ライフサイエンスコーパス: water solubility

1 its applications are restricted by its poor water solubility.

2 verlooked in previous studies because of its water solubility.

3 produce operations are limited by their low water solubility.

4 through a change in chain conformation or in water solubility.

5 sibility and, after hydroxylation, long-term water solubility.

6 upramolecular polymer assemblies that retain water solubility.

7 nt grains, probably because of their limited water solubility.

8 alpha-helical conformations without loss of water solubility.

9 e in the environment because of their higher water solubility.

10 f adenosine receptor antagonists, is the low water solubility.

11 d volume slightly in excess of the predicted water solubility.

12 , with two propyloxyammonium side chains for water solubility.

13 of membrane-bound hydrogenases (MBHs), poor water solubility.

14 vel A 2A receptor antagonists with excellent water solubility.

15 amine sites per molecule, which resulted in water solubility.

16 eir Henry's Law constant, vapor pressure and water solubility.

17 equires facile provisions for imparting high water solubility.

18 d/or overall molecular properties related to water solubility.

19 ake and molecular properties associated with water solubility.

20 toxicity for substrate or aglycon, and good water solubility.

21 ly eliminated from the body due to increased water solubility.

22 ial redesign of the sequence so as to confer water solubility.

23 me increasingly lipophilic while maintaining water solubility.

24 epare artemisinin O-glycosides with improved water solubility.

25 minimal aggregation in water, and excellent water solubility.

26 possessing greater bioactivity and improved water solubility.

27 s being nuclease resistant, can display good water solubility.

28 use of its difficult synthesis and very poor water solubility.

29 that would either act as prodrugs or confer water solubility.

30 croliter g(-1) min(-1), compatible with high water solubility.

31 e important property of measurable monomeric water solubility.

32 ure of these lipids is their relatively high water solubility.

33 th minimal cellular toxicity and appreciable water solubility.

34 tate, compared to PNQX, leading to increased water solubility.

35 s, rapid pharmokinetics, and relatively high water solubility.

36 f reactions including compounds with limited water solubility.

37 val in suspension, STAT3 phosphorylation and water solubility.

38 erial activities with significantly improved water solubility.

39 e in water, while nitrone 4 exhibited a poor water solubility.

40 and emission, high photostability, and good water solubility.

41 ent an effective method to overcome the poor water solubility.

42 including fluorescence, and their excellent water solubility.

43 des has been limited by its toxicity and low water solubility.

44 Both complexes show good water solubility.

45 /sulfonic acid derivative 3 showed excellent water solubilities.

46 lkali metal salts surprisingly displayed low water solubilities.

47 rials shown by FTIR, justify the increase in water solubility [0.072 (0.007) mg.mL(-1)] compared to t

48 rrolo[2,3-d]pyrimidine (16c) (IC50= 3 nM and water solubility = 32 +/- 9 microg/mL at pH 7.4), was fu

49 gonists; however, they display uniquely high water solubility (43 mM for 11).

50 Sulfonated molecules exhibit high water solubility, a property that is valuable for many b

51 An undesired property of ZnPT is its poor water-solubility, a problem that currently affects a lar

52 application is sometimes limited due to poor water solubility, aggregation, photodegradation, and slo

53 derivatives exhibit progressively increasing water solubility along with progressive decreases in cel

54 Less-oxidized oxygenated OA has the lowest water-solubility among all secondary OA factors, which a

55 eCF506 exhibits excellent water solubility, an optimal DMPK profile and oral bioav

56 Because of their low water solubilities and their tendency to persist and con

57 operties [color, porosimetry, crystallinity, water solubility and absorption, pasting properties, rec

58 The macrocycles have good water solubility and are readily characterized by standa

59 ) oligomers, as PEG substituents can improve water solubility and bioavailability, while retarding cl

60 +) ion binding and the glyco-moiety to bring water solubility and biocompatibility.

61 on cage was hydroxylated to provide improved water solubility and biodistribution.

