1 To investigate the underlying mechanisms,
we undertook (
1) bioinformatic, functional genomic annot
2 We undertook 2 phase 1 studies assessing safety and immu
3 w of the DNA damage response in human cells,
we undertook 31 CRISPR-Cas9 screens against 27 genotoxic
4 We undertook 4 phases of formative research, comprising
5 Here
we undertake a direct high-speed atomic force microscopy
6 Here,
we undertake a first step in this direction by focussing
7 In adopting this position,
we undertake a focused review of animal physiology and h
8 Here,
we undertake a genome-wide association study (GWAS) of a
9 We undertake a large-scale characterization of sex diffe
10 In this study,
we undertake a nationwide analysis of urban water access
11 We undertake a novel analysis describing spatial pattern
12 Here,
we undertake a rigorous biophysical analysis which leads
13 We undertook a 10-year study on the effects of invasive
14 We undertook a 12-month prospective observational cohort
15 To test this hypothesis,
we undertook a 15-mo-long longitudinal entomological sur
16 We undertook a 2-center audit of coding accuracy across
17 We undertook a 2-year national surveillance study (the U
18 We undertook a birth cohort study with not only intensiv
19 We undertook a bootstrapping validation and estimated th
20 erted functions of its different cell types,
we undertook a cell type-specific transcriptome analysis
21 We undertook a cluster-randomised controlled trial in So
22 We undertook a cohort study of 13,786 adults with SMI di
23 To gain insight into this issue,
we undertook a comparative analysis of the eight major h
24 between nodule and lateral root development,
we undertook a comparative analysis of these two root de
25 Consequently,
we undertook a comparative study of metabolites in our t
26 specialized 3' end deep sequencing methods,
we undertook a comprehensive analysis of APA following i
27 We undertook a comprehensive analysis of the tumor micro
28 nderstand the evolution of these structures,
we undertook a comprehensive assessment of their occurre
29 anxiety and fear through modulation of KARs,
we undertook a comprehensive behavioral analysis of adul
30 We undertook a comprehensive clinical and biological inv
31 We undertook a comprehensive effort to block the interac
32 Here,
we undertook a comprehensive effort to define mechanisms
33 We undertook a comprehensive meta-analysis to quantify b
34 We undertook a comprehensive proteogenomic characterizat
35 We undertook a comprehensive retrospective study of 162
36 We undertook a comprehensive review of community empower
37 We undertook a comprehensive review of the published lit
38 ition in different regions of the same mRNA,
we undertook a comprehensive search for phylogenetically
39 We undertook a comprehensive, systematic assessment of r
40 s of interaction of PAX with the BK channel,
we undertook a computational analysis of the interaction
41 We undertook a critical review of the effect of moderate
42 We undertook a cross-sectional study among 6-23 months o
43 We undertook a cross-sectional study of elderly inhabita
44 We undertook a data-driven time-series analysis to exami
45 ed siblings, and unrelated control children,
we undertook a detailed analysis of proliferation, activ
46 Here
we undertook a detailed examination of both Xenopus and
47 and how their nervous systems have diverged,
we undertook a detailed examination of the neuroanatomy
48 We undertook a detailed investigation of the biological
49 We undertook a directed proteomic analysis of the comple
50 METHODS AND
We undertook a double-blind randomised controlled trial
51 We undertook a focused medicinal chemistry campaign to s
52 We undertook a genome-wide association study (GWAS) in 1
53 genetic variation and biology underlying AF,
