1 We uncover 11 type I-F and/or I-E anti-CRISPR genes enco
2 ally ascertained rhegmatogenous RD patients,
we uncovered 11 genome-wide significant association sign
3 Using large-scale statistical tools,
we uncovered 13 distinct types of subjective experience
4 We uncover 14 mechanisms that can mediate the outcome of
5 We uncovered 17 genes from our ASD cohort in which CHD8,
6 Here,
we uncover 20-40 Ma of evolutionary history of a superge
7 Taken together,
we uncover a circadian kinome that potentially shapes th
8 Here,
we uncover a common liquid-liquid phase separation (LLPS
9 a patients with moderate-to-severe diseases,
we uncover a complex landscape of immunological pathways
10 In this study,
we uncover a conditional role for the endodermal and pul
11 Altogether,
we uncover a conserved mechanism of paternal epigenetic
12 We uncover a correlation between slower dynamics of wate
13 Altogether,
we uncover a critical role for ARID1A in maintaining lum
14 oral gene ablation in murine hair follicles,
we uncover a critical role for the transcription factors
15 Finally,
we uncover a cross-regulatory relationship between NOTCH
16 Altogether,
we uncover a deleterious role for Siglec-1 in TB-HIV-1 c
17 Here,
we uncover a direct connection from dorsal CA1 (dCA1) hi
18 hylogenetic patterning in population change,
we uncover a distinct taxonomic signal.
19 We uncover a dorsal raphe subpopulation with persistent
20 We uncover a duality where each TF is an inducer and rep
21 Here,
we uncover a dynamic translational mechanism that coordi
22 Here,
we uncover a function for ribosome collisions in signal
23 ng the understanding of endocytic recycling,
we uncover a fundamentally different function in which a
24 We uncover a general advance of breeding with a strong p
25 (STORM) for pathological tissue (PathSTORM),
we uncover a gradual decompaction and fragmentation of h
26 Here,
we uncover a hidden layer of Microprocessor regulation v
27 We uncover a large number of deregulated enhancers and a
28 Here,
we uncover a link between INM proteome identity and memb
29 Here,
we uncover a list of hyperacetylated proteins in the con
30 Here,
we uncover a mechanism by which budding yeast modulate v
31 Here,
we uncover a mechanism for how TPC1 regulates Ca(2+) hom
32 In the present work,
we uncover a mechanism mediating an increased SV cluster
33 Thus,
we uncover a mechanism of ORAI1 inactivation, and reveal
34 e development of a tissue-stretching device,
we uncover a mechanosensitive pathway that regulates tis
35 ation of biochemical and genomic approaches,
we uncover a molecular mechanism that regulates RNA edit
36 Here,
we uncover a network of RNA-binding proteins (RBPs) that
37 Furthermore,
we uncover a Nol9-encoded nucleolar localization sequenc
38 Altogether,
we uncover a nonredundant role for IFN-gamma and its dow
39 Overall,
we uncover a novel complementary mechanism by which LTB4
40 Here,
we uncover a novel feed-forward signalling circuit for c
41 oteomics data from Saccharomyces cerevisiae,
we uncover a novel group of proteins trafficking from th
42 Here,
we uncover a novel mechanism by which the human papillom
43 Thus
we uncover a novel relationship between FASN, RhoU and C
44 nputs onto these cells ex vivo Additionally,
we uncover a novel sex-dependent coexpression of Prkcd w
45 We uncover a phenomenon-crustal fingering-and demonstrat
46 Furthermore,
we uncover a potential new links between circRNA biogene
47 Unexpectedly,
we uncover a potentially generalizable activation site t
48 Here,
we uncover a range of conformational effects in full-len
49 een for genetic determinants of 2-OG levels,
we uncover a redox sensitive mitochondrial lipoylation p
50 study, while interrogating human databases,
we uncover a remarkable decrease in relapse-free surviva
51 cular dynamics simulations with experiments,
we uncover a remarkable sensitivity of the transcription
52 y engineered mouse models for breast cancer,
we uncover a role for cancer-cell-intrinsic p53 as a key
53 We uncover a role for non-classical monocytes in B-ALL s
54 , using purified recombinant human proteins,
we uncover a role for the dynein-binding protein LIS1 in
55 Here,
we uncover a signal processing mechanism involving multi
56 Here
we uncover a Slit-independent role of Robo in glial migr
57 Here,
we uncover a specialized circuit, from sensory neurons t
58 Using this ecologically derived framework,
we uncover a specific mechanism by which D2 dopamine rec
59 We uncover a specific requirement of CL for in vivo reco
60 We uncover a spectacular, extreme softening and reconstr
61 We uncover a striking phenomenon: memory associated with
62 We uncover a strong connection between the IC and the la
63 components including human TAPBPR variants,
we uncover a substantial contribution of the scoop loop
64 ing events from molecular simulations, here,
we uncover a systematic stepwise process driven by the a
65 We uncover a transient structure in GABAergic population
66 Using numerical modelling,
we uncover a universal principle underlying the influenc
67 t host and foreign cells (rabbit and yeast),