62 ature at physiological pH, resulting in good water solubility and cell-permeability, (2) an alkyne gr

63 and Skp2, in HEK 293 cells, confirming good water solubility and cell-permeability.

64 development through optimized lipophilicity, water solubility and charged van der Waals surface area.

65 ogical challenges mainly related to its poor water solubility and chemical instability.

66 ave narrow polydispersity indices, to impart water solubility and chemical sensitivity toward targete

67 oss of side chains neutral sugars, increased water solubility and decreased molar mass.

68 As expected, the OH groups improved the water solubility and decreased the lipophilicity of the

69 ositive allosteric modulator (PAM) with good water solubility and demonstrating consistent activity a

70 nds of a short PEG chain, where PEG promotes water solubility and DHLA provides anchoring onto the QD

71 yl or pyrazin-2-ylmethyl congeners increased water solubility and enhanced affinity for the human SRI

72 This compound possessed high water solubility and exhibited good metabolic profiles.

73 ptide BBAT1 which possessed greatly improved water solubility and formed discrete trimers.

74 The resulting compounds have better water solubility and generally lower log P values and me

75 ed or charged, dramatically increasing their water solubility and greatly altering the film propertie

76 rge percentage of drug compounds exhibit low water solubility and hence low bioavailability and thera

77 g to a release dynamics dependent on the low water solubility and high hydrophobicity of felodipine.

78 ave limited clinical utility because of poor water solubility and high systemic toxicity.

79 Derivative 18 showed water solubility and higher metabolic stability than 5 i

80 d by pyridine and pyrazine not only enhances water solubility and hydrogen bonding capacity as expect

81 The water solubility and hydrophilicity of GG were significa

82 ad-spectrum anti-tumor effects, but its poor water solubility and incompetent targeting property larg

83 s of measurements of water binding capacity, water solubility and intrinsic viscosity, that OSA addit

84 < 0.05) with physicochemical parameters like water solubility and log KOW.

85 al formulations is limited due to their poor water solubility and low bioaccessibility/bioavailabilit

86 However, its poor water solubility and low oral bioavailability (F) in rat

87 iletin (NOB), a flavonoid, has extremely low water solubility and low oral bioavailability; however,

88 hurdle; however, its use is limited by poor water solubility and low permeability.

89 for other flavonoids that also show both low water solubility and low permeability.

90 active ASBT inhibitor while also increasing water solubility and maintaining potency.

91 philic (cLogD = 5.01), which compromises its water solubility and may adversely affect its pharmacoki

92 x, which was manifested in moisture content, water solubility and mechanical properties of the result

93 rtebrates and fish toxicity data, as well as water solubility and melting point values, were collecte

94 e yielded CDs with high photostability, good water solubility and minimum by-products.

95 To enhance the water solubility and oral bioavailability of DCK analogu

96 To increase water solubility and oral bioavailability, the N,N-dimet

97 , the biopharmaceutical challenges like poor water solubility and permeability of the drugs, along wi

98 ied to enhance hydrolysis included increased water solubility and polyester hydrophilicity as well as

99 did not have efficacy in vivo due to its low water solubility and poor bioavailability.

100 hyl-4-methyl-DCK (4a), it provides increased water solubility and possible linkage to other moieties.

101 n solution to BODIPY photocages that imparts water solubility and provides control over cellular perm

102 detection limit (30 nM for Cys), appreciable water solubility and rapid response time (within 2 min f

103 rrocene fragment leads to the improvement of water solubility and reactivity in vitro but also decrea

104 peroxides, which are expected to have higher water solubility and reactivity, has not been examined.

105 as a pharmacokinetic modifier to improve the water solubility and renal clearance of three hydrophili

106 and tri-PEG chlorin conjugates increased the water solubility and sensitivity to hydrolysis and uptak

107 comparison to ABT-526, ABT-510 has increased water solubility and slower clearance in dog and monkey.

