ライフサイエンスコーパス: water channel

1 on a flat plate in a low-turbulence laminar water channel.

2 g serine phosphorylation associated with the water channel.

3 to mediate opening and closing of the buried water channel.

4 the network of hydrogen bonds in the buried water channel.

5 ransmembrane helix is eliminated to open the water channel.

6 s nor selected point mutations activated the water channel.

7 he methyl positioned to block formation of a water channel.

8 position, which forbids the formation of the water channel.

9 lm in direct contact with a tortuous flowing water channel.

10 pairs of active sites controlled by a unique water channel.

11 r switches for the formation of a continuous water channel.

12 es against aquaporin-4 (AQP4), an astrocytic water channel.

13 ps lining the water channels than within the water channels.

14 arene (PAH[4]), as a new class of artificial water channels.

15 eled by downregulation of aquaporin-2 (AQP2) water channels.

16 ironmental regulation and involves aquaporin water channels.

17 density of reconstituted aquaporin-0 (AQP0) water channels.

18 ciency of the major ocular surface aquaporin water channels.

19 r molecule, which is comparable to aquaporin water channels.

20 ivated MAPKAP kinases, or ion, glycerol, and water channels.

21 tibody targets astrocytic aquaporin-4 (AQP4) water channels.

22 odium counterions that are arrayed along the water channels.

23 tructure with pores formed by two interwoven water channels.

24 amorphous extracellular matrix with profound water channels.

25 ansferases is determined by the formation of water channels.

26 belongs to the growing list of NH3-permeable water channels.

27 ions and small molecules, can also behave as water channels.

28 This gives rise to a powerful synthetic water channel able to transport water at a speed of ~3 x

29 ductance (IC50 of 14 muM), with no effect on water channel activity (at up to 200 muM).

30 demonstrated that SlPIP2s protein displayed water channel activity and facilitated water transport i

31 nd oocyte swelling assays showed that PIP2;5 water channel activity is negatively affected by SYP121-

32 d down-regulation of both the expression and water channel activity of AQP4 is likely to originate fr

33 e, we report that the post-Golgi traffic and water channel activity of PIP2;5 are regulated by the SN

34 We demonstrate that FaPIP1;1 has a high water channel activity when coexpressed as well as how P

35 of 10xHis-OsPIP1;3 in liposomes demonstrated water channel activity, as revealed by stopped-flow ligh

36 In addition to a constitutive water channel activity, several studies suggest Aquapori

37 ctively inhibit the ion channel, but not the water channel, activity of AQP1.

38 n was held fixed, water molecules inside the water channel adopted the same positions as observed in

39 , we examined the role of aquaporin-4 (AQP4) water channels after experimental contusion injury in mi

40 Aquaporins (AQPs) are water channels allowing fast and passive diffusion of wa

41 The presence of a water channel allows dissociation of a proton to the sol

42 The water channel allows proton dissociation from both LSMT.

43 A subgroup of AQP water channels also facilitates transmembrane diffusion

44 ddition, the dimensionality of the synthetic water channels also imposes engineering difficulties to

45 lts confirm that AQP1 can function as both a water channel and a gated ion channel.

46 bonds, modifying the local architecture of a water channel and the interaction of second coordination

47 hioisatinate to a proton wire in an adjacent water channel and thus allows the proton released by the

48 f membrane transporters, including aquaporin water channels and sugar transporters, and mycorrhiza-in

49 minate in the phosphorylation of aquaporin-2 water channels and their redistribution from intracellul

50 aporins (AQPs), lens-specific AQP0 is a poor water channel, and its permeability was reported to be p

51 crystal water that is part of a proton wire water channel, and this syn beta-elimination reaction is

52 AQP1 is a water channel, and under permissive conditions, a nonsel

53 omplex, lysine deprotonation through dynamic water channels, and a nucleophilic substitution (SN2) tr

54 in activation kinetics, protonation states, water channels, and active-site accessibility between OT

55 The water channel appears in the presence of AdoMet (LSMT.Ly

56 The water channel appears in the presence of AdoMet, but is

57 wers the pK(a) of the Lys-NH(3)(+) entity, a water channel appears, and the proton escapes to the aqu

58 ing either the potassium channel KvAP or the water channel AQP0 to form membrane nanotubes with contr

59 responding residues in the high-permeability water channel AQP1 have additive effects and together in

60 of vesicles contain three proteins (ie, the water channel AQP1, the chloride channel CFTR, and the a

61 and Hsc70; and can directly ubiquitylate the water channel AQP2 in vitro shRNA knockdown of CHIP in C

62 In summary, these data suggest that the water channel AQP2 interacts with integrins to promote r

63 A total of 131 proteins, including the water channel AQP2, exhibited significant changes in abu

64 We conclude that the water channel AQP4 confers partial protection against ce

65 nic autoantibodies targeting the aquaporin-4 water channel (AQP4).

