ライフサイエンスコーパス: we designate

1 In a cluster-randomized study, we designated 15 clusters with 78,744 miners as either i

2 In the novel spliceoform, an exon we designate "15b" replaces the canonical exon "15a", an

3 We designate 18 ion channel genes that are differentiall

4 se, demographics, and greenness in the area, we designated 8 paired clusters of demographically- and

5 ining characteristic of the WrbA family that we designate a new type of NQO (type IV).

6 three distinct states of antithrombin, which we designate A, A', and B.

7 e with tumors expressing this profile, which we designated acini-like tumors, had a significantly low

8 the discovery of a novel AFX isoform, which we designated AFX zeta, in which the first 16 amino acid

9 tantial levels of a slower migrating species we designate age-specific mtDNAs.

10 We designated AH9 antigen as a limbic system associated

11 with a locus on distal chromosome 11, which we designate ahl8.

12 nases are AvtA, YfbQ (AlaA), and YfdZ (which we designate AlaC).

13 Of the total of 1,510,064 births, we designated all 86,224 preterm births as the case grou

14 DivIB comprises three discrete domains that we designate alpha, beta, and gamma from the N to C term

15 In P. aeruginosa, a gene, which we designated aminoglycoside response regulator (arr), w

16 ntified by electron cryo-microscopy and this we designate an R to R* transition.

17 ncoding an angiopoietin-related protein that we designate angioarrestin.

18 ed cationic lipid-PLGA hybrid nanoparticles; we designated antigen-adsorbed (out), antigen-encapsulat

19 metabolism to a sesquiterpene epoxide, which we designate arteannuin X.

20 WWG-ethanolamide, in which n = 4 or 8, which we designate as "N-anchored" and "C-anchored" peptides,

21 g families of positional loop isomers, which we designate as "rollamers".

22 d, short-armed Liaoning dromaeosaurid, which we designate as a new genus and species, Zhenyuanlong su

23 and show that it contains a lower gate-which we designate as an 'X-gate'-created by interaction of th

24 bin proteins, phycobiliprotein paralogs that we designate as BBAGs (bilin biosynthesis-associated glo

25 independent truncated isoform of ACE2, which we designate as deltaACE2 (dACE2).

26 similar to Com1 of Coxiella burnetii, which we designate as dsbA2.

27 The gene for VHZ, which we designate as DUSP25, is located on human chromosome 1

28 ally folded thermodynamic intermediates that we designate as F (most folded) and I (intermediately fo

29 ngs to the histone deacetylase family, which we designate as HDAC11.

30 ich is mediated by DNA looping, a phenomenon we designate as intersegmental hopping.

31 e identified approximately 135 proteins that we designate as long-lived asymmetrically retained prote

32 of objective evidence of inflammation, which we designate as non-inflammatory refractory RA (NIRRA).

33 ved with the Rad1-Rad10-Rad14 complex, which we designate as nucleotide excision repair factor-1, NEF

34 ave persistent inflammatory pathology, which we designate as persistent inflammatory refractory RA (P

35 the strict production of neutrophils, which we designate as proNeu1.

36 The enzyme, which we designate as PurP, is the product of the Methanocaldo

37 of the Cockayne syndrome A (CSA) gene, which we designate as RAD28.

38 s via modulating auxin homeostasis for which we designate as reset, not to be confused with the gravi

39 , and argue that this layer structure, which we designate as smectic-fA phase, is thermodynamically s

40 14D12 to amino acids Gln(29)-His(53), which we designate as specific epitope 1 (SE1).

41 f the bladder - a new concept and niche that we designate as the bladder TME (bTME) - during tumour e

42 Thus, the CRFB4 chain, which we designate as the IL-10R2 or IL-10Rbeta chain, serves

43 ocated in the periplasmic domain, in regions we designate as the lower part of the large external cle

44 ow that the N-terminal region of gp41, which we designate as the neurotoxic domain, induces iNOS prot

45 he first example of a class of proteins that we designate as trypanokines, i.e., factors secreted by

46 ndomized to receive electrical shocks (which we designated as "experimental shocks") immediately befo

47 lated rats received additional shocks (which we designated as "rescue shocks") after 8 mins of chest

48 and characterization of a novel protein that we designated as calcineurin/NFAT-activating and immunor

49 e genes is a member of a CT gene family that we designated as CT45.