we uncovered a 2-fold discriminatory mechanism of FH in
68 Thus,
we uncovered a capacity for intensive, and specific, fee
69 tal regulation of TSS selection in zebrafish
we uncovered a class of dual-initiation promoters in tho
70 broadly mapping function to neuronal class,
we uncovered a clear transcriptomic logic responsible fo
71 ong the transcripts spared from degradation,
we uncovered a cluster of transcripts that systematicall
72 n vaccine-induced signatures across seasons,
we uncovered a common transcriptional signature 28 days
73 We uncovered a compensatory adaptation which causes glob
74 We uncovered a decrease in CAV1 protein abundance as wel
75 ncluding wildtype and 10 mutant strains, and
we uncovered a design principle that describes how archi
76 We uncovered a dimeric state of UBE2S that confers autoi
77 We uncovered a family of seven Kunitz-type (FhKT) inhibi
78 e cells, and ex vivo and in vivo rat models,
we uncovered a function of 14-3-3zeta.
79 Moreover,
we uncovered a mixed-lineage population of cells that ma
80 Here,
we uncovered a molecular dependence of TNBC tumors on th
81 In summary,
we uncovered a molecular interplay that enables massive
82 Through integrative analyses,
we uncovered a multitude of statistically significant an
83 We uncovered a network of RNA-RNA interactions spanning
84 We uncovered a new locus, Genetic Variants in leaf Senes
85 Recently,
we uncovered a non-canonical signalling mechanism for th
86 We uncovered a non-genetic, non-epigenetic, non-microbia
87 In this study,
we uncovered a novel fusion-modulatory role of a third s
88 We uncovered a novel interplay between AR and PBK that r
89 Finally,
we uncovered a novel role for PAR-6 in organizing non-ce
90 In this study,
we uncovered a novel role of a third helical region (HR3
91 In investigating how N88K impairs the NMJ,
we uncovered a novel signaling pathway by which Agrin-LR
92 Furthermore,
we uncovered a novel stress-specific cis-element in intr
93 Through GWAS,
we uncovered a number of genes previously not known to b
94 We uncovered a number of previously unknown positive and
95 Here,
we uncovered a pathway in which delta-catenin, a compone
96 We uncovered a pattern of collective sinusoidal oscillat
97 We uncovered a previously unappreciated role for mTRF1 i
98 Furthermore,
we uncovered a previously unknown "synthetic-sick" inter
99 Here
we uncovered a previously unrecognized communication rou
100 Consequently,
we uncovered a reversible pH-induced switch of the heme
101 We uncovered a rich variety of pseudokinases with notabl
102 Thus,
we uncovered a role for Notch in controlling core-2 O-gl
103 Using Drosophila,
we uncovered a role for the innate immune transcription
104 Importantly,
we uncovered a role for the phospholipase PLA2G6 (PNPLA9
105 We uncovered a role for Xinbeta in signaling via the Hip
106 Importantly,
we uncovered a second and important role for the EMC.
107 ge or selection for Bd resistance genes, but
we uncovered a set of candidate genes that warrant furth
108 rt circadian period of upf-1(prd-6) mutants,
we uncovered a strong influence of the Nonsense Mediated
109 d the other in Turkoman/Thoroughbred horses,
we uncovered a third haplogroup containing Iberian lines
110 We uncovered a whole-genome duplication that occurred in
111 Here,
we uncovered acr loci on plasmids and other conjugative
112 ium falciparum than previously postulated as
we uncovered active de novo biosynthesis and substantial
113 Thus,
we uncover an axis whereby CD34(+)PRLR(+) GMPs inhibit C
114 Moreover,
we uncover an early neural component in the delta band t
115 Thus,
we uncover an endocytic-based mechanism able to generate
116 We uncover an endogenous strategy of functional gene res
117 Here
we uncover an evolutionarily conserved mechanism by whic
118 We uncover an excitatory D(1)-mediated effect of dopamin
119 We uncover an extensive cross-regulatory network of SR p
120 We uncover an Fe-related spectral transition of Fe:MoS(2
121 Further,
we uncover an inverse power law behaviour of spectral me
122 Here,
we uncover an unconventional pathway that activates mTOR
123 In this article,
we uncover an unexpected causal relationship between Fox
124 Thus,
we uncover an unexpected mechanism by which N-linked gly
125 Here,
we uncover an unexpected role for PARG in coordinating t
126 We uncover an unexpected versatility in cytoskeletal for
127 ools and epistasis experiments in P. putida,
we uncovered an 'upstream' cascade of three consecutive
128 Here,
we uncovered an ATR- and CHK1-mediated transcriptional r
129 By analyzing epigenetic data
we uncovered an enhancer cluster with super enhancer cha
130 Using a spatial exploration assay,
we uncovered an experience-dependent increase in momenta
131 Despite the shared ancestry,
we uncovered an extreme heterogeneity across these speci
132 Here,
we uncovered an unexpected specific interaction of LOTUS
133 Moreover,
we uncover and characterize several resistance-breaking
134 ure directions to fill the gaps in knowledge
we uncovered and inspire further research.