108 Water solubility and small particle size is achieved wit

109 ed a notably increase of Vitamin A Palmitate water solubility and stability in front of those variabl

110 The HD lines also had better water solubility and starch pasting profiles than LD lin

111 mental organic contaminants due to their low water solubility and strong sorption onto organic/minera

112 Consequently, COEs have excellent water solubility and the absence of nanoaggregates at co

113 Its poor water solubility and the lack of distribution to the ske

114 lts in a significant improvement of both the water solubility and the microsomal stability.

115 he nanoencapsulation using gelatin increased water solubility and the potential of application of mel

116 nd water vapor permeability (WVP), swelling, water solubility and UV-vis light transmittance have als

117 Amyloid fibrillation reduced water solubility and water vapor permeability while incr

118 All five containers exhibit good water solubility and weak self-association (Ks </= 624 M

119 d with functional terminal groups to promote water-solubility and biocompatibility of quantum dots (Q

120 Nevertheless, its use is limited by its poor water-solubility and chemical instability.

121 However, the poor water-solubility and low bioavailability of carotenoids

122 and low background fluorescence, shows good water-solubility and stability, and exhibits no sign of

123 (library of compounds 3) included to promote water-solubility and to allow incorporation of probes vi

124 s widely used in cancer treatments, but poor water-solubility and toxicity raise serious concerns.

125 nal bulk material, biodegradation, maturity, water solubility (and oil:water emulsion behavior), depo

126 dvantages over other epothilones in terms of water solubility, and can serve as a readily functionali

127 ate which agent could promote an increase in water solubility, and color stability in yogurt.

128 All the wall materials had high water solubility, and Hi-Cap 100 reported the best wetta

129 [2Fe-2S] clusters to provide site isolation, water solubility, and improved catalytic activity.

130 hat exhibited favorable functional efficacy, water solubility, and metabolic stability were selected

131 tin fibers reduced water vapor permeability, water solubility, and moisture content properties while

132 such as ultrasmall size, low toxicity, good water solubility, and near infrared (NIR) fluorescent em

133 yite and ringwoodite in particular have high water solubility, and recent high pressure experiments s

134 rehalose moiety to promote biocompatibility, water solubility, and stability against aggregation, ami

135 Increasing DS increased the particle size, water solubility, and swelling power, while decreasing t

136 toxicity at low muM concentrations, improved water solubility, and the ability to penetrate the blood

137 order to generate inhibitors with acceptable water solubility, and this often resulted in a loss of p

138 osiin is characterized by low toxicity, high water solubility, and wide distribution in nature.

139 resemble protein receptors in size, complete water-solubility, and tailored binding sites in their hy

140 ached through an amide bond and examined for water solubility, antitumor activity, and propensity to

141 to its small size ( approximately 15kDa) and water solubility, appears readily in the blood-stream fo

142 Ribbon structures with high water solubility are obtained.

143 ic solution model predicts that species with water solubility as low as 10(-4) g L(-1) contribute to

144 Results for water solubility assays demonstrated clear differences b

145 high setback and breakdown viscosities, high water solubility at 85 degrees C but low swelling volume

146 -pyridylcarbamoyl moiety that conferred good water solubility at low pH (<4.0) but poor solubility at

147 lic Newkome-type dendrons provide sufficient water solubility at slightly basic conditions.

148 wing changes occurred for both samples; cold water solubility (at 25 degrees C) increased, water abso

149 nal therapeutic agents, including their poor water solubility (at least, for most anticancer drugs),

150 hylene glycol) moiety, resulting in improved water solubility, binding affinity, and agonist potency.