50 n the largest of the encoded proteins, which we designated as eORFs, which can be up to ~45 kDa, we f

51 les, mitochondria, and lipid droplets, which we designated as granule-containing vesicles (GCVs) and

52 at the base of the isolated stem-loop, which we designated as high-frequency recombination sites 1 an

53 atecholamine-O-methyltransferase (COMT) that we designated as low pain sensitivity (LPS), average pai

54 histocompatibility complex (MHC) gene, which we designated as MHC Q1b, whose expression decreases in

55 gene identified on chromosome arm 5BS, which we designated as Snn3.

56 e discovered a 29-bp consensus sequence that we designated as the Clock-Associated Transcriptional Ac

57 allowed us to discover a novel compound that we designate aspercryptin and to propose a biosynthetic

58 homologous Arabidopsis thaliana gene, which we designated AtPGM.

59 ified the putative two-component system that we designated Bacillus anthracis respiratory response (B

60 to either K332 in L5, forming a product that we designated band 1, or to the major outer membrane pro

61 se genes mapped to two adjacent operons that we designated bbcABCDEF and bbcGHIJK.

62 a novel 399 bp repetitive DNA element (which we designate beta) 9bp upstream of a seryl-tRNA(CAG) gen

63 that include or exclude a short domain that we designate beta.

64 lly distinct lineage within subtype C, which we designate C(IN).

65 The majority member of the culture-which we designate 'Candidatus Manganitrophus noduliformans'-i

66 ew member of the alpha-CA gene family, which we designate carbonic anhydrase-related protein XI (CA-R

67 As such, we designated CBU0077 MceA (mitochondrial Coxiellaeffect

68 The two other proteins, which we designated CC1 (for crenarchaeal chromatin protein 1)

69 family transcription factor PGN_1373, which we designate CdhR, in this control pathway.

70 usly described cysteine desulfhydrase, which we designated cdsH (formerly STM0458).

71 Adjacent to the cepR2 gene is a gene that we designate cepS, which encodes an AraC-type transcript

72 f a novel subfamily of lanthipeptides, which we designate class V.

73 he human cytomegalovirus (CMV) genome, which we designated cmvIL-10.

74 ng a 27-kDa protein of unknown function that we designated COLD-REGULATED GENE 27 (COR27; At5g42900).

75 amily and is regulated by its product, which we designate ComR.

76 olecular transfer between E1 and Ubc9, which we designate "cross-sumoylation." Rhes binds directly to

77 d gene that regulates cdsH expression, which we designated cutR (formerly ybaO, or STM0459).

78 ma(54)) and an RpoN-dependent activator gene we designate dgaR.

79 We isolated a novel DGK, which we designated DGKiota, from human retina and brain libra

80 variants with R5-tropic-like V3 loops, which we designated "dual-R," use CCR5 much more efficiently t

81 A distinct superfamily of kinases, which we designated DxTN after its sequence signature, appears

82 rom an overlapping open reading frame, which we designate E10.

83 ntified a novel member of this family, which we designate endoglycan.

84 ced sequence of a novel beta-defensin, which we designate enteric beta-defensin (EBD).

85 sis and M. marinum genes in this region that we designate extRD1 (extended RD1).

86 rbohydrate recognition sequence motif, which we designate F-type.

87 ve domain in laminin-gamma3 domain IV, which we designate F5 peptide, and show that the overexpressio

88 That protein, which we designate FdIV, has now been purified.

89 oding a novel member of the FGF family, that we designate FGF-20.

90 1 via a 14-kDa, surface-exposed protein that we designated FhbB.

91 aled that these proteins are isoforms, which we designate G1 and G2.

92 three members in Arabidopsis thaliana, which we designated GALACTAN SYNTHASE1, (GALS1), GALS2 and GAL

93 that include or exclude a short domain that we designate gamma.

94 on the deduced amino acid sequence identity we designated GAPC1 and GAPC2 as group I (97% identical)

95 uman CMV, pp71 (UL82) and pp65 (UL83), which we designated GP82 and GP83, respectively.