135 pendent on mitotic Polo-like kinase 1, which
we uncover as a novel regulator of centriole elongation
136 Here
we uncover baseline blood transcriptional signatures pre
137 Using STAG,
we uncover bi-directional hybridization between and popu
138 osis, hypothyroidism, and genital anomalies,
we uncovered bi-allelic variants in UBR7.
139 Going further,
we uncover by both the magneto-optical Kerr effect and p
140 Second,
we uncover changes in cell fate caused by transcription
141 encing data from nearly 200,000 individuals,
we uncover clear evidence that natural selection optimiz
142 We uncover CNV associations with four major disease cate
143 We uncovered conserved, transcription-state-dependent ch
144 Herein
we uncover critical factors that influence the operation
145 We uncovered declines in aboveground carbon averaging 22
146 unit of system x(c)(-), xCT (xCT(-/-) mice),
we uncovered decreased neurotransmission at corticostria
147 We uncovered deficits in insulin secretion, partly due t
148 We uncovered deficits in insulin secretion, partly due t
149 Here,
we uncover developmental pluripotency associated 2 and 4
150 We uncover differences in resistance factors that strong
151 Further,
we uncover differential proteolysis rates for E2F8 at di
152 In this study,
we uncover distinct and novel functions for these kinase
153 We uncover distinct cellular and molecular mechanisms un
154 Moreover,
we uncover distinct exploration-exploitation pathways in
155 -cell proteomic and transcriptomic analyses,
we uncovered distinct features of both T cells and macro
156 We uncover dozens of kinase-disease associations spannin
157 We uncovered early-emerging flexibility and no privilege
158 We uncovered eight genes from Gloriosa superba for the b
159 We uncovered epidemiological patterns that highlight the
160 We uncover evidence for within-host recombination betwee
161 Furthermore,
we uncover evidence of parallel genetic evolution at som
162 reagents that react with the aldehyde group,
we uncovered evidence for abasic sites in nascent RNA, m
163 Here,
we uncover evolutionarily conserved rules of engagement
164 We uncover extensive genetic and metabolic diversity and
165 1,364 de novo metagenome-assembled genomes,
we uncover four distinct fundamental niche types.
166 ween genes in the major DNA repair pathways,
we uncovered functional relationships between individual
167 de from analysing the domain configurations,
we uncover fundamental intrinsic correlations between th
168 e distinct mRNA contexts in Escherichia coli
We uncovered generic principles governing the SD fitness
169 The mechanisms
we uncover have relevance to learning in the cerebellum,
170 ive to the inhibitors, but contrary to this,
we uncovered here that gefitinib and osimertinib increas
171 iments with Fe-replete and Fe-limited cells,
we uncover how soil Pseudomonas species reprogram their
172 We uncover how the impact of MDA campaigns is determined
173 We uncovered important functional properties of hypothal
174 We uncover inter-muscle divergence in the primary driver
175 We uncovered key deficits in FMRP-deficient cells demons
176 inding proteins with exon splicing profiles,
we uncovered likely causal variants underlying brain reg
177 We uncover local rules governing the identity of the top
178 We uncover many novel genes associated with PD but also
179 The mechanistic underpinnings
we uncover may shed light on the development of new trea
180 Consistent with this,
we uncovered MCL- and MINCLE-expressing cells in brain l
181 Here,
we uncover molecularly dissociable roles for nucleosome
182 We uncovered more than 3 million previously undescribed
183 We uncovered multiple CIC-DUX4 targets that negatively r
184 Overall,
we uncover new guidelines for effectively managing multi
185 In sum,
we uncover new pro- and anti-viral mechanisms of IFITM3,
186 Remarkably,
we uncover new sets of female gametophytic cell-specific
187 mouse models with unbiased-omic approaches,
we uncovered new target proteins, downstream pathways an
188 We uncovered new transcripts that share a differential e
189 in our sample of approximately 200 genomes,
we uncovered no fewer than 80 unique P-element insertion
190 reen designed to identify bile acid mimetics
we uncovered nonsteroidal small molecule scaffolds that
191 We uncover novel mechanisms by which alum impairs the to