66 65, amphiphysin); glycine receptors (GLY-R); water channels (AQP4).

67 , we show that GABA(A)Rs colocalize with the water channel aquaporin (AQP) 4 in prominin-1 immunoposi

68 hereas the mobility of the curvature-neutral water channel aquaporin 0 (AQP0) is insensitive to it.

69 The water channel aquaporin 1 (AQP1) and certain Rh-family m

70 colocalization studies that OEG express the water channel aquaporin 1 (AQP1), both in vivo and in vi

71 re associated with the overexpression of the water channel aquaporin 1, which was prevented by reacti

72 ew class of MRI reporters based on the human water channel aquaporin 1.

73 e localization of the vasopressin-responsive water channel aquaporin 2 compared with wild-type mice.

74 it Barttin, the urea transporter-A1, and the water channel aquaporin 2, all of which are regulated by

75 calcium-activated potassium channel and the water channel aquaporin 2, and improved polyuria and hyp

76 odies targeting the collecting duct-specific water channel aquaporin 2, whereas autoantibodies of the

77 ve synergistic cooperation between the glial water channel aquaporin 4 (AQP4) and the transient recep

78 Water channel aquaporin 4 (AQP4) plays a key role in the

79 in water homeostasis.SIGNIFICANCE STATEMENT Water channel aquaporin 4 (AQP4) plays a key role in the

80 berrant antibody responses to the astrocytic water channel aquaporin 4 have been described.

81 including mislocalization of the astrocytic water channel aquaporin 4 persisted long after injury, r

82 NMO-IgG reacts with the water channel aquaporin 4.

83 By contrast, expression of TMEM16A, the water channel aquaporin 5 (AQP5), and other regulators o

84 nducting subfamily into the Escherichia coli water channel aquaporin Z (AqpZ).

85 hannel-forming proteins in the eye lens, the water channel aquaporin-0 (AQP-0) and the connexins Cx46

86 rystallographic studies of the lens-specific water channel aquaporin-0 (AQP0) revealed atomistic view

87 Water channel aquaporin-1 (AQP1) is expressed at epithel

88 bitors of carbonic anhydrase enzymes and the water channel Aquaporin-1 for targeting this subpopulati

89 Regulation in the exosomal sorting of the water channel aquaporin-1 represents a newly described m

90 ns interact with phosphorylated forms of the water channel aquaporin-2 (AQP2) and modulate its functi

91 The interaction between the renal water channel aquaporin-2 (AQP2) and the lysosomal traff

92 V2 receptors promotes redistribution of the water channel aquaporin-2 (AQP2) from intracellular vesi

93 the basis of cell-specific expression of the water channel aquaporin-2 (AQP2) in the renal collecting

94 n part, by controlling the abundances of the water channel aquaporin-2 (AQP2) protein and regulatory

95 tion largely through actions to regulate the water channel aquaporin-2 in collecting duct principal c

96 Here we report that the water channel Aquaporin-3 (AQP3) can facilitate the upta

97 changes in the expression of the astrocytic water channel aquaporin-4 (AQP4) and changes in glymphat

98 Autoantibodies against astrocyte water channel aquaporin-4 (AQP4) are highly specific for

99 Autoantibodies against astrocyte water channel aquaporin-4 (AQP4) are thought to be patho

100 The shorter "M23" isoform of the glial cell water channel aquaporin-4 (AQP4) assembles into orthogon

101 (NMO-immunoglobulin [Ig]G) against astrocyte water channel aquaporin-4 (AQP4) cause complement- and c

102 The water channel aquaporin-4 (AQP4) forms supramolecular cl

103 The astrocyte water channel aquaporin-4 (AQP4) is expressed as heterot

104 s fluid transport system is supported by the water channel aquaporin-4 (AQP4) localized to vascular e

105 evidence suggests that the Muller/glial cell water channel aquaporin-4 (AQP4) modulates K(+) channel

106 ssion and cellular localization of the brain water channel aquaporin-4 (AQP4) was investigated during

107 ic IgG autoantibodies (NMO-IgG) to astrocyte water channel aquaporin-4 (AQP4).