96 A PAL gene we designated gPAL1, cloned from tobacco, consists of tw

97 Saccharomyces scSPT23 and scMGA2 genes that we designate here as caSPT23.

98 o identify a pelX paralogue, PFL_5533, which we designate here PgnE, that appears to be functionally

99 onarily distinct human haplogroups (HH) that we designated HHA, -B, -C, -D, -E, -F, and -G.

100 The AK000411 protein, which we designate hIntersex (human Intersex), shares signific

101 of the binding partner of human MUS81, which we designate hMMS4.

102 One of these genes, which we designated hmsP, encodes a putative phosphodiesterase

103 ectly upstream of the hmuR gene a gene which we designated hmuY.

104 One of these, which we designated HVEM-L, specifically bound to HVEM-Fc with

105 dispersed innate type 2 helper cells, which we designate Ih2 cells, play an integral role in type 2

106 cterized one kinase from this complex, which we designate IKKepsilon.

107 In this system, which we designated "in-microbe", reactions occur within 2 to

108 d into long-lived functional networks (which we designate iNets).

109 code distinct but paralogous proteins, which we designate interferon-lambda1 (IFN-lambda1), IFN-lambd

110 were confined to a short DNA sequence, which we designated ipeX for inhibition of porin expression, a

111 by an insertion sequence-like element which we designated IS195.

112 strategies, here we developed a method that we designate isotopic tagging of oxidized and reduced cy

113 w family of glycosyltransferases; therefore, we designate it as a GT-D glycosyltransferase fold.

114 (NAP1) and to a human homologue of NAP1, and we designate it hNAP2 (human nucleosome assembly protein

115 atography, and high-resolution LC-MS/MS, and we designate it LPHAMS.

116 We designate it Pa-MIG.

117 We designate it the ArnA transformylase domain and descr

118 natural ligand for the cortactin SH3 domain, we designated it CortBP1 for cortactin-binding protein 1

119 , such as cAR1 and GP80, during development, we designated it early gene expression A (ege A).

120 f this protein superfamily, and consequently we designated it HSP22.

121 rmation of an extended stem structure, which we designated JFH-SL9074.

122 ct polyribitol-containing teichoic acid that we designate K-WTA.

123 e KEEP ON GOING gene (KEG; At5g13530), which we designated keg-4.

124 Ralpha.IL-4.gammac]/[IL-4Ralpha.IL-4], which we designate KR.

125 ique mixed-domain lamellar morphology, which we designate LAMP Transmission electron microscopy indic

126 This gene, which we designated Ly-6M, shares several structural features

127 han any other member of the family and which we designate mammalian inositol phosphate multikinase (m

128 bacterial histidine acid phosphatase, which we designated Map for major acid phosphatase.

129 iruses associated with Thaumarchaeota, which we designated marthavirus.

130 The gene, which we designate mcrA, is conserved but uncharacterized, and

131 al evidence that the FLJ10193 protein, which we designate Med25, is a bona fide subunit of the mammal

132 n rare-cleaving nuclease architecture, which we designate 'megaTAL', in which the DNA binding region

133 ependent methyltransferase encoded by a gene we designated methylcysteine modification (mcmA) is resp

134 This phenomenon, which we designated "mitotic drive" , is a novel mechanism whi

135 here that a mouse Mps1p ortholog (esk, which we designate mMps1p) regulates centrosome duplication.

136 ovel ATP-binding cassette transporter, which we designated MOAT-B.

137 the odds [LOD] score = 6.9, P < .0001) that we designate Modifier of hemostasis (Mh).

138 d protein encoded by the FLJ10914 ORF, which we designate MRGBP, as a new component of the TRRAP/TIP6

139 es: Muscle RING Finger 1 (MuRF1), and a gene we designate Muscle Atrophy F-box (MAFbx), the latter be

140 The homology of the predicted protein, which we designated NAG (neuroblastoma amplified gene), to a C

141 Arabidopsis thaliana flagellin receptor that we designated NbFls2.

142 eration and activity of a truncated receptor we designate NDeltaCterm.