151 Advantages of this system include water solubility, biocompatibility, high quantum yield f

152 several novel EP2 antagonists with improved water solubility, brain penetration, high EP2 potency, a

153 es can be modified not just to improve their water solubility but also to enable these versatile nano

154 lternative to improve curcumin stability and water solubility but curcumin concentration inside the n

155 tinization temperatures, swelling power, and water solubility but higher amylose content, elasticity,

156 have tunable electronic properties and high water-solubility, but they are often difficult to synthe

157 The presence of the PEG group improved water solubility by 50-fold compared to the unsubstitute

158 for biological compatibility, imparting high water solubility by modifying rhodamine and cyanine dye

159 ctivities similar to that of 8a and enhanced water solubility (ca. 1 mg/mL).

160 We now report that water-solubility can be achieved by inserting an amino f

161 the dipolarophile is overcome by decreasing water solubility causing changeover to on-water conditio

162 ful as sulfofluoresceins have more favorable water solubility characteristics than fluoresceins that

163 eutical ingredient is compromised by its low water solubility, chemical stability, and bioavailabilit

164 MT starches were characterised by thickness, water solubility, colour, opacity, mechanical properties

165 3-Phosphonofluoresceins show enhanced water solubility compared to 3-carboxyfluorescein and pe

166 of amplified catalytic activity and improved water solubility compared to classic nanozymes.

167 showed 3 orders of magnitude improvement in water solubility compared to the gold-standard (N-MePhe)

168 Our results indicate that water solubility could function as a limiting factor for

169 Water solubility decreases with a decrease in the radius

170 A method for the measurement of the water solubility distribution of atmospheric organic aer

171 ackbone hydrogen bonds decreased polypeptide water solubility dramatically and accelerated the nanose

172 ops enhance imaging performance by promoting water solubility, eliminating probe self-aggregation, an

173 Sulfoxide groups bestowed water solubility for all homologues, which allowed their

174 s is currently limited because of their poor water-solubility, high melting point, chemical instabili

175 s is currently limited because of their poor water-solubility, high melting point, low bioavailabilit

176 mospheric urban organic aerosol analyzed had water solubility higher than 0.6 g L(-1).

177 10% of the fresh cooking organic aerosol had water solubility higher than 10 g L(-1), while 80% of th

178 in is a natural bioactive compound with poor water-solubility, however, the phase solubility test and

179 brates, odorant sorptiveness--volatility and water solubility--imposes physicochemical constraints on

180 mined temperature and pressure dependence of water solubility in magma reveals that, for many ascent

181 e required pharmaceutical properties of good water solubility (in weak acid) and stability at ambient

182 ajor component of CPM, demonstrated very low water-solubility, in contrast with the modestly water-so

183 Water solubility increased while water absorption reduce

184 and pasting properties were increased, while water solubility index (WSI), total phenolic content (TP

185 pH and NaCl concentration, on six responses: water solubility index (WSI), water absorption capacity

186 rsely, pressure processing did not alter the water solubility index of the flours.

187 easing the water-holding capacity, swelling, water solubility index, and cation-exchange capacity and

188 expansion, specific volume, hardness, color, water solubility index, and water absorption index] and

189 ncrease in its water absorption capacity and water solubility index.

190 Both log K(ow) and water solubility influenced the dermal bioaccessibility

191 ed because of poor oral bioavailability, low water solubility, instability in gastrointestinal fluids

192 Unlike its parent compound with low water solubility, intraperitoneally administered ZWC is

193 Water solubility is imparted to the dendrimers via a pal

194 of self-assembly and for applications where water solubility is required.

195 r toxicity is significantly lower, and their water solubility is up to 5000-fold higher than that of

196 The enhanced water solubility, its fast and efficient switching behav

197 a DNA model suffers from the compound's low water solubility, its lack of reactive oxygen sites, and

198 The water solubility, long-term storage and UV-light stabili

199 The low cost, water solubility, low toxicity and stabilizing propertie

200 s is currently limited because of their poor water-solubility, low bioavailability and chemical insta

201 lent metals and the core enzyme coupled with water solubility makes tetracyclines potential candidate

202 zed on both ends and were shown to have high water solubility, making them compatible with biological

203 However, ovomucin's limited water solubility might restrict its future applications.

204 a pharmacophore on the inhibition potencies, water solubilities, octanol/water partition coefficients

205 was evaluated on their inhibitor potencies, water solubility, octanol/water partition coefficients (

206 However, poor water solubilities of some of the other compounds preclu

207 n nitro groups and also tend to increase the water solubilities of the peptidomimetics.

