1 Herein
we disclose [
2]-ladderanes as a class of meta-substitute
2 Herein,
we disclose a 100% atom-economic and highly regio- and s
3 Here
we disclose a 7-nitrobenzo-2-oxa-1,3-diazole (NBD)-based
4 Herein,
we disclose a backbone rearrangement approach to tune th
5 We disclose a basal level of adult neurogenic activity c
6 Here
we disclose a bidirectional, rapidly charging aluminium-
7 Here
we disclose a bioinspired strain-driven ring opening of
8 Here,
we disclose a broadly applicable enantioselective [2 + 2
9 Here
we disclose a cascade strategy for naphthyne formation t
10 Herein
we disclose a catalytic synthesis of cycloalkanols that
11 In this Communication,
we disclose a catalytic, highly enantioselective (up to
12 Herein,
we disclose a cinchona-alkaloid-based squaramide-catalyz
13 Here,
we disclose a class of 6-chlorotacrine (huprine)-TPPU hy
14 Here,
we disclose a class of charge-altering releasable transp
15 Here,
we disclose a class of phosphines that enable the Ni-cat
16 Herein,
we disclose a combined experimental and theoretical stud
17 Herein
we disclose a conceptually novel organocatalytic approac
18 Herein,
we disclose a cost-effective and readily available Cu-ca
19 Herein
we disclose a desymmetrization that employs phosphinic a
20 In the process,
we disclose a detailed DFT study of equilibrium geometri
21 We disclose a detailed examination of a thermally induce
22 Herein
we disclose a detailed SAR study that led to the biaryl
23 Herein
we disclose a detailed study examining the structure of
24 Herein
we disclose a facile method for the preparation of (co)p
25 Herein,
we disclose a facile synthetic strategy to access an imp
26 Herein,
we disclose a facile way to realize designed micropatter
27 We disclose a facile, aerobic, transition-metal-free, di
28 Herein,
we disclose a full account of the syntheses, structure-a
29 Here,
we disclose a general and reliable reaction manifold for
30 In this work,
we disclose a general method for the synthesis of BCP-co
31 Herein,
we disclose a general prodrug approach that converts pro
32 Here,
we disclose a general solution to this problem in which
33 Herein,
we disclose a general strategy for aliphatic gamma-C(sp(
34 Herein,
we disclose a general strategy for precise tuning of loo
35 In this communication,
we disclose a generalizable strategy for developing agen
36 Here,
we disclose a heterobinuclear complex with an Al-Fe bond
37 We disclose a highly specific dual FMS and KIT kinase in
38 Furthermore,
we disclose a linear correlation of catalytic activities
39 Herein,
we disclose a metal-free regioselective cross-coupling o
40 In this work,
we disclose a metal-ion-mediated strategy to assemble tr
41 Here
we disclose a method for constructing C-(18)F bonds thro
42 Herein,
we disclose a method for its formation by intramolecular
43 Herein,
we disclose a method for the enantioretentive N-arylatio
44 Herein,
we disclose a method for the selective functionalization
45 Here,
we disclose a method for the union of N-alkylamines and
46 Here
we disclose a method to bond graphene and single-walled
47 Here,
we disclose a mild method for the fluorine-18 ((18)F)-fl
48 Herein
we disclose a mild protocol for the reductive functional
49 In this paper,
we disclose a mild, selective, and convenient method for
50 Here
we disclose a modular synthesis of pleuromutilins by the
51 Herein,
we disclose a new alkene carboacylation reaction initiat
52 Herein
we disclose a new class of chiral C(sp(2))-C(sp(3)) atro
53 Herein,
we disclose a new cyclopropane synthesis through the for
54 Herein,
we disclose a new electrochemical process to prepare ali
55 We disclose a new high-yielding and highly enantioselect
56 Here,
we disclose a new intracellular photocatalyst with minim
57 Here,
we disclose a new iteration-enabling group, CbzT (p-TIDA
58 Herein
we disclose a new photochemical process to prepare carbo
59 Herein,
we disclose a new strategy to prepare borylated cyclopro
60 Herein
we disclose a Ni-catalyzed electrochemically driven prot
61 We disclose a Ni-catalyzed vicinal difunctionalization o
62 We disclose a nickel/Bronsted acid-catalyzed tandem proc