143 tylase/GlcN N-sulfotransferase family, which we designate NDST4.

144 promoters were located upstream of loci that we designated nipAB and nipC, which correspond to hcp-hc

145 t encoding a G protein-coupled receptor that we designated NmU-R2 based on its homology to NmU-R1.

146 o identified a gene in N. gonorrhoeae, which we designated nuc.

147 iosulfate and vectorial sulfur transfer, and we designate NWMN_0026.5 as CstR (CsoR-like sulfur trans

148 hat the two components of this system, which we designate OtpA and OtpB, are not predicted to belong

149 involves a structural transition to a state we designate P.

150 6, 32, 38.9, 30.1, 12.7, and 75.7 kDa, which we designated p5.6, p32, p39 (NTPase), p30, p13 (VPg), a

151 matophilum We show that this receptor, which we designate pathogen clearance-defective receptor 1 (PC

152 e, and Caenorhabditis elegans homologs which we designate PET.

153 ich encodes a 6-phosphogluconolactonase that we designated pglA.

154 Intensely orange fluorescent adducts, which we designate phytofluors, are spontaneously formed upon

155 elated family of seven human proteins, which we designate PLUNC proteins.

156 B), also encodes a novel DNA polymerase that we designate poliota.

157 With these findings, we designate pp105 as Cas-L, lymphocyte-type Cas.

158 We designate PPE15 as mycobacterial perilipin-1 (MPER1).

159 We designate priority countries for such actions, recogn

160 ied type of disease involving the PrP, which we designated "protease-sensitive prionopathy" (or PSPr)

161 , we isolated an ethanolamine auxotroph that we designate pstA1-1.

162 ne-spanning enzyme II(Glc) of the PTS, which we designate ptsG-F.

163 ts in spatially discrete micro-domains which we designate "puncta," and the relative amounts of each

164 genes involved in PvGal biosynthesis, which we designated pvg1-pvg5.

165 We defined Rab-conserved sequences that we designate Rab family (RabF) motifs using the conserve

166 t of the plasmid can be attributed to a gene we designate rapP.

167 ial Y-box protein in Trypanosoma brucei that we designated RBP16.

168 0836 and SMu0837 encode ABC exporters, which we designated rcrPQ (rel competence-related) genes, resp

169 ion yeast homologue of mammalian Rheb, which we designated Rhb1, was identified by genome sequencing.

170 disruption of these regulatory elements that we designate "RNA kinetic switches" modified AS of NISCH

171 ithelial cells that is dependent upon a gene we designated rtxA.

172 he gene encodes a membrane-bound enzyme that we designate SCALD, for short-chain aldehyde reductase.

173 n over 125 genomes, featuring a peptide that we designate SCIFF (six cysteines in forty-five residues

174 ving multistage segmentation patterns, which we designate segmentation driving enhancers (SDE).

175 ulates in senescent human fibroblasts, which we designated senescence-associated heterochromatic foci

176 we propose that they belong to a group which we designate SIS, for SA-independent, systemically induc

177 nus, the l'hoest monkey (C. l'hoesti), which we designated SIVlhoest.

178 stationary phase and noted a protein, which we designated Snz1p (p35), that shows increased synthesi

179 and two fibronectin type-III domains, which we designate stretchin-MLCK.

180 eviously uncharacterized zinc-finger protein we designate TELOMERASE ACTIVATOR1 (TAC1) is overexpress

181 ons involving AR-interacting proteins, which we designate the "AR-interactome." Despite many years of

182 s a cavity masked by an acidic linker, which we designate the "FLAP." Analysis of three mutant moesin

183 e find that the NH(2)-terminal region, which we designate the actin-targeting domain, facilitates ZNF

184 We designate the alternative pathway for the interconver

185 a novel, full-length 6.9-kb muscle cDNA, and we designate the corresponding protein 'dysferlin'.

186 aracterized type of protein methylation, and we designate the enzyme as Rmt2 (protein arginine methyl

187 We designate the first complex as (pol beta)16 and the s

188 We designate the first complex as the (pol beta)16 bindi

189 ubunit complex from the two-subunit Polzeta, we designate the four-subunit enzyme "Polzeta-d," where

190 ialidase function - and for this distinction we designate the gene and encoded protein nonA/NonA.

