness in others.

193 suppressed despite pharmacologically induced wakefulness in the presence of anesthetic, with restorat

194 illate in mouse hippocampus as a function of wakefulness, in vitro and in vivo.

195 ribe the main modulatory drives of sleep and wakefulness, including homeostatic, circadian, and motiv

196 nputs inhibiting VTA(Vgat) neurons intensify wakefulness (increased activity, enhanced alertness and

197 y, which was similar to that observed during wakefulness induced after carbachol delivery to PFC.

198 xpected finding, but was not restored during wakefulness induced by carbachol delivery to PFC.

199 By contrast, wakefulness induced by nlp-2 overexpression is diminishe

200 This global wakefulness instability was mimicked with viral delivery

201 ctive sleep-promoting neurons that translate wakefulness into the depolarization of a sleep-active ne

202 cquisition of recovery sleep after prolonged wakefulness is an important issue in sleep research.

203 ORP), to determine whether abnormal sleep or wakefulness is associated with the outcome of spontaneou

204 Brain activity during wakefulness is characterized by rapid fluctuations in ne

205 Here we demonstrate that the level of wakefulness is critical for this arousal resetting of th

206 However, this increase is abolished when wakefulness is dominated by running wheel activity.

207 Wakefulness is driven by the widespread release of neuro

208 and cognition, but their role in regulating wakefulness is less clear.

209 systems and circuits that regulate sleep and wakefulness is often disrupted as part of the pathophysi

210 during REM sleep and during evening resting wakefulness is related to affective experiences in REM s

211 type-specific silencing of HA neurons during wakefulness is sufficient to not only impair arousal but

212 tion circuit for sleep-wake control in which wakefulness is supported by separate arousal and action

213 Prolonged wakefulness is thought to gradually increase 'sleep need

214 ed on is unclear because it is not known how wakefulness is translated into sleep-active neuron depol

215 ly control the generation and maintenance of wakefulness is unknown.

216 otional processing and emotion regulation in wakefulness-is related to dream emotions.

217 in non-REM (NREM) sleep and anesthesia than wakefulness, it is unknown how neuronal communication is

218 xcitation far better than inhibition; during wakefulness, it predicted them equally well, and visual

219 d in patients with heart failure (HF) during wakefulness, its persistence in an upright position is s

220 ction of sleep onset latency and increase in wakefulness later in the night may be related to the acu

221 Prolonged wakefulness leads to an increased pressure for sleep, bu

222 tivity strength directly proportional to the wakefulness level of the animal.

223 fluctuations in population synchrony during wakefulness modulate the accuracy of sensory encoding an

224 isomic Ts65Dn mouse model of DS during quiet wakefulness, natural sleep, and the performance of a mem

225 tion that the human ventilatory drive during wakefulness often results from a corticosubcortical coop

226 the effect of voluntary wheel running during wakefulness on neuronal activity in the motor and somato

227 We studied the effect of sleep and wakefulness on pattern separation (i.e., orthogonalizati

228 sure days (p = 0.002) with no differences in wakefulness or agitation.

229 y and are typically active during periods of wakefulness or arousal.

230 Pathological wakefulness or atypical sleep were highly prevalent, but

231 Thus, whether an animal exhibits wakefulness or not can be dissociated from cortical conn

232 e (up) and silent (down) states during quiet wakefulness or NREM sleep regulate fundamental cortical

233 during sharp-wave ripples observed in quiet wakefulness or slow wave sleep.

234 of the PB was highly effective in extending wakefulness over 4 days, although subsequent PB activati

235 tonic (median, 96% [86-120] vs. 75% [50-92] wakefulness; P = 0.01) but not phasic genioglossus activ

236 Following a 12-hour delay of sleep or wakefulness, participants completed an image recognition

237 We term this effect Prolonged Morning Wakefulness (PMW).

238 of interictal spikes during the last hour of wakefulness preceding sleep.

239 global neuronal activity during drug-induced wakefulness predicted the amount of subsequent rebound s

240 during REM sleep, and during evening resting wakefulness, predicted ratings of dream anger.

241 nd that acute silencing of HA neurons during wakefulness promotes slow-wave sleep, but not rapid eye

242 Wakefulness, rapid eye movement (REM) sleep, and non-rap

243 e of calcium transients was increased during wakefulness relative to an extremely low rate during ane

244 te to consolidating memories acquired during wakefulness remain unclear.

245 dulation of arousal states such as sleep and wakefulness remain unclear.

246 the intracellular mechanism regulating sleep/wakefulness remains unknown.

247 ng and decision making, control of sleep and wakefulness, sensory salience including pain, and the ph

248 tion of intermittent hypoxia during hours of wakefulness should be combined with continuous positive

249 12 sequential hours-capturing both sleep and wakefulness should be obtained to sufficiently sample th

250 rom a metabolic standpoint, induced extended wakefulness significantly reduced body weight and leptin

251 external driven stimulation in, for example, wakefulness, sleep, coma, or neuropsychiatric diseases.