we undertook a genome-wide association study (GWAS) of 6
54 We undertook a genome-wide association study of emotiona
55 In stage 1
we undertook a genome-wide association study of moderate
56 We undertook a genome-wide association study of SCAD (N(
57 igate the causes for brown and orange morphs
we undertook a genomics approach on corals collected at
58 Next,
we undertook a genotype-phenotype analysis of a large co
59 We undertook a global synthesis of the relationship betw
60 International Mouse Phenotyping Consortium,
we undertook a hearing loss screen in a cohort of 3006 m
61 We undertook a histology-independent phase 2 "basket" st
62 We undertook a large-scale approach at characterising mo
63 We undertook a longitudinal prospective study of 33 indi
64 Following our previous work,
we undertook a longitudinal study to examine the effects
65 We undertook a Mendelian randomization (MR) study to eva
66 as been shown to reverse this enterocolitis,
we undertook a Mendelian randomization study to test the
67 We undertook a Mendelian randomization study using data
68 We undertook a meta-analysis of genome-wide association
69 METHODS AND
We undertook a mixed methods investigation of reports of
70 We undertook a mixed-methods, situational analysis.
71 We undertook a multicenter clinical trial to determine t
72 We undertook a multicenter, randomized, controlled trial
73 We undertook a multidisciplinary framework-driven consen
74 We undertook a multifactorial analysis using the Cox pro
75 minimise redundancy and maximise discovery,
we undertook a multiplex screen of 80 apoptotic-inducing
76 We undertook a multiscale structural and functional inve
77 We undertook a multisite, randomized, placebo-controlled
78 We undertook a narrative synthesis of the data in each r
79 We undertook a nationwide follow-up study of a cohort of
80 Herein,
we undertook a pan-cancer analysis to identify actionabl
81 We undertook a phase 3 study to assess the efficacy and
82 We undertook a phase I double-blind, randomized placebo
83 Here,
we undertook a phase I/II pilot study of DES using a nov
84 We undertook a pilot case-control study to define the ex
85 Sunday June 15 and Wednesday June 18, 2014,
we undertook a point prevalence survey of hospital speci
86 We undertook a population-based analysis of the Swedish
87 We undertook a population-based cohort analysis, obtaini
88 ogy in France in the eculizumab era evolved,
we undertook a population-based cohort study that includ
89 We undertook a population-based, nested case-control stu
90 We undertook a post hoc analysis of 2 randomized clinica
91 on of the immune system to CDC pathogenesis,
we undertook a prospective multicentric exploratory stud
92 We undertook a prospective randomized controlled trial t
93 To explore the source of PlGF,
we undertook a prospective study enrolling normal pregna
94 From the United Kingdom TTP registry,
we undertook a prospective study investigating the impac
95 We undertook a prospective, matched cohort study of pati
96 We undertook a prospective, multicentre, single-arm, ope
97 activity of lactadherin sourced by equines,
we undertook a proteomic analysis of milk fat globule me
98 We undertook a qualitative study of staff caring for old
99 We undertook a quality improvement initiative with respe
100 We undertook a randomised trial testing the non-inferior
101 ety of primaquine regimens for radical cure,
we undertook a randomized controlled trial in Ethiopia.
102 We undertook a rapid systematic review and narrative syn
103 We undertook a re-analysis of the Canadian data from the
104 We undertook a retrospective analysis to evaluate whethe
105 We undertook a review of the literature to outline the c
106 We undertook a secondary analysis of data from the Promo
107 mine the Crs-mortality relationship.Methods:
We undertook a secondary analysis of patients with ARDS,
108 We undertook a secondary analysis of PROBIT (1996-2010),
109 In this study,
we undertook a sequential characterization of NK respons
110 We undertook a series of experiments to assess if ultra-
111 To test this,
we undertook a series of experiments to shed light on th
112 tive gene testing to at-risk family members,
we undertook a series of functional studies to character
113 attempt to better understand these problems,
we undertook a series of ground-based lidar measurements
114 and the etiology of the behavioral deficits,
we undertook a series of molecular studies in the dorsal
115 We undertook a single-center review of spinal injured ad
116 Using a luciferase reporter assay,
we undertook a small-molecule high-throughput screening
117 its contribution to copper resistance, here
we undertook a structural and biochemical characterizati
118 We undertook a study in healthy subjects, using the indu
119 is due to the predicted mechanism of action,
we undertook a study of OLIG2 dimerization using fluores
120 characterize AfSV diversity on this island,
we undertook a survey of a small agroecosystem using a n
121 ully understand the potential of this label,
we undertook a systematic and detailed analysis of the C
122 Here,
we undertook a systematic characterization of diverse ra
123 We undertook a systematic comparison of eTregs and iTreg
124 We undertook a systematic literature review to estimate
125 We undertook a systematic review (PROSPERO 2017 CRD42017
126 We undertook a systematic review (until October 2016) an
127 We undertook a systematic review and individual patient
128 We undertook a systematic review and meta-analysis asses
129 We undertook a systematic review and meta-analysis of ra
130 We undertook a systematic review and meta-analysis of st
131 We undertook a systematic review and meta-analysis to ev
132 We undertook a systematic review and meta-analysis, usin
133 We undertook a systematic review and meta-analysis.
134 We undertook a systematic review and mixed-effects meta-
135 We undertook a systematic review of primary research bas
136 We undertook a systematic review of the literature to es
137 We undertook a systematic review to assess SIT efficacy
138 We undertook a systematic review, which involved searchi
139 We undertook a systematic scoping review.
140 Here,
we undertook a systematic screen to uncover new RNA meth
141 We undertook a systematic study focused on the matricell
142 We undertook a systematic study of the effects of dietar
143 x cellular dynamics underlying this process,
we undertook a systematic, detailed analysis of pea (Pis
144 To gain insight into this
we undertook a systems biology approach, aiming to gener
145 We undertook a thematic analysis of the collected data,
146 We undertook a time-series analysis of data from the Hea
147 To understand SOX2 function,
we undertook a timed-deletion approach, revealing that e
148 lar mechanisms underpinning this phenomenon,
we undertook a transcriptional screen of salt stressed A
149 overall response to Marburg virus challenge,
we undertook a transcriptomic analysis of immune cells c
150 We undertook a transcriptomic characterization of primar
151 on is thought to contribute to AD pathology,
we undertook a triple-tracer small-animal PET study to a
152 Here,
we undertook a unique approach by deriving fibroblast su
153 ar basis of this exquisite fine specificity,
we undertook Ala substitution assays revealing that the
154 Here
we undertake an expansive phylogenetic analysis of swIAV
155 We undertake an information theoretic analysis of two st
156 amino acid composition of a socket and knob,
we undertake an investigation of the knob-socket constru
157 Here,
we undertake an unbiased, total genome screen for RNA tr
158 h evidence for viral crossover between taxa,
we undertook an additional examination of BQCV where 74
159 We undertook an analysis of all major channel systems on
160 We undertook an analysis of discarded kidneys to determi
161 ion by this post-translational modification,
we undertook an analysis of the X. laevis phosphoproteom
162 We undertook an ecological study of ASP in Scotland to d
163 We undertook an economic modelling study from the patien
164 We undertook an epidemiological and phylogenetic analysi
165 We undertook an exhaustive literature review to design a
166 d its lack of effective therapeutic targets,
we undertook an extensive analysis of human RCC tissue e
167 We undertook an extensive analysis of the PDAC transcrip
168 We undertook an extensive computational analysis using a
169 We undertook an extensive spectroscopic analysis of the
170 To address this,
we undertook an extensive survey of multiple vegetation
171 istant to SIV infection than RM macrophages,
we undertook an in vitro comparative assessment of monoc
172 To define the mechanism of action,
we undertook an in vivo chemical suppressor screen for r
173 lar activity and their evolutionary history,
we undertook an in-depth analysis of Vasohibin sequences
174 Here
we undertook an in-depth bioinformatical analysis of sep
175 Here
we undertook an in-depth study of alkylphenol-based anes
176 We undertook an independent and orthogonal analysis of c
177 To address this,
we undertook an individual patient data meta-analysis of
178 Here,
we undertook an integrated analysis of their functions i
179 We undertook an integrated genetic approach to discover
180 the complex genetics underlying aggression,
we undertook an integrated, cross-species approach.