108 MO-immunoglobulin G [IgG]) against astrocyte water channel aquaporin-4 (AQP4).

109 lterations, and maintained expression of the water channel aquaporin-4 at astrocytic perivascular end

110 nock-out of the gene encoding the astroglial water channel aquaporin-4, which is importantly involved

111 This biomarker targets the water channel aquaporin-4, which is lost in neuromyeliti

112 pathogenic autoantibodies against astrocyte water channel aquaporin-4.

113 o)/D of 2.9+/-0.3) in mice lacking the glial water channel aquaporin-4.

114 tin-immunopositive glia whereas GFAP and the water-channel aquaporin 4 were found at the periphery.

115 mbrane proteins, including the AVP-regulated water channel, aquaporin 2.

116 Moreover, mRNA expression of water channel, aquaporin 4 (AQP4) was increased after Dp

117 ansporter (EAAT2) and the astrocyte-specific water channel, aquaporin 4 (AQP4).

118 s in guard cell volume, the role of membrane water channels (aquaporins) has remained hypothetical.

119 ctural and functional features of biological water channels (aquaporins).

120 is evidence from other species that cellular water channels, aquaporins (AQP), are central to both pr

121 re, we show that increased expression of the water channel Aquoporin-1 is responsible for the deleter

122 ilic peptide loops of the aquaporin-4 (AQP4) water channel are delivered to cytosolic and lumenal com

123 Aquaporin-1 (AQP1) water channels are expressed in the plasma membrane of d

124 Aquaporin-4 (AQP4) water channels are expressed strongly in glial cells, wh

125 Aquaporin-1 (AQP1) water channels are expressed widely in organ and tumor m

126 Aquaporin (AQP) water channels are found throughout nature and confer hi

127 Artificial water channels are synthetic molecules that aim to mimic

128 g structures in a lipid bilayer, we mapped a water channel as one of the half-channels.

129 fic residue, E(52)[beta], which is part of a water channel at the subunit interface for rapid proton

130 The effective size of the Nafion water channels at various hydration levels are estimated

131 orter 1 (SGLT1) and of aquaporin 1 (Aqp1), a water channel, at the attachment site.

132 er mediated by pathogenic aquaporin-4 (AQP4) water channel autoantibodies (AQP4-IgG).

133 Here, we show that AQP2 is not only a water channel but also an integrin-binding membrane prot

134 quential sites within TM2 of the aquaporin-1 water channel by in vitro translation of truncated mRNAs

135 actant mesophase which forms 2.3 nm diameter water channels by lyotropic self-assembly.

136 Inhibition of aquaporin water channels by mercuric chloride eliminates XA21-medi

137 ave provided evidence for the involvement of water channels, called aquaporins.

138 opy (FFEM) indicates that aquaporin-4 (AQP4) water channels can assemble in cell plasma membranes in

139 and permeability changes indicate that hAQP1 water channels can transit from a high-water-permeabilit

140 The structure shows a buried water channel capable of facilitating peroxide access to

141 proton collection and timely closure of the water channel, conformational dynamics after photolysis

142 ng of the ligands induces different receptor water channel conformations to previously published stru

143 ary or inflammation-related abnormalities in water channels contribute to the exocrinopathy.

144 ed the expression of aquaporin 4, astrocytic water channels coupled to K(+) channels.

145 work revealed that aquaporin 5 expression, a water channel critical for salivary gland fluid secretio

146 l phase, in which hexagonal arrays of 3.4-nm water channels defined by lipid tubes are formed.