192 ng newly predicted drug-target associations,
we uncover novel opportunities of drug repurposing that
193 In this study
we uncovered novel epigenetic associations with kidney f
194 We uncovered NTD residues in the loop between helices A1
195 Furthermore,
we uncover numerous known regulators of epithelial morph
196 ypic betaherpesvirus, human cytomegalovirus,
we uncover numerous uORFs and iORFs conserved across bet
197 Here,
we uncover O-glycosylation as a novel PTM present on mou
198 Thus,
we uncover one mechanism by which fat oxidation can be s
199 obesity loci, for both early and late onset,
we uncovered one completely novel locus in this trans-an
200 Surprisingly,
we uncovered only modest region-specific alterations in
201 Using this tool,
we uncovered partial segregation of inhibitory spontaneo
202 lex cognitive process provided by the model,
we uncovered perirhinal-hippocampal desynchronization in
203 Using structure-guided sequence analysis
we uncover previously uncharacterized CIF peptides conse
204 Here
we uncover pronounced sexual dimorphism in T(reg) cells
205 Finally,
we uncover relatively high levels of genetic diversity,
206 K and E4orf6 are degraded by the proteasome,
we uncovered RNA-binding proteins as high-confidence sub
207 Here,
we uncover sequence-specific changes in RNA splicing enf
208 We uncovered serological evidence of exposure to Hendra-
209 Here,
we uncover Sh2b1 in leptin receptor (LepR) neurons as a
210 We uncover shifts in the folding mechanism among ordered
211 Inspired by the findings,
we uncovered similar concentration-independent behavior
212 We uncover specific conductance combinations that work s
213 From a list of 22 mutations,
we uncovered structural features for all, including a cr
214 Here,
we uncover substantial differences in the GA transcripto
215 At the translational level,
we uncovered sustained down-regulation of a set of 5'-te
216 Taken together,
we uncover T cell-derived GM-CSF as a key inducer of the
217 We uncover that a primary function of Myc is to control
218 compound screening and combination analyses,
we uncover that acetylating mutp53(R158G) could render c
219 Moreover,
we uncover that all four oocyte-derived centrioles lose
220 Finally,
we uncover that CST complex inactivation exacerbates gen
221 Here,
we uncover that epidermis specific transcription factors
222 Here,
we uncover that fusing a DNA binding domain to the NPC b
223 In conclusion,
we uncover that glucose acutely up-regulates miR-199 fam
224 Using this,
we uncover that immune checkpoint therapy induces T foll
225 We uncover that miR-371-373 are highly expressed in naiv
226 Furthermore,
we uncover that mTOR pathway participates in MYC/NOTCH-m
227 In addition,
we uncover that mycobacteria resist antibiotic lethality
228 Further,
we uncover that NRF2 agonists 4-octyl-itaconate (4-OI) a
229 We uncover that NuMA directly interacts with DNA via evo
230 rd genetic screen in Caenorhabditis elegans,
we uncover that TALP-3, a homolog of the Joubert syndrom
231 We uncover that the crucial role of Prdm14 in PGC specif
232 Furthermore,
we uncover that this phenomenon is, at least in part, me
233 We uncover that this substrate selectivity is based on t
234 g a unique cellular CRISPR activation model,
we uncover that, in contrast to MYCN and MYCL, MYC repre
235 We uncovered that abnormal increases in chromatin bindin
236 We uncovered that CXXC5, although lacks a transcription
237 Last,
we uncovered that FXR suppresses MMP7 transcription by b
238 We uncovered that IL17 recruits neutrophils, triggers ne
239 Third,
we uncovered that insulin-like growth factor 1 (IGF1) is
240 p(rd6) mice, which develop PRC degeneration,
we uncovered that membrane-type frizzled-related protein
241 rol (N = 25; 21 male and 4 female) subjects,
we uncovered that miR-223, an exosome-secreted miRNA tha
242 We uncovered that monoallelic expression of CDK1(AF) is
243 We uncovered that pharmacological manipulation of L-type
244 Here,
we uncovered that telomerase reverse transcriptase null
245 Using iterative genome-wide screens,
we uncovered that the cell surface glycosphingolipid (GS
246 Finally,
we uncovered that the longest codon dwell times could be
247 In this work,
we uncovered that the N-terminal 21 amino acids (aa 19 t
248 well as using cell biology approaches, here