191 Based on our findings, we designate the gene product corresponding to ct694-ctl

192 hosphotransferase system (PTS) permease, and we designate the genes encoding the permease dgaABCD (d-

193 We designate the large complex seen in wild-type cells c

194 uniqueness of this group of isolates, which we designate the Manila family of M. tuberculosis.

195 We designate the mutant xax1 for xylosyl arabinosyl subs

196 We designate the novel gene PAGE-1 because the expressio

197 We designate the original 4-phosphatase and the new isoz

198 ng frame is similar to that of rat APT1, and we designate the protein S. cerevisiae Apt1p.

199 Based on these differences, we designate the R1, R3 and R4 haplotypes as alleles Sr1

200 y a global termination control system, which we designate the S box system, as most of the genes are

201 pathway described in M. tuberculosis, which we designate the Snm pathway.

202 One of these is a novel sequence motif that we designate the SNOG element, because it occurs downstr

203 We designate the type strain NSH-16 (= ATCC BAA-2463 = N

204 ology with human DNA ligase IV; accordingly, we designate the yeast gene LIG4.

205 CTR contains a dimeric globular domain that we designated the "Claw" for its shape.

206 Therefore, we designated the agent as a helper-dependent E1-positiv

207 We designated the B. melitensis protein Omp28.

208 We designated the C. pneumoniae homologue as CPAFcp.

209 ently described 50.6% identical protein that we designated the CILP-2 isoform.

210 We designated the corresponding soybean gene GmPGM.

211 oth host cells were highly similar, and thus we designated the defective loci in these mutants pmi (f

212 new family of avian endogenous viruses that we designated the ev/J family.

213 We designated the first phase of dissemination "adherenc

214 on the phenotype displayed by its mutation, we designated the gene corresponding to Cj0643 as cbrR (

215 We designated the gene for this manganese efflux system

216 hly conserved in Bartonella hbp genes, which we designated the hbp family box, or "H-box." Fourth, we

217 the basis of their similarity to these loci, we designated the L. pneumophila genes helC, helB, and h

218 g motif within the nocturnin promoter, which we designated the nocturnin element (NE).

219 We designated the pattern as female if the J point was <

220 he phenotype of the C. jejuni Cj1242 mutant, we designated the protein Campylobacter invasion antigen

221 j1279c harbors fibronectin type III domains, we designated the protein FlpA, for fibronectin-like pro

222 rphism, CTG-->GTG (Leu-->Val), at codon 125; we designated the resulting alleles CD31.L and CD31.V, r

223 ntly aborted opposite template T, a property we designated the T stop.

224 ene uncovered a novel C-terminal domain that we designated the Tsunami Homology (TH) domain.

225 pneumophila to mammalian cells and protozoa, we designated the type IV pili CAP (for competence- and

226 ibed virus of the Flaviviridae family, which we designate "Theiler's disease-associated virus" (TDAV)

227 We designate them as "class I ERPs." We originally hypot

228 tionally distinct from the beta-subunits and we designate them as a gamma family of the BK channel au

229 Here we designate them as a new family, the Mohoidae.

230 We designate them as female-nest-coo-specific units.

231 Previously designated RepX and TubZ, we designate them here as TubZ-Ba and TubZ-Bt.

232 For this reason we designate them Ksust ('sustained current') channels.

233 pithelium and stroma are affected diffusely, we designated them as "atypical hyperplasia of Tag." Alt

234 Based on the characteristics of each class, we designated them as follows: 'Nonresponders' (n = 905,

235 We designate these isoforms SMRTalpha and SMRTtau and de

236 We designate these light chains type III.

237 We designate these mice BrtlIV (Brittle IV).

238 We designate these newly described cells as T1d B cells

239 We designate these populations transitional (T) 1 (AA4(+

240 We designate these proteins containing leucine (L) and i

241 We designated these as state S and state I.

242 related with the melanocyte growth kinetics; we designated these clusters the melanocyte growth arres

243 We designated these peptides Pepcan-12 (RVDPVNFKLLSH) to

244 We designated these proteins "magphinins," because they

245 known mammalian thiamine transporter, which we designate thiamine transporter-1 (THTR-1).