63 Herein,
we disclose a nitrogen complexation strategy that employ
64 In this work,
we disclose a non-invasive method for the monitoring and
65 Herein
we disclose a novel aminooxygenation of oxindoles with n
66 We disclose a novel class of 6-amino-tetrahydroquinazoli
67 Here,
we disclose a novel COE derivative, COE-CN, which enable
68 Here,
we disclose a novel gene-regulatory role of circHIPK3 by
69 In this study,
we disclose a novel immune-regulatory role for DA: inhib
70 Here
we disclose a novel ligand design based on the privilege
71 Herein
we disclose a novel method for the facile transfer of pr
72 Herein,
we disclose a novel method for trifluoroacetylation thro
73 We disclose a novel pathway to beta-cell death involving
74 We disclose a novel radical strategy for the fluorinatio
75 We disclose a novel series of indenopyrazole-based cycli
76 In this article,
we disclose a novel series of substituted 4-benzyl-2 H-p
77 Herein,
we disclose a novel, mild, transition-metal-free approac
78 Herein,
we disclose a palladium-catalyzed cross-coupling of aryl
79 Herein,
we disclose a pH-responsive water-soluble prodrug strate
80 Here,
we disclose a photoredox protocol for the replacement of
81 Here,
we disclose a porous, robust homochiral metal-organic fr
82 Herein,
we disclose a position-selective C(sp(3))-C(sp(2)) cross
83 In all,
we disclose a powerful and broad-scope strategy to edit
84 In this manuscript,
we disclose a powerful automated flow-based strategy for
85 the photoredox reactivity of nitroethylene,
we disclose a practical visible-light-induced homologati
86 Herein
we disclose a previously underappreciated aspect of aryl
87 We disclose a protocol for the palladium-catalyzed ortho
88 Here
we disclose a protocol that converts multiple classes of
89 Here,
we disclose a reagent platform that serves as a chiral s
90 Herein,
we disclose a semisynthetic, catalytic approach for stru
91 Herein
we disclose a series of ACC inhibitors based on a spiroc
92 Here,
we disclose a series of experiments that elucidate the m
93 In this report,
we disclose a series of potent and highly selective JNK
94 Here,
we disclose a series of supramolecular (co)polymers base
95 Herein,
we disclose a simple azidotriazine-based grafting agent
96 Herein,
we disclose a simple one-pot method for an efficient reg
97 Herein,
we disclose a simple protocol for SO(2)F(2)-free, hectog
98 Here
we disclose a simple route to nanoscopic 2D woven struct
99 Herein,
we disclose a simple strategy for the C-H alkylation of
100 Herein,
we disclose a single-step construction of atropisomers w
101 Here,
we disclose a Smiles-type rearrangement, triggered by a
102 Here
we disclose a stepwise dehydrogenative method to convert
103 Here
we disclose a strategy for biocatalytic cross-coupling t
104 We disclose a strategy for Ni-catalyzed dicarbofunctiona
105 Herein,
we disclose a strategy that harnesses an intramolecular
106 Herein
we disclose a strategy to promote the hydrocarboxylation
107 Herein,
we disclose a strictly stereoselective and furanosyl-sel
108 We disclose a study on nucleoside triphosphate (NTP) ana
109 Here
we disclose a sulfurane-mediated method for the formatio
110 Herein,
we disclose a synthetic route that allows access to eith
111 Here,
we disclose a system for sectioning electrospray plumes
112 Herein
we disclose a systematic study of a single CH HB by usin
113 Herein,
we disclose a template-assisted method for the regiosele
114 Herein
we disclose a three-component strategy to access quatern
115 s siderophore biosynthesis protein B (AsbB),
we disclose a three-dimensional model of a nonribosomal
116 Here,
we disclose a toughening strategy for self-healing elast
117 Herein,
we disclose a transformation that is run in water with t
118 Herein
we disclose a transition-metal-free, one-pot two-step st
119 Herein,
we disclose a two-dimensional naphthalenediimide (NDI)-b
120 Herein,
we disclose a versatile regioselective C-H alkylation of
121 In this report,
we disclose a very efficient catalytic protocol for site
122 Herein,
we disclose a visible-light-induced, oxidative di- and t
123 Recently,