208 Finally, the water solubility of a key intermediate necessitated the

209 es of these SWNT graft copolymers indicate a water solubility of about 5 mg/mL, and atomic force micr

210 Water solubility of AN was significantly improved upon c

211 limited volume of the nasal cavity and poor water solubility of anti-epileptics restrict absorption,

212 icelles and nanoparticles, that increase the water solubility of anticancer drugs for injection.

213 with the relatively low myosin affinity and water solubility of blebbistatin.

214 the carnosine, probably because of the high water solubility of carnosine and its homologues; cookin

215 However, the low stability and the low water solubility of certain vitamins make difficult thei

216 used as a complexation agent to improve the water solubility of cis- and trans-clomiphene without af

217 erial sciences, the low polarity and limited water solubility of commonly used cyclooctynes represent

218 f a novel prodrug approach for improving the water solubility of drugs containing a tertiary amine gr

219 tion, overcome drug resistance, and modulate water solubility of etoposide (1) analogues.

220 in B3) as a hydrotropic agent to enhance the water solubility of flavin mononucleotide.

221 26 h had a log P value of 4.9 and water solubility of greater than 10 mg/mL.

222 interactions, which are assisted by the low water solubility of guanine as compared to the other nuc

223 ty, and favorable relative influences on the water solubility of HPY conjugates are complementary to

224 The volatility and limited water solubility of linalool is a critical issue to be s

225 The water solubility of lyotropic liquid crystals (LCs) make

226 s limited due to lack of any charge and poor water solubility of molecules.

227 ver, the inferior catalytic activity and low water solubility of nanozymes remain as the major limita

228 tostatin (SRIF-14), we sought to improve the water solubility of our glycosides.

229 The water solubility of PA2808 showed a marked increase comp

230 Here we take advantage of the water solubility of pradimicin S (PRM-S), a sulfated glu

231 ability of phytoglycogen (PG) to improve the water solubility of quercetin (QC).

232 Therefore, achieving water solubility of quinoxalinediones without loss of se

233 Due to poor water solubility of SMART compounds, co-solvent delivery

234 d weakly basic pyridine moiety increased the water solubility of some analogues.

235 The high water solubility of TcO4(-) (11.3 mol L(-1) at 20 degree

236 The glycinate ester moiety increases the water solubility of the 10,11-methylenedioxy analogues 4

237 The low water solubility of the A(2)1 salts is attributed to the

238 incorporation of WP in the films reduced the water solubility of the Al films.

239 This method takes advantage of the low water solubility of the CHCA compared to its alkali salt

240 acyl chains, were synthesized to improve the water solubility of the corresponding gadolinium complex

241 in 4x and 5x) is sufficient to increase the water solubility of the corresponding synthetic analogue

242 In an effort to increase the potency and water solubility of the molecule, a structure-activity r

243 ion products mainly due to the extremely low water solubility of the organosiloxanes, low volatility

244 ater" environment, defined by the absence of water solubility of the reactants, has been reported to

245 ction limit concentrations decrease with the water solubility of the VOCs.