we uncovered that the T507K substitution alters both SHP
249 We uncovered that Theophylline's metabolism and eliminat
250 We uncovered that this regulation is mediated primarily
251 th CRISPR/Cas9-engineered isogenic controls,
we uncovered that TnT-R173W destabilizes molecular inter
252 In addition,
we uncovered that upon TTC17 knockdown, the polarized or
253 We uncovered that V3 INs are organized into early-born [
254 Here
we uncover the basis of AP site protection by SRAP domai
255 ge analyses of effective brain connectivity,
we uncover the brain networks differentiating neutral an
256 Here,
we uncover the essential role of a conserved EGF- and la
257 sing pan-cancer de novo transcript assembly,
we uncover the extent and complexity of ERE transcriptio
258 Here,
we uncover the factors that govern the low TOF in Fet3p,
259 Using this and other methods,
we uncover the first known examples of transient amplifi
260 Overall,
we uncover the functional importance for the restricted
261 via quantitative trait locus (QTL) mapping,
we uncover the genetic basis underlying distinct life cy
262 Here,
we uncover the genome-wide spectrum of intra- and inters
263 Using the zebrafish neural tube as a model,
we uncover the in vivo mechanisms allowing the generatio
264 Furthermore,
we uncover the involvement of GATAe in the maintenance o
265 aenorhabditis elegans model system, in which
we uncover the mechanisms that connect long-term fat oxi
266 d shell that they secrete and by each other,
we uncover the mechanistic basis for the interlocking pa
267 Here,
we uncover the molecular basis for transport in this wid
268 Here,
we uncover the molecular basis of specificity in Dpr-DIP
269 Here,
we uncover the molecular mechanism underlying zippering
270 We uncover the opposite roles by ARID1A to govern both e
271 ion of tungsten diselenide quantum emitters,
we uncover the possibility of realizing large-scale dete
272 l concentration of dihydroartemisinin (DHA),
we uncover the putative transporter Tmem14c whose disrup
273 In this study,
we uncover the role for the oxytocin-MCH signaling pathw
274 ll EMT datasets in cancer and embryogenesis,
we uncover the roles of ICS on adaptation, noise attenua
275 Finally,
we uncover the sex-dependent effects of mating on depres
276 Using an effective genetic algorithm,
we uncover the structure of a metastable Al(41)Sm(5) pha
277 with theoretical and computational modeling,
we uncover the underlying mechanical roles of a ubiquito
278 Here,
we uncover the unparalleled capability of liquid marbles
279 We uncovered the ATR-CHK1 pathway as essential for viabi
280 In this study,
we uncovered the central role of genetic dominance shapi
281 Using TBSV,
we uncovered the critical roles of Sac1 PI(4)P phosphata
282 Furthermore,
we uncovered the essential roles of the mechanosensory c
283 Here,
we uncovered the extensive regulatory and even opposing
284 nome assembly and re-sequencing 453 genomes,
we uncovered the genetic architecture of traits that hav
285 normal cilia formation in human fibroblasts,
we uncovered the leucine-zipper protein LUZP1 as an inte
286 In sum,
we uncovered the molecular mechanism of HuR regulating T
287 n beam imaging by time of flight (MIBI-TOF),
we uncovered the spatial organization of metabolic progr
288 We uncovered therapeutic genetic variation among eukaryo
289 ) across 2,778 tumor whole-genome sequences,
we uncovered three novel complex rearrangement phenomena
290 ell microscopy and microfluidics techniques,
we uncovered three previously overlooked features of thi
291 Thus,
we uncover transcriptional programs associated with CAR-
292 We uncovered translational control of transcripts encodi
293 Here,
we uncover tuning to subtle variations in frequency traj
294 Here,
we uncover two distinct mechanisms by which naturally oc
295 Using these predictions,
we uncovered two members of a new functional class of gl
296 Additionally,
we uncover unexpected differential distribution of disti
297 onal intercellular RNA exchange (CROSS-FIRE)
we uncover various genes involved in EV subtype biogenes
298 enotype to a pulmonary disease phenotype, as
we uncovered X4 viruses as potential agents in the patho
299 Thus,
we uncover ZBTB24 as a regulator of PARP1-dependent NHEJ
300 Furthermore,
we uncover ZNF202 and ZNF445 as additional KZNFs likely