we disclosed a (bpy)Cu(I)/TEMPO/NMI catalyst system (NMI
124 Herein,
we disclosed a copper-catalyzed approach for the enantio
125 In addition,
we disclosed a new approach towards the metal-free fluor
126 Recently,
we disclosed a new class of HCV polymerase inhibitors di
127 We disclosed a principle controlling Sirt1 activity and
128 otting and confocal fluorescence microscopy,
we disclosed a robust increase in the expression of geph
129 Herein,
we disclosed a simple, efficient, inexpensive organic ba
130 Herein,
we disclose an approach to synthesize tert-alkyl cyclopr
131 Here
we disclose an efficacious hybrid molecule 4-(5-Amino-1,
132 Herein
we disclose an efficient and flexible approach to achiev
133 We disclose an efficient and operationally simple protoc
134 In this paper,
we disclose an efficient one-pot procedure for the prepa
135 Herein,
we disclose an efficient ruthenium-catalyzed C-H functio
136 Herein,
we disclose an efficient synthesis of alpha-iminonitrile
137 Herein,
we disclose an electrochemical approach for the C(sp(2))
138 Here,
we disclose an electromechanical adhesion switch mechani
139 Herein,
we disclose an enantioconvergent carbamoylation of racem
140 Here,
we disclose an energy transfer-mediated, highly regio- a
141 Herein
we disclose an improved synthesis into the oxazepine and
142 Here,
we disclose an integrated microfluidic emulsion creamer
143 Herein,
we disclose an interrupted deaminative Ni-catalyzed chai
144 In this Communication,
we disclose an iron-based catalytic system for the funct
145 Herein,
we disclose an operationally and practically simple meth
146 Here, in offering an alternative solution,
we disclose an operationally simple, metal-free, one-pot
147 Herein
we disclose an organocatalytic aryl-aryl bond-forming pr
148 Herein
we disclose an umpolung strategy to achieve radical carb
149 Herein,
we disclose an unprecedented in vivo reduction process t
150 We disclose an unprecedented isomerization of some spiro
151 Herein,
we disclose an unprecedented radical relay 1,4-oxyiminat
152 Here
we disclose an unusual functional group transposition re
153 Herein,
we disclose analogues designed to prevent the metabolism
154 Here
we disclose bench-stable amino-acid-derived oxamic acid
155 We disclose by classical molecular dynamics simulations
156 Here,
we disclose chemical processes that result in formation
157 We disclose compartmentalized corelease of glutamate and
158 Herein
we disclose extensive structure-activity relationship an
159 We disclose here a new class of kinase inhibitors, obtai
160 We disclose here a new highly efficient and versatile ro
161 We disclose here for the first time the curative activit
162 T) from a small sample of the same material,
we disclose here the preliminary work directed toward th
163 We disclose herein that the clinical candidate (+)-SJ733
164 We disclose herein the development of functional and hig
165 We disclose herein the discovery of a new class of non-b
166 of linear free energy relationships (LFER),
we disclose how the formation of either imines or enamin
167 We disclose hundreds of commercially available activity-
168 We disclose in this paper a ligand-based drug design app
169 In this report,
we disclose LLY-507, a cell-active, potent small molecul
170 Here,
we disclose microED studies which establish that (-)-lom
171 With Notch signaling as the key regulator,
we disclose molecular proof and lineage tracing evidence
172 Here in,
we disclosed N-pyrimidyl-directed assisted palladium(II)
173 Herein,
we disclose new chemistry for the installation of divers
174 s and spectroscopic/diffractometric studies,
we disclose new gamma-/beta-turn and loop structures pre
175 In conclusion,
we disclose novel tentative evidence for the involvement
176 Here,
we disclose our clinical candidate CEE321, which is a po
177 Herein,
we disclose our efforts to identify potent, selective, a
178 Herein,
we disclose our journey toward the discovery of MK-1084,
179 Herein,
we disclose our novel MS-based quantitative proteomics s
180 Herein,
we disclose our optimization of the physicochemical and
181 Moreover,