147 r data show that substrate discrimination in water channels depends on a complex interplay between th

148 The water channel does not appear for proton dissociation fr

149 ever, this reaction does not occur because a water channel does not form to allow the proton dissocia

150 The formation of a water channel does not occur on formation of the SET7/9.

151 Teashirt controls the expression of the water channel Drip, the chloride conductance channel CLC

152 eu(25), Tyr(108), and Phe(253) The resulting water channel enables the binding/dissociation of the Na

153 Aquaporin-4 (AQP4) is the major water channel expressed at fluid-tissue barriers through

154 Aquaporin-4 (AQP4), a water channel expressed in astrocytes, plays a key role

155 e serum antibodies targeting the aquaporin-4 water channel expressed on the end-feet of astrocytes.

156 The aquaporin 2 (AQP2) water channel, expressed in kidney collecting ducts, con

157 dditionally suggests that aquaporin-4 (AQP4) water channels facilitate convective transport through b

158 Aquaporin (AQP) water channels facilitate water transport across cell me

159 ytes, overexpression of ion transporters and water channels facilitates fluid secretion into the cyst

160 Tetramers of aquaporin-4 (AQP4) water channels form supramolecular assemblies in cell me

161 ed for three-dimensional tower structure and water channel formation.

162 Human aquaporin 2 (AQP2) is a water channel found in the kidney collecting duct, where

163 Aquaporin-4 water channel gene deletion caused significant extracell

164 evealed a complete loss of expression of the water-channel gene Aqp2 in PKA knockout cells.

165 itis optica) a serum antibody to aquaporin-4 water channels has been detected.

166 e spatially heterogeneous diffusivity across water channels has never been shown to directly influenc

167 and that Aqp0b, though possibly a secondary water channel, has an unidentified function in the lens.

168 At 20 vol% water, the water channels have diameters of between 1.8 and 3.5 nm,

169 ter region of the channel approaches that of water, channel hydrophilicity dominated water conduction

170 s bacopaside II selectively blocked the AQP1 water channel (IC50 18 muM) without impairing the ionic

171 lowing events occur: (i) the appearance of a water channel, (ii) a depronation of p53-Lys4-NH 3 (+) v

172 Aquaporin-4 (AQP4), the principal water channel in astrocytes, is involved in brain water

173 lon, our results uncover a potential role of water channel in blood CO2 transport and respiration.

174 rin-1 and band 3 reveals a potential role of water channel in blood CO2 transport.

175 Aquaporin-4 (AQP4), the primary water channel in glial cells of the mammalian brain, pla

176 hrough its joining the aquaporin family as a water channel in its own right and discuss how regulatio

177 In addition to its function as a water channel in maintaining fluid homeostasis, AQP1 als

178 at regulate the abundance of the aquaporin-2 water channel in renal collecting duct cells.

179 isoform 4 (TRPV4) and the aquaporin 4 (AQP4) water channel in retinal Muller cells.

180 There is no water channel in the absence of AdoMet.

181 lore the role of an astrocyte-specific major water channel in the brain, aquaporin-4 (AQP4), in brain

182 -specific autoantibody to AQP4, the dominant water channel in the central nervous system densely expr

183 Aquaporin-4 (AQP4) is the major water channel in the CNS and is primarily expressed in a

184 ently, aquaporin-4 (AQP4), the most abundant water channel in the CNS, was identified as its target a

185 Aquaporin (AQP) 4 is the predominant water channel in the mammalian brain, abundantly express

186 Aquaporin-4 (AQP4) is the primary water channel in the mammalian brain, particularly abund

187 the enzyme, followed by attack by H2O via a water channel in the protein.

188 fiber cells, not only serves as the primary water channel in this tissue but also appears to mediate

189 A-tag at its N terminus converted Aqp0b to a water channel in Xenopus oocytes.

190 erize macrophage activation, but the role of water channels in inflammation remains unclear.

191 tional studies that have identified putative water channels in Photosystem II.

192 regulated trafficking of aquaporin-2 (AQP2) water channels in renal collecting duct epithelial cells

193 ulin G (NMO-IgG) binds to aquaporin-4 (AQP4) water channels in the central nervous system leading to

194 ese residues may be in contact with putative water channels in the photosystem.

195 a depronation of p53-Lys4-NH 3 (+) via this water channel into the aqueous solvent, and (iii) AdoMet

196 f the mitochondrial inner membrane through a water channel into the hydrogen bond network.