246 own that nonadditive cosolute effects on the water solubility of thermoresponsive polymers and on pro

247 The low water solubility of these BBB shuttles has, however, pre

248 Furthermore, the water solubility of UDMA/TEG-DVBE resins was reduced app

249 The objective was to increase the water solubility of Vitamin A Palmitate and its stabilit

250 Improving the water-solubility of BODIPY dyes remains an outstanding c

251 ter and artificial saliva) revealed that the water-solubility of curcumin was prominently improved by

252 This study on the water-solubility of OA factors provides insights for int

253 The water-solubility of OA factors, resolved with Positive M

254 em for direct and online characterization of water-solubility of organic aerosol (OA) by coupling a P

255 RNA nanoparticles as carriers increases the water-solubility of paclitaxel by 32,000-fold.

256 at are adjustable to specific needs, such as water solubility, on a very late stage of the multistep

257 As many drugs lack adequate water solubility, our formulations used oils, whose text

258 arrier amount had biggest impacts on product water solubility, pigments degradation and yield, respec

259 Its low water solubility, potential toxicities and undesirable s

260 TPW) method by adding a wash buffer with low water solubility prior to the elution step.

261 omega-carboxyl group was expected to improve water solubility relative to 1 or 2.

262 ent, and the oxidized lignin has much higher water solubility relative to the extracted lignin.

263 This, along with improved water solubility, resulted in compounds with enhanced bi

264 This, along with improved water-solubility results in compounds with enhanced biol

265 This, along with improved water solubility, results in compounds with enhanced bio

266 several charged residues aimed at improving water solubility seems to have led to the possible forma

267 d 13l was identified as a lead that exhibits water-solubility, stability in acidic solutions, and rap

268 zwitterion structure is tailored to decrease water solubility, stabilize emulsion droplets, and promo

269 e associated with lower light transmittance, water solubility, swelling power and viscosity.

270 ons were discussed by results of FT-IR scan, water solubility, swelling power, viscosity and degree o

271 conjugates displayed comparable or superior water solubility than native betaLg and betaLg/CA.

272 ose starches had higher moisture content and water solubility than the native high amylose starch fil

273 t tumor cells over normal cells with greater water solubility than triptolide.

274 ty of this compound class is limited by poor water solubility that can be attributed to the high ener

275 iable fraction of constituents with very low water-solubility that inhibited droplet growth through a

276 th the small molecular weight (~500 Da), the water solubility, the ease of functionalization, and the

277 To increase water solubility, the hydrophobic C4-phenylamino substit

278 Due to their moderate water solubility, the majority of the environmental burd

279 es are highly hydrophobic with extremely low water-solubilities, thereby making them difficult to stu

280 EPL presents some advantages such as good water solubility, thermal stability, biodegradability, a

281 ons, this double-wall chemistry enabled high water solubility through carboxylic acid functional grou

282 ins the C50-prenyl unit that shows very poor water solubility; thus, this chemical characteristic of

283 One construct showed the highest water solubility to a concentration of up to 4mg/ml in t

284 ssed a sufficient balance of polyvalency and water solubility to achieve crosslinking and establish a

285 Imparting water solubility to Gd@C(60) permits its evaluation as a

286 fonation is prized for its ability to impart water-solubility to hydrophobic molecules such as dyes.

287 x of subducting slabs) rises out of the high-water-solubility transition zone (between the 660 km and

288 ulated into NPM with significantly increased water solubility (up to 500 times).

289 Given this series' low water solubility, various polyethylene glycol derivative

290 The Si QDs were passivated for water solubility via two different methods: hydrosilylat

291 Water solubility was achieved through the addition of br

292 NAD(P), although high nicotinamide analogue water solubility was found to be a necessary trait for y

293 Their water solubility was found to be lower than 1 g/L irresp

294 antiviral potency, metabolic stability, and water solubility, we prioritized the GC376 scaffold as b

295 Water solubilities were lower (p<0.05) in films incorpor

296 ing NGO-PEG-SN38 complex exhibited excellent water solubility while maintaining its high cancer cell

297 This modification resulted in improved water solubility while retaining AK inhibition potency.

298 -azaindenoisoquinolines demonstrate improved water solubility without any decrease in Top1 inhibitory

299 the glycol substituent provides an enhanced water solubility without compromising the fluorescence (

300 fixed distance, the nanofibers exhibit high water solubility, without any signs of intramolecular tr