we disclosed reciprocal LDTg connections with structures
182 Here,
we disclose reliable and non-invasive recording of APs w
183 Here,
we disclose reverse-phase chromatography and MS dissocia
184 Here,
we disclose SAR investigation and ADME/PK optimization l
185 ne receptors are peptides, but in this study
we disclose small-molecule ligands that are able to acti
186 We disclose strategies for designing and synthesising fr
187 Herein,
we disclose structurally diverse small molecule inhibito
188 Here
we disclose structures and biological activity of the en
189 Herein,
we disclose studies aimed at determining the origin and
190 Here
we disclose that an iron catalyst in the presence of a c
191 Here
we disclose that butyric and valeric acid-derived tertia
192 Herein,
we disclose that compounds having the O-glycosidic bond
193 Herein,
we disclose that electrochemical stimulation induces new
194 For the first time, to our knowledge,
we disclose that IL-2 induces monocyte-derived hDC's fun
195 Herein,
we disclose that irradiation of a tris(phosphine)borane
196 Herein
we disclose that kinetics studies indicate the reaction
197 Herein,
we disclose that multinuclear Pd species, in the form of
198 Herein,
we disclose that pyridinium salts derived from abundant
199 Herein,
we disclose that such Au(III) complexes can undergo faci
200 We disclose that this metabolic reduction can be greatly
201 From spectroscopic studies,
we disclosed that [p-NO(2)-Nos]I binds to human hemoglob
202 Hybridization and Long Distance Inverse-PCR
we disclosed that these transcripts result from a genomi
203 Furthermore,
we disclosed that this proteolytic activity is metal ion
204 Herein,
we disclose the application of a new Ir(III) photocataly
205 Herein,
we disclose the asymmetric ring opening of meso aziridin
206 Additionally,
we disclose the co-crystal structure of our inhibitor se
207 Herein,
we disclose the combined NMR spectroscopic, single-cryst
208 We disclose the conformational transition of Cas9 from i
209 Herein,
we disclose the construction of aromatic nitriles via di
210 Herein,
we disclose the controlled chain-growth synthesis of mai
211 Herein,
we disclose the design and development of the first irid
212 Herein,
we disclose the design and evaluation of a low hydrogen
213 Here
we disclose the design and optimization of a series of h
214 Here,
we disclose the design and validation of a high-throughp
215 We disclose the design of a novel series of cyanoguanidi
216 Here
we disclose the design, synthesis, and evaluation of a f
217 Herein,
we disclose the design, synthesis, optimization, and ear
218 In this paper,
we disclose the detailed phenomenon of sublimation on th
219 Herein,
we disclose the development of a modular approach toward
220 Herein
we disclose the development of a nickel-catalyzed cross-
221 Herein,
we disclose the development of anionic N(1),N(2)-diarylb
222 Here,
we disclose the development of highly subunit-selective
223 Herein,
we disclose the direct introduction of methyl groups via
224 Here,
we disclose the discovery and characterization of potent
225 Herein,
we disclose the discovery and development of a site-, re
226 Here,
we disclose the discovery and in vitro characterization
227 Here,
we disclose the discovery and optimization of a 4-aminop
228 Herein,
we disclose the discovery and optimization of novel smal
229 Herein,
we disclose the discovery and preclinical characterizati
230 Herein,
we disclose the discovery and preclinical profile of LYS
231 Herein,
we disclose the discovery and preclinical profiling of t
232 Herein,
we disclose the discovery of 25, a potent and selective
233 Herein
we disclose the discovery of a new class of positive all
234 Here
we disclose the discovery of a series of chloro-nitro-ar
235 Herein,
we disclose the discovery of a spiro-indolinone series a
236 Here,
we disclose the discovery of a very potent and selective
237 Herein,
we disclose the discovery of the first benchmarking para
238 In addition,
we disclose the efficacy of 4a in a mouse EAE model, whi
239 Herein
we disclose the evolution of this chemotype to address t
240 Herein,