197 asma membrane assembly of aquaporin-4 (AQP4) water channels into orthogonal arrays of particles (OAPs

198 The aquaporin-1 (AQP1) water channel is a potentially important drug target, as

199 We suggest that the geometry of the water channel is an important feature for the molecular

200 lockage of spontaneous proton back-leak, the water channel is closed upon O2 binding to the second he

201 That the formation of a water channel is combined with AdoMet binding was first

202 The lack of formation of a water channel is due to the positioning of the methyl su

203 We find that a water channel is formed to allow escape of the proton to

204 A water channel is not formed in the ground state of SET7/

205 It was found that the appearance of a water channel is required for the stepwise methylation b

206 A central water channel is separated from two outer channels beari

207 The astrocytic aquaporin-4 (AQP4) water channel is the target of pathogenic antibodies in

208 estimated antimicrobial occupation in these water channels is nonlinear and jumps from approximately

209 Aquaporin-1 (AQP-1), the universal water channel, is responsible for rapid response of cell

210 nal H(II) phase, which consists of arrays of water channels, is induced by a small number of antimicr

211 ht include interactions with aquaporin (AQP) water channel isoforms, although the proposed requiremen

212 Aquaporins (AQPs) are biological water channels known for fast water transport ( approxim

213 including those induced by pathogens and the water-channel LeAqp2 gene.

214 rom approximately 1 to 3 per 4 nm of induced water channel length as the global antimicrobial concent

215 gGs) directed against the aquaporin-4 (AQP4) water channel located on astrocyte foot processes in the

216 t the two isoforms of the aquaporin-4 (AQP4) water channel may determine the fate of gliomas.

217 kcal/mol) corresponded to that reported for water-channel-mediated water transport in lipid membrane

218 This work widens the choice of water channel morphologies for water desalination applic

219 The detected pores had a water channel of radius 23-33 A.

220 ing to astrocytic aquaporin 4, the principal water channel of the central nervous system, is detected

221 se results suggest that Aqp0a is the primary water channel of the lens and that Aqp0b, though possibl

222 e proton-transfer kinetics in the nanoscopic water channels of Nafion fuel cell membranes at various

223 es having three-dimensionally interconnected water channels of uniform diameter, with reproducible gl

224 hogenic antibodies targeting the aquaporin-4 water channel on astrocytes are associated with relapsin

225 forms a gate that opens to form a continuous water channel only upon receptor activation.

226 Aquaporin-1 (AQP1) is a water channel, overexpressed in cirrhosis, that promotes

227 Calculation of the unitary water channel permeability, pf, yielded similar values f

228 d environment provides a means of regulating water channel permeability.

229 transcript abundance suggest that aquaporin water channels play a role in these processes.

230 horylation and activation of the aquaporin-2 water channel present in the principal cells of the coll

231 a coniferous tree which displays remarkable water channelling properties.

232 lating IgG1 antibodies against the astrocyte water channel protein aquaporin 4 (AQP4) and the evidenc

233 renal collecting duct cells to regulate the water channel protein aquaporin-2.

234 PDZ domain-ligand interaction involving the water channel protein aquaporin-2.

235 The glial water channel protein aquaporin-4 (AQP4) forms heterotet

236 The water channel protein aquaporin-4 (AQP4) is expressed in

237 hogenic autoantibodies against the astrocyte water channel protein aquaporin-4 (AQP4).

238 Abs, termed NMO-IgG, against the astrocytic water channel protein aquaporin-4.

239 ciated with autoantibodies against the glial water channel protein aquaporin-4.

240 Aquaporin-4 (AQP4) is a water channel protein expressed in astrocytes throughout

241 d protein, implicating a biological role for water channel protein function during invasion.

242 argets aquaporin-4 (AQP4), the most abundant water channel protein in the CNS, which is highly concen

243 ract more extensively with MAL than does the water channel protein not phosphorylated at this serine.

244 Induction of an astrocytic water channel protein, Aquaporin 4 (AQP4), is known to p

245 2) in the mRNA and protein expression of the water channel protein, aquaporin 4 in these mice.

246 kidney collecting duct system including the water channel protein, Aquaporin-3 and the tight junctio

247 ted an upregulation of aquaporin-4 (AQP4), a water channel protein, following brain injury.

248 ck-polymer vesicles containing the bacterial water-channel protein Aquaporin Z (AqpZ) were investigat

249 mutations were identified in AQP5, encoding water-channel protein aquaporin-5 (AQP5).