181 lecular features associated with EMT states,
we undertook an integrative approach combining mRNA, miR
182 Here,
we undertook an integrative phenotypic, molecular, and g
183 To better understand these mechanisms,
we undertook an intracellular analysis of the developmen
184 We undertook an open-label, dose-finding, standard 3+3 d
185 We undertook an unbiased discovery approach to identify
186 We undertook an untargeted metabolomics approach to disc
187 We undertake both selective sweep analyses and genome wi
188 e mutations in high-risk neuroblastoma (NB),
we undertook chromatin-focused small interfering RNA and
189 pmental context of C. elegans embryogenesis,
we undertook chromosome tracing to map the trajectories
190 nism(s) at the schizophrenia locus in 11q25,
we undertook cis expression quantitative trait loci (cis
191 For this analysis,
we undertook cluster random household surveys in Dhaka,
192 xpression at the post-transcriptional level,
we undertook complementary computational, comparative ge
193 We undertook comprehensive analyses addressing risk fact
194 tolerant European ash (Fraxinus excelsior),
we undertook comprehensive screening of secoiridoid glyc
195 We undertook country case studies in Papua New Guinea, U
196 We undertook cross-sectional analyses of 618 men and wom
197 Here,
we undertook cross-sectional surveillance for tuberculos
198 identify novel MTC/CCH predisposition genes
we undertook exome resequencing studies in a family with
199 We undertook exome sequencing in three unrelated familie
200 We undertake extensive simulations to identify which alg
201 We undertook extensive biochemical characterization of A
202 In August 2018,
we undertook fieldwork at LAM to sample the peat bog 30
203 METHODS AND
We undertook four country case studies in Lesotho, Mozam
204 y systemic interleukin-1beta administration,
we undertake gene network analysis of the microglial tra
205 Here,
we undertook gene profiling studies to identify chemokin
206 Here,
we undertake genome-wide association studies (GWAS) and
207 We undertake genome-wide association studies in females
208 We undertook genome sequencing and annotation, gene expr
209 We undertook genome-wide association analysis of data co
210 underlying growth promotion by LRH-1 in CRC,
we undertook global expression profiling following siRNA
211 emonstration of the software's capabilities,
we undertook ITC experiments to determine the respective
212 We undertook large-scale human genetic analyses to addre
213 We undertook logistic regression using data from the UK
214 Finally,
we undertook mechanistic experiments, demonstrating that
215 We undertook meta-analyses to derive pooled estimates of
216 We undertook meta-analyses to derive pooled estimates of
217 We undertook meta-analyses whenever values of inflammato
218 We undertook model development with data from the Nation
219 Subsequently,
we undertook moloc analyses to assess whether IMD trait,
220 We undertook morphological and functional studies to ass
221 We undertook mutation screening in 473 cases.
222 Here
we undertake native RNA sequencing of polyA + RNA from t
223 Here,
we undertook phosphoproteomic analyses to identify and q
224 Here,
we undertake physiological, structural and biochemical a
225 ue to central nervous system inaccessibility
we undertook quantification of phosphatidylethanolamine
226 ical or radiographic records were preserved,
we undertook radiographic examination of the skeletons o
227 We undertook replicate phase 3 studies to assess the eff
228 gen) from gestational day (GD) 14.5 to 18.5,
we undertook RNA sequencing from GD19 placentas.