we disclose the exploitation of an unconventional bifurc
241 Here,
we disclose the finding of human mitochondrial TSPO as a
242 We disclose the first catalytic activation of carbohydra
243 Herein,
we disclose the first catalytic generation of alkyl-I((I
244 Herein
we disclose the first convergent synthesis of alpha-bran
245 Herein,
we disclose the first crystal structures of these insect
246 Herein,
we disclose the first example of stainless-steel-induced
247 Herein,
we disclose the first examples of the sigma-bond metathe
248 Here
we disclose the first high resolution cocrystal structur
249 Herein,
we disclose the first light-controlled, cobalt-catalyzed
250 Herein,
we disclose the first metal-free synthesis of primary ar
251 Herein,
we disclose the first photoinduced [3sigma + 2sigma] cyc
252 Herein,
we disclose the first report on Ru(II)-catalyzed amidati
253 We disclose the first small molecule histone deacetylase
254 Herein,
we disclose the first solution to the problem of ECA of
255 Herein,
we disclose the first total syntheses of three members,
256 Here
we disclose the first total synthesis and structural con
257 We disclose the first total synthesis of stachybotrin C,
258 Herein,
we disclose the first total synthesis of this highly str
259 Herein,
we disclose the first X-ray crystal structures of inhibi
260 In this, a full account,
we disclose the first- and now second-generation synthes
261 Here, for the first time,
we disclose the HER electrocatalytic behavior of seven M
262 Here
we disclose the importance of complementing linear dimen
263 Importantly,
we disclose the long-awaited structure of the AHR PAS-B
264 Herein,
we disclose the medicinal chemistry discovery and the ea
265 We disclose the pharmacological properties of the novel,
266 Furthermore,
we disclose the proinflammatory potential of NKG2C(brigh
267 We disclose the results of an investigation designed to
268 Herein
we disclose the results of our investigations regarding
269 Herein,
we disclose the Rh(III)-catalyzed selective C8-alkylatio
270 We disclose the role of miR-708-KPNA4-TNF axes in PCa me
271 Guided by mechanistic studies,
we disclose the selective trapping of formaldehyde by in
272 We disclose the source code of our simulation.
273 Herein,
we disclose the structure-guided design of a small molec
274 Herein,
we disclose the subsequent discovery of a yield-boosting
275 Herein,
we disclose the syntheses and reactivity of three Ntau-i
276 Herein
we disclose the synthesis and full characterization of t
277 We disclose the synthesis and structural characterizatio
278 Here,
we disclose the synthesis of a new modular macrocyclic l
279 In this paper
we disclose the synthesis of the model adducts N(6)-(1-p
280 Additionally,
we disclose the top reaction conditions for the most req
281 Herein
we disclose the use of cyclopropylmethyl boronates as ge
282 Herein,
we disclose the use of polysulfide anions as visible lig
283 Herein
we disclose the use of property and structure-based drug
284 In this article,
we disclose the various routes and strategies we had to
285 In this paper
we disclose the X-ray structure of a complex between cat
286 Recently,
we disclosed the discovery of Boceprevir, SCH 503034 (1)
287 Recently,
we disclosed the first highly Z-selective isomerization
288 Finally,
we disclosed the guide RNA repertoire encoded by mcDNA a
289 Previously,
we disclosed the role of Cav1.2 alpha1 in mouse and huma
290 Herein,
we disclosed the structure-activity relationships of a s
291 We disclosed therein a new reaction of reductive isomeri
292 We disclose these dynamics by investigating three symmet
293 Herein
we disclose three new methods for the straightforward an
294 Herein,
we disclose three structurally differentiated gamma-secr
295 Here,
we disclose two distinct chemical classes that inhibit S
296 Here
we disclose two new chemical scaffolds that inhibit Notu
297 Here,
we disclose two PET tracers containing three key design
298 We disclosed various 3'-UTR length variants of ABCC1, C2
299 Here
we disclose VH298, a potent VHL inhibitor that stabilize
300 Herein,
we disclose visible light-driven conditions to directly