246 We designate this 5-phosphatase as type IV.

247 We designate this approach "genetic vaccinology," since

248 We designate this approach as Scanning Probe Potential E

249 We designate this approach the LD decay (LDD) test.

250 and chromosomal location of this chemokine, we designate this chemokine small inducible cytokine sub

251 Thus, by analogy to the Notch receptor, we designate this cleavage the S2 cleavage site, whereas

252 n of ADP ribosylation factor by cytohesin-1, we designate this cytokine-inducible protein Cybr (cytoh

253 We designate this difference DNA bending cooperativity.

254 Therefore, we designate this enzyme KAS IV, a medium chain specific

255 We designate this factor CPF, for CYP7A promoter binding

256 We designate this fusion protein as IcmF (isobutyryl-CoA

257 We designate this GAP43-CerFP-t-h-ras construct as hVoS

258 motility and a hyperbiofilm phenotype; thus, we designate this gene bifA, for biofilm formation.

259 gene with two HMG boxes and an acidic tail; we designate this gene LfHMG1.

260 membrane organic cation transporters; hence, we designate this gene ORCTL2 (organic cation transporte

261 We designate this hominin population 'Denisovans' and su

262 We designate this inhibitory site(s) as the I site.

263 By analogy with related regulatory systems, we designate this leader RNA pattern the "L box." Genes

264 We designate this mechanism-causing regulated inversion

265 To distinguish the two unrelated families we designate this new class DGAT2 and refer to the M. ra

266 We designate this novel gene lba for LPS-responsive, bei

267 We designate this nucleolar focus the No-body and propos

268 Based on sequence homologies, we designate this PDE as PDE7B.

269 We designate this phenomenon 'genomic hitchhiking'.

270 We designate this property "volatility" and apply it to

271 We designate this protein as Gab2.

272 We designate this protein enamel matrix serine proteinas

273 We designate this reaction pyrovanadolysis.

274 We designate this state as "preborder"; its transcriptom

275 ypic, homeostatic, and migratory properties, we designate this subset peripheral memory (tpm) cells a

276 We designated this autophagy-related (ATG) gene as ATG32

277 We designated this clone e3B1 for eps8 SH3 domain bindin

278 We designated this condition PMSE syndrome (polyhydramni

279 ns a functional cis element(s) in vitro, and we designated this element the DCE (downstream core elem

280 Based on these properties, we designated this enzyme Sf9 alpha-mannosidase III and

281 We designated this gene as POLYGALACTURONASE INVOLVED IN

282 Accordingly, we designated this gene CTL1 (capping enzyme RNAtriphosp

283 We designated this locus Mvwf for "modifier of VWF." Add

284 Therefore, we designated this molecule JIK for JNK/SAPK-inhibitory

285 tants described in motheaten (me, mev) mice; we designated this new genotype as Ptpn6(meB2/meB2) and

286 We designated this novel ubiquitously expressed nuclear

287 We designated this putative lipoprotein LipL45.

288 lized the disease locus to a region in 3q29; we designated this region the morbid obesity 1 (MO1) loc

289 We designated this regulator FarR to signify its role in

290 We designated this tally as the allogenomics mismatch sc

291 We designated those rats with an initial increase in car

292 ch is phylogenetically distinctive and which we designate topoisomerase IA(mt).

293 transferase in Saccharomyces cerevisiae that we designate Trm9.

294 Fibres we designated 'type alpha-cardiac' were different from t

295 This new splice variant, which we designate (V+C)-, represents the majority of fibronec

296 ) were lineage D2, 7 (8.4%) were a haplotype we designated "X6," and 3 (3.6%) were a haplotype we des

297 signated "X6," and 3 (3.6%) were a haplotype we designated "X7." Sequence analysis found 43 haplotype

298 Here we designate YKL741 as PXA2 and show that its protein pr

299 esis identified a LysR-like regulator, which we designated YtxR.

300 cia has an additional metalloprotease, which we designated ZmpB.