229 We undertook Scotland-wide record linkage of education (
230 We undertook semi-structured interviews by telephone wit
231 ifferences among groups in assay approaches,
we undertook side-by-side testing of published methods o
232 We undertook simulations to reveal the conditions (i.e.
233 lar subsystems of successive cortical areas,
we undertook simultaneous optical imaging of intrinsic s
234 We undertook single amino acid C and N isotope analysis
235 physicochemical properties of the chemotype,
we undertook structure based molecular design to identif
236 ntify novel dual TLR7/TLR8-active compounds,
we undertook structure-activity relationship studies in
237 ECAM-1-PECAM-1 homophilic-binding interface,
we undertook studies aimed at determining the crystal st
238 We undertook such a study.
239 the development of clinical recommendations,
we undertook systematic reviews to critically assess evi
240 We undertook systematic searching to identify qualitativ
241 Here
we undertake the first analysis of Caribbean spiny lobst
242 Here
we undertake the largest canine genome-wide association
243 In the present study,
we undertake the rigorous characterization of the proton
244 GF) in deceased donor renal transplantation,
we undertook the efficacy of mirococept (APT070) for pre
245 In this report,
we undertook the epidemiological and molecular character
246 We undertook the first comprehensive analysis on the tox
247 hese prodrugs in relation to their efficacy,
we undertook the first pharmacokinetic studies on these
248 We undertook the first population genomic investigation
249 We undertook the first population receptive field functi
250 We undertook the first randomized controlled trial of th
251 We undertook the first systematic review and meta-analys
252 We undertook the generation of Pf1 knockout mice to eluc
253 We undertook the largest genome-wide association study o
254 We undertook the largest genotype association study, to
255 We undertook the largest GWAS to date in individuals wit
256 We undertook the metabolome profiling of a large cohort
257 We undertook the placebo-controlled, randomised, double-
258 We undertook the present studies to search for potential
259 We undertook the present study to determine whether the
260 We undertook the SearchLyte trial programme to examine t
261 to identify additional informative markers,
we undertook the sequencing and analysis of the mitogeno
262 We undertook the Simplified Antibiotic Therapy Trial (SA
263 eron may be a factor in poor T-cell priming,
we undertook therapeutic vaccination in two chronically
264 We undertook this multicentre, open-label, randomised co
265 We undertook this phase 3, double-blind, placebo-control
266 We undertook this prospective cohort study at 22 public
267 We undertook this prospective cohort study to determine
268 We undertook this randomised, double-blind, efficacy, im
269 We undertook this randomised, double-blind, placebo-cont
270 We undertook this study at two hospitals in Zhejiang and
271 We undertook this study to compare the metabolic signatu
272 We undertook this study to determine whether the low-inc
273 We undertook this study to evaluate if, among patients u
274 We undertook this study to identify novel biomarkers in
275 We undertook this study to investigate the localisation
276 ental factors that lead to cuSCC initiation,
we undertook this study to test whether more acute molec
277 To address the growing Zika virus epidemic,
we undertook this study with two first, to develop a saf
278 We undertook three country case studies in Papua New Gui
279 es across field and greenhouse environments,
we undertook three independent experiments using the swi
280 Therefore,
we undertook to determine the costs, inpatient days, and
281 We undertook to determine the safety and efficacy of gas
282 Here,
we undertook to determine whether the secretase machiner
283 ncer resistance of the naked mole-rat (NMR),
we undertook to explore the structural and soft matter p
284 er the entire course of the healing process,
we undertook to identify strategies that would allow sel
285 n the signaling adaptor p66Shc in CLL cells,
we undertook to identify unique phenotypic traits caused
286 Therefore,
we undertook,
to the best of our knowledge, the first sy
287 , CDKN2A-B, IGF2BP2 and KCNQ1) are mediated,
we undertook transancestral fine-mapping in 22 086 cases
288 e insights into IPSE's protective mechanism,
we undertook transcriptional profiling of bladders from
289 thways involved in motor neuron dysfunction,
we undertook transcriptomic profiling of primary embryon
290 We undertook translatome analysis of CD8 T-cell activati
291 We undertook tumor typing to classify MMR defects to det
292 We undertook two parallel, pragmatic cluster-randomised
293 We undertook urinary drug tests and behavioural intervie
294 en the exploratory nature of the comparisons
we undertook;
we minimised this by lowering our signific
295 We undertook weighted burden analysis of whole-exome seq
296 gain insight into the underlying mechanisms,
we undertake whole exome sequencing and copy number anal
297 We undertook whole genome sequencing of E. faecalis asso
298 We undertook whole-genome sequencing (WGS) of 495 E. fae
299 We undertook whole-genome sequencing (WGS) of 660 pneumo
300 We undertook within-family association analysis after im