250 ies to aquaporin 4 (AQP4), the most abundant water-channel protein in the central nervous system.

251 re size, and polarity, and that using single water channel proteins as representative models has led

252 y: previous studies on single representative water channel proteins suggest narrow channels conduct w

253 Aquaporins (AQPs) are water channel proteins that are essential in biological

254 Aquaporins are water channel proteins that mediate the fine-tuning of c

255 Ps) are a ubiquitous family of transmembrane water channel proteins.

256 discusses the importance of the three brain water-channel proteins (AQP1, AQP4, AQP9) in brain physi

257 Aquaporins (AQPs) are integral membrane water channels, recognized for their importance in epith

258 e of the protein channels in these synthetic water channels remains a challenge.

259 The aquaporins are a family of membrane water channels, some of which also transport glycerol.

260 Aquaporin-4 (AQP4) water channel-specific IgG distinguishes neuromyelitis o

261 l as in individual thicker "ropes" that span water channels, suggesting that DNA could be imparting s

262 long parallel but otherwise randomly packed water channels surrounded by partially hydrophilic side

263 this report, we present the first synthetic water channel system with intriguing aquaproin-like feat

264 Among the currently available synthetic water channel systems, none possesses water transport pr

265 luorocarbon and the acidic groups lining the water channels than within the water channels.

266 proton relay that directs these protons to a water channel that connects the active sites on the subu

267 aporin-2 (AQP2) is the vasopressin-regulated water channel that controls renal water reabsorption and

268 breaks this ionic lock, forming a continuous water channel that leads to P2Y1 R activation.

269 uB induces the conformational changes of the water channel that stimulate the proton collection, and

270 the NADH-binding pocket and establishing the water channels that connect the active site to the centr

271 d to the active site for water oxidation via water channels that lead from the surface of the protein

272 ar pulsation, and is dependent on astroglial water channels that line paravascular CSF pathways.

273 Aquaporins (AQPs) are water channels that mediate a variety of biological proc

274 This also defines the proximal (presumably water) channel that opens in CYP46A1 upon substrate bind

275 The formation, or not, of a water channel, the distance between Sdelta(AdoMet) and N

276 Without a water channel, the substrate p53-Lys4-N(Me)H is not avai

277 lets may fuse together to form intralamellar water channels, thereby providing a pathway for the perm

278 through regulation of the aquaporin-2 (AQP2) water channel. This action is widely accepted to be asso

279 or intracellular organisation with nanoscale water channels threading between macromolecular regions

280 aquaporin 2 followed by trafficking of this water channel to the apical membrane of principal cells

281 l gene transfer of human aquaporin-1 (hAQP1) water channels to the liver of 17alpha-ethinylestradiol-

282 e hypertonic challenge on AQP2 (aquaporin-2) water channel trafficking.

283 d collecting ducts or decreases in aquaporin water channel type 2 levels.

284 Aquaporins (AQPs) are transmembrane water channels ubiquitously expressed in mammalian tissu

285 restriction, and the abundance of renal AQP2 water channels was reduced, implying that vasopressin ac

286 ut the expression of endothelial aquaporin-1 water channels was unaltered.

287 molecular strategy for constructing abiotic water channels, we demonstrate that a 20% enlargement in

288 iated with disrupted polarization of ion and water channels, we hypothesized that adhesion of astrocy

289 Synthetic water channels were developed with an aim to replace aqu

290 The pores of these water channels were found to be critically narrow in thr

291 Full-length Aqp0a is a functional water channel when expressed in Xenopus oocytes and in y

292 sidues to induce membrane expression of this water channel when VP signalling is defective.

293 e distinct aquaporin subfamily contains pure water channels, whereas a second subfamily contains chan

294 ar dynamics simulations revealed an extended water channel with additional water molecules bridging t

295 We report artificial imidazole-quartet water channels with 2.6 A pores, similar to AQP channels

296 l 1 the fastest among the existing synthetic water channels with high selectivity.

297 of ECS properties in adult mice lacking AQP4 water channels with wild-type animals and demonstrates a

298 ion films, are elongated and parallel to the water channels, with cross-sections of approximately (5

299 is confirmed by the distribution of the AQP1 water channel within endothelial membranes.

300 mental results indicate that the size of the water channel within water swollen P(AM-co-IA) hydrogel