252 e patients: 72 vegetative state/unresponsive wakefulness state (VS/UWS), 36 minimally-conscious state

253 y conscious state (MCS) and the unresponsive wakefulness syndrome (UWS) is a persistent clinical chal

254 getative state (VS)-also coined unresponsive wakefulness syndrome (UWS)-and minimally conscious state

255 (DoC) such as vegetative state/unresponsive wakefulness syndrome (VS/UWS) or minimally conscious sta

256 27 patients in vegetative state/unresponsive wakefulness syndrome (VS/UWS; n = 70) and minimally cons

257 te compared to vegetative state/unresponsive wakefulness syndrome encompassed bilateral auditory and

258 sed to be vigilant but unaware (Unresponsive Wakefulness Syndrome) and 17 patients revealing signs of

259 8 patients (11 vegetative state/unresponsive wakefulness syndrome, VS/UWS, and 7 minimally conscious

260 ious state and vegetative state/unresponsive wakefulness syndrome.

261 e algorithmically identify a theta-dominated wakefulness (TDW) substate underlying motivated behavior

262 ep latency <25 minutes on the Maintenance of Wakefulness Test (MWT), Epworth Sleepiness Scale (ESS) s

263 Coprimary endpoints (Maintenance of Wakefulness Test sleep latency and Epworth Sleepiness Sc

264 rate fluctuations) was globally stronger in wakefulness than in NREM sleep (with distinct traits for

265 d rats required more stimulation to maintain wakefulness than VEH- or ALM-treated rats.

266 ioning these neurons produced an increase in wakefulness that persisted for at least 4 months.

267 r the FG hypothesis and propose that, during wakefulness, the degradation of accumulating fragments i

268 In wakefulness, the ventilatory response to normoxic hyperc

269 aled that short Abeta oligomers induce acute wakefulness through Adrenergic receptor b2 (Adrb2) and P

270 id eye movement (REM) sleep-active, produced wakefulness through projections to the nucleus accumbens

271 e Drosophila model to map starvation-induced wakefulness to a single pair of peptidergic neurons and

272 ability to reversibly switch the brain from wakefulness to a state of unconsciousness, knowing how a

273 The mechanisms linking extended wakefulness to clock-gene expression are, however, not w

274 this novel and noninvasive model of induced wakefulness to explore the EEG and metabolic consequence

275 The transition from wakefulness to general anesthesia is widely attributed t

276 enioglossus muscle activity that occurs from wakefulness to non-REM sleep and reduces airway collapsi

277 rmal reduction of genioglossus activity from wakefulness to non-REM sleep that occurred on the placeb

278 state of arousal leading to transition from wakefulness to sleep and it is further considered to be

279 From wakefulness to sleep, and from moment to moment, the aro

280 k and suggest that a transitional state from wakefulness to unconsciousness is not a continuous proce

281 ween damped to sustained oscillations during wakefulness, to a stable focus during slow-wave sleep.

282 movement (NREM) sleep but did not affect REM-wakefulness transitions.

283 timulation in 22 participants during 29 h of wakefulness under constant conditions.

284 sleep/wake cycle prior to 24 h of continual wakefulness under highly controlled environmental condit

285 less, the clinical measures of awareness and wakefulness upon which differential diagnosis rely were

286 use ISF tau was increased ~90% during normal wakefulness versus sleep and ~100% during SD.

287 ABAergic neurons are maximally active during wakefulness (wake-max).

288 TSD period, but increased significantly when wakefulness was extended beyond 16 h.

289 Baseline wakefulness was modestly increased in OE compared with W

290 Conversely, for rats in which wakefulness was not restored, the functional gamma conne

291 The increase that was observed after 52 h of wakefulness was restored to control levels during a 14-h

292 n of consciousness (27 of 37, 73%), abnormal wakefulness when sedation was stopped (15 of 37, 41%), c

293 prolonged cortical activation and behavioral wakefulness, whereas inhibition reduced wakefulness and

294 of SuM(Nos1/Vglut2) neurons potently drives wakefulness, whereas inhibition reduces REM sleep theta

295 etic activation of PBel(CGRP) neurons caused wakefulness, whereas optogenetic inhibition of PBel(CGRP

296 TAAR1 overexpression modestly increases wakefulness, whereas TAAR1 partial agonism increases wak

297 EEG responses in association cortices during wakefulness, which were attenuated and restricted to aud

298 esia represents a unique state that combines wakefulness with clinically relevant anesthetic concentr

299 at a period of post-training rest (eg, quiet wakefulness with eyes closed) provides a similar memory

300 gic (VTA(Vgat)) neurons generated persistent wakefulness with mania-like qualities: locomotor activit